SF Scientist Wins Nobel for Stem Cell Breakthrough
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The image of a sperm being injected into an egg is courtesy of Eugene Ermolovich (CRMI).","credit":null,"description":null,"imgSizes":{"thumbnail":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-400x229.jpg","width":400,"height":229,"mimeType":"image/jpeg"},"guest-author-32":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-32x32.jpg","width":32,"height":32,"mimeType":"image/jpeg"},"guest-author-64":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-64x64.jpg","width":64,"height":64,"mimeType":"image/jpeg"},"guest-author-96":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-96x96.jpg","width":96,"height":96,"mimeType":"image/jpeg"},"guest-author-128":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-128x128.jpg","width":128,"height":128,"mimeType":"image/jpeg"},"detail":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-75x75.jpg","width":75,"height":75,"mimeType":"image/jpeg"},"kqedFullSize":{"file":"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI.jpg","width":640,"height":366}},"fetchFailed":false,"isLoading":false}},"audioPlayerReducer":{"postId":"stream_live"},"authorsReducer":{"dr-barry-starr":{"type":"authors","id":"6177","meta":{"index":"authors_1591205172","id":"6177","found":true},"name":"Dr. Barry Starr","firstName":"Dr. Barry","lastName":"Starr","slug":"dr-barry-starr","email":"bstarr@thetech.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Dr. Barry Starr (\u003ca href=\"https://twitter.com/geneticsboy\">@geneticsboy\u003c/a>) is a Geneticist-in-Residence at The Tech Museum of Innovation in San Jose, CA and runs their Stanford at The Tech program. 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She has also earned awards from the Jackson Hole Wildlife Film Festival, the Society of Professional Journalists and the Society of Environmental Journalists.\r\n\r\nHer videos for KQED have also aired on NOVA scienceNOW and the PBS NewsHour, and appeared on NPR.org.\r\n\r\nAs an independent filmmaker, she produced and directed the hour-long documentary \u003ca href=\"http://lpbp.org/beautiful-sin-qa-with-producer-gabriela-quiros/\">\u003cem>Beautiful Sin\u003c/em>\u003c/a>, about the surprising story of how Costa Rica became the only country in the world to outlaw in vitro fertilization. The film aired in 2015 on public television stations throughout the U.S., and in Costa Rica.\r\n\r\nShe started her journalism career as a newspaper reporter in Costa Rica, where she grew up. She won the National Science Journalism Award there for a series of articles about organic agriculture, and developed a life-long interest in health reporting. 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Gurdon. \u003c/p>\n\u003cp>Yamanaka, who is also an investigator at Kyoto University, in Japan, and a professor of anatomy at UCSF, won the prize for developing a technology to create stem cells that can become any type of cell in the body. His method creates cells that are like embryonic stem cells, without using human embryos. \u003c/p>\n\u003cp>These so-called induced pluripotent stem cells, or IPS cells, could one day lead to cures for a wide range of diseases, from Parkinson’s to heart disease. And they bypass the ethical issues surrounding the use of human embryos for research.\u003c/p>\n\u003cp>IPS cells are like embryonic stem cells in that they can be coaxed into becoming any type of cell in the body. But unlike embryonic stem cells, which are created from human embryos, IPS cells are developed by introducing a few genes into common adult cells like skin cells. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>“We knew that embryonic stem cells and skin cells, although they are very different, have the same blueprint, which consists of approximately 30,000 genes,” Yamanaka told KQED News during an interview at the Gladstone Institutes in San Francisco in 2010. His method consisted in getting the skin cells to “read” the genes that give embryonic stem cells their qualities. \u003c/p>\n\u003cfigure id=\"attachment_9072\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003cimg decoding=\"async\" loading=\"lazy\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/10/Shinya-Yamanaka_9-14-10_JO_BEST_resized1.jpg\" alt=\"Dr. Shinya Yamanaka, stem cell researcher at the Gladstone Institutes, in San Francisco, won the 2012 Nobel Prize in medicine. \" width=\"300\" height=\"200\" class=\"size-full wp-image-9072\">\u003cfigcaption class=\"wp-caption-text\">Dr. Shinya Yamanaka, stem cell researcher at the Gladstone