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Barry Starr","firstName":"Dr. Barry","lastName":"Starr","slug":"dr-barry-starr","email":"bstarr@thetech.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Dr. Barry Starr (\u003ca href=\"https://twitter.com/geneticsboy\">@geneticsboy\u003c/a>) is a Geneticist-in-Residence at The Tech Museum of Innovation in San Jose, CA and runs their Stanford at The Tech program. The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | 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FM","link":"/"}},"quest_23256":{"type":"posts","id":"quest_23256","meta":{"index":"posts_1591205157","site":"quest","id":"23256","score":null,"sort":[1314633398000]},"guestAuthors":[],"slug":"how-neanderthal-are-you","title":"How Neanderthal are You?","publishDate":1314633398,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_23286\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2011/08/29/how-neanderthal-are-you/percneanderthal/\" rel=\"attachment wp-att-23286\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/PercNeanderthal.jpg\" alt=\"\" title=\"PercNeanderthal\" width=\"640\" height=\"360\" class=\"size-full wp-image-23286\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/08/PercNeanderthal.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2011/08/PercNeanderthal-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">These results from the \"Interpretome\" tool show that there is a bit of a Neanderthal in me.\u003c/figcaption>\u003c/figure>\n\u003cp>Asking someone if they were a Neanderthal used to be an insult but is now kind of a valid question. If you have any Europeans, Asians or Native Americans in your family tree, odds are there is a \u003ca href=\"http://ww2.kqed.org/quest/2010/05/24/my-3000th-great-grandpa-was-a-neanderthal/\">bit of Neanderthal\u003c/a> in there as well.\u003c/p>\n\u003cp>As one of the whitest people on the planet, I almost certainly have mostly European ancestors. And if I had any doubts, my 23andMe ancestry results confirm the obvious…I am European through and through.\u003c/p>\n\u003cp>This means there is almost certainly some Neanderthal DNA squirreled away in my genome. But how much? I decided to try to find out.\u003c/p>\n\u003cp>First I asked \u003ca href=\"https://www.23andme.com/\">23andMe\u003c/a>. They quickly replied that they didn’t do that, sorry. So as often happens, I needed to take my genome on a jaunt through the internet to find a tool that could give me the answer I was looking for.\u003c/p>\n\u003cp>I first went to my favorite, \u003ca href=\"http://www.snpedia.com/index.php/SNPedia\">SNPedia\u003c/a>. No luck though. Just a piece about the \u003ca href=\"http://www.thetech.org/genetics/news.php?id=67\">Neanderthal red hair version of the MC1R gene\u003c/a> that hasn’t yet been found in humans. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Then I remembered a discussion at Stanford about which professor was genetically the most Neanderthal. Obviously they must have a way of figuring this out. \u003c/p>\n\u003cp>So I contacted Dr. Mike Snyder and he led me to Konrad Karczewski, a graduate student at Stanford. And he directed me to a tool called the \u003ca href=\"http://esquilax.stanford.edu/#start\">Interpretome \u003c/a>that he and some other Stanford folks had developed for their \u003ca href=\"http://stanford.edu/class/gene210/web/html/welcome.html\">personalized medicine class\u003c/a>.\u003c/p>\n\u003cp>This tool has a lot of cool features (feel free to explore) but I headed straight for the Neanderthal section. I plugged in my 23andMe raw data and out popped my results. There are definitely some Neanderthals in my family tree!\u003c/p>\n\u003cp>The site looks at 42 different markers and since we have two copies of each, there are 84 possible Neanderthal hits. I scored a 7 out of 84.\u003c/p>\n\u003cp>Now, since I don’t know if that is a lot, I asked Konrad about the kinds of ranges he sees. He said the average European has a score of around 7-10 which puts me at the lower end of average. He also said that someone in an online forum had reported a 26 but the highest Konrad had ever seen with his own eyes was 20. And that the lowest he has seen for Europeans or Asians was around 3-5.