From App Store To Drug Store, Digital Health Is Redefining Pharma
Most Americans Want Drug Prices Controlled. Why Won't Congress Act?
You've Heard About Precision Medicine. Now Get Ready for Precision Drug Ads
This Company Wants to Mine Your Data to Monitor Drug Safety in the 'Real World'
Sponsored
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She is also co-founder of Ladies Who Vino, a networking group for women in technology and business.","avatar":"https://secure.gravatar.com/avatar/22c63869a7901c61c15e204391c1261d?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"futureofyou","roles":["administrator"]},{"site":"stateofhealth","roles":["author"]},{"site":"science","roles":["editor"]}],"headData":{"title":"Christina Farr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/22c63869a7901c61c15e204391c1261d?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/22c63869a7901c61c15e204391c1261d?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/cfarr"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"futureofyou_440112":{"type":"posts","id":"futureofyou_440112","meta":{"index":"posts_1591205157","site":"futureofyou","id":"440112","score":null,"sort":[1521040226000]},"guestAuthors":[],"slug":"from-app-store-to-drug-store-digital-health-is-redefining-pharma","title":"From App Store To Drug Store, Digital Health Is Redefining Pharma","publishDate":1521040226,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>The pitches always sounded promising: A new software app could track glucose levels for people with diabetes or soothe the brains of insomniacs. Most pharma executives would politely smile and nod, but then park their money somewhere else.\u003c/p>\n\u003cp>Not anymore.\u003c/p>\n\u003cp>Backed by a growing body of evidence, software is itself becoming a prescription for diseases ranging from depression to heart disease, and drug companies are starting to take notice. In the past couple years, many have quickly ramped up their investments in digital startups, infusing software-based therapies into pipelines once dominated by traditional medicines.[contextly_sidebar id=\"vRMOcUiT66pyiT86wyEK8HoXGjDpcJLk\"]\u003c/p>\n\u003cp>These products, known broadly as digital therapeutics, deliver treatment to patients through video games, smartphone apps, and sensors buried in pills or attached to medication dispensers. They are designed to stimulate changes in behavior — and in some cases brain function — to help patients control a variety of illnesses and chronic conditions.\u003c/p>\n\u003cp>In 2017, global investment in these companies jumped to $11.5 billion, a fivefold increase from 2012, according to StartUp Health, a research firm that tracks the digital health market. The uptick in investment mirrors an increasing focus by many digital companies in achieving scientific backing for their inventions.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>And just as importantly as the money flowing in is the rising stature of digital health products. Specifically, in two key ways they’re starting to be treated as drugs: They’re seeking Food and Drug Administration approval, and they’re being covered by insurers. Increasingly, then, across the industry, digital health is moving from the app store to the drug store.\u003c/p>\n\u003cp>\u003cstrong>A Drug In App’s Clothes\u003c/strong>\u003cbr>\n“We’re a team of drug developers that just happens to be developing digital products,” said Dr. Corey McCann, president of Pear Therapeutics, a maker of apps for substance use disorder, post-traumatic stress, and other diseases. “What we’ve done as a company is to demonstrate that software can produce drug-like efficacy.”\u003c/p>\n\u003cp>In 2017, Pear’s reSET program, designed to treat substance use disorder, became the first digital product to receive FDA approval for the treatment of a specific disease. And last month the company inked a partnership with Novartis to develop prescription software to treat schizophrenia and mental health problems associated with multiple sclerosis.\u003c/p>\n\u003cp>The Novartis deal is one of many that highlights increasing investment in these therapies by prominent drug makers. Among the biggest spenders on digital health are GlaxoSmithKline, Roche, Johnson & Johnson, and Merck, whose $500 million global health innovation fund has invested in 24 companies since 2009.[contextly_sidebar id=\"GamWIkUUy1zvAmx2sFp4vTWRVfsXPCLs\"]\u003c/p>\n\u003cp>Analysts who follow the field say digital products are getting more direct attention from pharma CEOs who now see their development as a business imperative, as opposed to a supplemental service with marginal importance to their companies.\u003c/p>\n\u003cp>“The CEOs are coming to us and saying, ‘I have a strategic problem, which is that my R&D pipeline isn’t as productive as I need it to be and there are adjacent businesses my current [employees] just aren’t focused on,’” said Scott Bechtler-Levin, a director with BCG Digital Ventures, a consulting firm.