Vitamin E Supplements Increase Prostate Cancer Risk
D'OH! DHA Supplements Don't Reduce Alzheimer's Risks
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She shares her unique scientific perspective on health and enthusiasm for delicious foods at her website Summer Tomato. Follow her on Twitter @summertomato.","avatar":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Darya Pino | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/darya-pino"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_25915":{"type":"posts","id":"quest_25915","meta":{"index":"posts_1591205157","site":"quest","id":"25915","score":null,"sort":[1318597206000]},"guestAuthors":[],"slug":"vitamin-e-supplements-increase-prostate-cancer-risk","title":"Vitamin E Supplements Increase Prostate Cancer Risk ","publishDate":1318597206,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/10/vitamin-E.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/10/vitamin-E-253x169.jpg\" alt=\"\" title=\"vitamin E\" width=\"253\" height=\"169\" class=\"size-thumbnail wp-image-25917\">\u003c/a>\u003c/p>\n\u003cp>A clinical trial testing the effects of vitamin E and selenium supplementation on prostate cancer shows a statistically significant increase in cancer risk with vitamin E supplementation, according to the latest analysis.\u003c/p>\n\u003cp>The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was started in 2001 with \u003ca href=\"http://www.cancer.gov/newscenter/pressreleases/2001/select\">much enthusiasm\u003c/a> and was funded by the National Cancer Institute. Two previous cancer trials (for other forms of the disease) had suggested that people who supplemented with vitamin E and selenium had reduced risk of prostate cancer. This was the first trial designed to specifically test the benefits of these nutrients on prostate cancer, either alone or when administered together.\u003c/p>\n\u003cp>There were four conditions in the trial. In one condition participants were given a pill of 400 IU of vitamin E (oil based capsules) and another pill of 200 mg selenium (pressed tablets) to take daily. In another condition men were given the vitamin E pill and a placebo pill that looked like selenium. In the third condition participants were given the real selenium pill and a placebo that looked like vitamin E. And in the final condition both pills were placebo.\u003c/p>\n\u003cp>Researchers hoped they could achieve a 25% reduction in prostate cancer risk with vitamin E or selenium, but in 2008 researchers detected slightly more prostate cancer in men who were taking the vitamin E supplement alone. Though at that time the increase was not significant, the Data and Safety Monitoring Committee terminated the trial since it was obvious that the 25% reduction would not be met.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The latest analysis included 18 months of follow-up on those who had participated in the trial. The new data showed that men who were taking the vitamin E supplement had a 17% increase in prostate cancer risk compared to those taking placebo, and the increase has reached statistical significance. Men taking selenium alone or vitamin E and selenium together also had higher incidence of prostate cancer, though the results did not achieve statistical significance and could be due to chance.\u003c/p>\n\u003cp>Importantly, the vitamin E dosage of the SELECT trial was particularly high at 400 IU. The current US \u003ca href=\"http://ods.od.nih.gov/factsheets/vitamine\">Recommended Daily Allowance (RDA) for vitamin E\u003c/a> is only 22.4 IU, and the previous trial that showed a benefit of vitamin E for prostate cancer risk used only 50 IU. A typical multivitamin has closer to 30 IU of vitamin E, though vitamin E only supplements can often contain more than 100 IU. \u003c/p>\n\u003cp>Based on the current findings, vitamin E only supplements would not be recommended, particularly for men.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Click here for more info on the \u003ca href=\"http://www.cancer.gov/newscenter/qa/2008/selectqa\">SELECT trial\u003c/a>.\u003c/p>\n\n","blocks":[],"excerpt":"400 IU of vitamin E daily increases risk of prostate cancer by 17%.","status":"publish","parent":0,"modified":1325109108,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":11,"wordCount":434},"headData":{"title":"Vitamin E Supplements Increase Prostate Cancer Risk | KQED","description":"400 IU of vitamin E daily increases risk of prostate cancer by 17%.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Vitamin E Supplements Increase Prostate Cancer Risk ","datePublished":"2011-10-14T13:00:06.000Z","dateModified":"2011-12-28T21:51:48.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"25915 http://science.kqed.org/quest/?p=25915","disqusUrl":"https://ww2.kqed.org/quest/2011/10/14/vitamin-e-supplements-increase-prostate-cancer-risk/","disqusTitle":"Vitamin E Supplements Increase Prostate Cancer Risk ","path":"/quest/25915/vitamin-e-supplements-increase-prostate-cancer-risk","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/10/vitamin-E.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/10/vitamin-E-253x169.jpg\" alt=\"\" title=\"vitamin E\" width=\"253\" height=\"169\" class=\"size-thumbnail wp-image-25917\">\u003c/a>\u003c/p>\n\u003cp>A clinical trial testing the effects of vitamin E and selenium supplementation on prostate cancer shows a statistically significant increase in cancer risk with vitamin E supplementation, according to the latest analysis.