\u003c/p>\n\u003cp>So there you have it. I am on the low end of Neanderthalness for someone of European descent using these 42 \u003ca href=\"https://www.23andme.com/gen101/snps/\">SNPs\u003c/a>. And less Neanderthal than a number of Stanford professors!\u003c/p>\n\u003cp>How cool are genetics when it lets me figure out that I am definitely a bit Neanderthal but not as Neanderthal as certain unnamed Stanford professors? \u003c/p>\n\u003cp>\u003cstrong>More Information\u003c/strong>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/news.php?id=128\">Neanderthals and you.\u003c/a>\u003c/p>\n\n","blocks":[],"excerpt":"Graduate students at Stanford have created a tool called the Interpretome that lets you plug in your genome so you can figure out how Neanderthal you are.","status":"publish","parent":0,"modified":1314731355,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":483},"headData":{"title":"How Neanderthal are You? | KQED","description":"Graduate students at Stanford have created a tool called the Interpretome that lets you plug in your genome so you can figure out how Neanderthal you are.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"How Neanderthal are You?","datePublished":"2011-08-29T15:56:38.000Z","dateModified":"2011-08-30T19:09:15.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"23256 http://science.kqed.org/quest/?p=23256","disqusUrl":"https://ww2.kqed.org/quest/2011/08/29/how-neanderthal-are-you/","disqusTitle":"How Neanderthal are You?","path":"/quest/23256/how-neanderthal-are-you","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_23286\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2011/08/29/how-neanderthal-are-you/percneanderthal/\" rel=\"attachment wp-att-23286\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/PercNeanderthal.jpg\" alt=\"\" title=\"PercNeanderthal\" width=\"640\" height=\"360\" class=\"size-full wp-image-23286\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/08/PercNeanderthal.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2011/08/PercNeanderthal-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">These results from the \"Interpretome\" tool show that there is a bit of a Neanderthal in me.\u003c/figcaption>\u003c/figure>\n\u003cp>Asking someone if they were a Neanderthal used to be an insult but is now kind of a valid question. If you have any Europeans, Asians or Native Americans in your family tree, odds are there is a \u003ca href=\"http://ww2.kqed.org/quest/2010/05/24/my-3000th-great-grandpa-was-a-neanderthal/\">bit of Neanderthal\u003c/a> in there as well.\u003c/p>\n\u003cp>As one of the whitest people on the planet, I almost certainly have mostly European ancestors. And if I had any doubts, my 23andMe ancestry results confirm the obvious…I am European through and through.\u003c/p>\n\u003cp>This means there is almost certainly some Neanderthal DNA squirreled away in my genome. But how much? I decided to try to find out.\u003c/p>\n\u003cp>First I asked \u003ca href=\"https://www.23andme.com/\">23andMe\u003c/a>. They quickly replied that they didn’t do that, sorry. So as often happens, I needed to take my genome on a jaunt through the internet to find a tool that could give me the answer I was looking for.\u003c/p>\n\u003cp>I first went to my favorite, \u003ca href=\"http://www.snpedia.com/index.php/SNPedia\">SNPedia\u003c/a>. No luck though. Just a piece about the \u003ca href=\"http://www.thetech.org/genetics/news.php?id=67\">Neanderthal red hair version of the MC1R gene\u003c/a> that hasn’t yet been found in humans. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Then I remembered a discussion at Stanford about which professor was genetically the most Neanderthal. Obviously they must have a way of figuring this out. \u003c/p>\n\u003cp>So I contacted Dr. Mike Snyder and he led me to Konrad Karczewski, a graduate student at Stanford. And he directed me to a tool called the \u003ca href=\"http://esquilax.stanford.edu/#start\">Interpretome \u003c/a>that he and some other Stanford folks had developed for their \u003ca href=\"http://stanford.edu/class/gene210/web/html/welcome.html\">personalized medicine class\u003c/a>.