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The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_9227":{"type":"posts","id":"quest_9227","meta":{"index":"posts_1591205157","site":"quest","id":"9227","score":null,"sort":[1286812831000]},"guestAuthors":[],"slug":"test-tube-baby-nobel-prize","title":"Test Tube Baby Nobel Prize","publishDate":1286812831,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/10/EmbryoDevelopment.jpg\" alt=\"\">\u003c/a>\u003cem>Dr. Edwards got his Nobel Prize for getting this to work in a Petri dish.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>The 2010 Nobel Prize in Physiology or Medicine was given to Dr. Robert Edwards for his work on in vitro fertilization (IVF). Basically, he pioneered the fertilization of human eggs with sperm in a Petri dish.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>IVF has obviously had a huge impact on society. Millions of infertile couples have been able to have children. And families that have severe genetic diseases in their family tree have been able to have children without these diseases partly because of IVF. (Preimplantation Genetic Diagnosis or \u003ca href=\"http://www.thetech.org/genetics/news.php?id=23\">PGD\u003c/a> is the other part of that equation.) IVF has also provided a steady supply of embryonic stem cells for research. \u003c/p>\n\u003cp>Of course, there have been some downsides as well. Millions of frozen embryos will eventually be thrown away. This is mass murder to people who believe these embryos are a life. And being able to select embryos without genetic disease opens up the possibility of selecting embryos for more troubling, trivial traits like gender or hair, skin, and eye color.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>At first blush, though, the science itself might not seem to be all that Nobel-worthy. He put an egg and some sperm in a dish, let the sperm do their work and then put the embryo back into a mom. Sounds too simple for a Nobel Prize. But it wasn’t. \u003c/p>\n\u003cp>Getting eggs is hard. And getting eggs that can be successfully fertilized in a lab is really hard.\u003c/p>\n\u003cp>When they first tried IVF, his research group found that the fertilized egg would divide once and that was that. Hardly the bouncing baby the infertile parents were hoping for!\u003c/p>\n\u003cp>So Dr. Edwards and his lab had to research how eggs develop in order to get eggs that could be successfully fertilized. Among other things, they learned in incredible detail the cascade of hormones required to get an egg ready for fertilization. It was collateral knowledge like this on the way to IVF that was a big part of why Dr. Edwards earned his Nobel Prize.\u003c/p>\n\u003cp>All in all it looks like the Nobel committee made a good choice in finally giving Dr. Edwards the Nobel Prize. Click \u003ca href=\"http://en.wikipedia.org/wiki/List_of_Nobel_Laureates_in_Physiology_or_Medicine\">here \u003c/a>to see if you think this Nobel Prize stacks up to others in this category.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n","blocks":[],"excerpt":"Dr. Edwards recently received a Nobel Prize in medicine for figuring out how to fertilize an egg in a Petri dish. Huge social impact but was the science Nobel-worthy?","status":"publish","parent":0,"modified":1286812831,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":13,"wordCount":390},"headData":{"title":"Test Tube Baby Nobel Prize | KQED","description":"Dr. Edwards recently received a Nobel Prize in medicine for figuring out how to fertilize an egg in a Petri dish. Huge social impact but was the science Nobel-worthy?","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"9227 http://www.kqed.org/quest/blog/2010/10/11/test-tube-baby-nobel-prize/","disqusUrl":"https://ww2.kqed.org/quest/2010/10/11/test-tube-baby-nobel-prize/","disqusTitle":"Test Tube Baby Nobel Prize","path":"/quest/9227/test-tube-baby-nobel-prize","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/10/EmbryoDevelopment.jpg\" alt=\"\">\u003c/a>\u003cem>Dr. Edwards got his Nobel Prize for getting this to work in a Petri dish.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>The 2010 Nobel Prize in Physiology or Medicine was given to Dr. Robert Edwards for his work on in vitro fertilization (IVF). Basically, he pioneered the fertilization of human eggs with sperm in a Petri dish.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>IVF has obviously had a huge impact on society. Millions of infertile couples have been able to have children. And families that have severe genetic diseases in their family tree have been able to have children without these diseases partly because of IVF. (Preimplantation Genetic Diagnosis or \u003ca href=\"http://www.thetech.org/genetics/news.php?id=23\">PGD\u003c/a> is the other part of that equation.) IVF has also provided a steady supply of embryonic stem cells for research. \u003c/p>\n\u003cp>Of course, there have been some downsides as well. Millions of frozen embryos will eventually be thrown away. This is mass murder to people who believe these embryos are a life. And being able to select embryos without genetic disease opens up the possibility of selecting embryos for more troubling, trivial traits like gender or hair, skin, and eye color.