\u003c/p>\n\u003cp>That is causing many companies to buy stakes in these companies or form partnerships to develop and commercialize their products — either as standalone treatments, or as a complement to existing medicines.\u003c/p>\n\u003cp>\u003cstrong>Honing The Pitch To Insurers\u003c/strong>\u003cbr>\nThe rising investment in digital therapeutics does not guarantee their success. As a whole, the industry is still in its early stages of development, and so is the scientific evidence needed to show these products are safe and effective.\u003c/p>\n\u003cp>But some early entrants are winning over medical societies and insurers, putting themselves on more equal footing with traditional pharmaceutical products.\u003c/p>\n\u003cp>Omada Health, a maker of software to treat \u003ca href=\"https://www.statnews.com/2017/11/16/prediabetes-insurance-counseling-diabetes/\" target=\"_blank\" rel=\"noopener\">pre-diabetes\u003c/a>, obesity, and heart disease, now has contracts with more than 175 employers as well as dozens of insurance plans. Its program costs between $550 and $650 for the first year, with the price tied to the achievement of patient outcomes.[contextly_sidebar id=\"0QmrfLARboHh7FZkmCdqJRZJFkLkOMNT\"]\u003c/p>\n\u003cp>“Our big goal is to get to the point where in 70 percent of the country, if you’re in clinical need for a program like ours, it’s written by default into your insurance design,” said Omada’s co-founder and chief executive, Sean Duffy.\u003c/p>\n\u003cp>Founded in 2011, Omada describes itself as a digital behavior change company. Its pre-diabetes program is essentially a set of clinical prevention strategies wrapped in a digital package. The software tracks patients’ weight, food intake, and activity, as well as glucose and lipid levels, among other measures. It also pairs them with a health coach to help provide education and feedback on progress.\u003c/p>\n\u003cp>The company’s website features nine published studies that report either positive results for patients or a clinical validation of Omada’s programs. Many of the studies are small and observational, owing to the company’s short history and limited reach compared to other providers. But it has helped leverage key victories in the industry: Last year, the American Medical Association decided to issue its first ever billing code to cover digital health services like those provided by Omada.\u003c/p>\n\u003cp>The AMA’s designation is crucial, because it helps digital companies gain coverage for their services from private insurers. “It allows us to be categorized as a proper medical benefit,” Duffy said. “That’s always been the long game of Omada.”[contextly_sidebar id=\"qlS21f91d5rV5InQtLOUoNHm1y7ElbJX\"]\u003c/p>\n\u003cp>Medicare has not yet extended coverage for digital pre-diabetes treatment, but it is \u003ca href=\"https://www.cms.gov/Newsroom/MediaReleaseDatabase/Fact-sheets/2017-Fact-Sheet-items/2017-11-02.html\" target=\"_blank\" rel=\"noopener\">inching closer\u003c/a>. It has begun covering the prevention services Omada offers, just not in a digital format. Duffy argues doing so would greatly expand access to care, particularly for people who must travel long distances to see their doctors. “If you’re a Medicare beneficiary, you’re probably willing to drive three hours one time to get a knee replacement,” he said. “But it’s unlikely you’re going to do that for 16 straight weeks of a [diabetes prevention] program.”\u003c/p>\n\u003cp>\u003cstrong>A Scientific Formula For Business Success\u003cbr>\n\u003c/strong>The extent and type of regulatory validation sought by digital health companies varies widely. Some have sought to shield themselves from review, while others have achieved positive results by taking the exact opposite approach.\u003c/p>\n\u003cp>McCann, Pear’s chief executive, said running scientific trials — and ultimately gaining FDA approval — is a crucial part of the company’s business plan. Pear’s current product pipeline includes digital treatments for cancer, Parkinson’s disease, depression and schizophrenia, among others.\u003c/p>\n\u003cp>“If you want to say that something treats schizophrenia … then that’s something that absolutely requires regulatory oversight,” McCann said. “And in these very fragile patient populations, one absolutely needs to demonstrate safety data.”\u003c/p>\n\u003cfigure id=\"attachment_72940\" class=\"wp-caption alignnone\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-72940\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/ihealth-800x450.jpg\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth-800x450.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth-400x225.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth-960x540.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth.jpg 1024w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">A blood pressure monitor from iHealth. \u003ccite>(Juhan Sonin/Flickr)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>That approach has positioned Pear as a direct competitor to traditional pharmaceutical companies, as well as an attractive partner. Its deal with Novartis is designed to further develop its schizophrenia treatment and bring it into clinical use.