In Rare Sea Snail, Scientists Find Compound That Could Help Cancer Patients
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Thousands are suctioned onto the walls of 19 outdoor aquaculture tanks behind his office in Port Hueneme, California, south of Santa Barbara.\u003c/p>\n\u003cp>Shaped like oblong cinnamon rolls, the black, tan, and striped snails may live up to 60 years, although their population may be dwindling.\u003c/p>\n\u003cp>“This fragile California resource could be the basis of multiple life-saving drugs,” said Oakes, who is the CEO of \u003ca href=\"http://www.stellarbiotechnologies.com/\">Stellar Biotechnologies Inc.\u003c/a>, a biomedical company.\u003c/p>\n\u003cp>Giant keyhole limpets contain a valuable protein called KLH, or \u003ca href=\"http://en.wikipedia.org/wiki/Keyhole_limpet_hemocyanin\">keyhole limpet hemocyanin\u003c/a>, which is being tested in more than 20 different types of cancer vaccines and on autoimmune diseases like Alzheimer’s.\u003c/p>\n\u003cfigure id=\"attachment_72272\" class=\"wp-caption alignleft\" style=\"max-width: 365px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1.jpg\">\u003cimg class=\" wp-image-72272\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1-379x253.jpg\" alt=\"Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and automimmune diseases. Photo: Stellar Biotechnologies, Inc.\" width=\"365\" height=\"244\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and autoimmune diseases. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>The copper-based blood protein carries oxygen through the snail’s body, as hemoglobin does in humans.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In the 1950s, immunologists found that inserting KLH into patients triggered a powerful immune response. Such responses are critical in helping the body fight cancer and other diseases.\u003c/p>\n\u003cp>“There are lots of situations where we wish we could elicit an immune response,” said \u003ca href=\"http://www.oxy.edu/\">Occidental College\u003c/a> biology professor \u003ca href=\"https://www.oxy.edu/faculty/gary-martin\">Gary Martin\u003c/a>. “Cancer, for example, doesn’t stimulate a strong response.”\u003c/p>\n\u003cp>So researchers have figured out how to take markers for a specific type of cancer and attach KLH before inserting them into a vaccine.\u003c/p>\n\u003cp>Once administered, KLH wakes up the immune system and the patient’s antibodies see the markers. Like a signpost, the markers point toward the patient’s cancer. This process trains the immune system to fight the patient’s specific type of cancer.\u003c/p>\n\u003cp>“The hope with the cancer vaccines that contain KLH is that one day they will be preventative, much like the vaccines for measles and polio are today,” said \u003ca href=\"http://www.stellarbiotechnologies.com/about-stellar/leadership/management-team\">Catherine Brisson\u003c/a>, chief operating officer of Stellar Biotechnologies.\u003c/p>\n\u003cp>\u003cspan style=\"color: #ff8000\">\u003c/span>\u003c/p>\n\u003caside class=\"pullquote alignleft\">\"This fragile California resource could be the basis of multiple life-saving drugs\" -- Frank Oakes, CEO Stellar Biotechnologies, Inc.\u003c/aside>\n\u003cp>KLH-based vaccines are in phase III clinical trials, the last stage before a drug receives commercial approval from the \u003ca href=\"http://www.fda.gov/\">Food and Drug Administration\u003c/a>.\u003c/p>\n\u003cp>Other countries, including South Korea, China, and the Netherlands, have already approved KLH-based cancer vaccines. Stellar sells the purified blood protein to international companies for $50,000 per gram.\u003c/p>\n\u003cp>But generating a steady supply of KLH is tricky.\u003c/p>\n\u003cp>Giant keyhole limpets only live off the California coast and no one knows how many exist in the wild.\u003c/p>\n\u003cp>Most international pharmaceutical companies collect mollusks from the ocean, which are frozen and shipped overseas or bled to death and thrown back into the water.\u003c/p>\n\u003cfigure id=\"attachment_72274\" class=\"wp-caption alignleft\" style=\"max-width: 225px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1.jpg\">\u003cimg class=\" wp-image-72274\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1-168x253.jpg\" alt=\"One gram of the snails' purified blood protein is $50,000. Photo: Stellar Biotechnologies, Inc.\" width=\"225\" height=\"339\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">One gram of the snails' purified blood protein is sold to pharmaceutical companies for $50,000. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>“I have been working in our kelp forest since 1970 and have seen [them] become much more rare over the years,” \u003ca href=\"http://daytonlab.ucsd.edu/\">Paul Dayton\u003c/a>, a marine ecologist at \u003ca href=\"https://scripps.ucsd.edu/\">Scripps Institution of Oceanography\u003c/a>, said in an email.\u003c/p>\n\u003cp>Because of the market value for the blood protein, Dayton said, “it makes sense that they might be disappearing.”\u003c/p>\n\u003cp>What’s important, he said, is preserving a marine habitat that is vastly under studied.\u003c/p>\n\u003cp>“I do not think it is appropriate to have a commercial harvest…without first doing some research on the population biology.”\u003c/p>\n\u003cp>Dayton argued for restrictions on the number of snails that can be removed, since there are no catch limits.\u003c/p>\n\u003cp>And while Stellar is no longer taking limpets from the wild, it is relying on a supply that may not last if KLH-based treatments are approved.\u003c/p>\n\u003cp>“Should any of these clinical trials hit the jackpot, we don’t have a huge reservoir of these animals to supply the need for further clinical trials and treatments,” said Martin.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>\u003cem>This story was made possible, in part, by support from the \u003ca href=\"http://www.ijnr.org/\">Institute for Journalism & Natural Resources\u003c/a>.\u003c/em>\u003c/strong>\u003c/p>\n\n","blocks":[],"excerpt":"A marine mollusk with a coveted blood protein is shaping the way researchers treat cancer and autoimmune diseases.","status":"publish","parent":0,"modified":1457553692,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":26,"wordCount":676},"headData":{"title":"In Rare Sea Snail, Scientists Find Compound That Could Help Cancer Patients | KQED","description":"A marine mollusk with a coveted blood protein is shaping the way researchers treat cancer and autoimmune diseases.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"In Rare Sea Snail, Scientists Find Compound That Could Help Cancer Patients","datePublished":"2014-10-16T14:00:02.000Z","dateModified":"2016-03-09T20:01:32.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"70177 http://science.kqed.org/quest/?p=70177","disqusUrl":"https://ww2.kqed.org/quest/2014/10/16/in-rare-sea-snail-scientists-find-compound-that-could-help-cancer-patients/","disqusTitle":"In Rare Sea Snail, Scientists Find Compound That Could Help Cancer Patients","videoEmbed":"https://www.youtube.com/watch?v=5wSMe9hh66M","path":"/quest/70177/in-rare-sea-snail-scientists-find-compound-that-could-help-cancer-patients","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>PORT HUENEME -- Frank Oakes is betting his future on a snail. Thousands are suctioned onto the walls of 19 outdoor aquaculture tanks behind his office in Port Hueneme, California, south of Santa Barbara.\u003c/p>\n\u003cp>Shaped like oblong cinnamon rolls, the black, tan, and striped snails may live up to 60 years, although their population may be dwindling.\u003c/p>\n\u003cp>“This fragile California resource could be the basis of multiple life-saving drugs,” said Oakes, who is the CEO of \u003ca href=\"http://www.stellarbiotechnologies.com/\">Stellar Biotechnologies Inc.\u003c/a>, a biomedical company.\u003c/p>\n\u003cp>Giant keyhole limpets contain a valuable protein called KLH, or \u003ca href=\"http://en.wikipedia.org/wiki/Keyhole_limpet_hemocyanin\">keyhole limpet hemocyanin\u003c/a>, which is being tested in more than 20 different types of cancer vaccines and on autoimmune diseases like Alzheimer’s.\u003c/p>\n\u003cfigure id=\"attachment_72272\" class=\"wp-caption alignleft\" style=\"max-width: 365px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1.jpg\">\u003cimg class=\" wp-image-72272\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1-379x253.jpg\" alt=\"Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and automimmune diseases. Photo: Stellar Biotechnologies, Inc.\" width=\"365\" height=\"244\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and autoimmune diseases. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>The copper-based blood protein carries oxygen through the snail’s body, as hemoglobin does in humans.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In the 1950s, immunologists found that inserting KLH into patients triggered a powerful immune response. Such responses are critical in helping the body fight cancer and other diseases.