Secrets of the Global Seed Vault: A Conversation with Scientist Luigi Guarino
Why Your Newfound Uniqueness is a Nightmare for Your Doctor
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Cereal free of “genetically modified” ingredients. These food labels are everywhere, but what exactly do they mean? In the short animation above, we remove some of the mystery by showing that these terms refer to different ways of creating plants with appealing traits -- like a drought-resistant strain of wheat or a beautifully blushing apple.\u003c/p>\n\u003cp>Designing a better plant has always been part of agriculture, but as we’ve learned more about genetics, our toolkit for developing those plants has expanded. Plant varieties that used to be fine-tuned in the field over many generations can now be developed much more quickly in a greenhouse or lab. These advances have enabled us to bring new, high-performing crop species to market quickly, but they have inflicted some collateral damage on agricultural diversity. Watch the QUEST video \u003ca title=\"Saving Our Seeds\" href=\"http://ww2.kqed.org/quest/video/saving-our-seeds/\">“Saving Our Seeds”\u003c/a> to find out why this diversity matters and meet some of the people working to preserve it.\u003c/p>\n\u003cp> \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n","blocks":[],"excerpt":"In this short animation we tackle the confusing terms “heirloom,” “hybrid,” and “genetically modified,” and explain one reason the difference matters.","status":"publish","parent":0,"modified":1457553975,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":4,"wordCount":177},"headData":{"title":"What is an Heirloom Tomato, Anyway? | KQED","description":"In this short animation we tackle the confusing terms “heirloom,” “hybrid,” and “genetically modified,” and explain one reason the difference matters.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"What is an Heirloom Tomato, Anyway?","datePublished":"2014-07-29T14:00:30.000Z","dateModified":"2016-03-09T20:06:15.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"63679 http://science.kqed.org/quest/?p=63679","disqusUrl":"https://ww2.kqed.org/quest/2014/07/29/what-is-an-heirloom-tomato-anyway/","disqusTitle":"What is an Heirloom Tomato, Anyway?","videoEmbed":"https://www.youtube.com/watch?v=qzXstf9xTNI","source":"Biology","sourceUrl":"https://ww2.kqed.org/quest/category/biology/","path":"/quest/63679/what-is-an-heirloom-tomato-anyway","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>Animation by Michaela Vatcheva\u003cbr>\n\u003c/em>\u003cbr>\n“Heirloom” tomatoes. “Hybrid” cucumber seeds. Cereal free of “genetically modified” ingredients. These food labels are everywhere, but what exactly do they mean? In the short animation above, we remove some of the mystery by showing that these terms refer to different ways of creating plants with appealing traits -- like a drought-resistant strain of wheat or a beautifully blushing apple.\u003c/p>\n\u003cp>Designing a better plant has always been part of agriculture, but as we’ve learned more about genetics, our toolkit for developing those plants has expanded. Plant varieties that used to be fine-tuned in the field over many generations can now be developed much more quickly in a greenhouse or lab. These advances have enabled us to bring new, high-performing crop species to market quickly, but they have inflicted some collateral damage on agricultural diversity. Watch the QUEST video \u003ca title=\"Saving Our Seeds\" href=\"http://ww2.kqed.org/quest/video/saving-our-seeds/\">“Saving Our Seeds”\u003c/a> to find out why this diversity matters and meet some of the people working to preserve it.\u003c/p>\n\u003cp> \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/63679/what-is-an-heirloom-tomato-anyway","authors":["10441"],"categories":["quest_4","quest_9","quest_3229"],"tags":["quest_12269","quest_11155","quest_12881","quest_12822","quest_1423","quest_12355","quest_2579","quest_13364","quest_3071"],"featImg":"quest_70893","label":"source_quest_63679"},"quest_67581":{"type":"posts","id":"quest_67581","meta":{"index":"posts_1591205157","site":"quest","id":"67581","score":null,"sort":[1398434428000]},"guestAuthors":[],"slug":"secrets-of-the-svalbard-global-seed-vault","title":"Secrets of the Global Seed Vault: A Conversation with Scientist Luigi Guarino","publishDate":1398434428,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{},"content":"\u003cp>On a remote island near the North Pole, a disaster-proof underground vault holds millions of frozen seeds. Like something out of a James Bond movie, this high-security seed bank in Norway’s Svalbard archipelago was built to help ensure the survival of something incredibly precious: food diversity. If this seems extreme, consider that the U.S. has likely lost over \u003ca href=\"http://www.ecobooks.com/books/shatter.htm\">90 percent of fruit tree and vegetable varieties\u003c/a> since 1900 and India has lost an estimated 90 percent of its \u003ca href=\"http://webcache.googleusercontent.com/search?q=cache:http://agro.biodiver.se/2009/11/tracking-down-rice-genetic-erosion-numbers/\">rice varieties\u003c/a>, largely as a result of industrialization. If the trend continues and climate change compounds the toll, some of our favorite foods could disappear, and important staples like rice, wheat, and corn may become endangered.