Producer's Notes for Bio-inspiration: Nature as Muse
Chromosome Fusion: Chance or Design?
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The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"},"joan-johnson":{"type":"authors","id":"10193","meta":{"index":"authors_1591205172","id":"10193","found":true},"name":"Joan Johnson","firstName":"Joan","lastName":"Johnson","slug":"joan-johnson","email":"jjohnson@kqed.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Joan Johnson is an \u003cstrong>TV Associate Producer for QUEST\u003c/strong>. Joan got her start making science television back in 1998 when she joined the team at Sea Studios in Monterey, working as a researcher and production coordinator on \u003ca href=\"http://nationalgeographic.com/channel/\">National Geographic Television\u003c/a> projects for 4 years. Following that she pursued a career in features and network television down in Los Angeles, working on seven full length feature films, three television shows and several pilots. Joan graduated in 1993 from U.C. Santa Cruz with honors in Biology, and spent several years working as a marine biologist, naturalist and SCUBA guide. Originally from San Francisco, Joan is thrilled to be home and working on QUEST, fulfilling a long-term goal of combining her interests in science and entertainment.","avatar":"https://secure.gravatar.com/avatar/692b727df9469f1e643b6b30d399076e?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Joan Johnson | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/692b727df9469f1e643b6b30d399076e?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/692b727df9469f1e643b6b30d399076e?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/joan-johnson"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_22140":{"type":"posts","id":"quest_22140","meta":{"index":"posts_1591205157","site":"quest","id":"22140","score":null,"sort":[1313429863000]},"guestAuthors":[],"slug":"redesigning-life","title":"Redesigning Life","publishDate":1313429863,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_22143\" class=\"wp-caption aligncenter\" style=\"max-width: 639px\">\u003ca href=\"http://ww2.kqed.org/quest/2011/08/15/redesigning-life/coloredbacteria/\" rel=\"attachment wp-att-22143\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/ColoredBacteria.jpg\" alt=\"\" title=\"ColoredBacteria\" width=\"639\" height=\"359\" class=\"size-full wp-image-22143\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria.jpg 639w, https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria-400x225.jpg 400w\" sizes=\"(max-width: 639px) 100vw, 639px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Scientists are redesigning bacteria like these to “speak” a new language. \u003c/figcaption>\u003c/figure>\n\u003cp>All living things pretty much use the same language to read their genes. That is about to change. \u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/news.php?id=144\">Scientists in Boston\u003c/a> are close to teaching a strain of bacteria a new dialect of the genetic code. In combination with some work done by a different \u003ca href=\"http://www.thetech.org/genetics/news.php?id=129\">group in 2010\u003c/a>, we are now getting to the point where we can actually think about (re)designing life. Which is a big step from what we have been able to do up until now.\u003c/p>\n\u003cp>The genetic engineering we have done in the past has been pretty crude. We have mostly added pre-existing genes to cells to give the cells new properties or to have the cells make something for us. \u003c/p>\n\u003cp>So we add a human gene to bacteria so they will make insulin for us. Or we add a gene from bacteria to a plant to make the plant resistant to an herbicide like Round Up. Or we even add two genes to cause rice to make vitamin A like in \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=334\">golden rice\u003c/a>. \u003c/p>\n\u003cp>Now we aren’t always this unsophisticated. We have managed to do some \u003ca href=\"http://www.thetech.org/genetics/news.php?id=63\">pretty elegant things with genes in mice\u003c/a>. There we have tinkered with mouse genes to slightly change how they work or to control how they are expressed. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>But these new experiments are different. This is changing the language of life so we can make a living thing do things nothing living has yet been able to do. Maybe this is even the start of intelligent design…\u003c/p>\n\u003cp>A big reason this is all possible is because nature has given us a very simple template to work with. Not only does the genetic code have just four letters and 64, three letter words, but many of its words also have the same meaning. It is this last point that has allowed researchers to futz with the code.\u003c/p>\n\u003cp>The researchers plan to teach bacteria a new language by co-opting one of the words in the genetic code and giving it a new meaning. There are two things scientists need to do to make this happen.\u003c/p>\n\u003cp>The first is to replace all instances of one word in the bacteria’s genes with an equivalent word. Now the bacteria’s genes all still code for all the same things but a word has been freed up so it can be given a new meaning.