Unhealthy Lifestyle Linked To Increased Dementia Risk
D'OH! DHA Supplements Don't Reduce Alzheimer's Risks
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She shares her unique scientific perspective on health and enthusiasm for delicious foods at her website Summer Tomato. Follow her on Twitter @summertomato.","avatar":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Darya Pino | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/darya-pino"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_22284":{"type":"posts","id":"quest_22284","meta":{"index":"posts_1591205157","site":"quest","id":"22284","score":null,"sort":[1312571258000]},"guestAuthors":[],"slug":"unhealthy-lifestyle-linked-to-increased-dementia-risk","title":"Unhealthy Lifestyle Linked To Increased Dementia Risk ","publishDate":1312571258,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/brain.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/brain-300x169.jpg\" alt=\"\" title=\"brain\" width=\"300\" height=\"169\" class=\"alignleft size-thumbnail wp-image-22288\">\u003c/a>\u003c/p>\n\u003cp>Lifestyle factors that influence your risk of vascular disease including high blood pressure, obesity, diabetes and smoking also increase your risk of developing dementia, according to a \u003ca href=\"http://www.medicalnewstoday.com/articles/232123.php\">new study from UC Davis\u003c/a>.\u003c/p>\n\u003cp>\u003ca href=\"http://www.neurology.org/content/77/5/461.abstract?sid=7296cfc4-6e25-44e4-8e51-af135c790e4e\">Researchers from UC Davis\u003c/a> looked at data from the \u003ca href=\"http://www.framinghamheartstudy.org/participants/offspring.html\">Framingham Offspring Cohort Study\u003c/a>, a prospective cohort study beginning in 1978. They tracked participants for markers of vascular disease, which are known to be associated with diet and lifestyle choices.\u003c/p>\n\u003cp>Starting in 1999, researchers started measuring vascular disease in the brain including brain volume and white matter hyperintensities, and also conducting cognitive tests such as verbal and spatial memory and decision making.\u003c/p>\n\u003cp>Participants with higher blood pressure developed cognitive problems and hyperintensities more quickly. Obesity was highly correlated with increased cognitive decline on executive tasks. Diabetes was associated with decreased volume in a region of the brain called the hippocampus, which is responsible for memory formation. Smokers had a more rapid increase in hyperintensities.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Thus poor lifestyle choices that lead to vascular problems and obesity may also contribute to decline in cognitive health.\u003c/p>\n\n","blocks":[],"excerpt":"High blood pressure, obesity, diabetes and smoking are linked to more rapid cognitive decline.","status":"publish","parent":0,"modified":1312819580,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":8,"wordCount":176},"headData":{"title":"Unhealthy Lifestyle Linked To Increased Dementia Risk | KQED","description":"High blood pressure, obesity, diabetes and smoking are linked to more rapid cognitive decline.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"22284 http://science.kqed.org/quest/?p=22284","disqusUrl":"https://ww2.kqed.org/quest/2011/08/05/unhealthy-lifestyle-linked-to-increased-dementia-risk/","disqusTitle":"Unhealthy Lifestyle Linked To Increased Dementia Risk ","path":"/quest/22284/unhealthy-lifestyle-linked-to-increased-dementia-risk","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/brain.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/brain-300x169.jpg\" alt=\"\" title=\"brain\" width=\"300\" height=\"169\" class=\"alignleft size-thumbnail wp-image-22288\">\u003c/a>\u003c/p>\n\u003cp>Lifestyle factors that influence your risk of vascular disease including high blood pressure, obesity, diabetes and smoking also increase your risk of developing dementia, according to a \u003ca href=\"http://www.medicalnewstoday.com/articles/232123.php\">new study from UC Davis\u003c/a>.\u003c/p>\n\u003cp>\u003ca href=\"http://www.neurology.org/content/77/5/461.abstract?sid=7296cfc4-6e25-44e4-8e51-af135c790e4e\">Researchers from UC Davis\u003c/a> looked at data from the \u003ca href=\"http://www.framinghamheartstudy.org/participants/offspring.html\">Framingham Offspring Cohort Study\u003c/a>, a prospective cohort study beginning in 1978. They tracked participants for markers of vascular disease, which are known to be associated with diet and lifestyle choices.