\u003c/p>\n\u003caside class=\"pullquote alignleft\">This stuff is precious and unique, and you don’t want to take any risks with it. Once it’s gone, it’s gone forever... [Luigi Guarino]\u003c/aside>\n\u003cp>To understand why this loss of crop diversity matters and explore the inner workings of the \u003ca href=\"http://www.croptrust.org/content/svalbard-global-seed-vault\">Global Seed Vault\u003c/a>, QUEST TV host \u003ca href=\"http://simransethi.com\">Simran Sethi\u003c/a> talks to \u003ca href=\"https://www.croptrust.org/content/technical-team\">Luigi Guarino\u003c/a>, a scientist with the\u003ca href=\"http://www.croptrust.org/\"> Global Crop Diversity Trust\u003c/a>, an organization that helped establish this Arctic seed bank. During the interview Guarino answers questions about how seeds are acquired and stored, whether the vault accepts genetically modified seeds, and who owns and manages the collection.\u003c/p>\n\u003cp>Sethi herself has a particular interest and growing expertise in the subject of seeds, which was the focus of her \u003ca href=\"http://tedxtalks.ted.com/video/Seeds-The-Buried-Beginnings-of\">TEDx talk\u003c/a> in 2013. Sethi first met Guarino while conducting research for a book she is writing about the loss of biodiversity. She credits Guarino for reminding her -- and her book editor -- that seeds are not only sexy; they \u003cstrong>are\u003c/strong> sex. Watch their long-distance Google Hangout below.\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=Nmn8fQKg1YE\u003cbr>\n\u003cem>*See some footage of the Global Seed Vault \u003ca href=\"http://ww2.kqed.org/quest/video/saving-our-seeds/\">in this QUEST television segment\u003c/a> about efforts to preserve seed diversity in America’s Midwest.\u003c/em>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n","blocks":[],"excerpt":"Explore the inner workings of a mysterious seed vault on a remote island near the North Pole. Scientist Luigi Guarino talks to QUEST about this initiative to safeguard the future of the world’s food diversity.","status":"publish","parent":0,"modified":1442692790,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":5,"wordCount":325},"headData":{"title":"Secrets of the Global Seed Vault: A Conversation with Scientist Luigi Guarino | KQED","description":"Explore the inner workings of a mysterious seed vault on a remote island near the North Pole. Scientist Luigi Guarino talks to QUEST about this initiative to safeguard the future of the world’s food diversity.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Secrets of the Global Seed Vault: A Conversation with Scientist Luigi Guarino","datePublished":"2014-04-25T14:00:28.000Z","dateModified":"2015-09-19T19:59:50.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"67581 http://science.kqed.org/quest/?p=67581","disqusUrl":"https://ww2.kqed.org/quest/2014/04/25/secrets-of-the-svalbard-global-seed-vault/","disqusTitle":"Secrets of the Global Seed Vault: A Conversation with Scientist Luigi Guarino","source":"Biology","sourceUrl":"https://ww2.kqed.org/quest/category/biology/","path":"/quest/67581/secrets-of-the-svalbard-global-seed-vault","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>On a remote island near the North Pole, a disaster-proof underground vault holds millions of frozen seeds. Like something out of a James Bond movie, this high-security seed bank in Norway’s Svalbard archipelago was built to help ensure the survival of something incredibly precious: food diversity. If this seems extreme, consider that the U.S. has likely lost over \u003ca href=\"http://www.ecobooks.com/books/shatter.htm\">90 percent of fruit tree and vegetable varieties\u003c/a> since 1900 and India has lost an estimated 90 percent of its \u003ca href=\"http://webcache.googleusercontent.com/search?q=cache:http://agro.biodiver.se/2009/11/tracking-down-rice-genetic-erosion-numbers/\">rice varieties\u003c/a>, largely as a result of industrialization. If the trend continues and climate change compounds the toll, some of our favorite foods could disappear, and important staples like rice, wheat, and corn may become endangered.\u003c/p>\n\u003caside class=\"pullquote alignleft\">This stuff is precious and unique, and you don’t want to take any risks with it. Once it’s gone, it’s gone forever... [Luigi Guarino]\u003c/aside>\n\u003cp>To understand why this loss of crop diversity matters and explore the inner workings of the \u003ca href=\"http://www.croptrust.org/content/svalbard-global-seed-vault\">Global Seed Vault\u003c/a>, QUEST TV host \u003ca href=\"http://simransethi.com\">Simran Sethi\u003c/a> talks to \u003ca href=\"https://www.croptrust.org/content/technical-team\">Luigi Guarino\u003c/a>, a scientist with the\u003ca href=\"http://www.croptrust.org/\"> Global Crop Diversity Trust\u003c/a>, an organization that helped establish this Arctic seed bank. During the interview Guarino answers questions about how seeds are acquired and stored, whether the vault accepts genetically modified seeds, and who owns and manages the collection.