Exercise May Protect Against Stress-Related Cellular Aging
Meditation Training Improves Markers Of Cellular Health and Psychological Well-Being
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Image courtesy of \u003ca href=\"http://www.flickr.com/photos/mikebaird/3539161615/\">mikebaird\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>New research by Nobel Prize winning UCSF researcher, \u003ca href=\"http://biochemistry.ucsf.edu/labs/blackburn/\">Elizabeth Blackburn\u003c/a>, provides a possible mechanism by which exercise protects against stress-related chromosome aging.\u003c/p>\n\u003cp>The findings, presented this month at the \u003ca href=\"http://www.aacr.org/\">American Association for Cancer Research\u003c/a> 102nd Annual Meeting, were based on earlier research showing that stress accelerates telomere shortening. \u003ca href=\"http://en.wikipedia.org/wiki/Telomere\">Telomeres\u003c/a> are protective strands of DNA found on the end of chromosomes that protect them from degradation during cell division. Telomere length is associated with cellular health, and is a known marker of cell aging.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Shorter telomeres are associated with cell death and chromosome instability, which can lead to inflammation. In immune cells, short telomeres can predict poorer prognosis in patients with heart disease and cancer.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In a previous study by Blackburn, psychological stress was associated with shorter telomeres in the lymphocytes of caregivers of chronically ill children. This was the first demonstration that telomere length is correlated to perceived stress. In the current study, co-authored by biochemist Jue Lin, telomere length was again associated with stress levels, this time in primary caregivers looking after a family member with dementia. However when the researchers looked at the immune cells in those who exercised, there was no association between stress and telomere length.\u003c/p>\n\u003cp>Another study, led by Eli Puterman, examined the impact of exercise on the telomeres of healthy women who had been victims of child abuse. In this study those who exercised were protected against the effects of stress on telomere length.\u003c/p>\n\u003cp>“We saw a relationship between childhood trauma and short telomere length but the relationship seems to go away in people who exercise vigorously at least three times a week,” said Lin in a \u003ca href=\"http://www.universityofcalifornia.edu/news/article/25267\">press release\u003c/a>.\u003c/p>\n\u003cp>Exercise is known to beneficially impact immune function and several other aspects of health. This new research illuminates on one possible mechanism by which physical activity exerts its helpful effects.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n","blocks":[],"excerpt":"New research by Nobel Prize winning UCSF researcher, Elizabeth Blackburn, provides a possible mechanism by which exercise protects against stress-related chromosome aging.","status":"publish","parent":0,"modified":1302883204,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":12,"wordCount":329},"headData":{"title":"Exercise May Protect Against Stress-Related Cellular Aging | KQED","description":"New research by Nobel Prize winning UCSF researcher, Elizabeth Blackburn, provides a possible mechanism by which exercise protects against stress-related chromosome aging.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Exercise May Protect Against Stress-Related Cellular Aging","datePublished":"2011-04-15T16:00:04.000Z","dateModified":"2011-04-15T16:00:04.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"19213 http://www.kqed.org/quest/blog/?p=13800","disqusUrl":"https://ww2.kqed.org/quest/2011/04/15/exercise-may-protect-against-stress-related-cellular-aging/","disqusTitle":"Exercise May Protect Against Stress-Related Cellular Aging","path":"/quest/19213/exercise-may-protect-against-stress-related-cellular-aging","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/04/exercise.jpg\" alt=\"\">\u003cem> Exercise prevents the shortening of telomeres caused by psychological stress. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/mikebaird/3539161615/\">mikebaird\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>New research by Nobel Prize winning UCSF researcher, \u003ca href=\"http://biochemistry.ucsf.edu/labs/blackburn/\">Elizabeth Blackburn\u003c/a>, provides a possible mechanism by which exercise protects against stress-related chromosome aging.\u003c/p>\n\u003cp>The findings, presented this month at the \u003ca href=\"http://www.aacr.org/\">American Association for Cancer Research\u003c/a> 102nd Annual Meeting, were based on earlier research showing that stress accelerates telomere shortening. \u003ca href=\"http://en.wikipedia.org/wiki/Telomere\">Telomeres\u003c/a> are protective strands of DNA found on the end of chromosomes that protect them from degradation during cell division. Telomere length is associated with cellular health, and is a known marker of cell aging.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Shorter telomeres are associated with cell death and chromosome instability, which can lead to inflammation. In immune cells, short telomeres can predict poorer prognosis in patients with heart disease and cancer.