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Quirós","firstName":"Gabriela","lastName":"Quirós","slug":"gabriela-quiros","email":"gquiros@kqed.org","display_author_email":false,"staff_mastheads":["science"],"title":"Video Producer and Reporter","bio":"Gabriela Quirós is a \u003cstrong>video producer and the coordinating producer for KQED's web science video series \u003ca href=\"https://www.kqed.org/deeplook\">Deep Look\u003c/a>\u003c/strong>. She joined KQED as a TV producer when its science series QUEST started in 2006 and has covered everything from Alzheimer’s to bee die-offs to dark energy.\r\n\r\nShe won a 2022 AAAS Kavli Science Journalism Award with a team of her Deep Look colleagues. She has won five regional Emmys as a video producer and has shared seven more as the coordinating producer of Deep Look. The episode she produced about \u003ca href=\"https://www.kqed.org/science/728086/how-mosquitoes-use-six-needles-to-suck-your-blood\">How Mosquitoes Use Six Needles to Suck Your Blood\u003c/a> won a Webby \"People's Voice\" award. She has also earned awards from the Jackson Hole Wildlife Film Festival, the Society of Professional Journalists and the Society of Environmental Journalists.\r\n\r\nHer videos for KQED have also aired on NOVA scienceNOW and the PBS NewsHour, and appeared on NPR.org.\r\n\r\nAs an independent filmmaker, she produced and directed the hour-long documentary \u003ca href=\"http://lpbp.org/beautiful-sin-qa-with-producer-gabriela-quiros/\">\u003cem>Beautiful Sin\u003c/em>\u003c/a>, about the surprising story of how Costa Rica became the only country in the world to outlaw in vitro fertilization. The film aired in 2015 on public television stations throughout the U.S., and in Costa Rica.\r\n\r\nShe started her journalism career as a newspaper reporter in Costa Rica, where she grew up. She won the National Science Journalism Award there for a series of articles about organic agriculture, and developed a life-long interest in health reporting. She moved to the Bay Area in 1996 to study documentary filmmaking at the University of California, Berkeley, where she received master’s degrees in journalism and Latin American studies.","avatar":"https://secure.gravatar.com/avatar/6d82c20152affd1b434c31a904c40809?s=600&d=blank&r=g","twitter":"gabrielaquirosr","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["editor"]},{"site":"quest","roles":["editor","ef_view_calendar","ef_view_story_budget"]}],"headData":{"title":"Gabriela Quirós | KQED","description":"Video Producer and Reporter","ogImgSrc":"https://secure.gravatar.com/avatar/6d82c20152affd1b434c31a904c40809?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/6d82c20152affd1b434c31a904c40809?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/gabriela-quiros"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_35176":{"type":"posts","id":"quest_35176","meta":{"index":"posts_1591205157","site":"quest","id":"35176","score":null,"sort":[1334768406000]},"guestAuthors":[],"slug":"science-on-the-spot-new-hope-for-heart-repair","title":"Science on the SPOT: New Hope for Heart Repair","publishDate":1334768406,"format":"video","headTitle":"Science on the SPOT | QUEST | KQED Science","labelTerm":{"term":3296,"site":"quest"},"content":"\u003cp>More than 5 million people in the United States live with damaged hearts that make it difficult to walk and carry out other simple daily tasks. Pacemakers and drugs can help, but they don’t repair the heart muscle that has died as a result of a heart attack or clogged arteries.\u003c/p>\n\u003cp>Now, scientists in San Francisco say a more effective treatment might be on the way. \u003c/p>\n\u003cfigure id=\"attachment_35476\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized-300x169.jpg\" alt=\"Research mouse\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Three months after being injected with three genes, the hearts of mice that had suffered a heart attack pumped as much blood as a normal heart. Credit: Gabriela Quirós, QUEST \u003c/figcaption>\u003c/figure>\n\u003cp>The researchers from the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, affiliated with the University of California-San Francisco, reported today that using a new genetic technique, they have succeeded for the first time in repairing, from within, the hearts of mice weakened by heart attacks. \u003c/p>\n\u003cp>“There are a variety of approaches we use right now to help people who are left with damaged hearts,” said \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/srivastava/\" title=\"Dr. Deepak Srivastava\" target=\"_blank\">Dr. Deepak Srivastava\u003c/a>, senior author of the paper and director of cardiovascular research at the Gladstone Institutes, “but none of them actually get to the root of the problem, which is replacing that damaged heart muscle. And that’s where our focus has been.”