Career Spotlight: Developmental and Stem Cell Biology Graduate Student
Pump It Up: Heart Health Special Report
Science on the SPOT: New Hope for Heart Repair
New Life for Embryonic Stem Cell Research
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Since he was a young child, Martin has wanted to study the heart and he says attending graduate school will help turn his dream into a career.\u003c/p>\n\u003cp>This video is featured in our \u003cb>\u003ca href=\"http://foldscope.woop.ie/\" target=\"_blank\">Engineering Is: Diagnosing Diseases with Origami Microscopes\u003c/a>\u003c/b>e-book. You can find our other e-books at \u003ca href=\"http://blogs.kqed.org/education/e-books/\">kqed.org/ebooks\u003c/a>.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/74092/career-spotlight-developmental-and-stem-cell-biology-graduate-student","authors":["6544"],"series":["quest_13374"],"categories":["quest_4","quest_12"],"tags":["quest_13128","quest_793","quest_12946","quest_13173","quest_12269","quest_1218","quest_13172","quest_1331","quest_1332","quest_3351","quest_2349","quest_2791","quest_3025","quest_3071"],"collections":["quest_13175"],"featImg":"quest_74094","label":"source_quest_74092"},"quest_36263":{"type":"posts","id":"quest_36263","meta":{"index":"posts_1591205157","site":"quest","id":"36263","score":null,"sort":[1335897020000]},"guestAuthors":[],"slug":"pump-it-up-heart-health-special-report","title":"Pump It Up: Heart Health Special Report","publishDate":1335897020,"format":"video","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>The three stories in the half-hour QUEST TV show \u003cstrong>Pump It Up: Heart Health Special Report\u003c/strong> investigate the number one cause of death in America, heart disease, which kills 600,000 people each year – more than die from cancer, car accidents or AIDS. We look at the disease from the point of view of a teenager trying to lower her risk; a heart attack patient and the team that saved her life, and a researcher working to one day rebuild a damaged heart from the inside out.\u003c/p>\n\u003cfigure id=\"attachment_36372\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602A_Lorena_Ramos_talk_on_reading_labels_12-7-11_GQ_resized1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602A_Lorena_Ramos_talk_on_reading_labels_12-7-11_GQ_resized1-300x169.jpg\" alt=\"\" title=\"602A_Lorena_Ramos_talk_on_reading_labels_12-7-11_GQ_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-36372\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Lorena Ramos, 14, struggles to lose weight.\u003c/figcaption>\u003c/figure>\n\u003cp>The show opens with the 14-minute story \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/strong>. One in six kids in the United States is obese, a condition that doubles their risk of heart disease. Castro Valley teenager Lorena Ramos, 14, has been overweight since she was a small child. Now, with the help of her mother and the \u003ca href=\"http://www.childrenshospitaloakland.org/healthcare/depts/weight_management_healthy_hearts.asp\" title=\"Healthy Hearts clinic at Children's Hospital Oakland\" target=\"_blank\">Healthy Hearts clinic at Children’s Hospital Oakland\u003c/a>, she’s fighting to exercise, eat healthily and drop weight. Will she succeed?\u003c/p>\n\u003cp>\u003c/p>\n\u003cfigure id=\"attachment_36382\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602i_Angiogram_16_12-28-11_GQ_NICE_resized1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602i_Angiogram_16_12-28-11_GQ_NICE_resized1-300x169.jpg\" alt=\"A heart patient is treated at John Muir Medical Center in Concord.\" title=\"602i_Angiogram_16_12-28-11_GQ_NICE_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-36382\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A heart patient is treated at John Muir Medical Center in Concord.\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/strong> tells the story of Arlene Skuba, who survived a heart attack at 72, after doctors at the \u003ca href=\"http://www.johnmuirhealth.com/locations/john-muir-medical-center-concord.html\" title=\"John Muir Medical Center, Concord\" target=\"_blank\">John Muir Medical Center in Concord\u003c/a> rapidly unclogged her arteries. Just 30 years ago, doctors could only watch patients as they suffered their heart attacks. As many as 20 percent of them ended up dying. Now, by opening their blocked arteries while their heart attacks are underway, they save all but 5 percent of those who make it to a hospital.\u003c/p>\n\u003cfigure id=\"attachment_36266\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized1-300x169.jpg\" alt=\"Research mouse.