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>At first blush, though, the science itself might not seem to be all that Nobel-worthy. He put an egg and some sperm in a dish, let the sperm do their work and then put the embryo back into a mom. Sounds too simple for a Nobel Prize. But it wasn’t. \u003c/p>\n\u003cp>Getting eggs is hard. And getting eggs that can be successfully fertilized in a lab is really hard.\u003c/p>\n\u003cp>When they first tried IVF, his research group found that the fertilized egg would divide once and that was that. Hardly the bouncing baby the infertile parents were hoping for!\u003c/p>\n\u003cp>So Dr. Edwards and his lab had to research how eggs develop in order to get eggs that could be successfully fertilized. Among other things, they learned in incredible detail the cascade of hormones required to get an egg ready for fertilization. It was collateral knowledge like this on the way to IVF that was a big part of why Dr. Edwards earned his Nobel Prize.\u003c/p>\n\u003cp>All in all it looks like the Nobel committee made a good choice in finally giving Dr. Edwards the Nobel Prize. Click \u003ca href=\"http://en.wikipedia.org/wiki/List_of_Nobel_Laureates_in_Physiology_or_Medicine\">here \u003c/a>to see if you think this Nobel Prize stacks up to others in this category.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/9227/test-tube-baby-nobel-prize","authors":["6177"],"categories":["quest_4"],"tags":["quest_848","quest_1192","quest_1195","quest_1462","quest_1509","quest_2002","quest_2173"],"label":"quest"},"quest_4834":{"type":"posts","id":"quest_4834","meta":{"index":"posts_1591205157","site":"quest","id":"4834","score":null,"sort":[1263830401000]},"guestAuthors":[],"slug":"the-wild-wild-web","title":"The Wild, Wild Web","publishDate":1263830401,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/01/blog_800px-The_Cow_Boy_1888.jpg\" alt=\"\">\u003c/a>\u003cem>It can be hard to tell which science is good, bad, or ugly on the web.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>I have often thought that the percentage of good scientific information on the web must be pretty low. So I decided to test the idea out on a question I was recently working on.\u003c/p>\n\u003cp>Someone asked me if \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=342\">humans started out with O blood type\u003c/a> and then only later developed A and B. A quick look at \u003ca href=\"http://www.ncbi.nlm.nih.gov/PubMed\">PubMed\u003c/a> showed that this was not the case. Most of the recent genetics studies point to A coming first, followed by B about 3.5 million years ago and then, finally, about 1 million years ago, O.\u003c/p>\n\u003cp>This makes some intuitive sense if we think about what A, B, and O are. O is a form of A that doesn’t work any more because of a mutation*. This makes the idea that a broken gene came before a working one pretty unlikely. Not impossible, just not all that likely.\u003c/p>\n\u003cp>Now I researched this answer the way I usually do—I headed straight for PubMed to get the hard scientific data. I can do that because I work for Stanford and so have access to lots of journal articles and I have the scientific background to decipher the geneticsese these reports are written in.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>What I also did this time was to try to find the answer without PubMed. I started out on Yahoo searching for \u003cem>human blood type evolution\u003c/em>. Yikes.\u003c/p>\n\u003cp>Links 1, 2, and 7 talk about primate A and B blood types. Gorillas have B and chimpanzees have A and a bit of O. From this the authors try to conclude that we are somehow a mix of these two…perhaps gorillas and Neanderthals are closely related to each other and so are chimps and Cro Magnon. In this scenario, humans come from a mix of Cro Magnon and Neanderthals.\u003c/p>\n\u003cp>This is certainly not the case. Gorillas do have a blood type similar to B but it isn’t the same as ours at the gene level. And if current evolutionary history is to be believed, we split from gorillas way before our B blood type was born. So we did not get our B from gorillas.\u003c/p>\n\u003cp>Also, chimpanzee O is not the same as our O…it developed well after we split as well. We even know that Neanderthals have our O blood type and not a chimp’s (and certainly not a gorilla’s!).\u003c/p>\n\u003cp>Links 3, 5, and 9 use blood type genetics to show that Adam and Eve could have founded the human race. Links 4, 6, and 8 talk about the blood type diet. And link 10 connects blood groups to aliens.\u003c/p>\n\u003cp>Google does a bit better. You get eight similar links but you also get an NPR piece that does pretty well and a Dawkins forum comments piece that can get you to the answer eventually. However, you have to wade through a lot of stuff to get there and you only know to home in on the comment with the correct information if you already know the right answer.\u003c/p>\n\u003cp>Obviously what is popular isn’t always what is right. (And the prize for stating the obvious goes to Dr. Starr!) I thought I’d try Wikipedia next. Wikipedia can have many factual errors but it often gets the overall story line correct. Unfortunately there isn’t an article on this subject. There is on one the blood type diet though…\u003c/p>\n\u003cp>So what is a non-scientist to do? There don’t seem to be a lot of options.