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In a previous study by Blackburn, psychological stress was associated with shorter telomeres in the lymphocytes of caregivers of chronically ill children. This was the first demonstration that telomere length is correlated to perceived stress. In the current study, co-authored by biochemist Jue Lin, telomere length was again associated with stress levels, this time in primary caregivers looking after a family member with dementia. However when the researchers looked at the immune cells in those who exercised, there was no association between stress and telomere length.\u003c/p>\n\u003cp>Another study, led by Eli Puterman, examined the impact of exercise on the telomeres of healthy women who had been victims of child abuse. In this study those who exercised were protected against the effects of stress on telomere length.\u003c/p>\n\u003cp>“We saw a relationship between childhood trauma and short telomere length but the relationship seems to go away in people who exercise vigorously at least three times a week,” said Lin in a \u003ca href=\"http://www.universityofcalifornia.edu/news/article/25267\">press release\u003c/a>.\u003c/p>\n\u003cp>Exercise is known to beneficially impact immune function and several other aspects of health. This new research illuminates on one possible mechanism by which physical activity exerts its helpful effects.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/19213/exercise-may-protect-against-stress-related-cellular-aging","authors":["10218"],"categories":["quest_12"],"tags":["quest_83","quest_966","quest_1451","quest_3785","quest_2898","quest_3025"],"featImg":"quest_13803","label":"quest"},"quest_10162":{"type":"posts","id":"quest_10162","meta":{"index":"posts_1591205157","site":"quest","id":"10162","score":null,"sort":[1288973216000]},"guestAuthors":[],"slug":"meditation-training-improves-markers-of-cellular-health-and-psychological-well-being","title":"Meditation Training Improves Markers Of Cellular Health and Psychological Well-Being","publishDate":1288973216,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/11/mediation.jpg\" alt=\"\">\u003cem>Intensive meditation training increases psychological well-being and telomerase activity in immune cells. Image courtesy of \u003ca href=\"http://commons.wikimedia.org/wiki/User:Tevaprapas/\">Tevaprapas\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Well-being and psychological health are known to be closely associated with physical health, but the mechanistic links between the two are still relatively unknown.\u003c/p>\n\u003cp>New research from scientists at UC Davis and UC San Francisco shows that intensive meditation training improves several measures of psychological health, which in turn leads to an increase in the activity of an enzyme called \u003ca href=\"http://en.wikipedia.org/wiki/Telomerase\">telomerase\u003c/a>, a known marker of cellular health.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Telomeres are DNA sequences at the end of chromosomes that shorten every time a cell divides or is exposed to oxidative stress. When telomeres become too short, the ability of a cell to replicate is diminished along with the health of the cell. Telomerase is an enzyme that increases the length of telomeres by adding additional DNA to the end of chromosomes and stabilizing genetic structure.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Stress and pychological distress are known to negatively impact telomerase activity, and are also associated with deteriorating health. But previous research has not shown that improving psychological health could reverse the effect and increase the action of telomerase.\u003c/p>\n\u003cp>The current study investigated the effect of intense meditation on measures of both pscyhcological well-being and telomerase activity in immune cells. Thirty participants underwent meditation training at a three month intensive meditation retreat called the \u003ca href=\"http://www.shambhalamountain.org/shamatha/\">Shamatha Project\u003c/a>. The participants were evaluated for Perceived control (over one's life), Neuroticism, Mindfulness and Purpose in life both before and after the retreat. Telomerase activity was also measured before and after. The particpants were compared to 30 matched control subjects.\u003c/p>\n\u003cp>Retreat participants had statistically significant increases in measures of Perceived control, Purpose, Mindfulness, and decreases in Neuroticism. They also showed a 30% increase in telomerase activity after the retreat. Age and BMI were factored into the analysis as potential covariates. According to regression analysis, the psychological changes of Perceived control and Neuroticism mediate group differences observed in telomerase activity. Further, Mindfulness and Purpose of life significantly mediated changes in Perceived control and Neuroticism.\u003c/p>\n\u003cp>The current study does not imply that meditation directly affects telomerase activity, but that it can increase one's ability to cope with and counteract stress that may interfere with physical health.\u003c/p>\n\u003cp>Though the sample size is small and more studies are needed to confirm the ability of meditation to improve telomerase activity, this is one of the first well-designed studies to directly associate psychological training with measures of cellular health.\u003c/p>\n\u003cp>The work done by researchers at UC Davis and UC San Francisco and is currently in press at \u003cem>\u003ca href=\"http://www.news.ucdavis.edu/search/news_detail.lasso?id=9669\">Psychoneuroendocrinology\u003c/a>\u003c/em>. Contributing author and professor of biology and physiology at UCSF, Elizabeth Blackburn, won the 2009 Nobel Prize in medicine for her discovery of telomeres and telomerase.\u003c/p>\n\u003cp>The Shamatha Project is a meditation study and collaboration between UC Davis, The Santa Barbara Institute For Consciousness and the Shambhala Mountain Center.