\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-36266\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">After being injected with three genes, the hearts of mice who had suffered a heart attack pumped blood normally. All photos by Gabriela Quirós.\u003c/figcaption>\u003c/figure>\n\u003cp>The special report’s final 4-minute story, \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/video/science-on-the-spot-new-hope-for-heart-repair/\" title=\"Breakthrough Offers New Hope for Heart Repair\" target=\"_blank\">New Hope for Heart Repair\u003c/a>\u003c/strong>, takes us into the future, to a time when a single injection of three genes might be able to repair damaged hearts and give heart attack survivors their quality of life back. We visit the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, in San Francisco, and watch as researchers repair tiny mice hearts using the next generation of cell reprogramming. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003cbr clear=\"all\">\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>You can watch each of the three stories individually, as well, by following the links below:\u003c/strong> \u003c/p>\n\n","blocks":[],"excerpt":"This half-hour program looks at heart disease – the number one killer in the United States – from the point of view of a teenager trying to lower her risk, a heart attack survivor, and a scientist working to rebuild damaged hearts.","status":"publish","parent":0,"modified":1457569719,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":9,"wordCount":384},"headData":{"title":"Pump It Up: Heart Health Special Report | KQED","description":"This half-hour program looks at heart disease – the number one killer in the United States – from the point of view of a teenager trying to lower her risk, a heart attack survivor, and a scientist working to rebuild damaged hearts.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Pump It Up: Heart Health Special Report","datePublished":"2012-05-01T18:30:20.000Z","dateModified":"2016-03-10T00:28:39.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"36263 http://science.kqed.org/quest/?post_type=videos&p=36263","disqusUrl":"https://ww2.kqed.org/quest/2012/05/01/pump-it-up-heart-health-special-report/","disqusTitle":"Pump It Up: Heart Health Special Report","videoEmbed":"https://www.youtube.com/watch?v=NbfKYZ9UTwU","path":"/quest/36263/pump-it-up-heart-health-special-report","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>The three stories in the half-hour QUEST TV show \u003cstrong>Pump It Up: Heart Health Special Report\u003c/strong> investigate the number one cause of death in America, heart disease, which kills 600,000 people each year – more than die from cancer, car accidents or AIDS. We look at the disease from the point of view of a teenager trying to lower her risk; a heart attack patient and the team that saved her life, and a researcher working to one day rebuild a damaged heart from the inside out.\u003c/p>\n\u003cfigure id=\"attachment_36372\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602A_Lorena_Ramos_talk_on_reading_labels_12-7-11_GQ_resized1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602A_Lorena_Ramos_talk_on_reading_labels_12-7-11_GQ_resized1-300x169.jpg\" alt=\"\" title=\"602A_Lorena_Ramos_talk_on_reading_labels_12-7-11_GQ_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-36372\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Lorena Ramos, 14, struggles to lose weight.\u003c/figcaption>\u003c/figure>\n\u003cp>The show opens with the 14-minute story \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/strong>. One in six kids in the United States is obese, a condition that doubles their risk of heart disease. Castro Valley teenager Lorena Ramos, 14, has been overweight since she was a small child. Now, with the help of her mother and the \u003ca href=\"http://www.childrenshospitaloakland.org/healthcare/depts/weight_management_healthy_hearts.asp\" title=\"Healthy Hearts clinic at Children's Hospital Oakland\" target=\"_blank\">Healthy Hearts clinic at Children’s Hospital Oakland\u003c/a>, she’s fighting to exercise, eat healthily and drop weight. Will she succeed?\u003c/p>\n\u003cp>\u003c/p>\n\u003cfigure id=\"attachment_36382\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602i_Angiogram_16_12-28-11_GQ_NICE_resized1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602i_Angiogram_16_12-28-11_GQ_NICE_resized1-300x169.jpg\" alt=\"A heart patient is treated at John Muir Medical Center in Concord.\" title=\"602i_Angiogram_16_12-28-11_GQ_NICE_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-36382\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A heart patient is treated at John Muir Medical Center in Concord.