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Age","publishDate":1491244365,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>Sickle cell anemia is a genetic blood disorder characterized by episodes of severe pain, anemia and other complications. In more affluent countries, life expectancy for those who suffer from the disorder is 40-60 years.\u003c/p>\n\u003cp>Now, in a \u003ca href=\"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1609677\" target=\"_blank\">new study\u003c/a> out this month in \u003cem>The New England Journal of Medicine,\u003c/em> scientists report that a teenage boy with the disorder remained symptom-free for 15 months after undergoing gene therapy.\u003c/p>\n\u003cp>\"We may be on the threshold of finally being able to cure people of genetic diseases safely using gene therapy,\" said Stanford University's Mark Kay, a researcher in the field, in response to the study. Kay cited recent successful gene therapy treatments for \u003ca href=\"https://www.technologyreview.com/s/601651/gene-therapy-is-curing-hemophilia/\" target=\"_blank\">hemophilia\u003c/a>, \u003ca href=\"http://www.bbc.com/news/science-environment-36101786\" target=\"_blank\">hereditary blindness\u003c/a> and even \u003ca href=\"http://www.upi.com/Health_News/2017/01/25/Gene-therapy-helps-2-babies-fight-type-of-leukemia/6931485378663/\" target=\"_blank\">leukemia\u003c/a>.\u003c/p>\n\u003cp>Gene therapy is a simple concept — basically scientists add a working gene to a cell with only broken ones. The working gene then makes up for the broken copies of that gene and cures the genetic disease.\u003c/p>\n\u003caside class=\"pullquote alignright\">'We may be on the threshold of finally being able to cure people of genetic diseases safely using gene therapy.'\u003c/aside>\n\u003cp>But getting the right gene safely to the right spot, in enough cells for a long enough time, turns out to be a tall order. Such a tall order that gene therapy is only now coming into its own as a somewhat reliable way to treat genetic disease.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>This turnaround is not due to some leap of understanding, but because of slow, incremental improvements in every aspect of the process. Scientists are better at getting more cells to take up the therapeutic gene in a much safer way.\u003c/p>\n\u003cp>\u003cstrong>Safer Delivery\u003c/strong>\u003c/p>\n\u003cp>One of the biggest changes in gene therapy occurred in the 2000s, when scientists discovered how to better deliver to the patient functioning genes.\u003c/p>\n\u003cp>Most gene therapies take advantage of viruses, which are very skilled at inserting themselves into a cell’s DNA, where they would usually wreak havoc.\u003c/p>\n\u003cfigure id=\"attachment_357653\" class=\"wp-caption alignright\" style=\"max-width: 800px\">\u003cimg class=\"wp-image-357653 size-medium\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-800x602.jpg\" width=\"800\" height=\"602\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-800x602.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-160x120.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-768x578.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-1020x768.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-1180x888.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-960x722.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-240x181.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-375x282.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-520x391.jpg 520w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia.jpg 1600w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">The sickled red blood cells cause the symptoms of sickle cell anemia. Adding an engineered beta globin gene to bone marrow cells results in many fewer of the sickled cells. (Wikimedia)\u003c/figcaption>\u003c/figure>\n\u003cp>But with gene therapy, scientists strip out the parts of the virus that make it dangerous. It's this engineered virus they use to deliver the working genes.\u003c/p>\n\u003cp>In early gene therapy research, scientists used retroviruses \u003cb>,\u003c/b> which are easy to\u003cb> \u003c/b>work with and are very good at getting genes into a cell’s DNA.\u003c/p>\n\u003cp>Unfortunately, many of them tend to insert themselves into places in our DNA that switch on genes that can cause cancer; that \u003ca href=\"http://angt.austrianova.com/angt/Brevia.pdf\">happened in a study\u003c/a> back in 2002. Since then, scientists have worked hard to find retroviruses that wouldn’t cause this problem.