\u003c/p>\n\u003cp>Starting in 1999, researchers started measuring vascular disease in the brain including brain volume and white matter hyperintensities, and also conducting cognitive tests such as verbal and spatial memory and decision making.\u003c/p>\n\u003cp>Participants with higher blood pressure developed cognitive problems and hyperintensities more quickly. Obesity was highly correlated with increased cognitive decline on executive tasks. Diabetes was associated with decreased volume in a region of the brain called the hippocampus, which is responsible for memory formation. Smokers had a more rapid increase in hyperintensities.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Thus poor lifestyle choices that lead to vascular problems and obesity may also contribute to decline in cognitive health.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/22284/unhealthy-lifestyle-linked-to-increased-dementia-risk","authors":["10218"],"categories":["quest_12"],"tags":["quest_9966","quest_645","quest_9963","quest_821","quest_9965","quest_2031","quest_13202","quest_9964"],"label":"quest"},"quest_11083":{"type":"posts","id":"quest_11083","meta":{"index":"posts_1591205157","site":"quest","id":"11083","score":null,"sort":[1292007667000]},"guestAuthors":[],"slug":"doh-dha-supplements-dont-reduce-alzheimers-risks","title":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks","publishDate":1292007667,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/old-woman1.jpg\" alt=\"\">\u003cem>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/outcast104/1428795376/\">outcast104\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.\u003c/p>\n\u003cp>\u003ca href=\"http://en.wikipedia.org/wiki/Docosahexaenoic_acid\">DHA\u003c/a> (or docosahexaenoic acid for the geekier among you) is an omega-3 fatty acid that is abundant in the brain. Epidemiological studies have suggested that people who consume more DHA from fish have a lower incidence of Alzheimer's disease. Further, DHA supplementation has improved markers of cognitive impairment in mouse models of Alzheimer's disease.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Scientists speculated that DHA supplementation may be beneficial in treating cognitive decline because previous research has suggested that among all omega-3 fatty acids, DHA was the only one associated with a reduced incidence of impairment. Also, the other major omega-3 fatty acid found in fish, eicosapentaenoic acid (EPA), is not present in the human brain, whereas DHA is abundant.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The study, published in \u003cem>\u003ca href=\"http://jama.ama-assn.org/content/304/17/1903.short?rss=1&;ssource=mfc\">JAMA\u003c/a>\u003c/em>, was a collaborative effort by scientists from the Oregon Health and Science University, UC San Diego, Yale, UC San Francisco, NYU and others. It was a randomized, double-blind, placebo-controlled trial of DHA supplementation in patients with mild to moderate Alzheimer's disease.\u003c/p>\n\u003cp>The researchers found no benefit of 2 g/day DHA supplementation on cognitive performance on the Alzheimer's Disease Assessment Scale (ADAS) or Clinical Dementia Rating (CDR) compared to placebo. There was also no measurable benefit of DHA on brain volume, which typically declines with Alzheimer's progression.\u003c/p>\n\u003cp>Though this research does not rule out a benefit of DHA on cognitive health, it does not bode well for regular supplementation. The treatment lasted for 18 months and cognitive changes were detected in both groups. So if DHA had any effect on the rate of cognitive decline it should have been apparent.\u003c/p>\n\u003cp>It is possible that beginning DHA treatment after early signs of Alzheimer's have already been detected is too late for any meaningful protection offered by DHA. Maybe some benefit would have been found if the treatment began in healthy adults before symptoms of cognitive decline developed.\u003c/p>\n\u003cp>It may also be that DHA is beneficial, but is not effective in supplement form. DHA is very vulnerable to oxidative damage, and some research has shown that it provides more cognitive benefit when co-administered with an antioxidant (lutein) to protect it. DHA ingested in the form of food (fish) would not be subject to the same level of oxidative degradation, which may explain the results seen in epidemiological data.\u003c/p>\n\u003cp>It is not uncommon for supplements to fail to replicate epidemiological benefits seem from foods, and more careful studies are needed to determine the nutritional benefit, if any, of DHA on cognitive aging.