\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/strong> tells the story of Arlene Skuba, who survived a heart attack at 72, after doctors at the \u003ca href=\"http://www.johnmuirhealth.com/locations/john-muir-medical-center-concord.html\" title=\"John Muir Medical Center, Concord\" target=\"_blank\">John Muir Medical Center in Concord\u003c/a> rapidly unclogged her arteries. Just 30 years ago, doctors could only watch patients as they suffered their heart attacks. As many as 20 percent of them ended up dying. Now, by opening their blocked arteries while their heart attacks are underway, they save all but 5 percent of those who make it to a hospital.\u003c/p>\n\u003cfigure id=\"attachment_36266\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized1-300x169.jpg\" alt=\"Research mouse.\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-36266\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">After being injected with three genes, the hearts of mice who had suffered a heart attack pumped blood normally. All photos by Gabriela Quirós.\u003c/figcaption>\u003c/figure>\n\u003cp>The special report’s final 4-minute story, \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/video/science-on-the-spot-new-hope-for-heart-repair/\" title=\"Breakthrough Offers New Hope for Heart Repair\" target=\"_blank\">New Hope for Heart Repair\u003c/a>\u003c/strong>, takes us into the future, to a time when a single injection of three genes might be able to repair damaged hearts and give heart attack survivors their quality of life back. We visit the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, in San Francisco, and watch as researchers repair tiny mice hearts using the next generation of cell reprogramming. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cbr clear=\"all\">\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>You can watch each of the three stories individually, as well, by following the links below:\u003c/strong> \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/36263/pump-it-up-heart-health-special-report","authors":["6186"],"categories":["quest_12","quest_3422","quest_3233"],"tags":["quest_10999","quest_11027","quest_11029","quest_1189","quest_1218","quest_1331","quest_10997","quest_1332","quest_11032","quest_2031","quest_2095","quest_13","quest_2893","quest_3314","quest_3071"],"featImg":"quest_36367","label":"quest"},"quest_35176":{"type":"posts","id":"quest_35176","meta":{"index":"posts_1591205157","site":"quest","id":"35176","score":null,"sort":[1334768406000]},"guestAuthors":[],"slug":"science-on-the-spot-new-hope-for-heart-repair","title":"Science on the SPOT: New Hope for Heart Repair","publishDate":1334768406,"format":"video","headTitle":"Science on the SPOT | QUEST | KQED Science","labelTerm":{"term":3296,"site":"quest"},"content":"\u003cp>More than 5 million people in the United States live with damaged hearts that make it difficult to walk and carry out other simple daily tasks. Pacemakers and drugs can help, but they don’t repair the heart muscle that has died as a result of a heart attack or clogged arteries.\u003c/p>\n\u003cp>Now, scientists in San Francisco say a more effective treatment might be on the way. \u003c/p>\n\u003cfigure id=\"attachment_35476\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized-300x169.jpg\" alt=\"Research mouse\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Three months after being injected with three genes, the hearts of mice that had suffered a heart attack pumped as much blood as a normal heart. Credit: Gabriela Quirós, QUEST \u003c/figcaption>\u003c/figure>\n\u003cp>The researchers from the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, affiliated with the University of California-San Francisco, reported today that using a new genetic technique, they have succeeded for the first time in repairing, from within, the hearts of mice weakened by heart attacks. \u003c/p>\n\u003cp>“There are a variety of approaches we use right now to help people who are left with damaged hearts,” said \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/srivastava/\" title=\"Dr. Deepak Srivastava\" target=\"_blank\">Dr. Deepak Srivastava\u003c/a>, senior author of the paper and director of cardiovascular research at the Gladstone Institutes, “but none of them actually get to the root of the problem, which is replacing that damaged heart muscle. And that’s where our focus has been.”\u003c/p>\n\u003cp>The scientists injected three genes into the hearts of research mice that had been given mild heart attacks. Within three months, the genes transformed non-beating cells in the heart into cells that looked and acted just like beating heart muscle cells. These new beating cells restored the heart’s ability to pump blood to the rest of the body. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Human hearts have billions of non-beating cells, which support the beating cells by forming the heart’s structure, Srivastava said. Mice have millions of these support cells too. When a heart attack happens, the support cells rush to the site of the damage and form scar tissue, which preserves the heart’s structure, but doesn’t help it pump blood. \u003c/p>\n\u003cp>“We’ve found a way to take these support cells that should normally never become muscle, and convert them into new muscle cells that actually integrate with the rest of the heart, contribute to the force that it generates, and allow us to regenerate the heart from within the organ itself,” said Srivastava.\u003c/p>\n\u003cfigure id=\"attachment_35482\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized-300x169.jpg\" alt=\"Mouse heart muscle cells created by Gladstone Institutes researchers.\" title=\"yellow induced muscle cells with sarcomere structure_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35482\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Non-beating heart cells became beating heart cells like these. Credit: Li Qian, Gladstone Institutes \u003c/figcaption>\u003c/figure>\n\u003cp>The new research appears in the April 18 online edition of the journal \u003ca href=\"http://www.nature.com/nature/index.html\" title=\"Journal Nature\" target=\"_blank\">Nature\u003c/a> and was led by \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/736\" title=\"Li Qian wins prestigious award\" target=\"_blank\">Li Qian\u003c/a>, also from the Gladstone Institutes.\u003c/p>\n\u003cp>Heart attacks and other heart disease kill 600,000 people each year. Many more survive, yet lead diminished lives. Some 5.7 million people live with damaged hearts that pump less blood, making it difficult for them to climb a flight of stairs or walk across a parking lot. \u003c/p>\n\u003cp>During a heart attack, clots block one or several coronary arteries and cut off blood flow. By rushing patients to the operating table and unclogging their arteries with catheters and stents, doctors are able to save all but 5 percent of victims who make it to the hospital. \u003c/p>\n\u003cp>“While we’ve been doing better at saving lives, each time we save a life the patient still loses some of their muscle,” Srivastava said. “So the number of people who are left with damaged hearts is actually growing, even though the number of people who die from heart attacks is getting smaller.”\u003c/p>\n\u003cp>Treatments for humans could be six to seven years away, he added. The next step will be to test the treatment on pigs. Scientists still need to figure out if cell reprogramming is safe for humans; how to deliver the genes into the heart, and how to produce enough new beating heart cells to repair a human – rather than a mouse – heart.\u003c/p>\n\u003cp>\u003cstrong>More in our Series\u003c/strong>\u003c/p>\n\u003cul>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/pump-it-up-heart-health-special-report/\">Pump It Up: Heart Health Special Report\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/li>\n\u003c/ul>\n\u003cp>Nevertheless, the research is drawing the attention of other heart researchers.\u003c/p>\n\u003cp>“It’s a major discovery and certainly suggests a new approach to treat injury that previously had been thought to be irreversible,” said \u003ca href=\"http://www.cedars-sinai.edu/Bios---Physician/H-O/Eduardo-Marban-MD.aspx\" title=\"Dr. Eduardo Marban\" target=\"_blank\">Dr. Eduardo Marbán\u003c/a>, director of the \u003ca href=\"http://www.cedars-sinai.edu/Patients/Programs-and-Services/Heart-Institute/\" title=\"Cedars-Sinai Heart Institute\" target=\"_blank\">Cedars-Sinai Heart Institute\u003c/a> in Los Angeles.\u003c/p>\n\u003cp>Marbán said it’s been “a long-held dogma” that once scar tissue has formed in the heart, it can’t change into heart muscle. This finding in mice, and recent research by Marbán’s team on a small group of human patients, challenge that belief, he said.\u003c/p>\n\u003cp>Although the cell reprogramming research doesn’t involve stem cells, the Gladstone scientists used techniques that were discovered through stem cell research. \u003c/p>\n\u003cp>The scientists said their work was inspired by the discovery in 2007 that a few genes can transform an adult skin cell into a cell with the properties of a human embryonic stem cell. Researchers have been intensely interested in \u003ca href=\"http://ww2.kqed.org/quest/video/stem-cell-gold-rush/\" title=\"QUEST TV segment about stem cell research in California\" target=\"_blank\">embryonic stem cells\u003c/a> as a possible source of treatments for diseases like Parkinson’s because they can be coaxed to turn into virtually any type of cell in the body. But because embryonic stem cells are plucked from embryos left over from fertility treatments, and require the destruction of these embryos, their study has been controversial.