Keeping Internal Clocks Regular Sets Stage for Good Health
Seasons May Tweak Genes That Trigger Some Chronic Diseases
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FM","link":"/"}},"futureofyou_435777":{"type":"posts","id":"futureofyou_435777","meta":{"index":"posts_1591205157","site":"futureofyou","id":"435777","score":null,"sort":[1507100499000]},"guestAuthors":[],"slug":"how-messing-with-our-body-clocks-can-raise-alarms-with-health","title":"Keeping Internal Clocks Regular Sets Stage for Good Health","publishDate":1507100499,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{"site":"futureofyou"},"content":"\u003cp>Research that helped discover the clocks running in every cell in our bodies earned three scientists a Nobel Prize in medicine on Monday.\u003c/p>\n\u003caside class=\"pullquote alignright\">We humans are time-keeping machines.\u003c/aside>\n\u003cp>\"With exquisite precision, our inner clock adapts our physiology to the dramatically different phases of the day,\" the Nobel Prize committee \u003ca href=\"http://www.npr.org/sections/thetwo-way/2017/10/02/554993385/nobel-prize-in-medicine-is-awarded-to-3-americans-for-work-on-circadian-rhythm\">wrote\u003c/a> of the work of Jeffrey C. Hall, Michael Rosbash and Michael W. Young. \"The clock regulates critical functions such as behavior, hormone levels, sleep, body temperature and metabolism.\"\u003c/p>\n\u003cp>We humans are time-keeping machines. And it seems we need regular sleeping and eating schedules to keep all of our clocks in sync.\u003c/p>\n\u003cp>Studies show that if we mess with the body's natural sleep-wake cycle — say, by working an overnight shift, taking a trans-Aatlantic flight or staying up all night with a new baby or puppy — we pay the price.\u003c/p>\n\u003cp>Our blood pressure goes up, hunger hormones get thrown off and blood sugar control goes south.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>[contextly_sidebar id=\"7S0R6t5jB019yBlneO6IBb620pV8FH0F\"]We can all recover from an occasional all-nighter, an episode of \u003ca href=\"http://www.npr.org/blogs/thesalt/2012/05/15/152690836/jetlagged-by-your-social-calendar-better-check-your-waistline\">jet lag\u003c/a> or short-term disruptions.\u003c/p>\n\u003cp>But over time, if living against the clock becomes a way of life, this may set the stage for weight gain and metabolic diseases such as Type 2 diabetes.\u003c/p>\n\u003cp>\"What happens is that you get a total de-synchronization of the clocks within us,\" explains \u003ca href=\"http://www.neurobiology.northwestern.edu/people/core-faculty/fred-turek.html\">Fred Turek\u003c/a>, a circadian scientist at Northwestern University. \"Which may be underlying the chronic diseases we face in our society today.\"\u003c/p>\n\u003cp>So consider what happens, for instance, if we eat late or in the middle of the night. The master clock — which is set by the light-dark cycle — is cuing all other clocks in the body that it's night. Time to rest.\u003c/p>\n\u003cp>\"The clock in the brain is sending signals saying: Do not eat, do not eat!\" says Turek.\u003c/p>\n\u003cp>But when we override this signal and eat anyway, the clock in the pancreas, for instance, has to start releasing insulin to deal with the meal. And, research suggests, this late-night munching may start to reset the clock in the organ. The result? Competing time cues.\u003c/p>\n\u003cp>\"The pancreas is listening to signals related to food intake. But that's out of sync with what the brain is telling it to do,\" says Turek. \"So if we're sending signals to those organs at the wrong time of day — such as eating at the wrong time of day — [we're] upsetting the balance.\"\u003c/p>\n\u003cp>And there's accumulating evidence that we may be more sensitive to these timing cues than scientists ever imagined.