\u003c/p>\n\u003cp>The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was started in 2001 with \u003ca href=\"http://www.cancer.gov/newscenter/pressreleases/2001/select\">much enthusiasm\u003c/a> and was funded by the National Cancer Institute. Two previous cancer trials (for other forms of the disease) had suggested that people who supplemented with vitamin E and selenium had reduced risk of prostate cancer. This was the first trial designed to specifically test the benefits of these nutrients on prostate cancer, either alone or when administered together.\u003c/p>\n\u003cp>There were four conditions in the trial. In one condition participants were given a pill of 400 IU of vitamin E (oil based capsules) and another pill of 200 mg selenium (pressed tablets) to take daily. In another condition men were given the vitamin E pill and a placebo pill that looked like selenium. In the third condition participants were given the real selenium pill and a placebo that looked like vitamin E. And in the final condition both pills were placebo.\u003c/p>\n\u003cp>Researchers hoped they could achieve a 25% reduction in prostate cancer risk with vitamin E or selenium, but in 2008 researchers detected slightly more prostate cancer in men who were taking the vitamin E supplement alone. Though at that time the increase was not significant, the Data and Safety Monitoring Committee terminated the trial since it was obvious that the 25% reduction would not be met.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The latest analysis included 18 months of follow-up on those who had participated in the trial. The new data showed that men who were taking the vitamin E supplement had a 17% increase in prostate cancer risk compared to those taking placebo, and the increase has reached statistical significance. Men taking selenium alone or vitamin E and selenium together also had higher incidence of prostate cancer, though the results did not achieve statistical significance and could be due to chance.\u003c/p>\n\u003cp>Importantly, the vitamin E dosage of the SELECT trial was particularly high at 400 IU. The current US \u003ca href=\"http://ods.od.nih.gov/factsheets/vitamine\">Recommended Daily Allowance (RDA) for vitamin E\u003c/a> is only 22.4 IU, and the previous trial that showed a benefit of vitamin E for prostate cancer risk used only 50 IU. A typical multivitamin has closer to 30 IU of vitamin E, though vitamin E only supplements can often contain more than 100 IU. \u003c/p>\n\u003cp>Based on the current findings, vitamin E only supplements would not be recommended, particularly for men.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Click here for more info on the \u003ca href=\"http://www.cancer.gov/newscenter/qa/2008/selectqa\">SELECT trial\u003c/a>.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/25915/vitamin-e-supplements-increase-prostate-cancer-risk","authors":["10218"],"categories":["quest_12"],"tags":["quest_10273","quest_13202","quest_10274","quest_2839","quest_10272"],"featImg":"quest_25917","label":"quest"},"quest_11083":{"type":"posts","id":"quest_11083","meta":{"index":"posts_1591205157","site":"quest","id":"11083","score":null,"sort":[1292007667000]},"guestAuthors":[],"slug":"doh-dha-supplements-dont-reduce-alzheimers-risks","title":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks","publishDate":1292007667,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/old-woman1.jpg\" alt=\"\">\u003cem>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/outcast104/1428795376/\">outcast104\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.\u003c/p>\n\u003cp>\u003ca href=\"http://en.wikipedia.org/wiki/Docosahexaenoic_acid\">DHA\u003c/a> (or docosahexaenoic acid for the geekier among you) is an omega-3 fatty acid that is abundant in the brain. Epidemiological studies have suggested that people who consume more DHA from fish have a lower incidence of Alzheimer's disease. Further, DHA supplementation has improved markers of cognitive impairment in mouse models of Alzheimer's disease.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Scientists speculated that DHA supplementation may be beneficial in treating cognitive decline because previous research has suggested that among all omega-3 fatty acids, DHA was the only one associated with a reduced incidence of impairment. Also, the other major omega-3 fatty acid found in fish, eicosapentaenoic acid (EPA), is not present in the human brain, whereas DHA is abundant.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The study, published in \u003cem>\u003ca href=\"http://jama.ama-assn.org/content/304/17/1903.short?rss=1&;ssource=mfc\">JAMA\u003c/a>\u003c/em>, was a collaborative effort by scientists from the Oregon Health and Science University, UC San Diego, Yale, UC San Francisco, NYU and others. It was a randomized, double-blind, placebo-controlled trial of DHA supplementation in patients with mild to moderate Alzheimer's disease.\u003c/p>\n\u003cp>The researchers found no benefit of 2 g/day DHA supplementation on cognitive performance on the Alzheimer's Disease Assessment Scale (ADAS) or Clinical Dementia Rating (CDR) compared to placebo. There was also no measurable benefit of DHA on brain volume, which typically declines with Alzheimer's progression.\u003c/p>\n\u003cp>Though this research does not rule out a benefit of DHA on cognitive health, it does not bode well for regular supplementation. The treatment lasted for 18 months and cognitive changes were detected in both groups. So if DHA had any effect on the rate of cognitive decline it should have been apparent.