\u003c/p>\n\u003cp>An alternative to embryonic stem cells came with the skin cell breakthrough five years ago. Then, \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/yamanaka/\" title=\"Dr. Shinya Yamanaka\" target=\"_blank\">Dr. Shinya Yamanaka\u003c/a>, of the Gladstone Institutes and Kyoto University in Japan, inserted four genes that are present in embryonic stem cells into adult skin cells. The four genes \u003ca href=\"http://ww2.kqed.org/quest/2007/06/11/turning-skin-cells-into-embryonic-stem-cells/\" title=\"QUEST blog post about induced pluripotent stem cells\" target=\"_blank\">reprogrammed the skin cells to become embryonic-like stem cells\u003c/a>. \u003c/p>\n\u003cp>That led scientists to look for a way to transform one type of adult cell into another type of adult cell without the need to create stem cells at all.\u003c/p>\n\u003cp>“Yamanaka opened up the idea that adult cells weren’t permanently fixed,” said Srivastava. “That led us to ask whether or not we could convert one of these heart support cells into a heart muscle cell.” \u003c/p>\n\u003cp>Bypassing the creation of stem cells has several advantages. Though stem cells are versatile, when they’re introduced into the body they can behave as cancer cells and form tumors. \u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>“It’s a dramatic and heady possibility that vindicates for the first time the idea that we might be able to harness truly regenerative medicine,” Marbán said. \u003c/p>\n\n","blocks":[],"excerpt":"Scientists in San Francisco have coaxed mouse hearts to repair themselves from within.The breakthrough could lead to treatments for 5 million people in the United States whose hearts were damaged after they survived heart attacks. ","status":"publish","parent":0,"modified":1457569468,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":25,"wordCount":1094},"headData":{"title":"Science on the SPOT: New Hope for Heart Repair | KQED","description":"Scientists in San Francisco have coaxed mouse hearts to repair themselves from within.The breakthrough could lead to treatments for 5 million people in the United States whose hearts were damaged after they survived heart attacks. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Science on the SPOT: New Hope for Heart Repair","datePublished":"2012-04-18T17:00:06.000Z","dateModified":"2016-03-10T00:24:28.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"35176 http://science.kqed.org/quest/?post_type=videos&p=35176","disqusUrl":"https://ww2.kqed.org/quest/2012/04/18/science-on-the-spot-new-hope-for-heart-repair/","disqusTitle":"Science on the SPOT: New Hope for Heart Repair","videoEmbed":"https://youtu.be/9EvI1hVq5Ys","path":"/quest/35176/science-on-the-spot-new-hope-for-heart-repair","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>More than 5 million people in the United States live with damaged hearts that make it difficult to walk and carry out other simple daily tasks. Pacemakers and drugs can help, but they don’t repair the heart muscle that has died as a result of a heart attack or clogged arteries.\u003c/p>\n\u003cp>Now, scientists in San Francisco say a more effective treatment might be on the way. \u003c/p>\n\u003cfigure id=\"attachment_35476\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized-300x169.jpg\" alt=\"Research mouse\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Three months after being injected with three genes, the hearts of mice that had suffered a heart attack pumped as much blood as a normal heart. Credit: Gabriela Quirós, QUEST \u003c/figcaption>\u003c/figure>\n\u003cp>The researchers from the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, affiliated with the University of California-San Francisco, reported today that using a new genetic technique, they have succeeded for the first time in repairing, from within, the hearts of mice weakened by heart attacks. \u003c/p>\n\u003cp>“There are a variety of approaches we use right now to help people who are left with damaged hearts,” said \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/srivastava/\" title=\"Dr. Deepak Srivastava\" target=\"_blank\">Dr. Deepak Srivastava\u003c/a>, senior author of the paper and director of cardiovascular research at the Gladstone Institutes, “but none of them actually get to the root of the problem, which is replacing that damaged heart muscle. And that’s where our focus has been.”