\u003c/p>\n\u003cp>The scientists injected three genes into the hearts of research mice that had been given mild heart attacks. Within three months, the genes transformed non-beating cells in the heart into cells that looked and acted just like beating heart muscle cells. These new beating cells restored the heart’s ability to pump blood to the rest of the body. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Human hearts have billions of non-beating cells, which support the beating cells by forming the heart’s structure, Srivastava said. Mice have millions of these support cells too. When a heart attack happens, the support cells rush to the site of the damage and form scar tissue, which preserves the heart’s structure, but doesn’t help it pump blood. \u003c/p>\n\u003cp>“We’ve found a way to take these support cells that should normally never become muscle, and convert them into new muscle cells that actually integrate with the rest of the heart, contribute to the force that it generates, and allow us to regenerate the heart from within the organ itself,” said Srivastava.\u003c/p>\n\u003cfigure id=\"attachment_35482\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized-300x169.jpg\" alt=\"Mouse heart muscle cells created by Gladstone Institutes researchers.\" title=\"yellow induced muscle cells with sarcomere structure_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35482\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Non-beating heart cells became beating heart cells like these. Credit: Li Qian, Gladstone Institutes \u003c/figcaption>\u003c/figure>\n\u003cp>The new research appears in the April 18 online edition of the journal \u003ca href=\"http://www.nature.com/nature/index.html\" title=\"Journal Nature\" target=\"_blank\">Nature\u003c/a> and was led by \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/736\" title=\"Li Qian wins prestigious award\" target=\"_blank\">Li Qian\u003c/a>, also from the Gladstone Institutes.\u003c/p>\n\u003cp>Heart attacks and other heart disease kill 600,000 people each year. Many more survive, yet lead diminished lives. Some 5.7 million people live with damaged hearts that pump less blood, making it difficult for them to climb a flight of stairs or walk across a parking lot. \u003c/p>\n\u003cp>During a heart attack, clots block one or several coronary arteries and cut off blood flow. By rushing patients to the operating table and unclogging their arteries with catheters and stents, doctors are able to save all but 5 percent of victims who make it to the hospital. \u003c/p>\n\u003cp>“While we’ve been doing better at saving lives, each time we save a life the patient still loses some of their muscle,” Srivastava said. “So the number of people who are left with damaged hearts is actually growing, even though the number of people who die from heart attacks is getting smaller.”\u003c/p>\n\u003cp>Treatments for humans could be six to seven years away, he added. The next step will be to test the treatment on pigs. Scientists still need to figure out if cell reprogramming is safe for humans; how to deliver the genes into the heart, and how to produce enough new beating heart cells to repair a human – rather than a mouse – heart.\u003c/p>\n\u003cp>\u003cstrong>More in our Series\u003c/strong>\u003c/p>\n\u003cul>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/pump-it-up-heart-health-special-report/\">Pump It Up: Heart Health Special Report\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/li>\n\u003c/ul>\n\u003cp>Nevertheless, the research is drawing the attention of other heart researchers.\u003c/p>\n\u003cp>“It’s a major discovery and certainly suggests a new approach to treat injury that previously had been thought to be irreversible,” said \u003ca href=\"http://www.cedars-sinai.edu/Bios---Physician/H-O/Eduardo-Marban-MD.aspx\" title=\"Dr. Eduardo Marban\" target=\"_blank\">Dr. Eduardo Marbán\u003c/a>, director of the \u003ca href=\"http://www.cedars-sinai.edu/Patients/Programs-and-Services/Heart-Institute/\" title=\"Cedars-Sinai Heart Institute\" target=\"_blank\">Cedars-Sinai Heart Institute\u003c/a> in Los Angeles.\u003c/p>\n\u003cp>Marbán said it’s been “a long-held dogma” that once scar tissue has formed in the heart, it can’t change into heart muscle. This finding in mice, and recent research by Marbán’s team on a small group of human patients, challenge that belief, he said.\u003c/p>\n\u003cp>Although the cell reprogramming research doesn’t involve stem cells, the Gladstone scientists used techniques that were discovered through stem cell research. \u003c/p>\n\u003cp>The scientists said their work was inspired by the discovery in 2007 that a few genes can transform an adult skin cell into a cell with the properties of a human embryonic stem cell. Researchers have been intensely interested in \u003ca href=\"http://ww2.kqed.org/quest/video/stem-cell-gold-rush/\" title=\"QUEST TV segment about stem cell research in California\" target=\"_blank\">embryonic stem cells\u003c/a> as a possible source of treatments for diseases like Parkinson’s because they can be coaxed to turn into virtually any type of cell in the body. But because embryonic stem cells are plucked from embryos left over from fertility treatments, and require the destruction of these embryos, their study has been controversial.