\u003c/p>\n\u003cp>The product, known as THRIVE, currently consists of a smartphone app that uses branching logic — similar to what one might find in a choose-your-own-adventure game — to help patients identify and counteract delusions and other symptoms. Novartis may contribute by developing complementary drug therapies for schizophrenia patients as well as those with mental health problems arising from multiple sclerosis.\u003c/p>\n\u003cp>Dr. Jay Bradner, president of the Novartis Institutes for BioMedical Research, said Pear’s success in gaining FDA approval for reSET is seen as a model for others in the industry to follow.\u003c/p>\n\u003cp>“It was a heavy lift, but the path that they have carved through the forest is very appealing,” he said. “The proof of concept offered by reSET is indeed encouraging to suggest that other forms of cognitive behavioral therapy might likewise be delivered through digital devices.”[contextly_sidebar id=\"NJID6CERRgAHMSQb34OqsGPaMEPkrsBk\"]\u003c/p>\n\u003cp>The partnership with Pear is part of a broader digital transformation at Novartis. The company has hired a new chief digital officer and is investing in software to allow clinical trials to be carried out in patients’ homes, a move to speed up research and development and reach a more diverse group of patients.\u003c/p>\n\u003cp>“It’s a full reconsideration of the research, development, and commercialization model,” Bradner said, adding that such change is long overdue in an industry famous for its half-hearted embrace of technology.\u003c/p>\n\u003cp>“My mother in her retirement home is running AI when she logs onto the Amazon Prime website, without her even knowing,” he said. “Yet in science and medicine, as sophisticated as these fields have become, there is no pervasive impact of artificial intelligence and deep neural networks, as yet realized.”\u003c/p>\n\u003cp>\u003cem>This story was originally published by \u003ca href=\"https://www.statnews.com/\" target=\"_blank\" rel=\"noopener\">STAT\u003c/a>, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery.intern\u003c/em>\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cstrong> \u003c/strong>\u003c/p>\n\n","blocks":[],"excerpt":"Backed by a growing body of evidence, software is itself becoming a prescription for diseases.","status":"publish","parent":0,"modified":1521074525,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":33,"wordCount":1534},"headData":{"title":"From App Store To Drug Store, Digital Health Is Redefining Pharma | KQED","description":"Backed by a growing body of evidence, software is itself becoming a prescription for diseases.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"From App Store To Drug Store, Digital Health Is Redefining Pharma","datePublished":"2018-03-14T15:10:26.000Z","dateModified":"2018-03-15T00:42:05.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"440112 https://ww2.kqed.org/futureofyou/?p=440112","disqusUrl":"https://ww2.kqed.org/futureofyou/2018/03/14/from-app-store-to-drug-store-digital-health-is-redefining-pharma/","disqusTitle":"From App Store To Drug Store, Digital Health Is Redefining Pharma","source":"DYI Health","nprByline":"Casey Ross\u003cbr />STAT","path":"/futureofyou/440112/from-app-store-to-drug-store-digital-health-is-redefining-pharma","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>The pitches always sounded promising: A new software app could track glucose levels for people with diabetes or soothe the brains of insomniacs. Most pharma executives would politely smile and nod, but then park their money somewhere else.\u003c/p>\n\u003cp>Not anymore.\u003c/p>\n\u003cp>Backed by a growing body of evidence, software is itself becoming a prescription for diseases ranging from depression to heart disease, and drug companies are starting to take notice. In the past couple years, many have quickly ramped up their investments in digital startups, infusing software-based therapies into pipelines once dominated by traditional medicines.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>These products, known broadly as digital therapeutics, deliver treatment to patients through video games, smartphone apps, and sensors buried in pills or attached to medication dispensers. They are designed to stimulate changes in behavior — and in some cases brain function — to help patients control a variety of illnesses and chronic conditions.\u003c/p>\n\u003cp>In 2017, global investment in these companies jumped to $11.5 billion, a fivefold increase from 2012, according to StartUp Health, a research firm that tracks the digital health market. The uptick in investment mirrors an increasing focus by many digital companies in achieving scientific backing for their inventions.