\u003c/p>\n\u003cp>The second step is to redefine the replaced word. This will probably be done by mutating the cell’s reading machinery using some pretty well established genetic techniques.\u003c/p>\n\u003cp>Church’s group has nearly finished the first step. They managed to create four strains of bacteria each with ¼ of all 314 instances of TAG changed to TAA. They are now in the process of combining these four strains in such a way to generate a single strain with no functional TAG’s. After this first step is done (which should be soon), this group of researchers will be ready to teach these bacteria a new language.\u003c/p>\n\u003cp>An easy first thing they can do is to change the definition of the TAG so it means the same thing as one of the other words. So the TAG will no longer mean STOP but instead will mean Met or Lys or some other amino acid. (The genetic words or \u003ca href=\"http://www.thetech.org/genetics/news.php?id=118\">codons\u003c/a> really just tell a cell which amino acid to put where in a protein.) \u003c/p>\n\u003cp>Done correctly, this would probably make the bacteria immune to viral infection.* Which would be a boon for the biotech industry as it loses millions of dollars every year because of infected bacterial strains.\u003c/p>\n\u003cp>This is pretty pedestrian stuff though. The cool thing will be when they redefine TAG as a word that isn’t already in the genetic code. Then we’ll be able to easily create different proteins with properties useful as medicines, industrial enzymes or who knows what else. At least that is the hope.\u003c/p>\n\u003cp>And this is just one word. There are another 30-40 codons that may be able to be freed up and given new meanings as well. \u003c/p>\n\u003cp>We are stepping into a whole new area of research. We are retraining life to do what we want. Let’s hope we know what we’re doing…\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>*This is because viruses use a cell’s machinery to read its own genes. If the machinery changes, the virus will misread its own genes and die.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"All living things pretty much use the same language to read their genes. That is about to change. ","status":"publish","parent":0,"modified":1314127050,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":19,"wordCount":762},"headData":{"title":"Redesigning Life | KQED","description":"All living things pretty much use the same language to read their genes. That is about to change. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"22140 http://science.kqed.org/quest/?p=22140","disqusUrl":"https://ww2.kqed.org/quest/2011/08/15/redesigning-life/","disqusTitle":"Redesigning Life","path":"/quest/22140/redesigning-life","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_22143\" class=\"wp-caption aligncenter\" style=\"max-width: 639px\">\u003ca href=\"http://ww2.kqed.org/quest/2011/08/15/redesigning-life/coloredbacteria/\" rel=\"attachment wp-att-22143\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/ColoredBacteria.jpg\" alt=\"\" title=\"ColoredBacteria\" width=\"639\" height=\"359\" class=\"size-full wp-image-22143\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria.jpg 639w, https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria-400x225.jpg 400w\" sizes=\"(max-width: 639px) 100vw, 639px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Scientists are redesigning bacteria like these to “speak” a new language. \u003c/figcaption>\u003c/figure>\n\u003cp>All living things pretty much use the same language to read their genes. That is about to change. \u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/news.php?id=144\">Scientists in Boston\u003c/a> are close to teaching a strain of bacteria a new dialect of the genetic code. In combination with some work done by a different \u003ca href=\"http://www.thetech.org/genetics/news.php?id=129\">group in 2010\u003c/a>, we are now getting to the point where we can actually think about (re)designing life. Which is a big step from what we have been able to do up until now.\u003c/p>\n\u003cp>The genetic engineering we have done in the past has been pretty crude. We have mostly added pre-existing genes to cells to give the cells new properties or to have the cells make something for us. \u003c/p>\n\u003cp>So we add a human gene to bacteria so they will make insulin for us. Or we add a gene from bacteria to a plant to make the plant resistant to an herbicide like Round Up. Or we even add two genes to cause rice to make vitamin A like in \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=334\">golden rice\u003c/a>. \u003c/p>\n\u003cp>Now we aren’t always this unsophisticated. We have managed to do some \u003ca href=\"http://www.thetech.org/genetics/news.php?id=63\">pretty elegant things with genes in mice\u003c/a>. There we have tinkered with mouse genes to slightly change how they work or to control how they are expressed. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>But these new experiments are different. This is changing the language of life so we can make a living thing do things nothing living has yet been able to do. Maybe this is even the start of intelligent design…\u003c/p>\n\u003cp>A big reason this is all possible is because nature has given us a very simple template to work with. Not only does the genetic code have just four letters and 64, three letter words, but many of its words also have the same meaning. It is this last point that has allowed researchers to futz with the code.