\u003c/p>\n\u003cp>Consider, for instance, the results of a weight-loss study that we \u003ca href=\"http://www.npr.org/blogs/thesalt/2013/01/30/170591028/to-maximize-weight-loss-eat-early-in-the-day-not-late\">reported\u003c/a> on, which was \u003ca href=\"http://www.nature.com/articles/ijo2012229.epdf?referrer_access_token=dfwcZDpYAoJZu6Z-jfDWKNRgN0jAjWel9jnR3ZoTv0OoXMYxeUF5K1SF8LoOyYhWHpTWbYAprLsgGQpZUO-8dRgCsqvc69Y6ybR2icWqKNZrh_6mGhPVx5UkksCfOoxHL20408_DDob5XOcvWupyp7UK9qL-EM1cBouacqb4ctvAQEttrbhdfb73szArvXfotICQ2OLQHwSxoMZuG_s0AKrTt1X14w0q94UPGaCHOdB-HeTw-VJC8ISkWpFd62jb&tracking_referrer=www.npr.org\">published\u003c/a> in 2013 in the \u003cem>International Journal of Obesity\u003c/em>. Researchers found that the timing of meals can influence how much weight people lose.\u003c/p>\n\u003cp>\"The finding that we had was that people who ate their main meal earlier in the day were much more successful at losing weight,\" says study author \u003ca href=\"https://sleep.med.harvard.edu/people/faculty/242/frank+a+j+l+scheer+phd\">Frank Scheer\u003c/a>, a Harvard neuroscientist who directs the \u003ca href=\"https://sleep.med.harvard.edu/research/labs/54/Medical+Chronobiology+Program+MCP+Research+on+Circadian+Rhythms+in+Health+and+Di\">Medical Chronobiology Program\u003c/a> at Brigham and Women's Hospital.\u003c/p>\n\u003cp>In fact, early eaters lost 25 percent more weight than later eaters — \"a surprisingly large difference,\" Scheer says. Another\u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/23512957\"> study\u003c/a> found that eating a big breakfast was more conducive to weight loss, compared with a big dinner — adding to the evidence that the timing of meals is important.\u003c/p>\n\u003cp>Beyond weight management, there's evidence that the clocks in our bodies — and the timing of our sleeping, eating and activities — play multiple roles in helping us maintain good health. And different systems in the body are programmed to do different tasks at different times.\u003c/p>\n\u003cp>For instance, doctors have long known that the time of day you take a drug can influence its potency. \"If you take a drug at one time of day, it might be much more toxic than another time of day,\" Turek says. Part of this effect could be that the liver is better at detoxifying at certain times of day.\u003c/p>\n\u003cp>Turek says his hope is that, down the road, circadian science will be integrated into the practice of medicine.\u003c/p>\n\u003cp>\"We'd like to be in a position where we'd be able to monitor hundreds of different rhythms in your body and see if they're out of sync — and then try to normalize them,\" Turek says.\u003c/p>\n\u003cp>Whether — or how quickly — this may happen is hard to say. But what's clear is that the study of the biology of time is exploding.\u003c/p>\n\u003cp>\"What we're doing now in medicine is what Einstein did for physics,\" says Turek. \"He brought time to physics. We're bringing time to biology.\"\u003c/p>\n\u003cp>The irony, of course, is that this insight comes at a time when the demands of our 24/7 society mean more and more of us are overriding our internal clocks.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>A previous \u003c/em>\u003ca href=\"http://www.npr.org/sections/thesalt/2015/03/10/389596946/circadian-surprise-how-our-body-clocks-help-shape-our-waistlines\">\u003cem>version\u003c/em>\u003c/a>\u003cem> of this story was published in 2015. \u003c/em>\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2017 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"https://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=How+Messing+With+Our+Body+Clocks+Can+Raise+Alarms+With+Health&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n","blocks":[],"excerpt":"The scientists honored with a Nobel Prize in medicine helped discover that every cell in the body has its own clock. When we ignore those clocks, we increase the risk of weight gain and diabetes.","status":"publish","parent":0,"modified":1507058365,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":26,"wordCount":840},"headData":{"title":"Keeping Internal Clocks Regular Sets Stage for Good Health | KQED","description":"The scientists honored with a Nobel Prize in medicine helped discover that every cell in the body has its own clock. When we ignore those clocks, we increase the risk of weight gain and diabetes.