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>And just as importantly as the money flowing in is the rising stature of digital health products. Specifically, in two key ways they’re starting to be treated as drugs: They’re seeking Food and Drug Administration approval, and they’re being covered by insurers. Increasingly, then, across the industry, digital health is moving from the app store to the drug store.\u003c/p>\n\u003cp>\u003cstrong>A Drug In App’s Clothes\u003c/strong>\u003cbr>\n“We’re a team of drug developers that just happens to be developing digital products,” said Dr. Corey McCann, president of Pear Therapeutics, a maker of apps for substance use disorder, post-traumatic stress, and other diseases. “What we’ve done as a company is to demonstrate that software can produce drug-like efficacy.”\u003c/p>\n\u003cp>In 2017, Pear’s reSET program, designed to treat substance use disorder, became the first digital product to receive FDA approval for the treatment of a specific disease. And last month the company inked a partnership with Novartis to develop prescription software to treat schizophrenia and mental health problems associated with multiple sclerosis.\u003c/p>\n\u003cp>The Novartis deal is one of many that highlights increasing investment in these therapies by prominent drug makers. Among the biggest spenders on digital health are GlaxoSmithKline, Roche, Johnson & Johnson, and Merck, whose $500 million global health innovation fund has invested in 24 companies since 2009.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>Analysts who follow the field say digital products are getting more direct attention from pharma CEOs who now see their development as a business imperative, as opposed to a supplemental service with marginal importance to their companies.\u003c/p>\n\u003cp>“The CEOs are coming to us and saying, ‘I have a strategic problem, which is that my R&D pipeline isn’t as productive as I need it to be and there are adjacent businesses my current [employees] just aren’t focused on,’” said Scott Bechtler-Levin, a director with BCG Digital Ventures, a consulting firm.\u003c/p>\n\u003cp>That is causing many companies to buy stakes in these companies or form partnerships to develop and commercialize their products — either as standalone treatments, or as a complement to existing medicines.\u003c/p>\n\u003cp>\u003cstrong>Honing The Pitch To Insurers\u003c/strong>\u003cbr>\nThe rising investment in digital therapeutics does not guarantee their success. As a whole, the industry is still in its early stages of development, and so is the scientific evidence needed to show these products are safe and effective.\u003c/p>\n\u003cp>But some early entrants are winning over medical societies and insurers, putting themselves on more equal footing with traditional pharmaceutical products.\u003c/p>\n\u003cp>Omada Health, a maker of software to treat \u003ca href=\"https://www.statnews.com/2017/11/16/prediabetes-insurance-counseling-diabetes/\" target=\"_blank\" rel=\"noopener\">pre-diabetes\u003c/a>, obesity, and heart disease, now has contracts with more than 175 employers as well as dozens of insurance plans. Its program costs between $550 and $650 for the first year, with the price tied to the achievement of patient outcomes.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>“Our big goal is to get to the point where in 70 percent of the country, if you’re in clinical need for a program like ours, it’s written by default into your insurance design,” said Omada’s co-founder and chief executive, Sean Duffy.\u003c/p>\n\u003cp>Founded in 2011, Omada describes itself as a digital behavior change company. Its pre-diabetes program is essentially a set of clinical prevention strategies wrapped in a digital package. The software tracks patients’ weight, food intake, and activity, as well as glucose and lipid levels, among other measures. It also pairs them with a health coach to help provide education and feedback on progress.\u003c/p>\n\u003cp>The company’s website features nine published studies that report either positive results for patients or a clinical validation of Omada’s programs. Many of the studies are small and observational, owing to the company’s short history and limited reach compared to other providers. But it has helped leverage key victories in the industry: Last year, the American Medical Association decided to issue its first ever billing code to cover digital health services like those provided by Omada.\u003c/p>\n\u003cp>The AMA’s designation is crucial, because it helps digital companies gain coverage for their services from private insurers. “It allows us to be categorized as a proper medical benefit,” Duffy said. “That’s always been the long game of Omada.”\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>Medicare has not yet extended coverage for digital pre-diabetes treatment, but it is \u003ca href=\"https://www.cms.gov/Newsroom/MediaReleaseDatabase/Fact-sheets/2017-Fact-Sheet-items/2017-11-02.html\" target=\"_blank\" rel=\"noopener\">inching closer\u003c/a>. It has begun covering the prevention services Omada offers, just not in a digital format. Duffy argues doing so would greatly expand access to care, particularly for people who must travel long distances to see their doctors. “If you’re a Medicare beneficiary, you’re probably willing to drive three hours one time to get a knee replacement,” he said. “But it’s unlikely you’re going to do that for 16 straight weeks of a [diabetes prevention] program.”