\u003c/p>\n\u003cp>The researchers plan to teach bacteria a new language by co-opting one of the words in the genetic code and giving it a new meaning. There are two things scientists need to do to make this happen.\u003c/p>\n\u003cp>The first is to replace all instances of one word in the bacteria’s genes with an equivalent word. Now the bacteria’s genes all still code for all the same things but a word has been freed up so it can be given a new meaning.\u003c/p>\n\u003cp>The second step is to redefine the replaced word. This will probably be done by mutating the cell’s reading machinery using some pretty well established genetic techniques.\u003c/p>\n\u003cp>Church’s group has nearly finished the first step. They managed to create four strains of bacteria each with ¼ of all 314 instances of TAG changed to TAA. They are now in the process of combining these four strains in such a way to generate a single strain with no functional TAG’s. After this first step is done (which should be soon), this group of researchers will be ready to teach these bacteria a new language.\u003c/p>\n\u003cp>An easy first thing they can do is to change the definition of the TAG so it means the same thing as one of the other words. So the TAG will no longer mean STOP but instead will mean Met or Lys or some other amino acid. (The genetic words or \u003ca href=\"http://www.thetech.org/genetics/news.php?id=118\">codons\u003c/a> really just tell a cell which amino acid to put where in a protein.) \u003c/p>\n\u003cp>Done correctly, this would probably make the bacteria immune to viral infection.* Which would be a boon for the biotech industry as it loses millions of dollars every year because of infected bacterial strains.\u003c/p>\n\u003cp>This is pretty pedestrian stuff though. The cool thing will be when they redefine TAG as a word that isn’t already in the genetic code. Then we’ll be able to easily create different proteins with properties useful as medicines, industrial enzymes or who knows what else. At least that is the hope.\u003c/p>\n\u003cp>And this is just one word. There are another 30-40 codons that may be able to be freed up and given new meanings as well. \u003c/p>\n\u003cp>We are stepping into a whole new area of research. We are retraining life to do what we want. Let’s hope we know what we’re doing…\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>*This is because viruses use a cell’s machinery to read its own genes. If the machinery changes, the virus will misread its own genes and die.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/22140/redesigning-life","authors":["6177"],"categories":["quest_4"],"tags":["quest_267","quest_9951","quest_9949","quest_1032","quest_1188","quest_1193","quest_9948","quest_9950","quest_1479","quest_13202","quest_3319"],"featImg":"quest_22143","label":"quest"},"quest_895":{"type":"posts","id":"quest_895","meta":{"index":"posts_1591205157","site":"quest","id":"895","score":null,"sort":[1224612983000]},"guestAuthors":[],"slug":"producers-notes-for-bio-inspiration-nature-as-muse","title":"Producer's Notes for Bio-inspiration: Nature as Muse","publishDate":1224612983,"format":"video","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>I was a biologist once, before I got into television, so I find these times particularly trying when I see schoolteachers and otherwise intelligent people calling evolution into question. That's part of the reason that I jumped at the chance to co-produce a story about bio-inspiration (the other reason being that I LOVE geckos...which will make more sense if you watch our QUEST \u003ca href=\"http://ww2.kqed.org/quest/video/bioinspiration-nature-as-muse\">Bio-inspiration segment\u003c/a>).\u003c/p>\n\u003cp>\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/10/217a_bio300-21.jpg\" alt=\"217a_bio300-2\" width=\"300\" height=\"200\" class=\"alignright size-full wp-image-899\">\u003c/p>\n\u003cp>Bio-inspired design borrows its creative inspiration from models and systems in nature, that is, plant and animal parts that have been slowly tweaked for over 3.8 billion years. But that doesn't mean that nature's designs are perfect. In fact, that's what makes the process of engineering things based on natural models so difficult. You have to figure out how to pull the aces from the evolutionary discard pile. As professor Bob Full at U.C. Berkeley explained in our first phone conversation, that's also why scientists now use the term \"bio-inspiration\" rather than the more commonly known term \"biomimicry.\" Biologists and engineers are not looking to simply mimic nature, because there are all kinds of dead ends and redundancies in natural systems that would be pointless to recreate in an optimized, man-made piece of technology. One of the examples he gave me is a kind of grasshopper that if you were to copy it, you would copy neurons that go to nothing, they don't connect to any muscles, and that's because during evolution the adults lost their ability to fly. The neurons going to the muscles are still there, but the muscles aren't there anymore. No need to copy that, right?