\u003c/p>\n\u003cp>It is possible that beginning DHA treatment after early signs of Alzheimer's have already been detected is too late for any meaningful protection offered by DHA. Maybe some benefit would have been found if the treatment began in healthy adults before symptoms of cognitive decline developed.\u003c/p>\n\u003cp>It may also be that DHA is beneficial, but is not effective in supplement form. DHA is very vulnerable to oxidative damage, and some research has shown that it provides more cognitive benefit when co-administered with an antioxidant (lutein) to protect it. DHA ingested in the form of food (fish) would not be subject to the same level of oxidative degradation, which may explain the results seen in epidemiological data.\u003c/p>\n\u003cp>It is not uncommon for supplements to fail to replicate epidemiological benefits seem from foods, and more careful studies are needed to determine the nutritional benefit, if any, of DHA on cognitive aging.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n","blocks":[],"excerpt":"Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.","status":"publish","parent":0,"modified":1292007667,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":14,"wordCount":461},"headData":{"title":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks | KQED","description":"Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks","datePublished":"2010-12-10T19:01:07.000Z","dateModified":"2010-12-10T19:01:07.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"11083 http://www.kqed.org/quest/blog/?p=11083","disqusUrl":"https://ww2.kqed.org/quest/2010/12/10/doh-dha-supplements-dont-reduce-alzheimers-risks/","disqusTitle":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks","path":"/quest/11083/doh-dha-supplements-dont-reduce-alzheimers-risks","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/old-woman1.jpg\" alt=\"\">\u003cem>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/outcast104/1428795376/\">outcast104\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.\u003c/p>\n\u003cp>\u003ca href=\"http://en.wikipedia.org/wiki/Docosahexaenoic_acid\">DHA\u003c/a> (or docosahexaenoic acid for the geekier among you) is an omega-3 fatty acid that is abundant in the brain. Epidemiological studies have suggested that people who consume more DHA from fish have a lower incidence of Alzheimer's disease. Further, DHA supplementation has improved markers of cognitive impairment in mouse models of Alzheimer's disease.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Scientists speculated that DHA supplementation may be beneficial in treating cognitive decline because previous research has suggested that among all omega-3 fatty acids, DHA was the only one associated with a reduced incidence of impairment. Also, the other major omega-3 fatty acid found in fish, eicosapentaenoic acid (EPA), is not present in the human brain, whereas DHA is abundant.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The study, published in \u003cem>\u003ca href=\"http://jama.ama-assn.org/content/304/17/1903.short?rss=1&;ssource=mfc\">JAMA\u003c/a>\u003c/em>, was a collaborative effort by scientists from the Oregon Health and Science University, UC San Diego, Yale, UC San Francisco, NYU and others. It was a randomized, double-blind, placebo-controlled trial of DHA supplementation in patients with mild to moderate Alzheimer's disease.\u003c/p>\n\u003cp>The researchers found no benefit of 2 g/day DHA supplementation on cognitive performance on the Alzheimer's Disease Assessment Scale (ADAS) or Clinical Dementia Rating (CDR) compared to placebo. There was also no measurable benefit of DHA on brain volume, which typically declines with Alzheimer's progression.\u003c/p>\n\u003cp>Though this research does not rule out a benefit of DHA on cognitive health, it does not bode well for regular supplementation. The treatment lasted for 18 months and cognitive changes were detected in both groups. So if DHA had any effect on the rate of cognitive decline it should have been apparent.\u003c/p>\n\u003cp>It is possible that beginning DHA treatment after early signs of Alzheimer's have already been detected is too late for any meaningful protection offered by DHA. Maybe some benefit would have been found if the treatment began in healthy adults before symptoms of cognitive decline developed.\u003c/p>\n\u003cp>It may also be that DHA is beneficial, but is not effective in supplement form. DHA is very vulnerable to oxidative damage, and some research has shown that it provides more cognitive benefit when co-administered with an antioxidant (lutein) to protect it. DHA ingested in the form of food (fish) would not be subject to the same level of oxidative degradation, which may explain the results seen in epidemiological data.\u003c/p>\n\u003cp>It is not uncommon for supplements to fail to replicate epidemiological benefits seem from foods, and more careful studies are needed to determine the nutritional benefit, if any, of DHA on cognitive aging.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/11083/doh-dha-supplements-dont-reduce-alzheimers-risks","authors":["10218"],"categories":["quest_12"],"tags":["quest_83","quest_135","quest_645","quest_820","quest_1009","quest_1079","quest_2022","quest_2065","quest_2839"],"featImg":"quest_11174","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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