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Keeping Internal Clocks Regular Sets Stage for Good Health","datePublished":"2017-10-04T07:01:39.000Z","dateModified":"2017-10-03T19:19:25.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"435777 https://ww2.kqed.org/futureofyou/?p=435777","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/10/04/how-messing-with-our-body-clocks-can-raise-alarms-with-health/","disqusTitle":"Keeping Internal Clocks Regular Sets Stage for Good Health","nprByline":"Allison Aubrey\u003cbr/>NPR Shots","nprImageAgency":"Katherine Streeter for NPR","nprStoryId":"555054483","nprApiLink":"http://api.npr.org/query?id=555054483&apiKey=MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004","nprHtmlLink":"http://www.npr.org/sections/health-shots/2017/10/02/555054483/how-messing-with-our-body-clocks-can-raise-alarms-with-health?ft=nprml&f=555054483","nprRetrievedStory":"1","nprPubDate":"Mon, 02 Oct 2017 15:57:00 -0400","nprStoryDate":"Mon, 02 Oct 2017 12:31:00 -0400","nprLastModifiedDate":"Mon, 02 Oct 2017 15:57:45 -0400","path":"/futureofyou/435777/how-messing-with-our-body-clocks-can-raise-alarms-with-health","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Research that helped discover the clocks running in every cell in our bodies earned three scientists a Nobel Prize in medicine on Monday.\u003c/p>\n\u003caside class=\"pullquote alignright\">We humans are time-keeping machines.\u003c/aside>\n\u003cp>\"With exquisite precision, our inner clock adapts our physiology to the dramatically different phases of the day,\" the Nobel Prize committee \u003ca href=\"http://www.npr.org/sections/thetwo-way/2017/10/02/554993385/nobel-prize-in-medicine-is-awarded-to-3-americans-for-work-on-circadian-rhythm\">wrote\u003c/a> of the work of Jeffrey C. Hall, Michael Rosbash and Michael W. Young. \"The clock regulates critical functions such as behavior, hormone levels, sleep, body temperature and metabolism.\"\u003c/p>\n\u003cp>We humans are time-keeping machines. And it seems we need regular sleeping and eating schedules to keep all of our clocks in sync.\u003c/p>\n\u003cp>Studies show that if we mess with the body's natural sleep-wake cycle — say, by working an overnight shift, taking a trans-Aatlantic flight or staying up all night with a new baby or puppy — we pay the price.\u003c/p>\n\u003cp>Our blood pressure goes up, hunger hormones get thrown off and blood sugar control goes south.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>We can all recover from an occasional all-nighter, an episode of \u003ca href=\"http://www.npr.org/blogs/thesalt/2012/05/15/152690836/jetlagged-by-your-social-calendar-better-check-your-waistline\">jet lag\u003c/a> or short-term disruptions.\u003c/p>\n\u003cp>But over time, if living against the clock becomes a way of life, this may set the stage for weight gain and metabolic diseases such as Type 2 diabetes.\u003c/p>\n\u003cp>\"What happens is that you get a total de-synchronization of the clocks within us,\" explains \u003ca href=\"http://www.neurobiology.northwestern.edu/people/core-faculty/fred-turek.html\">Fred Turek\u003c/a>, a circadian scientist at Northwestern University. \"Which may be underlying the chronic diseases we face in our society today.\"\u003c/p>\n\u003cp>So consider what happens, for instance, if we eat late or in the middle of the night. The master clock — which is set by the light-dark cycle — is cuing all other clocks in the body that it's night. Time to rest.\u003c/p>\n\u003cp>\"The clock in the brain is sending signals saying: Do not eat, do not eat!\" says Turek.\u003c/p>\n\u003cp>But when we override this signal and eat anyway, the clock in the pancreas, for instance, has to start releasing insulin to deal with the meal. And, research suggests, this late-night munching may start to reset the clock in the organ. The result? Competing time cues.