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 40.742626 -105.543262\u003c/p>\n\n","blocks":[],"excerpt":"Intensive meditation training increases psychological well-being and telomerase activity in immune cells.","status":"publish","parent":0,"modified":1288973216,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":486},"headData":{"title":"Meditation Training Improves Markers Of Cellular Health and Psychological Well-Being | KQED","description":"Intensive meditation training increases psychological well-being and telomerase activity in immune cells.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Meditation Training Improves Markers Of Cellular Health and Psychological Well-Being","datePublished":"2010-11-05T16:06:56.000Z","dateModified":"2010-11-05T16:06:56.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"10162 http://www.kqed.org/quest/blog/?p=10162","disqusUrl":"https://ww2.kqed.org/quest/2010/11/05/meditation-training-improves-markers-of-cellular-health-and-psychological-well-being/","disqusTitle":"Meditation Training Improves Markers Of Cellular Health and Psychological Well-Being","path":"/quest/10162/meditation-training-improves-markers-of-cellular-health-and-psychological-well-being","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/11/mediation.jpg\" alt=\"\">\u003cem>Intensive meditation training increases psychological well-being and telomerase activity in immune cells. Image courtesy of \u003ca href=\"http://commons.wikimedia.org/wiki/User:Tevaprapas/\">Tevaprapas\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Well-being and psychological health are known to be closely associated with physical health, but the mechanistic links between the two are still relatively unknown.\u003c/p>\n\u003cp>New research from scientists at UC Davis and UC San Francisco shows that intensive meditation training improves several measures of psychological health, which in turn leads to an increase in the activity of an enzyme called \u003ca href=\"http://en.wikipedia.org/wiki/Telomerase\">telomerase\u003c/a>, a known marker of cellular health.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Telomeres are DNA sequences at the end of chromosomes that shorten every time a cell divides or is exposed to oxidative stress. When telomeres become too short, the ability of a cell to replicate is diminished along with the health of the cell. Telomerase is an enzyme that increases the length of telomeres by adding additional DNA to the end of chromosomes and stabilizing genetic structure.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Stress and pychological distress are known to negatively impact telomerase activity, and are also associated with deteriorating health. But previous research has not shown that improving psychological health could reverse the effect and increase the action of telomerase.\u003c/p>\n\u003cp>The current study investigated the effect of intense meditation on measures of both pscyhcological well-being and telomerase activity in immune cells. Thirty participants underwent meditation training at a three month intensive meditation retreat called the \u003ca href=\"http://www.shambhalamountain.org/shamatha/\">Shamatha Project\u003c/a>. The participants were evaluated for Perceived control (over one's life), Neuroticism, Mindfulness and Purpose in life both before and after the retreat. Telomerase activity was also measured before and after. The particpants were compared to 30 matched control subjects.\u003c/p>\n\u003cp>Retreat participants had statistically significant increases in measures of Perceived control, Purpose, Mindfulness, and decreases in Neuroticism. They also showed a 30% increase in telomerase activity after the retreat. Age and BMI were factored into the analysis as potential covariates. According to regression analysis, the psychological changes of Perceived control and Neuroticism mediate group differences observed in telomerase activity. Further, Mindfulness and Purpose of life significantly mediated changes in Perceived control and Neuroticism.\u003c/p>\n\u003cp>The current study does not imply that meditation directly affects telomerase activity, but that it can increase one's ability to cope with and counteract stress that may interfere with physical health.\u003c/p>\n\u003cp>Though the sample size is small and more studies are needed to confirm the ability of meditation to improve telomerase activity, this is one of the first well-designed studies to directly associate psychological training with measures of cellular health.\u003c/p>\n\u003cp>The work done by researchers at UC Davis and UC San Francisco and is currently in press at \u003cem>\u003ca href=\"http://www.news.ucdavis.edu/search/news_detail.lasso?id=9669\">Psychoneuroendocrinology\u003c/a>\u003c/em>. Contributing author and professor of biology and physiology at UCSF, Elizabeth Blackburn, won the 2009 Nobel Prize in medicine for her discovery of telomeres and telomerase.\u003c/p>\n\u003cp>The Shamatha Project is a meditation study and collaboration between UC Davis, The Santa Barbara Institute For Consciousness and the Shambhala Mountain Center.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 40.742626 -105.543262\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/10162/meditation-training-improves-markers-of-cellular-health-and-psychological-well-being","authors":["10218"],"categories":["quest_12"],"tags":["quest_848","quest_966","quest_1784","quest_2607","quest_2896","quest_2898"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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