\u003c/p>\n\u003cp>The scientists injected three genes into the hearts of research mice that had been given mild heart attacks. Within three months, the genes transformed non-beating cells in the heart into cells that looked and acted just like beating heart muscle cells. These new beating cells restored the heart’s ability to pump blood to the rest of the body. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Human hearts have billions of non-beating cells, which support the beating cells by forming the heart’s structure, Srivastava said. Mice have millions of these support cells too. When a heart attack happens, the support cells rush to the site of the damage and form scar tissue, which preserves the heart’s structure, but doesn’t help it pump blood. \u003c/p>\n\u003cp>“We’ve found a way to take these support cells that should normally never become muscle, and convert them into new muscle cells that actually integrate with the rest of the heart, contribute to the force that it generates, and allow us to regenerate the heart from within the organ itself,” said Srivastava.\u003c/p>\n\u003cfigure id=\"attachment_35482\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized-300x169.jpg\" alt=\"Mouse heart muscle cells created by Gladstone Institutes researchers.\" title=\"yellow induced muscle cells with sarcomere structure_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35482\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Non-beating heart cells became beating heart cells like these. Credit: Li Qian, Gladstone Institutes \u003c/figcaption>\u003c/figure>\n\u003cp>The new research appears in the April 18 online edition of the journal \u003ca href=\"http://www.nature.com/nature/index.html\" title=\"Journal Nature\" target=\"_blank\">Nature\u003c/a> and was led by \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/736\" title=\"Li Qian wins prestigious award\" target=\"_blank\">Li Qian\u003c/a>, also from the Gladstone Institutes.\u003c/p>\n\u003cp>Heart attacks and other heart disease kill 600,000 people each year. Many more survive, yet lead diminished lives. Some 5.7 million people live with damaged hearts that pump less blood, making it difficult for them to climb a flight of stairs or walk across a parking lot. \u003c/p>\n\u003cp>During a heart attack, clots block one or several coronary arteries and cut off blood flow. By rushing patients to the operating table and unclogging their arteries with catheters and stents, doctors are able to save all but 5 percent of victims who make it to the hospital. \u003c/p>\n\u003cp>“While we’ve been doing better at saving lives, each time we save a life the patient still loses some of their muscle,” Srivastava said. “So the number of people who are left with damaged hearts is actually growing, even though the number of people who die from heart attacks is getting smaller.”\u003c/p>\n\u003cp>Treatments for humans could be six to seven years away, he added. The next step will be to test the treatment on pigs. Scientists still need to figure out if cell reprogramming is safe for humans; how to deliver the genes into the heart, and how to produce enough new beating heart cells to repair a human – rather than a mouse – heart.\u003c/p>\n\u003cp>\u003cstrong>More in our Series\u003c/strong>\u003c/p>\n\u003cul>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/pump-it-up-heart-health-special-report/\">Pump It Up: Heart Health Special Report\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/li>\n\u003c/ul>\n\u003cp>Nevertheless, the research is drawing the attention of other heart researchers.\u003c/p>\n\u003cp>“It’s a major discovery and certainly suggests a new approach to treat injury that previously had been thought to be irreversible,” said \u003ca href=\"http://www.cedars-sinai.edu/Bios---Physician/H-O/Eduardo-Marban-MD.aspx\" title=\"Dr. Eduardo Marban\" target=\"_blank\">Dr. Eduardo Marbán\u003c/a>, director of the \u003ca href=\"http://www.cedars-sinai.edu/Patients/Programs-and-Services/Heart-Institute/\" title=\"Cedars-Sinai Heart Institute\" target=\"_blank\">Cedars-Sinai Heart Institute\u003c/a> in Los Angeles.\u003c/p>\n\u003cp>Marbán said it’s been “a long-held dogma” that once scar tissue has formed in the heart, it can’t change into heart muscle. This finding in mice, and recent research by Marbán’s team on a small group of human patients, challenge that belief, he said.