\u003c/p>\n\u003cp>So what a biomimeticist does is look to nature to find plants & animals with remarkable performance abilities, and studies their adaptations for inspiration to design something new. For example, if you want to make a tiny robot that can fly, then look at the best fliers. If you want to design a blade that moves quickly through fluids, or an Olympic swimsuit that minimizes drag, then look to the most efficient swimmers. Now that's what I call \"intelligent design!\"\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n","blocks":[],"excerpt":"Bio-inspired design borrows its creative inspiration from models and systems in nature, that is, plant and animal parts that have been slowly tweaked for over 3.8 billion years. But that doesn't mean that nature's designs are perfect.","status":"publish","parent":0,"modified":1457808857,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":6,"wordCount":365},"headData":{"title":"Producer's Notes for Bio-inspiration: Nature as Muse | KQED","description":"Bio-inspired design borrows its creative inspiration from models and systems in nature, that is, plant and animal parts that have been slowly tweaked for over 3.8 billion years. But that doesn't mean that nature's designs are perfect.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"895 http://www.kqed.org/quest/blog/?p=895","disqusUrl":"https://ww2.kqed.org/quest/2008/10/21/producers-notes-for-bio-inspiration-nature-as-muse/","disqusTitle":"Producer's Notes for Bio-inspiration: Nature as Muse","videoEmbed":"https://www.youtube.com/watch?v=JnBkbaFsZOY","path":"/quest/895/producers-notes-for-bio-inspiration-nature-as-muse","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>I was a biologist once, before I got into television, so I find these times particularly trying when I see schoolteachers and otherwise intelligent people calling evolution into question. That's part of the reason that I jumped at the chance to co-produce a story about bio-inspiration (the other reason being that I LOVE geckos...which will make more sense if you watch our QUEST \u003ca href=\"http://ww2.kqed.org/quest/video/bioinspiration-nature-as-muse\">Bio-inspiration segment\u003c/a>).\u003c/p>\n\u003cp>\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/10/217a_bio300-21.jpg\" alt=\"217a_bio300-2\" width=\"300\" height=\"200\" class=\"alignright size-full wp-image-899\">\u003c/p>\n\u003cp>Bio-inspired design borrows its creative inspiration from models and systems in nature, that is, plant and animal parts that have been slowly tweaked for over 3.8 billion years. But that doesn't mean that nature's designs are perfect. In fact, that's what makes the process of engineering things based on natural models so difficult. You have to figure out how to pull the aces from the evolutionary discard pile. As professor Bob Full at U.C. Berkeley explained in our first phone conversation, that's also why scientists now use the term \"bio-inspiration\" rather than the more commonly known term \"biomimicry.\" Biologists and engineers are not looking to simply mimic nature, because there are all kinds of dead ends and redundancies in natural systems that would be pointless to recreate in an optimized, man-made piece of technology. One of the examples he gave me is a kind of grasshopper that if you were to copy it, you would copy neurons that go to nothing, they don't connect to any muscles, and that's because during evolution the adults lost their ability to fly. The neurons going to the muscles are still there, but the muscles aren't there anymore. No need to copy that, right?\u003c/p>\n\u003cp>So what a biomimeticist does is look to nature to find plants & animals with remarkable performance abilities, and studies their adaptations for inspiration to design something new. For example, if you want to make a tiny robot that can fly, then look at the best fliers. If you want to design a blade that moves quickly through fluids, or an Olympic swimsuit that minimizes drag, then look to the most efficient swimmers. Now that's what I call \"intelligent design!\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/895/producers-notes-for-bio-inspiration-nature-as-muse","authors":["10193"],"categories":["quest_4","quest_8","quest_3422","quest_3233"],"tags":["quest_88","quest_220","quest_323","quest_13193","quest_332","quest_13197","quest_1479","quest_1895","quest_1978","quest_2441","quest_2443","quest_2771","quest_2893","quest_3021"],"featImg":"quest_899","label":"quest"},"quest_586":{"type":"posts","id":"quest_586","meta":{"index":"posts_1591205157","site":"quest","id":"586","score":null,"sort":[1210616816000]},"guestAuthors":[],"slug":"chromosome-fusion-chance-or-design","title":"Chromosome Fusion: Chance or Design?","publishDate":1210616816,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure class=\"wp-caption alignleft\" style=\"max-width: 287px\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/05/hum-chimpchromosomes.gif\" width=\"287\" height=\"488\">\u003cfigcaption class=\"wp-caption-text\">Human and chimpanzee chromosomes are very similar. Note that human chromosome 2 is very similar to a fusion of two chimpanzee chromosomes.