\u003c/p>\n\u003cp>\"The pancreas is listening to signals related to food intake. But that's out of sync with what the brain is telling it to do,\" says Turek. \"So if we're sending signals to those organs at the wrong time of day — such as eating at the wrong time of day — [we're] upsetting the balance.\"\u003c/p>\n\u003cp>And there's accumulating evidence that we may be more sensitive to these timing cues than scientists ever imagined.\u003c/p>\n\u003cp>Consider, for instance, the results of a weight-loss study that we \u003ca href=\"http://www.npr.org/blogs/thesalt/2013/01/30/170591028/to-maximize-weight-loss-eat-early-in-the-day-not-late\">reported\u003c/a> on, which was \u003ca href=\"http://www.nature.com/articles/ijo2012229.epdf?referrer_access_token=dfwcZDpYAoJZu6Z-jfDWKNRgN0jAjWel9jnR3ZoTv0OoXMYxeUF5K1SF8LoOyYhWHpTWbYAprLsgGQpZUO-8dRgCsqvc69Y6ybR2icWqKNZrh_6mGhPVx5UkksCfOoxHL20408_DDob5XOcvWupyp7UK9qL-EM1cBouacqb4ctvAQEttrbhdfb73szArvXfotICQ2OLQHwSxoMZuG_s0AKrTt1X14w0q94UPGaCHOdB-HeTw-VJC8ISkWpFd62jb&tracking_referrer=www.npr.org\">published\u003c/a> in 2013 in the \u003cem>International Journal of Obesity\u003c/em>. Researchers found that the timing of meals can influence how much weight people lose.\u003c/p>\n\u003cp>\"The finding that we had was that people who ate their main meal earlier in the day were much more successful at losing weight,\" says study author \u003ca href=\"https://sleep.med.harvard.edu/people/faculty/242/frank+a+j+l+scheer+phd\">Frank Scheer\u003c/a>, a Harvard neuroscientist who directs the \u003ca href=\"https://sleep.med.harvard.edu/research/labs/54/Medical+Chronobiology+Program+MCP+Research+on+Circadian+Rhythms+in+Health+and+Di\">Medical Chronobiology Program\u003c/a> at Brigham and Women's Hospital.\u003c/p>\n\u003cp>In fact, early eaters lost 25 percent more weight than later eaters — \"a surprisingly large difference,\" Scheer says. Another\u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/23512957\"> study\u003c/a> found that eating a big breakfast was more conducive to weight loss, compared with a big dinner — adding to the evidence that the timing of meals is important.\u003c/p>\n\u003cp>Beyond weight management, there's evidence that the clocks in our bodies — and the timing of our sleeping, eating and activities — play multiple roles in helping us maintain good health. And different systems in the body are programmed to do different tasks at different times.\u003c/p>\n\u003cp>For instance, doctors have long known that the time of day you take a drug can influence its potency. \"If you take a drug at one time of day, it might be much more toxic than another time of day,\" Turek says. Part of this effect could be that the liver is better at detoxifying at certain times of day.\u003c/p>\n\u003cp>Turek says his hope is that, down the road, circadian science will be integrated into the practice of medicine.\u003c/p>\n\u003cp>\"We'd like to be in a position where we'd be able to monitor hundreds of different rhythms in your body and see if they're out of sync — and then try to normalize them,\" Turek says.\u003c/p>\n\u003cp>Whether — or how quickly — this may happen is hard to say. But what's clear is that the study of the biology of time is exploding.\u003c/p>\n\u003cp>\"What we're doing now in medicine is what Einstein did for physics,\" says Turek. \"He brought time to physics. We're bringing time to biology.\"\u003c/p>\n\u003cp>The irony, of course, is that this insight comes at a time when the demands of our 24/7 society mean more and more of us are overriding our internal clocks.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>A previous \u003c/em>\u003ca href=\"http://www.npr.org/sections/thesalt/2015/03/10/389596946/circadian-surprise-how-our-body-clocks-help-shape-our-waistlines\">\u003cem>version\u003c/em>\u003c/a>\u003cem> of this story was published in 2015. \u003c/em>\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2017 