\u003c/p>\n\u003cp>“There are lots of situations where we wish we could elicit an immune response,” said \u003ca href=\"http://www.oxy.edu/\">Occidental College\u003c/a> biology professor \u003ca href=\"https://www.oxy.edu/faculty/gary-martin\">Gary Martin\u003c/a>. “Cancer, for example, doesn’t stimulate a strong response.”\u003c/p>\n\u003cp>So researchers have figured out how to take markers for a specific type of cancer and attach KLH before inserting them into a vaccine.\u003c/p>\n\u003cp>Once administered, KLH wakes up the immune system and the patient’s antibodies see the markers. Like a signpost, the markers point toward the patient’s cancer. This process trains the immune system to fight the patient’s specific type of cancer.\u003c/p>\n\u003cp>“The hope with the cancer vaccines that contain KLH is that one day they will be preventative, much like the vaccines for measles and polio are today,” said \u003ca href=\"http://www.stellarbiotechnologies.com/about-stellar/leadership/management-team\">Catherine Brisson\u003c/a>, chief operating officer of Stellar Biotechnologies.\u003c/p>\n\u003cp>\u003cspan style=\"color: #ff8000\">\u003c/span>\u003c/p>\n\u003caside class=\"pullquote alignleft\">\"This fragile California resource could be the basis of multiple life-saving drugs\" -- Frank Oakes, CEO Stellar Biotechnologies, Inc.\u003c/aside>\n\u003cp>KLH-based vaccines are in phase III clinical trials, the last stage before a drug receives commercial approval from the \u003ca href=\"http://www.fda.gov/\">Food and Drug Administration\u003c/a>.\u003c/p>\n\u003cp>Other countries, including South Korea, China, and the Netherlands, have already approved KLH-based cancer vaccines. Stellar sells the purified blood protein to international companies for $50,000 per gram.\u003c/p>\n\u003cp>But generating a steady supply of KLH is tricky.\u003c/p>\n\u003cp>Giant keyhole limpets only live off the California coast and no one knows how many exist in the wild.\u003c/p>\n\u003cp>Most international pharmaceutical companies collect mollusks from the ocean, which are frozen and shipped overseas or bled to death and thrown back into the water.\u003c/p>\n\u003cfigure id=\"attachment_72274\" class=\"wp-caption alignleft\" style=\"max-width: 225px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1.jpg\">\u003cimg class=\" wp-image-72274\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1-168x253.jpg\" alt=\"One gram of the snails' purified blood protein is $50,000. Photo: Stellar Biotechnologies, Inc.\" width=\"225\" height=\"339\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">One gram of the snails' purified blood protein is sold to pharmaceutical companies for $50,000. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>“I have been working in our kelp forest since 1970 and have seen [them] become much more rare over the years,” \u003ca href=\"http://daytonlab.ucsd.edu/\">Paul Dayton\u003c/a>, a marine ecologist at \u003ca href=\"https://scripps.ucsd.edu/\">Scripps Institution of Oceanography\u003c/a>, said in an email.\u003c/p>\n\u003cp>Because of the market value for the blood protein, Dayton said, “it makes sense that they might be disappearing.”\u003c/p>\n\u003cp>What’s important, he said, is preserving a marine habitat that is vastly under studied.\u003c/p>\n\u003cp>“I do not think it is appropriate to have a commercial harvest…without first doing some research on the population biology.”\u003c/p>\n\u003cp>Dayton argued for restrictions on the number of snails that can be removed, since there are no catch limits.\u003c/p>\n\u003cp>And while Stellar is no longer taking limpets from the wild, it is relying on a supply that may not last if KLH-based treatments are approved.\u003c/p>\n\u003cp>“Should any of these clinical trials hit the jackpot, we don’t have a huge reservoir of these animals to supply the need for further clinical trials and treatments,” said Martin.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>\u003cem>This story was made possible, in part, by support from the \u003ca href=\"http://www.ijnr.org/\">Institute for Journalism & Natural Resources\u003c/a>.\u003c/em>\u003c/strong>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/70177/in-rare-sea-snail-scientists-find-compound-that-could-help-cancer-patients","authors":["5432"],"categories":["quest_4","quest_9","quest_12"],"tags":["quest_12994","quest_326","quest_475","quest_12269","quest_12996","quest_2034","quest_12995","quest_13","quest_12997","quest_12992","quest_12993","quest_13365","quest_3056","quest_3071"],"featImg":"quest_72198","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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