\u003c/p>\n\u003cp>An alternative to embryonic stem cells came with the skin cell breakthrough five years ago. Then, \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/yamanaka/\" title=\"Dr. Shinya Yamanaka\" target=\"_blank\">Dr. Shinya Yamanaka\u003c/a>, of the Gladstone Institutes and Kyoto University in Japan, inserted four genes that are present in embryonic stem cells into adult skin cells. The four genes \u003ca href=\"http://ww2.kqed.org/quest/2007/06/11/turning-skin-cells-into-embryonic-stem-cells/\" title=\"QUEST blog post about induced pluripotent stem cells\" target=\"_blank\">reprogrammed the skin cells to become embryonic-like stem cells\u003c/a>. \u003c/p>\n\u003cp>That led scientists to look for a way to transform one type of adult cell into another type of adult cell without the need to create stem cells at all.\u003c/p>\n\u003cp>“Yamanaka opened up the idea that adult cells weren’t permanently fixed,” said Srivastava. “That led us to ask whether or not we could convert one of these heart support cells into a heart muscle cell.” \u003c/p>\n\u003cp>Bypassing the creation of stem cells has several advantages. Though stem cells are versatile, when they’re introduced into the body they can behave as cancer cells and form tumors. \u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>“It’s a dramatic and heady possibility that vindicates for the first time the idea that we might be able to harness truly regenerative medicine,” Marbán said. \u003c/p>\n\n","blocks":[],"excerpt":"Scientists in San Francisco have coaxed mouse hearts to repair themselves from within.The breakthrough could lead to treatments for 5 million people in the United States whose hearts were damaged after they survived heart attacks. ","status":"publish","parent":0,"modified":1457569468,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":25,"wordCount":1094},"headData":{"title":"Science on the SPOT: New Hope for Heart Repair | KQED","description":"Scientists in San Francisco have coaxed mouse hearts to repair themselves from within.The breakthrough could lead to treatments for 5 million people in the United States whose hearts were damaged after they survived heart attacks. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Science on the SPOT: New Hope for Heart Repair","datePublished":"2012-04-18T17:00:06.000Z","dateModified":"2016-03-10T00:24:28.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"35176 http://science.kqed.org/quest/?post_type=videos&p=35176","disqusUrl":"https://ww2.kqed.org/quest/2012/04/18/science-on-the-spot-new-hope-for-heart-repair/","disqusTitle":"Science on the SPOT: New Hope for Heart Repair","videoEmbed":"https://youtu.be/9EvI1hVq5Ys","path":"/quest/35176/science-on-the-spot-new-hope-for-heart-repair","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>More than 5 million people in the United States live with damaged hearts that make it difficult to walk and carry out other simple daily tasks. Pacemakers and drugs can help, but they don’t repair the heart muscle that has died as a result of a heart attack or clogged arteries.\u003c/p>\n\u003cp>Now, scientists in San Francisco say a more effective treatment might be on the way. \u003c/p>\n\u003cfigure id=\"attachment_35476\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized-300x169.jpg\" alt=\"Research mouse\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Three months after being injected with three genes, the hearts of mice that had suffered a heart attack pumped as much blood as a normal heart. Credit: Gabriela Quirós, QUEST \u003c/figcaption>\u003c/figure>\n\u003cp>The researchers from the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, affiliated with the University of California-San Francisco, reported today that using a new genetic technique, they have succeeded for the first time in repairing, from within, the hearts of mice weakened by heart attacks. \u003c/p>\n\u003cp>“There are a variety of approaches we use right now to help people who are left with damaged hearts,” said \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/srivastava/\" title=\"Dr. Deepak Srivastava\" target=\"_blank\">Dr. Deepak Srivastava\u003c/a>, senior author of the paper and director of cardiovascular research at the Gladstone Institutes, “but none of them actually get to the root of the problem, which is replacing that damaged heart muscle. And that’s where our focus has been.”\u003c/p>\n\u003cp>The scientists injected three genes into the hearts of research mice that had been given mild heart attacks. Within three months, the genes transformed non-beating cells in the heart into cells that looked and acted just like beating heart muscle cells. These new beating cells restored the heart’s ability to pump blood to the rest of the body. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Human hearts have billions of non-beating cells, which support the beating cells by forming the heart’s structure, Srivastava said. Mice have millions of these support cells too. When a heart attack happens, the support cells rush to the site of the damage and form scar tissue, which preserves the heart’s structure, but doesn’t help it pump blood. \u003c/p>\n\u003cp>“We’ve found a way to take these support cells that should normally never become muscle, and convert them into new muscle cells that actually integrate with the rest of the heart, contribute to the force that it generates, and allow us to regenerate the heart from within the organ itself,” said Srivastava.\u003c/p>\n\u003cfigure id=\"attachment_35482\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized-300x169.jpg\" alt=\"Mouse heart muscle cells created by Gladstone Institutes researchers.\" title=\"yellow induced muscle cells with sarcomere structure_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35482\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Non-beating heart cells became beating heart cells like these. Credit: Li Qian, Gladstone Institutes \u003c/figcaption>\u003c/figure>\n\u003cp>The new research appears in the April 18 online edition of the journal \u003ca href=\"http://www.nature.com/nature/index.html\" title=\"Journal Nature\" target=\"_blank\">Nature\u003c/a> and was led by \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/736\" title=\"Li Qian wins prestigious award\" target=\"_blank\">Li Qian\u003c/a>, also from the Gladstone Institutes.\u003c/p>\n\u003cp>Heart attacks and other heart disease kill 600,000 people each year. Many more survive, yet lead diminished lives. Some 5.7 million people live with damaged hearts that pump less blood, making it difficult for them to climb a flight of stairs or walk across a parking lot. \u003c/p>\n\u003cp>During a heart attack, clots block one or several coronary arteries and cut off blood flow. By rushing patients to the operating table and unclogging their arteries with catheters and stents, doctors are able to save all but 5 percent of victims who make it to the hospital. \u003c/p>\n\u003cp>“While we’ve been doing better at saving lives, each time we save a life the patient still loses some of their muscle,” Srivastava said. “So the number of people who are left with damaged hearts is actually growing, even though the number of people who die from heart attacks is getting smaller.”\u003c/p>\n\u003cp>Treatments for humans could be six to seven years away, he added. The next step will be to test the treatment on pigs. Scientists still need to figure out if cell reprogramming is safe for humans; how to deliver the genes into the heart, and how to produce enough new beating heart cells to repair a human – rather than a mouse – heart.\u003c/p>\n\u003cp>\u003cstrong>More in our Series\u003c/strong>\u003c/p>\n\u003cul>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/pump-it-up-heart-health-special-report/\">Pump It Up: Heart Health Special Report\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/li>\n\u003c/ul>\n\u003cp>Nevertheless, the research is drawing the attention of other heart researchers.\u003c/p>\n\u003cp>“It’s a major discovery and certainly suggests a new approach to treat injury that previously had been thought to be irreversible,” said \u003ca href=\"http://www.cedars-sinai.edu/Bios---Physician/H-O/Eduardo-Marban-MD.aspx\" title=\"Dr. Eduardo Marban\" target=\"_blank\">Dr. Eduardo Marbán\u003c/a>, director of the \u003ca href=\"http://www.cedars-sinai.edu/Patients/Programs-and-Services/Heart-Institute/\" title=\"Cedars-Sinai Heart Institute\" target=\"_blank\">Cedars-Sinai Heart Institute\u003c/a> in Los Angeles.\u003c/p>\n\u003cp>Marbán said it’s been “a long-held dogma” that once scar tissue has formed in the heart, it can’t change into heart muscle. This finding in mice, and recent research by Marbán’s team on a small group of human patients, challenge that belief, he said.\u003c/p>\n\u003cp>Although the cell reprogramming research doesn’t involve stem cells, the Gladstone scientists used techniques that were discovered through stem cell research. \u003c/p>\n\u003cp>The scientists said their work was inspired by the discovery in 2007 that a few genes can transform an adult skin cell into a cell with the properties of a human embryonic stem cell. Researchers have been intensely interested in \u003ca href=\"http://ww2.kqed.org/quest/video/stem-cell-gold-rush/\" title=\"QUEST TV segment about stem cell research in California\" target=\"_blank\">embryonic stem cells\u003c/a> as a possible source of treatments for diseases like Parkinson’s because they can be coaxed to turn into virtually any type of cell in the body. But because embryonic stem cells are plucked from embryos left over from fertility treatments, and require the destruction of these embryos, their study has been controversial.