\u003c/p>\n\u003cp>There are websites like mine at \u003ca href=\"http://www.thetech.org/genetics/index.php\">Understanding Genetics \u003c/a>that try to give the real scoop on what current science says about various issues. But they tend to focus on a single topic and don’t often appear at the top of a website search. (Understanding Genetics is an exception in that it gets enough hits to often be on the first or second page if the query is worded in the right way.)\u003c/p>\n\u003cp>I am not sure what the answer is to getting better science via the web. Maybe we need a web based encyclopedia about science written by scientists.\u003c/p>\n\u003cp>The tricky part will be to get them to do it. And to have it make sense to anyone but another scientist in that particular field. And for them to do it impartially.\u003c/p>\n\u003cp>I’m curious how other people find their science online. And how they make sure it is reliable.\u003c/p>\n\u003cp>\u003cem>* This isn’t weird, blue eyes and red hair work the same way.\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n","blocks":[],"excerpt":"I have often thought that the percentage of good scientific information on the web must be pretty low. So I decided to test the idea out on a question I was recently working on.","status":"publish","parent":0,"modified":1263830401,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":21,"wordCount":815},"headData":{"title":"The Wild, Wild Web | KQED","description":"I have often thought that the percentage of good scientific information on the web must be pretty low. So I decided to test the idea out on a question I was recently working on.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"4834 http://www.kqed.org/quest/blog/2010/01/18/the-wild-wild-web/","disqusUrl":"https://ww2.kqed.org/quest/2010/01/18/the-wild-wild-web/","disqusTitle":"The Wild, Wild Web","path":"/quest/4834/the-wild-wild-web","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/01/blog_800px-The_Cow_Boy_1888.jpg\" alt=\"\">\u003c/a>\u003cem>It can be hard to tell which science is good, bad, or ugly on the web.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>I have often thought that the percentage of good scientific information on the web must be pretty low. So I decided to test the idea out on a question I was recently working on.\u003c/p>\n\u003cp>Someone asked me if \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=342\">humans started out with O blood type\u003c/a> and then only later developed A and B. A quick look at \u003ca href=\"http://www.ncbi.nlm.nih.gov/PubMed\">PubMed\u003c/a> showed that this was not the case. Most of the recent genetics studies point to A coming first, followed by B about 3.5 million years ago and then, finally, about 1 million years ago, O.\u003c/p>\n\u003cp>This makes some intuitive sense if we think about what A, B, and O are. O is a form of A that doesn’t work any more because of a mutation*. This makes the idea that a broken gene came before a working one pretty unlikely. Not impossible, just not all that likely.\u003c/p>\n\u003cp>Now I researched this answer the way I usually do—I headed straight for PubMed to get the hard scientific data. I can do that because I work for Stanford and so have access to lots of journal articles and I have the scientific background to decipher the geneticsese these reports are written in.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>What I also did this time was to try to find the answer without PubMed. I started out on Yahoo searching for \u003cem>human blood type evolution\u003c/em>. Yikes.\u003c/p>\n\u003cp>Links 1, 2, and 7 talk about primate A and B blood types. Gorillas have B and chimpanzees have A and a bit of O. From this the authors try to conclude that we are somehow a mix of these two…perhaps gorillas and Neanderthals are closely related to each other and so are chimps and Cro Magnon. In this scenario, humans come from a mix of Cro Magnon and Neanderthals.\u003c/p>\n\u003cp>This is certainly not the case. Gorillas do have a blood type similar to B but it isn’t the same as ours at the gene level. And if current evolutionary history is to be believed, we split from gorillas way before our B blood type was born. So we did not get our B from gorillas.\u003c/p>\n\u003cp>Also, chimpanzee O is not the same as our O…it developed well after we split as well. We even know that Neanderthals have our O blood type and not a chimp’s (and certainly not a gorilla’s!).\u003c/p>\n\u003cp>Links 3, 5, and 9 use blood type genetics to show that Adam and Eve could have founded the human race. Links 4, 6, and 8 talk about the blood type diet. And link 10 connects blood groups to aliens.\u003c/p>\n\u003cp>Google does a bit better. You get eight similar links but you also get an NPR piece that does pretty well and a Dawkins forum comments piece that can get you to the answer eventually. However, you have to wade through a lot of stuff to get there and you only know to home in on the comment with the correct information if you already know the right answer.\u003c/p>\n\u003cp>Obviously what is popular isn’t always what is right. (And the prize for stating the obvious goes to Dr. Starr!) I thought I’d try Wikipedia next. Wikipedia can have many factual errors but it often gets the overall story line correct. Unfortunately there isn’t an article on this subject. There is on one the blood type diet though…\u003c/p>\n\u003cp>So what is a non-scientist to do? There don’t seem to be a lot of options.