\u003c/p>\n\u003cp>Sethi herself has a particular interest and growing expertise in the subject of seeds, which was the focus of her \u003ca href=\"http://tedxtalks.ted.com/video/Seeds-The-Buried-Beginnings-of\">TEDx talk\u003c/a> in 2013. Sethi first met Guarino while conducting research for a book she is writing about the loss of biodiversity. She credits Guarino for reminding her -- and her book editor -- that seeds are not only sexy; they \u003cstrong>are\u003c/strong> sex. Watch their long-distance Google Hangout below.\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=Nmn8fQKg1YE\u003cbr>\n\u003cem>*See some footage of the Global Seed Vault \u003ca href=\"http://ww2.kqed.org/quest/video/saving-our-seeds/\">in this QUEST television segment\u003c/a> about efforts to preserve seed diversity in America’s Midwest.\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/67581/secrets-of-the-svalbard-global-seed-vault","authors":["5412"],"categories":["quest_4","quest_6","quest_8","quest_9","quest_3229"],"tags":["quest_326","quest_12269","quest_11155","quest_12840","quest_12841","quest_2349","quest_2352","quest_12839","quest_12297","quest_13364","quest_12838"],"featImg":"quest_70082","label":"source_quest_67581"},"quest_38751":{"type":"posts","id":"quest_38751","meta":{"index":"posts_1591205157","site":"quest","id":"38751","score":null,"sort":[1338217230000]},"guestAuthors":[],"slug":"why-your-newfound-uniqueness-a-nightmare-for-your-doctor","title":"Why Your Newfound Uniqueness is a Nightmare for Your Doctor","publishDate":1338217230,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_38754\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/28/why-your-newfound-uniqueness-a-nightmare-for-your-doctor/humdivinasia/\" rel=\"attachment wp-att-38754\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/HumDivInAsia.jpg\" alt=\"\" title=\"HumDivInAsia\" width=\"640\" height=\"356\" class=\"size-full wp-image-38754\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/05/HumDivInAsia.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/05/HumDivInAsia-400x223.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Our surprising genetic diversity will give scientists fits for years.\u003c/figcaption>\u003c/figure>\n\u003cp>A couple of new studies confirm what many of us have feared: each of us is surprisingly unique genetically. This is to be feared because of the impact it will have on the future of personalized medicine. Our individual uniqueness will make predicting our risk for disease much trickier than we thought. And it will make finding treatments that much harder too.\u003c/p>\n\u003cp>You’ve probably read that all humans share somewhere between 99.5% and 99.9% of their DNA. Usually this is translated into saying that we have a difference in our DNA every 1000 bases or so. (By bases I mean the A’s, G’s, C’s, and T’s that make up our DNA.)\u003c/p>\n\u003cp>These differences were supposed to be shared by many people. So a lot of people would have a G at a certain position and the rest of us would have a T. The first \u003ca href=\"http://www.sciencemag.org/content/early/2012/05/16/science.1217876\">study \u003c/a>shows that this is not the case.\u003c/p>\n\u003cp>Instead, we all have many rare DNA differences scattered throughout our DNA. When the researchers looked at 202 different genes from 14,002 people, they found a rare variant every 17 bases or so. This is way higher than many people thought.\u003c/p>\n\u003cp>What’s worse is that these differences aren’t all benign. The other \u003ca href=\"http://www.sciencemag.org/content/early/2012/05/21/science.1219240\">study published in \u003cem>Science\u003c/em>\u003c/a> showed that a surprisingly high percentage, around 2.3%, is predicted to significantly impact a gene. In other words, we are all burdened with many gene-altering and so potentially harmful DNA differences. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>So the world of genetics is getting turned on its head yet again. Not so long ago, the idea was that diseases shared a common set of DNA differences. So everyone with sickle cell anemia had a certain DNA difference (or at least a certain few). Same thing with cystic fibrosis and all the other genetic diseases.\u003c/p>\n\u003cfigure id=\"attachment_38759\" class=\"wp-caption alignright\" style=\"max-width: 150px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/28/why-your-newfound-uniqueness-a-nightmare-for-your-doctor/manypaths/\" rel=\"attachment wp-att-38759\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/ManyPaths.jpg\" alt=\"\" title=\"ManyPaths\" width=\"150\" height=\"343\" class=\"size-full wp-image-38759\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">There are many paths to the same illness.