Although California voters failed to approve the legalization of marijuana at the polls a couple of weeks ago, I think it's safe to say that use of the substance has already been almost completely destigmatized culturally.

Witness Seth Rogen's appearance on the premiere of the new Conan O'Brien show, posted on the East Bay Express.

Rogen:

"I have a medical marijuana prescription personally. I went in and they said what do yo need it for. I said I have a very specific ailment. It's called 'I ain't got no weed on me right now.' That was how i worded it. The lady said, 'we actually have just the thing for that.'

Laughter and prompting from Conan all the way through. That's a far cry from the "Just Say No" years.

Conan O'BrienConan O'Brien

Seth Rogen Discusses Easy Pot Availability on Conan