\u003c/p>\n\u003cp>Although the cell reprogramming research doesn’t involve stem cells, the Gladstone scientists used techniques that were discovered through stem cell research. \u003c/p>\n\u003cp>The scientists said their work was inspired by the discovery in 2007 that a few genes can transform an adult skin cell into a cell with the properties of a human embryonic stem cell. Researchers have been intensely interested in \u003ca href=\"http://ww2.kqed.org/quest/video/stem-cell-gold-rush/\" title=\"QUEST TV segment about stem cell research in California\" target=\"_blank\">embryonic stem cells\u003c/a> as a possible source of treatments for diseases like Parkinson’s because they can be coaxed to turn into virtually any type of cell in the body. But because embryonic stem cells are plucked from embryos left over from fertility treatments, and require the destruction of these embryos, their study has been controversial.\u003c/p>\n\u003cp>An alternative to embryonic stem cells came with the skin cell breakthrough five years ago. Then, \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/yamanaka/\" title=\"Dr. Shinya Yamanaka\" target=\"_blank\">Dr. Shinya Yamanaka\u003c/a>, of the Gladstone Institutes and Kyoto University in Japan, inserted four genes that are present in embryonic stem cells into adult skin cells. The four genes \u003ca href=\"http://ww2.kqed.org/quest/2007/06/11/turning-skin-cells-into-embryonic-stem-cells/\" title=\"QUEST blog post about induced pluripotent stem cells\" target=\"_blank\">reprogrammed the skin cells to become embryonic-like stem cells\u003c/a>. \u003c/p>\n\u003cp>That led scientists to look for a way to transform one type of adult cell into another type of adult cell without the need to create stem cells at all.\u003c/p>\n\u003cp>“Yamanaka opened up the idea that adult cells weren’t permanently fixed,” said Srivastava. “That led us to ask whether or not we could convert one of these heart support cells into a heart muscle cell.” \u003c/p>\n\u003cp>Bypassing the creation of stem cells has several advantages. Though stem cells are versatile, when they’re introduced into the body they can behave as cancer cells and form tumors. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“It’s a dramatic and heady possibility that vindicates for the first time the idea that we might be able to harness truly regenerative medicine,” Marbán said. \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/35176/science-on-the-spot-new-hope-for-heart-repair","authors":["6186"],"series":["quest_3296"],"categories":["quest_4","quest_12","quest_3422","quest_3233"],"tags":["quest_10999","quest_793","quest_1218","quest_13201","quest_1331","quest_10997","quest_1332","quest_10998","quest_3351","quest_1783","quest_13203","quest_2349","quest_13","quest_2530","quest_2789","quest_3314","quest_3071"],"featImg":"quest_35485","label":"quest_3296"},"quest_16976":{"type":"posts","id":"quest_16976","meta":{"index":"posts_1591205157","site":"quest","id":"16976","score":null,"sort":[1232382600000]},"guestAuthors":[],"slug":"new-life-for-embryonic-stem-cell-research","title":"New Life for Embryonic Stem Cell Research","publishDate":1232382600,"format":"audio","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp> http://www.kqed.org/.stream/anon/radio/quest/2009/01/2009-01-19-quest.mp3\u003c/p>\n\u003cp>Soon after Barack Obama is sworn in as President next week, he is expected to reverse the ban on federal funding for embryonic stem cell research. The resulting boom in this cutting-edge medical technology will benefit California's research institutes in a big way.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n","blocks":[],"excerpt":"Soon after Barack Obama is sworn in as President next week, he is expected to reverse the ban on federal funding for embryonic stem cell research. The resulting boom in this cutting-edge medical technology will benefit California's research institutes in a big way.","status":"publish","parent":0,"modified":1344633920,"stats":{"hasAudio":true,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":4,"wordCount":62},"headData":{"title":"New Life for Embryonic Stem Cell Research | KQED","description":"Soon after Barack Obama is sworn in as President next week, he is expected to reverse the ban on federal funding for embryonic stem cell research. 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The resulting boom in this cutting-edge medical technology will benefit California's research institutes in a big way.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/16976/new-life-for-embryonic-stem-cell-research","authors":["8656"],"categories":["quest_12"],"tags":["quest_252","quest_13201","quest_1331","quest_3351","quest_1783","quest_2349","quest_13202"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. 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