\u003c/figcaption>\u003c/figure>\n\u003cp>For the last few weeks I have been corresponding with someone about intelligent design (ID). More specifically, we have been chatting about why humans have 46 chromosomes and most of the great apes have 48.\u003c/p>\n\u003cp>To me, this is great evidence for evolution. Why? Because if you look at the chromosomes closely, you can see that human chromosome 2 is really just a fusion of two great ape chromosomes.\u003c/p>\n\u003cp>The idea is that a few million years ago, a common human-chimpanzee ancestor of ours had two of his or her chromosomes fused together. This sort of thing happens all the time even today. Around 1 in 1000 live births has one of these kinds of fusions.\u003c/p>\n\u003cp>Then, probably through chance, \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=229\">this ancestor with the fused chromosomes went on to found the human race\u003c/a>. Now people have 46 chromosomes and chimpanzees have 48.\u003c/p>\n\u003cp>An alternative explanation is that the designers fused the two chromosomes together when they created humans. The idea would be that the designer wouldn't create every plant, animal, bacteria, and virus from scratch--why reinvent the wheel every time? Instead the designers would mix and match parts that worked.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>So as part of the process of designing a human, the designer fused two ape chromosomes together. This would presumably be simpler than creating a human chromosome 2 the way the other chromosomes were made.\u003c/p>\n\u003cp>The difficulty with this idea is that there is no obvious advantage to having 46 chromosomes instead of 48. What matters is our DNA, not how it happens \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=257\">to be packaged\u003c/a>.\u003c/p>\n\u003cp>It is possible that there was some advantage to fusing the chromosomes together. For example, maybe a new gene was created at the fusion point. Or maybe genes that were shut off before were now turned on in the new fused chromosomes.\u003c/p>\n\u003cp>There isn't any evidence of these kinds of things. And even if there were, a designer who can easily put in the 60 million or so differences between humans and chimpanzees should be able to accomplish whatever results a chromosome fusion gives more elegantly than sticking two ape chromosomes together.\u003c/p>\n\u003cp>Also, when you look at the fusion point, you can see that the DNA isn't exactly what you would expect if a fusion happened in the last 10,000 or even 100,000 years. The results look more like an event that happened millions of years ago.\u003c/p>\n\u003cp>The ends of a chromosome have a defined sequence of DNA repeats called a telomere. The DNA at the fusion point looks \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=264\">very similar to a string of telomeres\u003c/a> (as we would expect from a fusion) but it isn't perfect. This is just what you would expect if the fusion happened millions of years ago. Because our DNA gets changed a little all of the time.\u003c/p>\n\u003cp>The environment or even our own cells can cause the wrong letter to end up in our DNA. Our cells are pretty good at fixing these mistakes but they don't catch them all. What this means is that our DNA builds up mutations over time.\u003c/p>\n\u003cp>When an unfixed change happens in a sperm or egg, then it is passed down to the next generation. If the changes that aren't fixed happen somewhere important, then they are selected for or against. But if they're neutral, then they just build up over time. Scientists can even use these sorts of errors to predict how long ago something happened. Or to \u003ca href=\"http://ww2.kqed.org/quest/2008/03/03/tracing-the-travels-of-the-human-race/\">trace human migration patterns\u003c/a>.\u003c/p>\n\u003cp>These DNA changes at the fusion point do not fit with ID if they don't serve a purpose. Otherwise, why put them there? It will be interesting to see the results of experiments that might show if these sequences matter or not.\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/imp/icon_barry.jpg\">\u003c/span>\u003cem>\u003cstrong>Dr. Barry Starr\u003c/strong> is a Geneticist-in-Residence at \u003ca href=\"http://www.thetech.org\">The Tech Museum of Innovation\u003c/a> in San Jose, CA.\u003c/em>\u003c/p>\n\u003cp> \u003c/p>\n\u003cp>\u003c/p>\n\u003cp>37.332 -121.903\u003c/p>\n\n","blocks":[],"excerpt":null,"status":"publish","parent":0,"modified":1478827825,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":673},"headData":{"title":"Chromosome Fusion: Chance or Design? | KQED","description":"For the last few weeks I have been corresponding with someone about intelligent design (ID). More specifically, we have been chatting about why humans have 46 chromosomes and most of the great apes have 48. To me, this is great evidence for evolution. Why? Because if you look at the chromosomes closely, you can see","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"586 http://www.kqed.org/quest/blog/2008/05/12/chromosome-fusion-chance-or-design/","disqusUrl":"https://ww2.kqed.org/quest/2008/05/12/chromosome-fusion-chance-or-design/","disqusTitle":"Chromosome Fusion: Chance or Design?","path":"/quest/586/chromosome-fusion-chance-or-design","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure class=\"wp-caption alignleft\" style=\"max-width: 287px\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/05/hum-chimpchromosomes.gif\" width=\"287\" height=\"488\">\u003cfigcaption class=\"wp-caption-text\">Human and chimpanzee chromosomes are very similar. Note that human chromosome 2 is very similar to a fusion of two chimpanzee chromosomes.