\u003c/p>\n\u003cp>\u003cstrong>A Scientific Formula For Business Success\u003cbr>\n\u003c/strong>The extent and type of regulatory validation sought by digital health companies varies widely. Some have sought to shield themselves from review, while others have achieved positive results by taking the exact opposite approach.\u003c/p>\n\u003cp>McCann, Pear’s chief executive, said running scientific trials — and ultimately gaining FDA approval — is a crucial part of the company’s business plan. Pear’s current product pipeline includes digital treatments for cancer, Parkinson’s disease, depression and schizophrenia, among others.\u003c/p>\n\u003cp>“If you want to say that something treats schizophrenia … then that’s something that absolutely requires regulatory oversight,” McCann said. “And in these very fragile patient populations, one absolutely needs to demonstrate safety data.”\u003c/p>\n\u003cfigure id=\"attachment_72940\" class=\"wp-caption alignnone\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-72940\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/ihealth-800x450.jpg\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth-800x450.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth-400x225.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth-960x540.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/ihealth.jpg 1024w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">A blood pressure monitor from iHealth. \u003ccite>(Juhan Sonin/Flickr)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>That approach has positioned Pear as a direct competitor to traditional pharmaceutical companies, as well as an attractive partner. Its deal with Novartis is designed to further develop its schizophrenia treatment and bring it into clinical use.\u003c/p>\n\u003cp>The product, known as THRIVE, currently consists of a smartphone app that uses branching logic — similar to what one might find in a choose-your-own-adventure game — to help patients identify and counteract delusions and other symptoms. Novartis may contribute by developing complementary drug therapies for schizophrenia patients as well as those with mental health problems arising from multiple sclerosis.\u003c/p>\n\u003cp>Dr. Jay Bradner, president of the Novartis Institutes for BioMedical Research, said Pear’s success in gaining FDA approval for reSET is seen as a model for others in the industry to follow.\u003c/p>\n\u003cp>“It was a heavy lift, but the path that they have carved through the forest is very appealing,” he said. “The proof of concept offered by reSET is indeed encouraging to suggest that other forms of cognitive behavioral therapy might likewise be delivered through digital devices.”\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>The partnership with Pear is part of a broader digital transformation at Novartis. The company has hired a new chief digital officer and is investing in software to allow clinical trials to be carried out in patients’ homes, a move to speed up research and development and reach a more diverse group of patients.\u003c/p>\n\u003cp>“It’s a full reconsideration of the research, development, and commercialization model,” Bradner said, adding that such change is long overdue in an industry famous for its half-hearted embrace of technology.\u003c/p>\n\u003cp>“My mother in her retirement home is running AI when she logs onto the Amazon Prime website, without her even knowing,” he said. “Yet in science and medicine, as sophisticated as these fields have become, there is no pervasive impact of artificial intelligence and deep neural networks, as yet realized.”\u003c/p>\n\u003cp>\u003cem>This story was originally published by \u003ca href=\"https://www.statnews.com/\" target=\"_blank\" rel=\"noopener\">STAT\u003c/a>, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery.intern\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cstrong> \u003c/strong>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/440112/from-app-store-to-drug-store-digital-health-is-redefining-pharma","authors":["byline_futureofyou_440112"],"categories":["futureofyou_1060","futureofyou_1"],"tags":["futureofyou_26","futureofyou_191","futureofyou_952","futureofyou_442","futureofyou_774","futureofyou_35"],"collections":["futureofyou_1093"],"featImg":"futureofyou_440113","label":"source_futureofyou_440112"},"futureofyou_435763":{"type":"posts","id":"futureofyou_435763","meta":{"index":"posts_1591205157","site":"futureofyou","id":"435763","score":null,"sort":[1507051849000]},"guestAuthors":[],"slug":"most-americans-want-drug-prices-controlled-why-wont-congress-act","title":"Most Americans Want Drug Prices Controlled. Why Won't Congress Act?","publishDate":1507051849,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{"site":"futureofyou"},"content":"\u003cp>Of all the promises President Donald Trump made for the early part of his term, controlling stinging drug prices might have seemed the easiest to achieve.