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"https://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=How+Messing+With+Our+Body+Clocks+Can+Raise+Alarms+With+Health&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/435777/how-messing-with-our-body-clocks-can-raise-alarms-with-health","authors":["byline_futureofyou_435777"],"categories":["futureofyou_1"],"tags":["futureofyou_607","futureofyou_326"],"featImg":"futureofyou_435778","label":"futureofyou"},"futureofyou_3016":{"type":"posts","id":"futureofyou_3016","meta":{"index":"posts_1591205157","site":"futureofyou","id":"3016","score":null,"sort":[1431536788000]},"guestAuthors":[],"slug":"seasons-may-tweak-genes-that-trigger-some-chronic-diseases","title":"Seasons May Tweak Genes That Trigger Some Chronic Diseases","publishDate":1431536788,"format":"standard","headTitle":"Contributor | KQED Future of You | KQED Science","labelTerm":{"term":172,"site":"futureofyou"},"content":"\u003cp>The seasons appear to influence when certain genes are active, with those associated with inflammation being more active in the winter, according to new research released Tuesday.\u003c/p>\n\u003cp>A study involving more than 16,000 people found that the activity of about 4,000 of those genes appears to be affected by the season, researchers \u003ca href=\"http://nature.com/articles/doi:10.1038/ncomms8000\">reported\u003c/a> in the journal \u003cem>Nature Communications\u003c/em>. The findings could help explain why certain diseases are more likely than others to strike for the first time during certain seasons, the researchers say.\u003c/p>\n\u003cp>\"Certain chronic diseases are very seasonal — like \u003ca href=\"http://www.npr.org/2011/11/11/142244046/cure-winter-blues-with-light-therapy\">seasonal affective disorder \u003c/a>or cardiovascular disease or type 1 diabetes or multiple sclerosis or rheumatoid arthritis,\" says \u003ca href=\"http://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/todd\">John Todd\u003c/a>, a geneticist at the University of Cambridge who led the research. \"But people have been wondering for decades what the explanation for that is.\"\u003c/p>\n\u003cp>Todd and his colleagues decided to try to find out. They analyzed the genes in cells from more than 16,000 people in five countries, including the United States and European countries in the Northern Hemisphere, and Australia in the Southern Hemisphere. And they spotted the same trend — in both hemispheres, and among men as well as women.\u003c/p>\n\u003cp>\"It's one of those observations where ... the first time you see it, you go, 'Wow, somebody must have seen this before,' \" Todd says.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>When the researchers looked more closely at which genes were more or less active during some seasons than others, one big thing jumped out.\u003c/p>\n\u003cp>\"One of the standout results was that genes promoting inflammation were increased in winter, whereas genes suppressing inflammation were decreased in the winter. So overall it looked as if this gene activity pattern really goes with increased inflammation in the winter,\" he says.\u003c/p>\n\u003cp>Inflammation, which is caused by the immune system becoming overactive, Todd says, has long been associated with a lot of the health problems that spike in the winter.\u003c/p>\n\u003cp>No one knows how the seasons affect our genes. But there are some obvious possibilities, Todd thinks.\u003c/p>\n\u003cp>\"As the seasons come on it gets colder, the days get shorter,\" he says. \"So daylight and temperature could be factors.\"\u003c/p>\n\u003cp>Other researchers say the findings could have far-reaching implications.\u003c/p>\n\u003cp>\"The fact that they find so many genes that go up and down over the seasons is very interesting because we just didn't know that our bodies go through this type of seasonal change before,\" says \u003ca href=\"http://www.neuroscience.cam.ac.uk/directory/profile.php?abreddy\">Akhilesh Reddy\u003c/a>, who studies circadian rhythms at the University of Cambridge but was not involved in the new research. \"And if you look at the actual genetic evidence for the first time, it's pretty profound really.\"\u003c/p>\n\u003cp>Reddy thinks the findings will prompt other scientists to look into how the seasons may have power over our genes.