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n","blocks":[],"excerpt":"Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.","status":"publish","parent":0,"modified":1292007667,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":14,"wordCount":461},"headData":{"title":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks | KQED","description":"Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"11083 http://www.kqed.org/quest/blog/?p=11083","disqusUrl":"https://ww2.kqed.org/quest/2010/12/10/doh-dha-supplements-dont-reduce-alzheimers-risks/","disqusTitle":"D'OH! DHA Supplements Don't Reduce Alzheimer's Risks","path":"/quest/11083/doh-dha-supplements-dont-reduce-alzheimers-risks","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/old-woman1.jpg\" alt=\"\">\u003cem>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/outcast104/1428795376/\">outcast104\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Another promising dietary supplement fails to deliver protection against a target disease, this time Alzheimer's.\u003c/p>\n\u003cp>\u003ca href=\"http://en.wikipedia.org/wiki/Docosahexaenoic_acid\">DHA\u003c/a> (or docosahexaenoic acid for the geekier among you) is an omega-3 fatty acid that is abundant in the brain. Epidemiological studies have suggested that people who consume more DHA from fish have a lower incidence of Alzheimer's disease. Further, DHA supplementation has improved markers of cognitive impairment in mouse models of Alzheimer's disease.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Scientists speculated that DHA supplementation may be beneficial in treating cognitive decline because previous research has suggested that among all omega-3 fatty acids, DHA was the only one associated with a reduced incidence of impairment. Also, the other major omega-3 fatty acid found in fish, eicosapentaenoic acid (EPA), is not present in the human brain, whereas DHA is abundant.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The study, published in \u003cem>\u003ca href=\"http://jama.ama-assn.org/content/304/17/1903.short?rss=1&;ssource=mfc\">JAMA\u003c/a>\u003c/em>, was a collaborative effort by scientists from the Oregon Health and Science University, UC San Diego, Yale, UC San Francisco, NYU and others. It was a randomized, double-blind, placebo-controlled trial of DHA supplementation in patients with mild to moderate Alzheimer's disease.\u003c/p>\n\u003cp>The researchers found no benefit of 2 g/day DHA supplementation on cognitive performance on the Alzheimer's Disease Assessment Scale (ADAS) or Clinical Dementia Rating (CDR) compared to placebo. There was also no measurable benefit of DHA on brain volume, which typically declines with Alzheimer's progression.\u003c/p>\n\u003cp>Though this research does not rule out a benefit of DHA on cognitive health, it does not bode well for regular supplementation. The treatment lasted for 18 months and cognitive changes were detected in both groups. So if DHA had any effect on the rate of cognitive decline it should have been apparent.\u003c/p>\n\u003cp>It is possible that beginning DHA treatment after early signs of Alzheimer's have already been detected is too late for any meaningful protection offered by DHA. Maybe some benefit would have been found if the treatment began in healthy adults before symptoms of cognitive decline developed.\u003c/p>\n\u003cp>It may also be that DHA is beneficial, but is not effective in supplement form. DHA is very vulnerable to oxidative damage, and some research has shown that it provides more cognitive benefit when co-administered with an antioxidant (lutein) to protect it. DHA ingested in the form of food (fish) would not be subject to the same level of oxidative degradation, which may explain the results seen in epidemiological data.\u003c/p>\n\u003cp>It is not uncommon for supplements to fail to replicate epidemiological benefits seem from foods, and more careful studies are needed to determine the nutritional benefit, if any, of DHA on cognitive aging.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/11083/doh-dha-supplements-dont-reduce-alzheimers-risks","authors":["10218"],"categories":["quest_12"],"tags":["quest_83","quest_135","quest_645","quest_820","quest_1009","quest_1079","quest_2022","quest_2065","quest_2839"],"featImg":"quest_11174","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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