\u003c/p>\n\u003caside class=\"pullquote alignright\">'There is a very aggressive lobby that is finding any and all means to thwart any reform to a system that has produced very lucrative profits.'\u003ccite>Ameet Sarpatwari, Harvard Medical School\u003c/cite>\u003c/aside>\n\u003cp>An angry public overwhelmingly wants change in an easily vilified industry. Big pharma’s recent publicity nightmare included thousand-percent price increases and a \u003ca href=\"https://www.vanityfair.com/news/2017/08/martin-shkreli-verdict\" target=\"_blank\" rel=\"noopener\">smirking CEO who said\u003c/a>, “I liken myself to the robber barons.” Even powerful members of Congress from both parties have said that drug prices are too high.\u003c/p>\n\u003cp>But any momentum to address prescription drug costs — a problem that \u003ca href=\"http://www.kff.org/slideshow/public-opinion-on-prescription-drugs-and-their-prices/\" target=\"_blank\" rel=\"noopener\">a large number of Americans\u003c/a> now believe government should solve — has been lost amid rancorous debates over replacing Obamacare and stalled by roadblocks erected via lobbying and industry cash.\u003c/p>\n\u003cp>“There is a very aggressive lobby that is finding any and all means to thwart any reform to a system that has produced very lucrative profits,” said Ameet Sarpatwari, an epidemiologist and lawyer at Harvard Medical School who follows drug legislation. “Everything that’s coming out is being hit and hit hard — even stuff that’s commonsensical.”\u003c/p>\n\u003cp>[contextly_sidebar id=\"RiRCaAhGLSSzIv8VTS6OBlnq3jBDwE0j\"]Those in Congress concerned with health policy have spent much of the year advancing proposals to overhaul the Affordable Care Act, none of which would affect pharmaceutical pricing. The latest Republican proposal, by Senators Lindsey Graham of South Carolina and Bill Cassidy of Louisiana, is no different.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Meanwhile, more than two dozen bills aimed at curbing drug costs have been introduced in this or the previous Congress, according to the Drug Pricing Lab, a Memorial Sloan Kettering Cancer Center program \u003ca href=\"https://drugpricinglab.org/tools/dpl-policy-tracker/\" target=\"_blank\" rel=\"noopener\">that has catalogued ideas for reducing prices.\u003c/a> Many have bipartisan support.\u003c/p>\n\u003cp>Proposals include importation from other developed countries, where regulations keep prices down; allowing government to negotiate the price of Medicare-covered drugs; speeding approval of cheaper generics; requiring notification before raising drug prices; and restricting consumer drug ads.\u003c/p>\n\u003cp>Other ideas that haven’t made it to legislation include banning patents for pills that simply copy or repackage existing medicines; and adjusting prices according to a drug’s effectiveness.\u003c/p>\n\u003cp>“There’s clearly no single solution out there that will solve this rapidly rising spending,” said Dr. Peter Bach, who leads the lab. But, he added, “there’s not a lot of fundamental disagreement about the direction this needs to move.”\u003c/p>\n\u003cp>Trump drew new attention to the issue last month by tweeting that Merck’s chief executive, Kenneth Frazier, “will have more time to LOWER RIPOFF DRUG PRICES!” after Frazier quit the president’s manufacturing council to protest his remarks about white supremacists in Charlottesville, Va.\u003c/p>\n\u003cp>Those comments matched Trump’s \u003ca href=\"http://www.politico.com/story/2017/01/trump-press-conference-drug-industry-233475\" target=\"_blank\" rel=\"noopener\">characterization earlier this year of drug companies\u003c/a>as “getting away with murder.” That same January day, a dozen Republican senators, including Ted Cruz of Texas, John McCain of Arizona and Mike Lee of Utah, voted for the old liberal idea of letting Americans buy less-expensive drugs from Canada.\u003c/p>\n\u003cp>[contextly_sidebar id=\"urt72cNaNX4YKl7iNuU8fZ3qlRARZvTT\"]The measure was attached to a budget resolution and \u003ca href=\"http://www.politifact.com/truth-o-meter/statements/2017/jan/18/other-98/viral-image-about-democratic-senators-and-big-phar/\" target=\"_blank\" rel=\"noopener\">wouldn’t, by itself,\u003c/a> have allowed importation. It failed 52 to 46 after 13 Democrats voted against it, with some citing safety concerns about foreign-sourced medicine — an idea promoted by American drugmakers.\u003c/p>\n\u003cp>Even so, the vote prompted speculation that a pharma price deal might be within reach.\u003c/p>\n\u003cp>Sen. Lee is one of the Republicans who favor importation as a way to increase competition. “When we’re talking about garden-variety, generic drugs that can be easily imported from another country that has regulatory procedures that make them safe?” he said in an interview. “I don’t see why not.”