\u003c/p>\n\u003cp>\"People might have a variation in their responses to all sorts of things that we haven't really thought about yet,\" Reddy says.\u003c/p>\n\u003cp>For example, the seasons may affect how people metabolize drugs.\u003c/p>\n\u003cp>\"Even your cognitive performance ... might be influenced subtly by the time of year at which you're assessed,\" he says. \"There's never been a marker before that you can look at in the blood, or whatever, to say, 'You're looking like you're a winter person now versus a summer person.' \"\u003c/p>\n\u003cdiv class=\"fullattribution\">\u003cem>Copyright 2015 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Seasons+May+Tweak+Genes+That+Trigger+Some+Chronic+Diseases&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\" alt=\"\">\u003c/em>\u003c/div>\n\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n","blocks":[],"excerpt":"Genes linked to inflammation are more active in winter, a study hints. That might partly explain why some diseases, including type 1 diabetes and rheumatoid arthritis, are more likely to start then.","status":"publish","parent":0,"modified":1477282590,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":556},"headData":{"title":"Seasons May Tweak Genes That Trigger Some Chronic Diseases | KQED","description":"Genes linked to inflammation are more active in winter, a study hints. That might partly explain why some diseases, including type 1 diabetes and rheumatoid arthritis, are more likely to start then.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Seasons May Tweak Genes That Trigger Some Chronic Diseases","datePublished":"2015-05-13T17:06:28.000Z","dateModified":"2016-10-24T04:16:30.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"3016 http://ww2.kqed.org/futureofyou/?p=3016","disqusUrl":"https://ww2.kqed.org/futureofyou/2015/05/13/seasons-may-tweak-genes-that-trigger-some-chronic-diseases/","disqusTitle":"Seasons May Tweak Genes That Trigger Some Chronic Diseases","nprByline":"Rob Stein","nprStoryId":"406139368","nprApiLink":"http://api.npr.org/query?id=406139368&apiKey=MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004","nprHtmlLink":"http://www.npr.org/sections/health-shots/2015/05/12/406139368/seasons-may-tweak-genes-that-trigger-some-chronic-diseases?ft=nprml&f=406139368","nprRetrievedStory":"1","nprPubDate":"Tue, 12 May 2015 19:22:00 -0400","nprStoryDate":"Tue, 12 May 2015 13:10:00 -0400","nprLastModifiedDate":"Tue, 12 May 2015 18:29:07 -0400","nprAudio":"http://pd.npr.org/anon.npr-mp3/npr/atc/2015/05/20150512_atc_seasons_may_tweak_genes_that_trigger_some_chronic_diseases.mp3?orgId=1&topicId=1128&d=253&p=2&story=406139368&t=progseg&e=406171776&seg=15&ft=nprml&f=406139368","nprAudioM3u":"http://api.npr.org/m3u/1406241886-d6e873.m3u?orgId=1&topicId=1128&d=253&p=2&story=406139368&t=progseg&e=406171776&seg=15&ft=nprml&f=406139368","path":"/futureofyou/3016/seasons-may-tweak-genes-that-trigger-some-chronic-diseases","audioUrl":"http://pd.npr.org/anon.npr-mp3/npr/atc/2015/05/20150512_atc_seasons_may_tweak_genes_that_trigger_some_chronic_diseases.mp3?orgId=1&topicId=1128&d=253&p=2&story=406139368&t=progseg&e=406171776&seg=15&ft=nprml&f=406139368","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>The seasons appear to influence when certain genes are active, with those associated with inflammation being more active in the winter, according to new research released Tuesday.\u003c/p>\n\u003cp>A study involving more than 16,000 people found that the activity of about 4,000 of those genes appears to be affected by the season, researchers \u003ca href=\"http://nature.com/articles/doi:10.1038/ncomms8000\">reported\u003c/a> in the journal \u003cem>Nature Communications\u003c/em>. The findings could help explain why certain diseases are more likely than others to strike for the first time during certain seasons, the researchers say.