\u003c/p>\n\u003cp>There are websites like mine at \u003ca href=\"http://www.thetech.org/genetics/index.php\">Understanding Genetics \u003c/a>that try to give the real scoop on what current science says about various issues. But they tend to focus on a single topic and don’t often appear at the top of a website search. (Understanding Genetics is an exception in that it gets enough hits to often be on the first or second page if the query is worded in the right way.)\u003c/p>\n\u003cp>I am not sure what the answer is to getting better science via the web. Maybe we need a web based encyclopedia about science written by scientists.\u003c/p>\n\u003cp>The tricky part will be to get them to do it. And to have it make sense to anyone but another scientist in that particular field. And for them to do it impartially.\u003c/p>\n\u003cp>I’m curious how other people find their science online. And how they make sure it is reliable.\u003c/p>\n\u003cp>\u003cem>* This isn’t weird, blue eyes and red hair work the same way.\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/4834/the-wild-wild-web","authors":["6177"],"categories":["quest_12"],"tags":["quest_518","quest_809","quest_848","quest_1188","quest_1455","quest_1509"],"label":"quest"},"quest_4737":{"type":"posts","id":"quest_4737","meta":{"index":"posts_1591205157","site":"quest","id":"4737","score":null,"sort":[1262631625000]},"guestAuthors":[],"slug":"careful-what-you-choose","title":"Careful What You Choose","publishDate":1262631625,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/01/blog_sf-morula.jpg\" alt=\"\">\u003c/a>\u003cem>When choosing an embryo, a little bit of knowledge is a dangerous thing.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>People often think about certain versions of a gene as either good or bad. One that leads to depression is bad while one that protects you from HIV infection is good.\u003c/p>\n\u003cp>For most genes this is almost certainly too simplistic a view. Many versions of genes can be good or bad depending on your situation.\u003c/p>\n\u003cp>For example, the delta 32 version of the CCR5 gene can make you more resistant to HIV infection. But it also makes you more susceptible to infection by the West Nile Virus.\u003c/p>\n\u003cp>Which version is best for you depends on where and how you live. If you’re an IV drug user who lives somewhere up north, then you would probably benefit most from the delta 32 version. But if you are a faithfully monogamous man in Africa or Central America, then you might do better with the more common version of the CCR5 gene.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>As I talk about in a recent \u003ca href=\"http://www.councilforresponsiblegenetics.org/GeneWatch/GeneWatchPage.aspx?pageId=226\">GeneWatch article\u003c/a>, the same is true for the SERT gene and depression. This gene comes in two versions, long and short.\u003c/p>\n\u003cp>Studies have shown that people who only have the short version are at a higher risk for depression. A deeper look at the data shows that this is only the case if these people had a traumatic childhood. People with two short versions who had a happy childhood are actually more resistant to depression than people with the longer gene versions.\u003c/p>\n\u003cp>This all matters because we are at the point where you can choose some of your child’s gene versions. And too simplistic a view of genes could cause you to make the wrong choice.\u003c/p>\n\u003cp>People who undergo in vitro fertilization (IVF) can go through an additional procedure called preimplantation genetic diagnosis (PGD). Basically PGD allows you to look at an embryo’s DNA before it is placed in the womb. This means that when multiple embryos are created, you can choose which one to implant based on its genes.\u003c/p>\n\u003cp>Fortunately we \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=140\">can’t really change the embryo’s DNA\u003c/a> for the foreseeable future so you’re stuck with whatever genes you and your partner can contribute. But as we are able to look at more and more genes with less and less DNA, we are getting very close to a Gattaca-like future where we can choose many of our children’s genes.\u003c/p>\n\u003cp>And as the two previous examples showed, this won’t be a simple choice! There are undoubtedly hundreds of genes just like these where what effect they have on someone depends on how and where that person lives, how they were raised, etc. It might be best to restrict this sort of thing except for cases where the child might end up with a devastating illness like cystic fibrosis or sickle cell anemia.\u003c/p>\n\u003cp>In some ways, this sort of thing is already being restricted. For example, when a fertility doctor in L.A. suggested that he might offer parents a chance to choose what eye, hair, and skin color their children might have, the public uproar \u003ca href=\"http://ww2.kqed.org/quest/2009/03/30/designer-babies/\">shut down the service\u003c/a> before it even began.