\u003c/p>\n\u003cp>In response to the new threats, the Pharmaceutical Research and Manufacturers of America, already one of Washington’s biggest-spending trade groups, \u003ca href=\"http://www.politico.com/story/2016/10/phrma-lobby-pricing-battle-230277\" target=\"_blank\" rel=\"noopener\">increased member dues by half\u003c/a> last year to prepare for battle.\u003c/p>\n\u003cp>The pharmaceutical and health products industries \u003ca href=\"https://www.opensecrets.org/lobby/indus.php?id=H&year=2017\" target=\"_blank\" rel=\"noopener\">spent $145 million\u003c/a> on lobbying for the first half of 2017, according to data from the Center for Responsive Politics.\u003c/p>\n\u003cp>Drug manufacturers gave $4.5 million to congressional campaigns in that period, including six-figure donations to House Speaker Paul Ryan; Rep. Greg Walden, head of the House Energy and Commerce Committee; and Sen. Orrin Hatch, head of the Senate Finance Committee, according to a Kaiser Health News analysis.\u003c/p>\n\u003cp>PhRMA’s “Go Boldly” campaign, showing heroic researchers seeking cures, has spent $28 million so far this year on six ads shown on about 4,600 national TV channels, according to iSpot.tv, an ad tracker.\u003c/p>\n\u003cp>The industry hired former FBI director Louis Freeh \u003ca href=\"https://storage.googleapis.com/m1738/20170605_Report%20on%20Counterfeit%20Drugs.pdf\" target=\"_blank\" rel=\"noopener\">to study\u003c/a> the impact of importation. He concluded that it would “leave the safety of the U.S. prescription drug supply vulnerable to criminals seeking to harm patients.” Import proponents argue the Food and Drug Administration could easily ensure safety by licensing and inspecting Canadian suppliers.\u003c/p>\n\u003cp>Drugmakers say that high prices reflect heavy investment in innovation and drug development. They reject the notion that the industry wields too much influence in Washington.\u003c/p>\n\u003cp>“These are important issues with significant ramifications,” Holly Campbell, a PhRMA spokeswoman, said. “So we will continue to be engaged with the administration to advance solutions that improve the marketplace and make it more responsive to the needs of patients.”\u003c/p>\n\u003cp>The top 10 publicly traded U.S. drug companies made $67.8 billion last year, after taxes, regulatory filings show.\u003c/p>\n\u003cp>Efforts to restrain prices have made little progress in the executive branch, either.\u003c/p>\n\u003cp>The White House has long been expected to issue an executive order on drug costs. But \u003ca href=\"https://www.nytimes.com/2017/06/20/health/draft-order-on-drug-prices-proposes-easing-regulations.html?_r=0\" target=\"_blank\" rel=\"noopener\">leaked documents\u003c/a> show that deliberations have focused on things the industry wants, such as \u003ca href=\"https://khn.org/news/exclusive-white-house-task-force-echoes-pharma-proposals/\" target=\"_blank\" rel=\"noopener\">extending overseas patents\u003c/a> and changing a drug-discount program for hospitals, and not so much on lowering prices.\u003c/p>\n\u003cp>Gerard Anderson, a health policy professor at Johns Hopkins University, said Trump’s draft order “did not talk at all about branded drugs or about specialty drugs,” including for rheumatoid arthritis and cancer, that have seen especially steep price increases. “If that represents the administration’s thinking, then my guess is there is not much effort.”\u003c/p>\n\u003cp>Trump’s ongoing feud with congressional Republicans, especially Senate Majority Leader Mitch McConnell, means “you’re not going to get any strong direction or leadership out of the White House” on drug prices, said Vishnu Lekraj, who follows pharma stocks for Morningstar, an investment research firm.\u003c/p>\n\u003cp>Trump isn’t the only one in his administration criticizing drug companies. Scott Gottlieb, the FDA commissioner, has accused the industry of \u003ca href=\"https://blogs.fda.gov/fdavoice/index.php/2017/06/fda-working-to-lift-barriers-to-generic-drug-competition/\" target=\"_blank\" rel=\"noopener\">“gaming” the system\u003c/a> to delay the appearance of cheap generics after patents expire. He has pledged to speed applications for generics when there is little competition as part of a \u003ca href=\"https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm564725.htm\" target=\"_blank\" rel=\"noopener\">“drug competition action plan”\u003c/a>while opposing stronger measures like allowing importation.\u003c/p>\n\u003cp>But promoting generics is “reasonably small potatoes” compared with the money that could be saved by putting direct pressure on brand-drug prices, Anderson said. Gottlieb has served on the boards of \u003ca href=\"https://www.opensecrets.org/news/2017/04/fda-nominee-gottlieb/\" target=\"_blank\" rel=\"noopener\">several pharmaceutical companies\u003c/a> and reaped large consulting and speaking fees from the industry.