Institutes, in San Francisco, won the 2012 Nobel Prize in medicine. \u003ccite>(Jenny Oh)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>In announcing the award today in Stockholm, Sweden, the Nobel Committee for Physiology or Medicine said that “These groundbreaking discoveries have completely changed our view of the development and cellular specialization. We now understand that the mature cell does not have to be confined forever to its specialized state.” \u003c/p>\n\u003cp>Yamanaka won the award jointly with John B. Gurdon, from the University of Cambridge and the Gurdon Institute, in Cambridge, England. The Nobel Committee recognized Gurdon for his pioneering work in animal cloning. In 1962, Gurdon discovered that “the specialization of cells into different tissues is reversible,” said the Committee. \u003c/p>\n\u003cp>Yamanaka, who was an orthopedic surgeon before becoming a research scientist, became interested in stem cells as a way to potentially help patients suffering from spinal cord injuries, for which there are no treatments today. He decided to look for an alternative to embryonic stem cells in response to the controversy around the use of embryos for research. \u003c/p>\n\u003cp>“What I’m hoping is that by using IPS cells, which are free from ethical issues, we can speed everything up,” he said. \u003c/p>\n\u003cp>Though \u003ca href=\"http://www.cirm.ca.gov/\">funding is available in California \u003c/a>for researchers using embryonic stem cells, federal funds have been subject to the political pendulum. President George W. Bush restricted funding in 2001. On his first day in office in 2009, President Obama overturned Bush’s decision and made federal funding available for the research. \u003c/p>\n\u003cp>In 2006, Yamanaka was able to create IPS cells from mice adult cells. His big breakthrough came in 2007, when he created the embryonic-like cells from human skin cells. He then took these IPS cells, and using their ability to become any cell in the body, coaxed them into becoming heart cells. Proof of his success arrived in the form of an email from a researcher at his lab in Kyoto.\u003c/p>\n\u003cp>“I was in San Francisco. He sent me a video showing beating heart cells,” Yamanaka said. “But those heart cells were not from a heart. They were actually from skin.”\u003c/p>\n\u003cp>In this 2008 \u003ca href=\"http://www.pbs.org/wgbh/nova/body/stem-cells-breakthrough.html\">NOVA ScienceNow video\u003c/a>, Yamanaka explains how he made his breakthrough.\u003c/p>\n\u003cp>Treatments based on IPS cells would be based on their ability to become stem cells that could regenerate damaged cells in different organs. Yamanaka said that stem cell transplants on animals with spinal injuries have shown promising results in his lab. Clinical trials could be five years away, he said. He is also using IPS cells to test drugs against Lou Gehrig’s disease. \u003c/p>\n\u003cp>In addition to bypassing the ethical issues, IPS cells have another advantage over embryonic stem cells. Because they’re created from patients’ own cells, they would be less likely to be rejected by their bodies. \u003c/p>\n\u003cp>Since Yamanaka’s breakthrough, scientists have taken his cellular reprogramming techniques one step further and are now able to transform one type of adult cell directly into another, bypassing the stem cell stage altogether. Deepak Srivastava and his team at the Gladstone Institute of Cardiovascular Disease \u003ca href=\"http://ww2.kqed.org/quest/video/science-on-the-spot-new-hope-for-heart-repair/\" title=\"New Hope for Heart Repair\" target=\"_blank\" rel=\"noopener\">have created beating heart muscle cells in mice\u003c/a> from another type of heart cell that normally becomes scar tissue after a heart attack. \u003c/p>\n\u003cp>Yamanaka is only the second Japanese scientist to win the Nobel Prize in medicine. In 1987, Susumo Tonegawa, from the Massachusetts Institute of Technology, received the award. Yamanaka said he plans to use his award money to fund young researchers. \u003c/p>\n\u003cp>Yamanaka, 50, spends a few days each month in San Francisco working at the Gladstone Institutes, where he began his research career in 1993 as a postdoctoral fellow. \u003c/p>\n\u003cp>He lives in Osaka with his wife, a dermatologist, and two daughters, aged 22 and 20, both of whom are in medical school. \u003c/p>\n\u003cp>“I’m the least busy person in my house,” he joked.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Stem cell researcher Shinya Yamanaka talks about how he created embryonic-like stem cells from skin cells; when treatments might be available, and why researchers still need to study embryonic stem cells.