\u003c/p>\n\u003cp>\u003cstrong>Other Important Tweaks\u003c/strong>\u003c/p>\n\u003cp>But a good delivery vehicle isn’t enough to treat sickle cell anemia. Scientists also need to replace the mutated genetic material that’s causing the illness with a working gene powerful enough to keep the disease at bay. In a 2004 study, scientists \u003ca href=\"http://www.jbc.org/content/279/26/27518.full\" target=\"_blank\">engineered a gene\u003c/a> that seems to do the job for sickle cell anemia.\u003c/p>\n\u003cp>In the case of the boy reported earlier this month, researchers removed his bone marrow cells, used a virus to insert a working gene into them, then returned the engineered bone marrow cells back to the patient. Bone marrow cells are where all new blood cells are made.\u003c/p>\n\u003cp>Another key improvement was to treat the patient with a drug, busulfan. This allowed for more of the engineered cells to take root in the patient’s bone marrow, meaning more of his red blood cells returned to normal.\u003c/p>\n\u003cp>“All of these changes and more have led to a successful outcome,” says Stanford genetic researcher Dr. Michele Calos, speaking of the new study. “This successful study is the culmination of more than 30 years of work by many people.”\u003c/p>\n\u003cp>We may be on the threshold of finally being able to cure people of genetic diseases safely using gene therapy. Or then again, we might not.\u003c/p>\n\u003cp>Over the years, scientists have been heralding the coming gene therapy age again and again. Each time there was a setback that held the field back.\u003c/p>\n\u003cp>Gene therapy is still a very expensive and time-consuming procedure, but if it can be streamlined, it holds promise for the millions of people worldwide struggling with sickle cell anemia, cystic fibrosis and other genetic diseases.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>\u003cspan style=\"font-weight: 400\">Dr. Barry Starr is a scientist in the\u003c/span>\u003ca href=\"https://med.stanford.edu/genetics.html\"> \u003cspan style=\"font-weight: 400\">Department of Genetics\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> at Stanford University. He runs the\u003c/span>\u003ca href=\"https://med.stanford.edu/genetics/tech.html\"> \u003cspan style=\"font-weight: 400\">Stanford at The Tech\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> program and the\u003c/span>\u003ca href=\"http://genetics.thetech.org/\"> \u003cspan style=\"font-weight: 400\">Understanding Genetics\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> website with\u003c/span>\u003ca href=\"https://www.thetech.org/\"> \u003cspan style=\"font-weight: 400\">The Tech Museum of Innovation\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> in San Jose, California. \u003c/span>\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"Slow, incremental advances in medical technologies have made gene therapy more effective and less dangerous.","status":"publish","parent":0,"modified":1491244268,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":23,"wordCount":784},"headData":{"title":"Gene Therapy May Finally Be Coming of Age | KQED","description":"Slow, incremental advances in medical technologies have made gene therapy more effective and less dangerous.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"354044 https://ww2.kqed.org/futureofyou/?p=354044","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/04/03/gene-therapy-may-finally-be-coming-of-age/","disqusTitle":"Gene Therapy May Finally Be Coming of Age","source":"Your Genes","customPermalink":"2017/03/20/gene-therapy-may-finally-be-coming-of-age/","nprByline":"Barry Starr","path":"/futureofyou/354044/gene-therapy-may-finally-be-coming-of-age","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Sickle cell anemia is a genetic blood disorder characterized by episodes of severe pain, anemia and other complications. In more affluent countries, life expectancy for those who suffer from the disorder is 40-60 years.\u003c/p>\n\u003cp>Now, in a \u003ca href=\"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1609677\" target=\"_blank\">new study\u003c/a> out this month in \u003cem>The New England Journal of Medicine,\u003c/em> scientists report that a teenage boy with the disorder remained symptom-free for 15 months after undergoing gene therapy.