\u003c/p>\n\u003cp>An alternative to embryonic stem cells came with the skin cell breakthrough five years ago. Then, \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/yamanaka/\" title=\"Dr. Shinya Yamanaka\" target=\"_blank\">Dr. Shinya Yamanaka\u003c/a>, of the Gladstone Institutes and Kyoto University in Japan, inserted four genes that are present in embryonic stem cells into adult skin cells. The four genes \u003ca href=\"http://ww2.kqed.org/quest/2007/06/11/turning-skin-cells-into-embryonic-stem-cells/\" title=\"QUEST blog post about induced pluripotent stem cells\" target=\"_blank\">reprogrammed the skin cells to become embryonic-like stem cells\u003c/a>. \u003c/p>\n\u003cp>That led scientists to look for a way to transform one type of adult cell into another type of adult cell without the need to create stem cells at all.\u003c/p>\n\u003cp>“Yamanaka opened up the idea that adult cells weren’t permanently fixed,” said Srivastava. “That led us to ask whether or not we could convert one of these heart support cells into a heart muscle cell.” \u003c/p>\n\u003cp>Bypassing the creation of stem cells has several advantages. Though stem cells are versatile, when they’re introduced into the body they can behave as cancer cells and form tumors. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“It’s a dramatic and heady possibility that vindicates for the first time the idea that we might be able to harness truly regenerative medicine,” Marbán said. \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/35176/science-on-the-spot-new-hope-for-heart-repair","authors":["6186"],"series":["quest_3296"],"categories":["quest_4","quest_12","quest_3422","quest_3233"],"tags":["quest_10999","quest_793","quest_1218","quest_13201","quest_1331","quest_10997","quest_1332","quest_10998","quest_3351","quest_1783","quest_13203","quest_2349","quest_13","quest_2530","quest_2789","quest_3314","quest_3071"],"featImg":"quest_35485","label":"quest_3296"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.","airtime":"THU 10pm, FRI 1am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.commonwealthclub.org/podcasts","meta":{"site":"news","source":"Commonwealth Club of California"},"link":"/radio/program/commonwealth-club","subscribe":{"apple":"https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2","google":"https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw","tuneIn":"https://tunein.com/radio/Commonwealth-Club-of-California-p1060/"}},"considerthis":{"id":"considerthis","title":"Consider This","tagline":"Make sense of the day","info":"Make sense of the day. Every weekday afternoon, Consider This helps you consider the major stories of the day in less than 15 minutes, featuring the reporting and storytelling resources of NPR. Plus, KQED’s Bianca Taylor brings you the local KQED news you need to know.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Consider-This-Podcast-Tile-703x703-1.jpg","imageAlt":"Consider This from NPR and KQED","officialWebsiteLink":"/podcasts/considerthis","meta":{"site":"news","source":"kqed","order":"7"},"link":"/podcasts/considerthis","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1503226625?mt=2&at=11l79Y&ct=nprdirectory","npr":"https://rpb3r.app.goo.gl/coronavirusdaily","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM1NS9wb2RjYXN0LnhtbA","spotify":"https://open.spotify.com/show/3Z6JdCS2d0eFEpXHKI6WqH"}},"forum":{"id":"forum","title":"Forum","tagline":"The conversation starts here","info":"KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.","airtime":"MON-FRI 9am-11am, 10pm-11pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED Forum with Mina Kim and Alexis Madrigal","officialWebsiteLink":"/forum","meta":{"site":"news","source":"kqed","order":"8"},"link":"/forum","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/kqeds-forum/id73329719","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz","npr":"https://www.npr.org/podcasts/432307980/forum","stitcher":"https://www.stitcher.com/podcast/kqedfm-kqeds-forum-podcast","rss":"https://feeds.megaphone.fm/KQINC9557381633"}},"freakonomics-radio":{"id":"freakonomics-radio","title":"Freakonomics Radio","info":"Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. It is produced in partnership with WNYC.","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/freakonomicsRadio.png","officialWebsiteLink":"http://freakonomics.com/","airtime":"SUN 1am-2am, SAT 3pm-4pm","meta":{"site":"radio","source":"WNYC"},"link":"/radio/program/freakonomics-radio","subscribe":{"npr":"https://rpb3r.app.goo.gl/4s8b","apple":"https://itunes.apple.com/us/podcast/freakonomics-radio/id354668519","tuneIn":"https://tunein.com/podcasts/WNYC-Podcasts/Freakonomics-Radio-p272293/","rss":"https://feeds.feedburner.com/freakonomicsradio"}},"fresh-air":{"id":"fresh-air","title":"Fresh Air","info":"Hosted by Terry Gross, \u003cem>Fresh Air from WHYY\u003c/em> is the Peabody Award-winning weekday magazine of contemporary arts and issues. 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