\u003c/p>\n\n","blocks":[],"excerpt":"Shinya Yamanaka, a stem cell researcher at the Gladstone Institutes and professor at the University of California, San Francisco, has won this year's Nobel Prize in medicine.","status":"publish","parent":0,"modified":1684973740,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":24,"wordCount":943},"headData":{"title":"SF Scientist Wins Nobel for Stem Cell Breakthrough | KQED","description":"Shinya Yamanaka, a stem cell researcher at the Gladstone Institutes and professor at the University of California, San Francisco, has won this year's Nobel Prize in medicine.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"videoEmbed":"https://www.youtube.com/watch?v=rcFibJmKZrU","templateType":"standard","featuredImageType":"standard","excludeFromSiteSearch":"Include","articleAge":"0","path":"/quest/9059/sf-scientist-wins-nobel-for-stem-cell-breakthrough","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>Reported for \u003ca href=\"http://www.kqed.org/news/\">KQEDnews.org\u003c/a>\u003c/em>\u003c/p>\n\u003cp>Shinya Yamanaka, a stem cell researcher at the \u003ca href=\"http://www.gladstone.ucsf.edu/\">Gladstone Institutes\u003c/a>, which is affiliated with the University of California, San Francisco, has won this year’s Nobel Prize in Physiology or Medicine jointly with English researcher John B. Gurdon. \u003c/p>\n\u003cp>Yamanaka, who is also an investigator at Kyoto University, in Japan, and a professor of anatomy at UCSF, won the prize for developing a technology to create stem cells that can become any type of cell in the body. His method creates cells that are like embryonic stem cells, without using human embryos. \u003c/p>\n\u003cp>These so-called induced pluripotent stem cells, or IPS cells, could one day lead to cures for a wide range of diseases, from Parkinson’s to heart disease. And they bypass the ethical issues surrounding the use of human embryos for research.\u003c/p>\n\u003cp>IPS cells are like embryonic stem cells in that they can be coaxed into becoming any type of cell in the body. But unlike embryonic stem cells, which are created from human embryos, IPS cells are developed by introducing a few genes into common adult cells like skin cells. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“We knew that embryonic stem cells and skin cells, although they are very different, have the same blueprint, which consists of approximately 30,000 genes,” Yamanaka told KQED News during an interview at the Gladstone Institutes in San Francisco in 2010. His method consisted in getting the skin cells to “read” the genes that give embryonic stem cells their qualities. \u003c/p>\n\u003cfigure id=\"attachment_9072\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003cimg decoding=\"async\" loading=\"lazy\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/10/Shinya-Yamanaka_9-14-10_JO_BEST_resized1.jpg\" alt=\"Dr. Shinya Yamanaka, stem cell researcher at the Gladstone Institutes, in San Francisco, won the 2012 Nobel Prize in medicine. \" width=\"300\" height=\"200\" class=\"size-full wp-image-9072\">\u003cfigcaption class=\"wp-caption-text\">Dr. Shinya Yamanaka, stem cell researcher at the Gladstone Institutes, in San Francisco, won the 2012 Nobel Prize in medicine. \u003ccite>(Jenny Oh)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>In announcing the award today in Stockholm, Sweden, the Nobel Committee for Physiology or Medicine said that “These groundbreaking discoveries have completely changed our view of the development and cellular specialization. We now understand that the mature cell does not have to be confined forever to its specialized state.” \u003c/p>\n\u003cp>Yamanaka won the award jointly with John B. Gurdon, from the University of Cambridge and the Gurdon Institute, in Cambridge, England. The Nobel Committee recognized Gurdon for his pioneering work in animal cloning. In 1962, Gurdon discovered that “the specialization of cells into different tissues is reversible,” said the Committee. \u003c/p>\n\u003cp>Yamanaka, who was an orthopedic surgeon before becoming a research scientist, became interested in stem cells as a way to potentially help patients suffering from spinal cord injuries, for which there are no treatments today. He decided to look for an alternative to embryonic stem cells in response to the controversy around the use of embryos for research. \u003c/p>\n\u003cp>“What I’m hoping is that by using IPS cells, which are free from ethical issues, we can speed everything up,” he