\u003c/p>\n\u003cp>\"We may be on the threshold of finally being able to cure people of genetic diseases safely using gene therapy,\" said Stanford University's Mark Kay, a researcher in the field, in response to the study. Kay cited recent successful gene therapy treatments for \u003ca href=\"https://www.technologyreview.com/s/601651/gene-therapy-is-curing-hemophilia/\" target=\"_blank\">hemophilia\u003c/a>, \u003ca href=\"http://www.bbc.com/news/science-environment-36101786\" target=\"_blank\">hereditary blindness\u003c/a> and even \u003ca href=\"http://www.upi.com/Health_News/2017/01/25/Gene-therapy-helps-2-babies-fight-type-of-leukemia/6931485378663/\" target=\"_blank\">leukemia\u003c/a>.\u003c/p>\n\u003cp>Gene therapy is a simple concept — basically scientists add a working gene to a cell with only broken ones. The working gene then makes up for the broken copies of that gene and cures the genetic disease.\u003c/p>\n\u003caside class=\"pullquote alignright\">'We may be on the threshold of finally being able to cure people of genetic diseases safely using gene therapy.'\u003c/aside>\n\u003cp>But getting the right gene safely to the right spot, in enough cells for a long enough time, turns out to be a tall order. Such a tall order that gene therapy is only now coming into its own as a somewhat reliable way to treat genetic disease.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>This turnaround is not due to some leap of understanding, but because of slow, incremental improvements in every aspect of the process. Scientists are better at getting more cells to take up the therapeutic gene in a much safer way.\u003c/p>\n\u003cp>\u003cstrong>Safer Delivery\u003c/strong>\u003c/p>\n\u003cp>One of the biggest changes in gene therapy occurred in the 2000s, when scientists discovered how to better deliver to the patient functioning genes.\u003c/p>\n\u003cp>Most gene therapies take advantage of viruses, which are very skilled at inserting themselves into a cell’s DNA, where they would usually wreak havoc.\u003c/p>\n\u003cfigure id=\"attachment_357653\" class=\"wp-caption alignright\" style=\"max-width: 800px\">\u003cimg class=\"wp-image-357653 size-medium\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-800x602.jpg\" width=\"800\" height=\"602\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-800x602.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-160x120.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-768x578.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-1020x768.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-1180x888.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-960x722.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-240x181.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-375x282.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia-520x391.jpg 520w, https://ww2.kqed.org/app/uploads/sites/13/2017/03/Risk-Factors-for-Sickle-Cell-Anemia.jpg 1600w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">The sickled red blood cells cause the symptoms of sickle cell anemia. Adding an engineered beta globin gene to bone marrow cells results in many fewer of the sickled cells. (Wikimedia)\u003c/figcaption>\u003c/figure>\n\u003cp>But with gene therapy, scientists strip out the parts of the virus that make it dangerous. It's this engineered virus they use to deliver the working genes.\u003c/p>\n\u003cp>In early gene therapy research, scientists used retroviruses \u003cb>,\u003c/b> which are easy to\u003cb> \u003c/b>work with and are very good at getting genes into a cell’s DNA.\u003c/p>\n\u003cp>Unfortunately, many of them tend to insert themselves into places in our DNA that switch on genes that can cause cancer; that \u003ca href=\"http://angt.austrianova.com/angt/Brevia.pdf\">happened in a study\u003c/a> back in 2002. Since then, scientists have worked hard to find retroviruses that wouldn’t cause this problem.\u003c/p>\n\u003cp>\u003cstrong>Other Important Tweaks\u003c/strong>\u003c/p>\n\u003cp>But a good delivery vehicle isn’t enough to treat sickle cell anemia. Scientists also need to replace the mutated genetic material that’s causing the illness with a working gene powerful enough to keep the disease at bay. In a 2004 study, scientists \u003ca href=\"http://www.jbc.org/content/279/26/27518.full\" target=\"_blank\">engineered a gene\u003c/a> that seems to do the job for sickle cell anemia.\u003c/p>\n\u003cp>In the case of the boy reported earlier this month, researchers removed his bone marrow cells, used a virus to insert a working gene into them, then returned the engineered bone marrow cells back to the patient. Bone marrow cells are where all new blood cells are made.