\u003c/figcaption>\u003c/figure>\n\u003cp>Now it looks like there are many individual paths to a disease. For example, while most cases of cystic fibrosis do involve glitches in the CFTR gene, there are lots of glitches that can cause the disease. And that makes figuring out your chances for getting or passing cystic fibrosis to your children even harder.\u003c/p>\n\u003cp>Many (perhaps even most) of us will have DNA differences in our CFTR genes that haven’t been seen before. We don’t yet know which differences can lead to cystic fibrosis.\u003c/p>\n\u003cp>Believe it or not, cystic fibrosis is the easy case; at least it usually involves just one gene. More complex genetic diseases like Type 2 diabetes or \u003ca href=\"http://ww2.kqed.org/quest/video/alzheimers-is-the-cure-in-the-genes/\">Alzheimer’s \u003c/a>are going to be complicated by the fact that many different genes can be involved and we are all littered with unique differences in these genes. \u003c/p>\n\u003cp>For example, there will be a huge set of genes involved in Type 2 diabetes. Each of us will have numerous unique DNA differences strewn throughout these genes. Some of these changes will increase your risk for getting Type 2 diabetes and some will lower your risk.\u003c/p>\n\u003cp>Unfortunately the way scientists can tell if a difference is involved in a disease is by comparing two large groups of people with and without the disease. If a certain DNA difference turns up more often in the disease group, then it may be involved in causing the disease.\u003c/p>\n\u003cp>But now everyone has lots of unique DNA differences, many of which can contribute to disease. The people in the disease group won’t share a lot of the same differences that lead to disease. This means it is going to be hard to figure out which differences matter.\u003c/p>\n\u003cp>Our best bet may be to figure out as much DNA from as many people as possible so we can at least start to get a handle on which genes are involved in a particular disease. Then we can start to explore which DNA differences matter and which ones don’t. One thing is for sure, this is going to take awhile to sort out.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://www.sciencecodex.com/knowing_genetic_makeup_may_not_significantly_improve_disease_risk_prediction-92164\">\u003cem>This\u003c/em> \u003c/a>\u003cem>came out after I wrote the blog. More evidence that knowing our DNA may not help us out as much as we had hoped.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"A couple of new studies confirm what many of us have feared: each of us is surprisingly unique genetically. This is to be feared because of the impact it will have on the future of personalized medicine. ","status":"publish","parent":0,"modified":1340306592,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":718},"headData":{"title":"Why Your Newfound Uniqueness is a Nightmare for Your Doctor | KQED","description":"A couple of new studies confirm what many of us have feared: each of us is surprisingly unique genetically. This is to be feared because of the impact it will have on the future of personalized medicine. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Why Your Newfound Uniqueness is a Nightmare for Your Doctor","datePublished":"2012-05-28T15:00:30.000Z","dateModified":"2012-06-21T19:23:12.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"38751 http://science.kqed.org/quest/?p=38751","disqusUrl":"https://ww2.kqed.org/quest/2012/05/28/why-your-newfound-uniqueness-a-nightmare-for-your-doctor/","disqusTitle":"Why Your Newfound Uniqueness is a Nightmare for Your Doctor","path":"/quest/38751/why-your-newfound-uniqueness-a-nightmare-for-your-doctor","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_38754\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/28/why-your-newfound-uniqueness-a-nightmare-for-your-doctor/humdivinasia/\" rel=\"attachment wp-att-38754\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/HumDivInAsia.jpg\" alt=\"\" title=\"HumDivInAsia\" width=\"640\" height=\"356\" class=\"size-full wp-image-38754\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/05/HumDivInAsia.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/05/HumDivInAsia-400x223.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Our surprising genetic diversity will give scientists fits for years.\u003c/figcaption>\u003c/figure>\n\u003cp>A couple of new studies confirm what many of us have feared: each of us is surprisingly unique genetically. This is to be feared because of the impact it will have on the future of personalized medicine. Our individual uniqueness will make predicting our risk for disease much trickier than we thought. And it will make finding treatments that much harder too.