said. \u003c/p>\n\u003cp>Though \u003ca href=\"http://www.cirm.ca.gov/\">funding is available in California \u003c/a>for researchers using embryonic stem cells, federal funds have been subject to the political pendulum. President George W. Bush restricted funding in 2001. On his first day in office in 2009, President Obama overturned Bush’s decision and made federal funding available for the research. \u003c/p>\n\u003cp>In 2006, Yamanaka was able to create IPS cells from mice adult cells. His big breakthrough came in 2007, when he created the embryonic-like cells from human skin cells. He then took these IPS cells, and using their ability to become any cell in the body, coaxed them into becoming heart cells. Proof of his success arrived in the form of an email from a researcher at his lab in Kyoto.\u003c/p>\n\u003cp>“I was in San Francisco. He sent me a video showing beating heart cells,” Yamanaka said. “But those heart cells were not from a heart. They were actually from skin.”\u003c/p>\n\u003cp>In this 2008 \u003ca href=\"http://www.pbs.org/wgbh/nova/body/stem-cells-breakthrough.html\">NOVA ScienceNow video\u003c/a>, Yamanaka explains how he made his breakthrough.\u003c/p>\n\u003cp>Treatments based on IPS cells would be based on their ability to become stem cells that could regenerate damaged cells in different organs. Yamanaka said that stem cell transplants on animals with spinal injuries have shown promising results in his lab. Clinical trials could be five years away, he said. He is also using IPS cells to test drugs against Lou Gehrig’s disease. \u003c/p>\n\u003cp>In addition to bypassing the ethical issues, IPS cells have another advantage over embryonic stem cells. Because they’re created from patients’ own cells, they would be less likely to be rejected by their bodies. \u003c/p>\n\u003cp>Since Yamanaka’s breakthrough, scientists have taken his cellular reprogramming techniques one step further and are now able to transform one type of adult cell directly into another, bypassing the stem cell stage altogether. Deepak Srivastava and his team at the Gladstone Institute of Cardiovascular Disease \u003ca href=\"http://ww2.kqed.org/quest/video/science-on-the-spot-new-hope-for-heart-repair/\" title=\"New Hope for Heart Repair\" target=\"_blank\" rel=\"noopener\">have created beating heart muscle cells in mice\u003c/a> from another type of heart cell that normally becomes scar tissue after a heart attack. \u003c/p>\n\u003cp>Yamanaka is only the second Japanese scientist to win the Nobel Prize in medicine. In 1987, Susumo Tonegawa, from the Massachusetts Institute of Technology, received the award. Yamanaka said he plans to use his award money to fund young researchers. \u003c/p>\n\u003cp>Yamanaka, 50, spends a few days each month in San Francisco working at the Gladstone Institutes, where he began his research career in 1993 as a postdoctoral fellow. \u003c/p>\n\u003cp>He lives in Osaka with his wife, a dermatologist, and two daughters, aged 22 and 20, both of whom are in medical school. \u003c/p>\n\u003cp>“I’m the least busy person in my house,” he joked.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Stem cell researcher Shinya Yamanaka talks about how he created embryonic-like stem cells from skin cells; when treatments might be available, and why researchers still need to study embryonic stem cells.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/9059/sf-scientist-wins-nobel-for-stem-cell-breakthrough","authors":["6186"],"categories":["quest_12","quest_3422","quest_3233"],"tags":["quest_1407","quest_1459","quest_13203","quest_13","quest_2789","quest_3314","quest_3071"],"featImg":"quest_9072","label":"quest"},"quest_31832":{"type":"posts","id":"quest_31832","meta":{"index":"posts_1591205157","site":"quest","id":"31832","score":null,"sort":[1330963725000]},"guestAuthors":[],"slug":"reproduction-unleashed","title":"Reproduction Unleashed","publishDate":1330963725,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2012/03/05/reproduction-unleashed/icsi/\" rel=\"attachment wp-att-31837\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/02/ICSI.jpg\" alt=\"\" title=\"ICSI\" width=\"640\" height=\"366\" class=\"size-full wp-image-31837\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-400x229.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003c/p>\n\u003cp>Scientists are getting pretty good at turning regular cells into those magical embryonic stem (ES) cells that can become any other kind of cell. They haven’t perfected their technique yet but when they do, all sorts of possibilities open up for prospective parents.