\u003c/figcaption>\u003c/figure>\n\u003cp>For the last few weeks I have been corresponding with someone about intelligent design (ID). More specifically, we have been chatting about why humans have 46 chromosomes and most of the great apes have 48.\u003c/p>\n\u003cp>To me, this is great evidence for evolution. Why? Because if you look at the chromosomes closely, you can see that human chromosome 2 is really just a fusion of two great ape chromosomes.\u003c/p>\n\u003cp>The idea is that a few million years ago, a common human-chimpanzee ancestor of ours had two of his or her chromosomes fused together. This sort of thing happens all the time even today. Around 1 in 1000 live births has one of these kinds of fusions.\u003c/p>\n\u003cp>Then, probably through chance, \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=229\">this ancestor with the fused chromosomes went on to found the human race\u003c/a>. Now people have 46 chromosomes and chimpanzees have 48.\u003c/p>\n\u003cp>An alternative explanation is that the designers fused the two chromosomes together when they created humans. The idea would be that the designer wouldn't create every plant, animal, bacteria, and virus from scratch--why reinvent the wheel every time? Instead the designers would mix and match parts that worked.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>So as part of the process of designing a human, the designer fused two ape chromosomes together. This would presumably be simpler than creating a human chromosome 2 the way the other chromosomes were made.\u003c/p>\n\u003cp>The difficulty with this idea is that there is no obvious advantage to having 46 chromosomes instead of 48. What matters is our DNA, not how it happens \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=257\">to be packaged\u003c/a>.\u003c/p>\n\u003cp>It is possible that there was some advantage to fusing the chromosomes together. For example, maybe a new gene was created at the fusion point. Or maybe genes that were shut off before were now turned on in the new fused chromosomes.\u003c/p>\n\u003cp>There isn't any evidence of these kinds of things. And even if there were, a designer who can easily put in the 60 million or so differences between humans and chimpanzees should be able to accomplish whatever results a chromosome fusion gives more elegantly than sticking two ape chromosomes together.\u003c/p>\n\u003cp>Also, when you look at the fusion point, you can see that the DNA isn't exactly what you would expect if a fusion happened in the last 10,000 or even 100,000 years. The results look more like an event that happened millions of years ago.\u003c/p>\n\u003cp>The ends of a chromosome have a defined sequence of DNA repeats called a telomere. The DNA at the fusion point looks \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=264\">very similar to a string of telomeres\u003c/a> (as we would expect from a fusion) but it isn't perfect. This is just what you would expect if the fusion happened millions of years ago. Because our DNA gets changed a little all of the time.\u003c/p>\n\u003cp>The environment or even our own cells can cause the wrong letter to end up in our DNA. Our cells are pretty good at fixing these mistakes but they don't catch them all. What this means is that our DNA builds up mutations over time.\u003c/p>\n\u003cp>When an unfixed change happens in a sperm or egg, then it is passed down to the next generation. If the changes that aren't fixed happen somewhere important, then they are selected for or against. But if they're neutral, then they just build up over time. Scientists can even use these sorts of errors to predict how long ago something happened. Or to \u003ca href=\"http://ww2.kqed.org/quest/2008/03/03/tracing-the-travels-of-the-human-race/\">trace human migration patterns\u003c/a>.\u003c/p>\n\u003cp>These DNA changes at the fusion point do not fit with ID if they don't serve a purpose. Otherwise, why put them there? It will be interesting to see the results of experiments that might show if these sequences matter or not.\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/imp/icon_barry.jpg\">\u003c/span>\u003cem>\u003cstrong>Dr. Barry Starr\u003c/strong> is a Geneticist-in-Residence at \u003ca href=\"http://www.thetech.org\">The Tech Museum of Innovation\u003c/a> in San Jose, CA.\u003c/em>\u003c/p>\n\u003cp> \u003c/p>\n\u003cp>\u003c/p>\n\u003cp>37.332 -121.903\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/586/chromosome-fusion-chance-or-design","authors":["6177"],"categories":["quest_4"],"tags":["quest_580","quest_597","quest_848","quest_1197","quest_1479","quest_3351","quest_1901","quest_2530"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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