\u003c/p>\n\u003cp>Another key improvement was to treat the patient with a drug, busulfan. This allowed for more of the engineered cells to take root in the patient’s bone marrow, meaning more of his red blood cells returned to normal.\u003c/p>\n\u003cp>“All of these changes and more have led to a successful outcome,” says Stanford genetic researcher Dr. Michele Calos, speaking of the new study. “This successful study is the culmination of more than 30 years of work by many people.”\u003c/p>\n\u003cp>We may be on the threshold of finally being able to cure people of genetic diseases safely using gene therapy. Or then again, we might not.\u003c/p>\n\u003cp>Over the years, scientists have been heralding the coming gene therapy age again and again. Each time there was a setback that held the field back.\u003c/p>\n\u003cp>Gene therapy is still a very expensive and time-consuming procedure, but if it can be streamlined, it holds promise for the millions of people worldwide struggling with sickle cell anemia, cystic fibrosis and other genetic diseases.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>\u003cspan style=\"font-weight: 400\">Dr. Barry Starr is a scientist in the\u003c/span>\u003ca href=\"https://med.stanford.edu/genetics.html\"> \u003cspan style=\"font-weight: 400\">Department of Genetics\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> at Stanford University. He runs the\u003c/span>\u003ca href=\"https://med.stanford.edu/genetics/tech.html\"> \u003cspan style=\"font-weight: 400\">Stanford at The Tech\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> program and the\u003c/span>\u003ca href=\"http://genetics.thetech.org/\"> \u003cspan style=\"font-weight: 400\">Understanding Genetics\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> website with\u003c/span>\u003ca href=\"https://www.thetech.org/\"> \u003cspan style=\"font-weight: 400\">The Tech Museum of Innovation\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\"> in San Jose, California. \u003c/span>\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/354044/gene-therapy-may-finally-be-coming-of-age","authors":["byline_futureofyou_354044"],"categories":["futureofyou_1064"],"tags":["futureofyou_1209","futureofyou_1210","futureofyou_1211"],"featImg":"futureofyou_357651","label":"source_futureofyou_354044"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.","airtime":"THU 10pm, FRI 1am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.commonwealthclub.org/podcasts","meta":{"site":"news","source":"Commonwealth Club of California"},"link":"/radio/program/commonwealth-club","subscribe":{"apple":"https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2","google":"https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw","tuneIn":"https://tunein.com/radio/Commonwealth-Club-of-California-p1060/"}},"considerthis":{"id":"considerthis","title":"Consider This","tagline":"Make sense of the day","info":"Make sense of the day. Every weekday afternoon, Consider This helps you consider the major stories of the day in less than 15 minutes, featuring the reporting and storytelling resources of NPR. Plus, KQED’s Bianca Taylor brings you the local KQED news you need to know.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Consider-This-Podcast-Tile-703x703-1.jpg","imageAlt":"Consider This from NPR and KQED","officialWebsiteLink":"/podcasts/considerthis","meta":{"site":"news","source":"kqed","order":"7"},"link":"/podcasts/considerthis","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1503226625?mt=2&at=11l79Y&ct=nprdirectory","npr":"https://rpb3r.app.goo.gl/coronavirusdaily","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM1NS9wb2RjYXN0LnhtbA","spotify":"https://open.spotify.com/show/3Z6JdCS2d0eFEpXHKI6WqH"}},"forum":{"id":"forum","title":"Forum","tagline":"The conversation starts here","info":"KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.","airtime":"MON-FRI 9am-11am, 10pm-11pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED Forum with Mina Kim and Alexis Madrigal","officialWebsiteLink":"/forum","meta":{"site":"news","source":"kqed","order":"8"},"link":"/forum","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/kqeds-forum/id73329719","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz","npr":"https://www.npr.org/podcasts/432307980/forum","stitcher":"https://www.stitcher.com/podcast/kqedfm-kqeds-forum-podcast","rss":"https://feeds.megaphone.fm/KQINC9557381633"}},"freakonomics-radio":{"id":"freakonomics-radio","title":"Freakonomics Radio","info":"Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. 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