\u003c/p>\n\u003cp>There may come a time when infertile men can have their cells coaxed into ES cells and then coaxed back into sperm cells. Or when the same thing can happen with women (except her cells will be persuaded to become eggs). Now these folks may be able to have kids when they couldn’t before.\u003c/p>\n\u003cp>This technology brings up an even more interesting possibility. Imagine a man’s cells are transformed into ES cells and then turned into egg cells. Or a woman’s cells undergo something similar except that the end result is a sperm cell. Now same sex couples could conceivably have children that share both partners’ DNA.\u003c/p>\n\u003cp>Before we get too far ahead of ourselves, I do want to emphasize that we aren’t there yet. No one has done anything like this with artificially created ES cells. (Scientists call these artificially created ES cells \u003ca href=\"http://www.thetech.org/genetics/news.php?id=109\">induced pluripotent stem cells\u003c/a> or iPS cells to distinguish them from true ES cells.) \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>But scientists have at least managed to \u003ca href=\"http://news.sciencemag.org/sciencenow/2011/08/sperm-made-mostly-in-a-dish-produce.html\">turn natural mouse ES cells into a sperm\u003c/a> cell that can fertilize an egg which then results in a living pup. And they have done similar things in mice to \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/16903421\">create precursor egg cells\u003c/a> from natural ES cells. So it should only be a matter of time before they get these working with human ES cells too.\u003c/p>\n\u003cp>The next step would be to try to get these to work with iPS cells. Scientists have managed to \u003ca href=\"http://www.sciencedaily.com/releases/2009/01/090127090732.htm\">make sperm and egg precursors\u003c/a> from mouse iPS cells. But to my knowledge, no one has yet created a fertilized egg from a sperm and an egg derived from these cells. \u003c/p>\n\u003ctable align=\"right\">\n\u003ctr>\n\u003ctd>\u003cimg src=\"http://www.thetech.org/genetics/images/ask/mouse.jpg\">\u003cbr>\u003cfont size=\"-1\" color=\"#999999\">This mouse named\u003cbr>Kaguya had two moms.\u003c/font>\u003c/td>\n\u003c/tr>\n\u003c/table>\n\u003cp>While iPS cells appear to be very similar to natural ES cells, the proof will be in the cells that come from them. Someone needs to do the experiment where a mouse iPS cell is turned into a sperm or an egg that is then used to create a viable mouse pup. Then, as long as we can solve the problem that these cells sometimes turn cancerous, we’ll be in business for helping infertile couples this way. (As opposed to the approach suggested by a \u003ca href=\"http://news.sciencemag.org/sciencenow/2012/02/human-egg-stem-cells-isolated.html?ref=hp\">recent report\u003c/a> where scientists found egg stem cells in adult women’s ovaries.)\u003c/p>\n\u003cp>So far this all seems doable. There aren’t any paradigm shifts or anything like that…mostly just technical hurdles to be overcome. The same may not be true for turning a man’s cells into eggs or a woman’s into sperm.\u003c/p>\n\u003cp>This is much harder for lots of different reasons. A big potential problem is that a man’s DNA is fundamentally different from a woman’s DNA. This is why, for example, we can’t just fuse two eggs and get a baby. Scientists \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=16\">pulled this off in mice\u003c/a> but only by changing one egg’s DNA to make it more like a man’s. No way we could do something similar in people.\u003c/p>\n\u003cp>The hope would be that the iPS process would wipe the DNA clean of any gender. We don’t yet know if it does though. And if a bit of maleness remains in a man’s iPS cells or a bit of femaleness in a woman’s iPS cells, then we may not be able to get a working egg or sperm. We’ll just have to wait and see!\u003c/p>\n\u003cp>One thing we don’t have to worry about is some narcissist making an egg and a sperm from his cells to make a baby entirely out of his genes. Because of how DNA is distributed into eggs and sperm, you wouldn’t get a clone. Instead you’d get the most inbred individual you’ve ever seen. Odds are that the child would suffer from some devastating genetic disease that lay hidden in the parent’s DNA.\u003c/p>\n\u003cp>[youtube=http://www.youtube.com/watch?v=fGNchPdlaGU]\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>Nice primer on making iPS cells.