\u003c/p>\n\u003cp>You’ve probably read that all humans share somewhere between 99.5% and 99.9% of their DNA. Usually this is translated into saying that we have a difference in our DNA every 1000 bases or so. (By bases I mean the A’s, G’s, C’s, and T’s that make up our DNA.)\u003c/p>\n\u003cp>These differences were supposed to be shared by many people. So a lot of people would have a G at a certain position and the rest of us would have a T. The first \u003ca href=\"http://www.sciencemag.org/content/early/2012/05/16/science.1217876\">study \u003c/a>shows that this is not the case.\u003c/p>\n\u003cp>Instead, we all have many rare DNA differences scattered throughout our DNA. When the researchers looked at 202 different genes from 14,002 people, they found a rare variant every 17 bases or so. This is way higher than many people thought.\u003c/p>\n\u003cp>What’s worse is that these differences aren’t all benign. The other \u003ca href=\"http://www.sciencemag.org/content/early/2012/05/21/science.1219240\">study published in \u003cem>Science\u003c/em>\u003c/a> showed that a surprisingly high percentage, around 2.3%, is predicted to significantly impact a gene. In other words, we are all burdened with many gene-altering and so potentially harmful DNA differences. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>So the world of genetics is getting turned on its head yet again. Not so long ago, the idea was that diseases shared a common set of DNA differences. So everyone with sickle cell anemia had a certain DNA difference (or at least a certain few). Same thing with cystic fibrosis and all the other genetic diseases.\u003c/p>\n\u003cfigure id=\"attachment_38759\" class=\"wp-caption alignright\" style=\"max-width: 150px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/28/why-your-newfound-uniqueness-a-nightmare-for-your-doctor/manypaths/\" rel=\"attachment wp-att-38759\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/ManyPaths.jpg\" alt=\"\" title=\"ManyPaths\" width=\"150\" height=\"343\" class=\"size-full wp-image-38759\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">There are many paths to the same illness.\u003c/figcaption>\u003c/figure>\n\u003cp>Now it looks like there are many individual paths to a disease. For example, while most cases of cystic fibrosis do involve glitches in the CFTR gene, there are lots of glitches that can cause the disease. And that makes figuring out your chances for getting or passing cystic fibrosis to your children even harder.\u003c/p>\n\u003cp>Many (perhaps even most) of us will have DNA differences in our CFTR genes that haven’t been seen before. We don’t yet know which differences can lead to cystic fibrosis.\u003c/p>\n\u003cp>Believe it or not, cystic fibrosis is the easy case; at least it usually involves just one gene. More complex genetic diseases like Type 2 diabetes or \u003ca href=\"http://ww2.kqed.org/quest/video/alzheimers-is-the-cure-in-the-genes/\">Alzheimer’s \u003c/a>are going to be complicated by the fact that many different genes can be involved and we are all littered with unique differences in these genes. \u003c/p>\n\u003cp>For example, there will be a huge set of genes involved in Type 2 diabetes. Each of us will have numerous unique DNA differences strewn throughout these genes. Some of these changes will increase your risk for getting Type 2 diabetes and some will lower your risk.\u003c/p>\n\u003cp>Unfortunately the way scientists can tell if a difference is involved in a disease is by comparing two large groups of people with and without the disease. If a certain DNA difference turns up more often in the disease group, then it may be involved in causing the disease.\u003c/p>\n\u003cp>But now everyone has lots of unique DNA differences, many of which can contribute to disease. The people in the disease group won’t share a lot of the same differences that lead to disease. This means it is going to be hard to figure out which differences matter.\u003c/p>\n\u003cp>Our best bet may be to figure out as much DNA from as many people as possible so we can at least start to get a handle on which genes are involved in a particular disease. Then we can start to explore which DNA differences matter and which ones don’t. One thing is for sure, this is going to take awhile to sort out.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://www.sciencecodex.com/knowing_genetic_makeup_may_not_significantly_improve_disease_risk_prediction-92164\">\u003cem>This\u003c/em> \u003c/a>\u003cem>came out after I wrote the blog. More evidence that knowing our DNA may not help us out as much as we had hoped.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/38751/why-your-newfound-uniqueness-a-nightmare-for-your-doctor","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_838","quest_3546","quest_1192","quest_11155","quest_1197","quest_3974","quest_13202","quest_3319"],"featImg":"quest_38754","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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