\u003c/p>\n\u003cp>I’m not sure that less politically sensitive gene selection would cause such a furor. It may be that we need some sort of government regulation to protect people from what they don’t know. Or maybe parents need to take a course before selecting which embryo they want…\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n","blocks":[],"excerpt":"People often think about certain versions of a gene as either good or bad. One that leads to depression is bad while one that protects you from HIV infection is good. For most genes this is almost certainly too simplistic a view. Many versions of genes can be good or bad depending on your situation.","status":"publish","parent":0,"modified":1316922017,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":596},"headData":{"title":"Careful What You Choose | KQED","description":"People often think about certain versions of a gene as either good or bad. One that leads to depression is bad while one that protects you from HIV infection is good. For most genes this is almost certainly too simplistic a view. Many versions of genes can be good or bad depending on your situation.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"4737 http://www.kqed.org/quest/blog/?p=4737","disqusUrl":"https://ww2.kqed.org/quest/2010/01/04/careful-what-you-choose/","disqusTitle":"Careful What You Choose","path":"/quest/4737/careful-what-you-choose","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/01/blog_sf-morula.jpg\" alt=\"\">\u003c/a>\u003cem>When choosing an embryo, a little bit of knowledge is a dangerous thing.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>People often think about certain versions of a gene as either good or bad. One that leads to depression is bad while one that protects you from HIV infection is good.\u003c/p>\n\u003cp>For most genes this is almost certainly too simplistic a view. Many versions of genes can be good or bad depending on your situation.\u003c/p>\n\u003cp>For example, the delta 32 version of the CCR5 gene can make you more resistant to HIV infection. But it also makes you more susceptible to infection by the West Nile Virus.\u003c/p>\n\u003cp>Which version is best for you depends on where and how you live. If you’re an IV drug user who lives somewhere up north, then you would probably benefit most from the delta 32 version. But if you are a faithfully monogamous man in Africa or Central America, then you might do better with the more common version of the CCR5 gene.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>As I talk about in a recent \u003ca href=\"http://www.councilforresponsiblegenetics.org/GeneWatch/GeneWatchPage.aspx?pageId=226\">GeneWatch article\u003c/a>, the same is true for the SERT gene and depression. This gene comes in two versions, long and short.\u003c/p>\n\u003cp>Studies have shown that people who only have the short version are at a higher risk for depression. A deeper look at the data shows that this is only the case if these people had a traumatic childhood. People with two short versions who had a happy childhood are actually more resistant to depression than people with the longer gene versions.\u003c/p>\n\u003cp>This all matters because we are at the point where you can choose some of your child’s gene versions. And too simplistic a view of genes could cause you to make the wrong choice.\u003c/p>\n\u003cp>People who undergo in vitro fertilization (IVF) can go through an additional procedure called preimplantation genetic diagnosis (PGD). Basically PGD allows you to look at an embryo’s DNA before it is placed in the womb. This means that when multiple embryos are created, you can choose which one to implant based on its genes.\u003c/p>\n\u003cp>Fortunately we \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=140\">can’t really change the embryo’s DNA\u003c/a> for the foreseeable future so you’re stuck with whatever genes you and your partner can contribute. But as we are able to look at more and more genes with less and less DNA, we are getting very close to a Gattaca-like future where we can choose many of our children’s genes.\u003c/p>\n\u003cp>And as the two previous examples showed, this won’t be a simple choice! There are undoubtedly hundreds of genes just like these where what effect they have on someone depends on how and where that person lives, how they were raised, etc. It might be best to restrict this sort of thing except for cases where the child might end up with a devastating illness like cystic fibrosis or sickle cell anemia.\u003c/p>\n\u003cp>In some ways, this sort of thing is already being restricted. For example, when a fertility doctor in L.A. suggested that he might offer parents a chance to choose what eye, hair, and skin color their children might have, the public uproar \u003ca href=\"http://ww2.kqed.org/quest/2009/03/30/designer-babies/\">shut down the service\u003c/a> before it even began.\u003c/p>\n\u003cp>I’m not sure that less politically sensitive gene selection would cause such a furor. It may be that we need some sort of government regulation to protect people from what they don’t know. Or maybe parents need to take a course before selecting which embryo they want…\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/4737/careful-what-you-choose","authors":["6177"],"categories":["quest_12"],"tags":["quest_518","quest_809","quest_848","quest_1188","quest_1455","quest_1509"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? 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