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"Stem cell technology may one day help infertile couples conceive. And it might even allow same sex couples to conceive as well.","status":"publish","parent":0,"modified":1331669678,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":732},"headData":{"title":"Reproduction Unleashed | KQED","description":"Stem cell technology may one day help infertile couples conceive. And it might even allow same sex couples to conceive as well.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"31832 http://science.kqed.org/quest/?p=31832","disqusUrl":"https://ww2.kqed.org/quest/2012/03/05/reproduction-unleashed/","disqusTitle":"Reproduction Unleashed","path":"/quest/31832/reproduction-unleashed","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2012/03/05/reproduction-unleashed/icsi/\" rel=\"attachment wp-att-31837\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/02/ICSI.jpg\" alt=\"\" title=\"ICSI\" width=\"640\" height=\"366\" class=\"size-full wp-image-31837\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/02/ICSI-400x229.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003c/p>\n\u003cp>Scientists are getting pretty good at turning regular cells into those magical embryonic stem (ES) cells that can become any other kind of cell. They haven’t perfected their technique yet but when they do, all sorts of possibilities open up for prospective parents.\u003c/p>\n\u003cp>There may come a time when infertile men can have their cells coaxed into ES cells and then coaxed back into sperm cells. Or when the same thing can happen with women (except her cells will be persuaded to become eggs). Now these folks may be able to have kids when they couldn’t before.\u003c/p>\n\u003cp>This technology brings up an even more interesting possibility. Imagine a man’s cells are transformed into ES cells and then turned into egg cells. Or a woman’s cells undergo something similar except that the end result is a sperm cell. Now same sex couples could conceivably have children that share both partners’ DNA.\u003c/p>\n\u003cp>Before we get too far ahead of ourselves, I do want to emphasize that we aren’t there yet. No one has done anything like this with artificially created ES cells. (Scientists call these artificially created ES cells \u003ca href=\"http://www.thetech.org/genetics/news.php?id=109\">induced pluripotent stem cells\u003c/a> or iPS cells to distinguish them from true ES cells.) \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>But scientists have at least managed to \u003ca href=\"http://news.sciencemag.org/sciencenow/2011/08/sperm-made-mostly-in-a-dish-produce.html\">turn natural mouse ES cells into a sperm\u003c/a> cell that can fertilize an egg which then results in a living pup. And they have done similar things in mice to \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/16903421\">create precursor egg cells\u003c/a> from natural ES cells. So it should only be a matter of time before they get these working with human ES cells too.\u003c/p>\n\u003cp>The next step would be to try to get these to work with iPS cells. Scientists have managed to \u003ca href=\"http://www.sciencedaily.com/releases/2009/01/090127090732.htm\">make sperm and egg precursors\u003c/a> from mouse iPS cells. But to my knowledge, no one has yet created a fertilized egg from a sperm and an egg derived from these cells. \u003c/p>\n\u003ctable align=\"right\">\n\u003ctr>\n\u003ctd>\u003cimg src=\"http://www.thetech.org/genetics/images/ask/mouse.jpg\">\u003cbr>\u003cfont size=\"-1\" color=\"#999999\">This mouse named\u003cbr>Kaguya had two moms.\u003c/font>\u003c/td>\n\u003c/tr>\n\u003c/table>\n\u003cp>While iPS cells appear to be very similar to natural ES cells, the proof will be in the cells that come from them. Someone needs to do the experiment where a mouse iPS cell is turned into a sperm or an egg that is then used to create a viable mouse pup. Then, as long as we can solve the problem that these cells sometimes turn cancerous, we’ll be in business for helping infertile couples this way. (As opposed to the approach suggested by a \u003ca href=\"http://news.sciencemag.org/sciencenow/2012/02/human-egg-stem-cells-isolated.html?ref=hp\">recent report\u003c/a> where scientists found egg stem cells in adult women’s ovaries.)\u003c/p>\n\u003cp>So far this all seems doable. There aren’t any paradigm shifts or anything like that…mostly just technical hurdles to be overcome. The same may not be true for turning a man’s cells into eggs or a woman’s into sperm.