\u003c/p>\n\u003cp>This tool has a lot of cool features (feel free to explore) but I headed straight for the Neanderthal section. I plugged in my 23andMe raw data and out popped my results. There are definitely some Neanderthals in my family tree!\u003c/p>\n\u003cp>The site looks at 42 different markers and since we have two copies of each, there are 84 possible Neanderthal hits. I scored a 7 out of 84.\u003c/p>\n\u003cp>Now, since I don’t know if that is a lot, I asked Konrad about the kinds of ranges he sees. He said the average European has a score of around 7-10 which puts me at the lower end of average. He also said that someone in an online forum had reported a 26 but the highest Konrad had ever seen with his own eyes was 20. And that the lowest he has seen for Europeans or Asians was around 3-5.\u003c/p>\n\u003cp>So there you have it. I am on the low end of Neanderthalness for someone of European descent using these 42 \u003ca href=\"https://www.23andme.com/gen101/snps/\">SNPs\u003c/a>. And less Neanderthal than a number of Stanford professors!\u003c/p>\n\u003cp>How cool are genetics when it lets me figure out that I am definitely a bit Neanderthal but not as Neanderthal as certain unnamed Stanford professors? \u003c/p>\n\u003cp>\u003cstrong>More Information\u003c/strong>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/news.php?id=128\">Neanderthals and you.\u003c/a>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/23256/how-neanderthal-are-you","authors":["6177"],"categories":["quest_4"],"tags":["quest_159","quest_1197","quest_1198","quest_10035","quest_10034","quest_13202","quest_2684","quest_3768","quest_10036","quest_3319"],"featImg":"quest_23286","label":"quest"},"quest_14601":{"type":"posts","id":"quest_14601","meta":{"index":"posts_1591205157","site":"quest","id":"14601","score":null,"sort":[1306166662000]},"guestAuthors":[],"slug":"uncovering-risk-one-gene-at-a-time","title":"Uncovering Risk One Gene at a Time","publishDate":1306166662,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/05/MathFormula2.jpg\" alt=\"\">\u003c/a>\u003cem>Many genetic tests just uncover one small bit of\u003cbr>your disease risk formula.\u003cbr>Image courtesy of \u003ca href=\"http://en.wikipedia.org/wiki/File:Math_lecture_at_TKK.JPG\">Tungsten\u003c/a>\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Since 23andMe is offering data on Alzheimer’s risk but only with an upgrade, I decided to get that upgrade. I got the new results last week and opened it right up. There was a new Alzheimer’s link with a little lock on it.\u003c/p>\n\u003cp>The lock is to keep me out until I feel ready to deal with the news. Well, I’m ready…\u003c/p>\n\u003cp>When I opened the lock, I was given information about one gene, APOE. This was pretty disappointing. In my case, I was able to guess my APOE status with the old information. \u003c/p>\n\u003cp>I understand that for people who couldn’t guess their APOE status before that these new results might be useful. But I expected more. Lots of genes all impact our risk of getting Alzheimer’s and scientists are making real progress figuring these out.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>What I was hoping to see was a compilation of all the information out there. See, my APOE data suggests that I am at a lower risk. But what if all my other genes are of the wrong type and put me at a higher risk? Then I might be at a higher risk than I think I am.\u003c/p>\n\u003cp>And my situation is better than people who have APOE gene versions that put them at a higher risk. What if all of their other genes put them at a lower risk? Now they are worried for no reason.\u003c/p>\n\u003cp>This points to one of the big issues with genetic tests and complex genetic diseases. Right now we know a bit about some of the genes involved but we don’t yet know the whole story. \u003c/p>\n\u003cp>It is kind of like having a whiteboard with a vast, awful, Jimmy Neutronesque formula scrawled across it. This is our genetic risk for getting something like Alzheimer’s. \u003c/p>\n\u003cp>Unfortunately, a blanket of ignorance hides most of the formula from us. We can only get a glimpse of one small part of it. What we then try to do is figure out our risk from that glimpse.