\u003c/p>\n\u003cp>\"Certain chronic diseases are very seasonal — like \u003ca href=\"http://www.npr.org/2011/11/11/142244046/cure-winter-blues-with-light-therapy\">seasonal affective disorder \u003c/a>or cardiovascular disease or type 1 diabetes or multiple sclerosis or rheumatoid arthritis,\" says \u003ca href=\"http://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/todd\">John Todd\u003c/a>, a geneticist at the University of Cambridge who led the research. \"But people have been wondering for decades what the explanation for that is.\"\u003c/p>\n\u003cp>Todd and his colleagues decided to try to find out. They analyzed the genes in cells from more than 16,000 people in five countries, including the United States and European countries in the Northern Hemisphere, and Australia in the Southern Hemisphere. And they spotted the same trend — in both hemispheres, and among men as well as women.\u003c/p>\n\u003cp>\"It's one of those observations where ... the first time you see it, you go, 'Wow, somebody must have seen this before,' \" Todd says.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>When the researchers looked more closely at which genes were more or less active during some seasons than others, one big thing jumped out.\u003c/p>\n\u003cp>\"One of the standout results was that genes promoting inflammation were increased in winter, whereas genes suppressing inflammation were decreased in the winter. So overall it looked as if this gene activity pattern really goes with increased inflammation in the winter,\" he says.\u003c/p>\n\u003cp>Inflammation, which is caused by the immune system becoming overactive, Todd says, has long been associated with a lot of the health problems that spike in the winter.\u003c/p>\n\u003cp>No one knows how the seasons affect our genes. But there are some obvious possibilities, Todd thinks.\u003c/p>\n\u003cp>\"As the seasons come on it gets colder, the days get shorter,\" he says. \"So daylight and temperature could be factors.\"\u003c/p>\n\u003cp>Other researchers say the findings could have far-reaching implications.\u003c/p>\n\u003cp>\"The fact that they find so many genes that go up and down over the seasons is very interesting because we just didn't know that our bodies go through this type of seasonal change before,\" says \u003ca href=\"http://www.neuroscience.cam.ac.uk/directory/profile.php?abreddy\">Akhilesh Reddy\u003c/a>, who studies circadian rhythms at the University of Cambridge but was not involved in the new research. \"And if you look at the actual genetic evidence for the first time, it's pretty profound really.\"\u003c/p>\n\u003cp>Reddy thinks the findings will prompt other scientists to look into how the seasons may have power over our genes.\u003c/p>\n\u003cp>\"People might have a variation in their responses to all sorts of things that we haven't really thought about yet,\" Reddy says.\u003c/p>\n\u003cp>For example, the seasons may affect how people metabolize drugs.\u003c/p>\n\u003cp>\"Even your cognitive performance ... might be influenced subtly by the time of year at which you're assessed,\" he says. \"There's never been a marker before that you can look at in the blood, or whatever, to say, 'You're looking like you're a winter person now versus a summer person.' \"\u003c/p>\n\u003cdiv class=\"fullattribution\">\u003cem>Copyright 2015 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Seasons+May+Tweak+Genes+That+Trigger+Some+Chronic+Diseases&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\" alt=\"\">\u003c/em>\u003c/div>\n\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/3016/seasons-may-tweak-genes-that-trigger-some-chronic-diseases","authors":["byline_futureofyou_3016"],"series":["futureofyou_172"],"categories":["futureofyou_1064"],"tags":["futureofyou_138","futureofyou_324","futureofyou_327","futureofyou_80","futureofyou_125","futureofyou_326","futureofyou_328","futureofyou_325"],"featImg":"futureofyou_3019","label":"futureofyou_172"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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You ask the questions. You decide what Bay Curious investigates. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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