\u003c/p>\n\u003cp>This is much harder for lots of different reasons. A big potential problem is that a man’s DNA is fundamentally different from a woman’s DNA. This is why, for example, we can’t just fuse two eggs and get a baby. Scientists \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=16\">pulled this off in mice\u003c/a> but only by changing one egg’s DNA to make it more like a man’s. No way we could do something similar in people.\u003c/p>\n\u003cp>The hope would be that the iPS process would wipe the DNA clean of any gender. We don’t yet know if it does though. And if a bit of maleness remains in a man’s iPS cells or a bit of femaleness in a woman’s iPS cells, then we may not be able to get a working egg or sperm. We’ll just have to wait and see!\u003c/p>\n\u003cp>One thing we don’t have to worry about is some narcissist making an egg and a sperm from his cells to make a baby entirely out of his genes. Because of how DNA is distributed into eggs and sperm, you wouldn’t get a clone. Instead you’d get the most inbred individual you’ve ever seen. Odds are that the child would suffer from some devastating genetic disease that lay hidden in the parent’s DNA.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/fGNchPdlaGU'\n title='//www.youtube.com/embed/fGNchPdlaGU'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>Nice primer on making iPS cells.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/31832/reproduction-unleashed","authors":["6177"],"categories":["quest_4"],"tags":["quest_20","quest_10745","quest_1459","quest_13202","quest_9929","quest_10746","quest_3319"],"featImg":"quest_31837","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg","imageAlt":"On Our Watch from NPR and KQED","officialWebsiteLink":"/podcasts/onourwatch","meta":{"site":"news","source":"kqed","order":"1"},"link":"/podcasts/onourwatch","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1567098962","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw","npr":"https://rpb3r.app.goo.gl/onourwatch","spotify":"https://open.spotify.com/show/0OLWoyizopu6tY1XiuX70x","tuneIn":"https://tunein.com/radio/On-Our-Watch-p1436229/","stitcher":"https://www.stitcher.com/show/on-our-watch","rss":"https://feeds.npr.org/510360/podcast.xml"}},"on-the-media":{"id":"on-the-media","title":"On The Media","info":"Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us","airtime":"SUN 2pm-3pm, MON 12am-1am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png","officialWebsiteLink":"https://www.wnycstudios.org/shows/otm","meta":{"site":"news","source":"wnyc"},"link":"/radio/program/on-the-media","subscribe":{"apple":"https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2","tuneIn":"https://tunein.com/radio/On-the-Media-p69/","rss":"http://feeds.wnyc.org/onthemedia"}},"our-body-politic":{"id":"our-body-politic","title":"Our Body Politic","info":"Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.","airtime":"SAT 6pm-7pm, SUN 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://our-body-politic.simplecast.com/","meta":{"site":"news","source":"kcrw"},"link":"/radio/program/our-body-politic","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/our-body-politic/id1533069868","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw","spotify":"https://open.spotify.com/show/4ApAiLT1kV153TttWAmqmc","rss":"https://feeds.simplecast.com/_xaPhs1s","tuneIn":"https://tunein.com/podcasts/News--Politics-Podcasts/Our-Body-Politic-p1369211/"}},"pbs-newshour":{"id":"pbs-newshour","title":"PBS NewsHour","info":"Analysis, background reports and updates from the PBS NewsHour putting today's news in context.","airtime":"MON-FRI 3pm-4pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.pbs.org/newshour/","meta":{"site":"news","source":"pbs"},"link":"/radio/program/pbs-newshour","subscribe":{"apple":"https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2","tuneIn":"https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/","rss":"https://www.pbs.org/newshour/feeds/rss/podcasts/show"}},"perspectives":{"id":"perspectives","title":"Perspectives","tagline":"KQED's series of of daily listener commentaries since 1991","info":"KQED's series of of daily listener commentaries since 1991.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Perspectives-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/perspectives/","meta":{"site":"radio","source":"kqed","order":"15"},"link":"/perspectives","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/id73801135","npr":"https://www.npr.org/podcasts/432309616/perspectives","rss":"https://ww2.kqed.org/perspectives/category/perspectives/feed/","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"}},"planet-money":{"id":"planet-money","title":"Planet Money","info":"The economy explained. 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