\u003c/p>\n\u003cp>So let’s say we manage to uncover a bit of the blanket in the corner and we see a 0.5X. Does that mean that I am half as likely to get Alzheimer’s? Hardly. We have managed to see a piece of the whole formula but the rest remains hidden.\u003c/p>\n\u003cp>My APOE status is really just a bit of the formula for my Alzheimer’s risk peeking out from under the blanket. I don’t know the rest of the formula and so don’t know the rest of the risk.\u003c/p>\n\u003cp>APOE status is a well-studied risk that we know a lot about. We have completely uncovered it on our whiteboard. Some studies are staring to reveal other parts of the board but they aren’t completely clear yet. This is probably why 23andMe left them out.\u003c/p>\n\u003cp>I decided to look at the hazy parts of my equation using good old \u003ca href=\"http://www.snpedia.com/index.php/SNPedia\">SNPedia\u003c/a>. Remember, they have lots of information about DNA variants and disease that isn’t as filtered as is 23andMe’s. \u003c/p>\n\u003cp>Here is what I found when I put my data from 23andMe through SNPedia. I have listed the SNP, what I have at the SNP (the allele), and my risk for Alzheimer’s for those that give me a higher or lower chance for Alzheimer’s. I haven’t put in the ones that have normal risk.\u003c/p>\n\u003cp>\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/05/AlzTable2.jpg\">\u003c/p>\n\u003cp>I came out very well here. I am at a much lower risk for getting Alzheimer’s when I look at these SNPs. Yay! \u003c/p>\n\u003cp>But what if I just had s4934 data? I would come out thinking I was at a higher risk when I am actually at a lower one. Lots of needless worry over nothing…\u003c/p>\n\u003cp>Now I shouldn’t get complacent, this is still only a bit of my risk for Alzheimer’s. There may be some killer SNP lurking in my DNA, ready to spring Alzheimer’s on me. Or a long list of small, not-yet-discovered SNPs that will eat away at my supposed lower risk for Alzheimer’s. We just don’t know yet.\u003c/p>\n\u003cp>And I haven’t even begun to talk about environmental impacts. We know so little about that one with Alzheimer’s that we haven’t even found the whiteboard yet!\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n","blocks":[],"excerpt":"Genetic tests for complex diseases just tell you part of your genetic risk and nothing about your environmental risks.","status":"publish","parent":0,"modified":1306166662,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":24,"wordCount":774},"headData":{"title":"Uncovering Risk One Gene at a Time | KQED","description":"Genetic tests for complex diseases just tell you part of your genetic risk and nothing about your environmental risks.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Uncovering Risk One Gene at a Time","datePublished":"2011-05-23T16:04:22.000Z","dateModified":"2011-05-23T16:04:22.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"14601 http://www.kqed.org/quest/blog/2011/05/23/uncovering-risk-one-gene-at-a-time/","disqusUrl":"https://ww2.kqed.org/quest/2011/05/23/uncovering-risk-one-gene-at-a-time/","disqusTitle":"Uncovering Risk One Gene at a Time","path":"/quest/14601/uncovering-risk-one-gene-at-a-time","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/05/MathFormula2.jpg\" alt=\"\">\u003c/a>\u003cem>Many genetic tests just uncover one small bit of\u003cbr>your disease risk formula.\u003cbr>Image courtesy of \u003ca href=\"http://en.wikipedia.org/wiki/File:Math_lecture_at_TKK.JPG\">Tungsten\u003c/a>\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Since 23andMe is offering data on Alzheimer’s risk but only with an upgrade, I decided to get that upgrade. I got the new results last week and opened it right up. There was a new Alzheimer’s link with a little lock on it.\u003c/p>\n\u003cp>The lock is to keep me out until I feel ready to deal with the news. Well, I’m ready…\u003c/p>\n\u003cp>When I opened the lock, I was given information about one gene, APOE. This was pretty disappointing. In my case, I was able to guess my APOE status with the old information. \u003c/p>\n\u003cp>I understand that for people who couldn’t guess their APOE status before that these new results might be useful. But I expected more. Lots of genes all impact our risk of getting Alzheimer’s and scientists are making real progress figuring these out.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>What I was hoping to see was a compilation of all the information out there. See, my APOE data suggests that I am at a lower risk. But what if all my other genes are of the wrong type and put me at a higher risk? Then I might be at a higher risk than I think I am.\u003c/p>\n\u003cp>And my situation is better than people who have APOE gene versions that put them at a higher risk. What if all of their other genes put them at a lower risk? Now they are worried for no reason.\u003c/p>\n\u003cp>This points to one of the big issues with genetic tests and complex genetic diseases. Right now we know a bit about some of the genes involved but we don’t yet know the whole story. \u003c/p>\n\u003cp>It is kind of like having a whiteboard with a vast, awful, Jimmy Neutronesque formula scrawled across it. This is our genetic risk for getting something like Alzheimer’s. \u003c/p>\n\u003cp>Unfortunately, a blanket of ignorance hides most of the formula from us. We can only get a glimpse of one small part of it. What we then try to do is figure out our risk from that glimpse.\u003c/p>\n\u003cp>So let’s say we manage to uncover a bit of the blanket in the corner and we see a 0.5X. Does that mean that I am half as likely to get Alzheimer’s? Hardly. We have managed to see a piece of the whole formula but the rest remains hidden.\u003c/p>\n\u003cp>My APOE status is really just a bit of the formula for my Alzheimer’s risk peeking out from under the blanket. I don’t know the rest of the formula and so don’t know the rest of the risk.\u003c/p>\n\u003cp>APOE status is a well-studied risk that we know a lot about. We have completely uncovered it on our whiteboard. Some studies are staring to reveal other parts of the board but they aren’t completely clear yet. This is probably why 23andMe left them out.\u003c/p>\n\u003cp>I decided to look at the hazy parts of my equation using good old \u003ca href=\"http://www.snpedia.com/index.php/SNPedia\">SNPedia\u003c/a>. Remember, they have lots of information about DNA variants and disease that isn’t as filtered as is 23andMe’s. \u003c/p>\n\u003cp>Here is what I found when I put my data from 23andMe through SNPedia. I have listed the SNP, what I have at the SNP (the allele), and my risk for Alzheimer’s for those that give me a higher or lower chance for Alzheimer’s. I haven’t put in the ones that have normal risk.\u003c/p>\n\u003cp>\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/05/AlzTable2.jpg\">\u003c/p>\n\u003cp>I came out very well here. I am at a much lower risk for getting Alzheimer’s when I look at these SNPs. Yay! \u003c/p>\n\u003cp>But what if I just had s4934 data? I would come out thinking I was at a higher risk when I am actually at a lower one. Lots of needless worry over nothing…\u003c/p>\n\u003cp>Now I shouldn’t get complacent, this is still only a bit of my risk for Alzheimer’s. There may be some killer SNP lurking in my DNA, ready to spring Alzheimer’s on me. Or a long list of small, not-yet-discovered SNPs that will eat away at my supposed lower risk for Alzheimer’s. We just don’t know yet.\u003c/p>\n\u003cp>And I haven’t even begun to talk about environmental impacts. We know so little about that one with Alzheimer’s that we haven’t even found the whiteboard yet!\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/14601/uncovering-risk-one-gene-at-a-time","authors":["6177"],"categories":["quest_4"],"tags":["quest_43","quest_134","quest_135","quest_3458","quest_3530","quest_3545","quest_3546","quest_3552","quest_1195","quest_2436","quest_3768"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. 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