\u003c/p>\n\u003cp>Yet even small potatoes might be a long shot — despite widespread agreement that change is needed.\u003c/p>\n\u003cp>“It is sort of remarkable to see just how far the system can bend before meaningful reform is taken,” said Sarpatwari of Harvard. “If there ever was a time to strike while it’s hot, it’s now.”\u003c/p>\n\u003cp>\u003cem>Elizabeth Lucas and Sydney Lupkin contributed to this report.\u003c/em>\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>KHN’s coverage of prescription drug development, costs and pricing is supported in part by the \u003ca href=\"http://www.arnoldfoundation.org/\" target=\"_blank\" rel=\"noopener\">Laura and John Arnold Foundation\u003c/a>.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"Any momentum to address prescription drug costs has been lost amid rancorous debates over replacing Obamacare and stalled by roadblocks erected via lobbying and industry cash.","status":"publish","parent":0,"modified":1507051849,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":34,"wordCount":1355},"headData":{"title":"Most Americans Want Drug Prices Controlled. Why Won't Congress Act? | KQED","description":"Any momentum to address prescription drug costs has been lost amid rancorous debates over replacing Obamacare and stalled by roadblocks erected via lobbying and industry cash.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Most Americans Want Drug Prices Controlled. Why Won't Congress Act?","datePublished":"2017-10-03T17:30:49.000Z","dateModified":"2017-10-03T17:30:49.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"435763 https://ww2.kqed.org/futureofyou/?p=435763","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/10/03/most-americans-want-drug-prices-controlled-why-wont-congress-act/","disqusTitle":"Most Americans Want Drug Prices Controlled. Why Won't Congress Act?","nprByline":"Jay Hancock\u003c/br>Kaiser Health News","path":"/futureofyou/435763/most-americans-want-drug-prices-controlled-why-wont-congress-act","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Of all the promises President Donald Trump made for the early part of his term, controlling stinging drug prices might have seemed the easiest to achieve.\u003c/p>\n\u003caside class=\"pullquote alignright\">'There is a very aggressive lobby that is finding any and all means to thwart any reform to a system that has produced very lucrative profits.'\u003ccite>Ameet Sarpatwari, Harvard Medical School\u003c/cite>\u003c/aside>\n\u003cp>An angry public overwhelmingly wants change in an easily vilified industry. Big pharma’s recent publicity nightmare included thousand-percent price increases and a \u003ca href=\"https://www.vanityfair.com/news/2017/08/martin-shkreli-verdict\" target=\"_blank\" rel=\"noopener\">smirking CEO who said\u003c/a>, “I liken myself to the robber barons.” Even powerful members of Congress from both parties have said that drug prices are too high.\u003c/p>\n\u003cp>But any momentum to address prescription drug costs — a problem that \u003ca href=\"http://www.kff.org/slideshow/public-opinion-on-prescription-drugs-and-their-prices/\" target=\"_blank\" rel=\"noopener\">a large number of Americans\u003c/a> now believe government should solve — has been lost amid rancorous debates over replacing Obamacare and stalled by roadblocks erected via lobbying and industry cash.\u003c/p>\n\u003cp>“There is a very aggressive lobby that is finding any and all means to thwart any reform to a system that has produced very lucrative profits,” said Ameet Sarpatwari, an epidemiologist and lawyer at Harvard Medical School who follows drug legislation. “Everything that’s coming out is being hit and hit hard — even stuff that’s commonsensical.”\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>Those in Congress concerned with health policy have spent much of the year advancing proposals to overhaul the Affordable Care Act, none of which would affect pharmaceutical pricing. The latest Republican proposal, by Senators Lindsey Graham of South Carolina and Bill Cassidy of Louisiana, is no different.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Meanwhile, more than two dozen bills aimed at curbing drug costs have been introduced in this or the previous Congress, according to the Drug Pricing Lab, a Memorial Sloan Kettering Cancer Center program \u003ca href=\"https://drugpricinglab.org/tools/dpl-policy-tracker/\" target=\"_blank\" rel=\"noopener\">that has catalogued ideas for reducing prices.\u003c/a> Many have bipartisan support.\u003c/p>\n\u003cp>Proposals include importation from other developed countries, where regulations keep prices down; allowing government to negotiate the price of Medicare-covered drugs; speeding approval of cheaper generics; requiring notification before raising drug prices; and restricting consumer drug ads.\u003c/p>\n\u003cp>Other ideas that haven’t made it to legislation include banning patents for pills that simply copy or repackage existing medicines; and adjusting prices according to a drug’s effectiveness.\u003c/p>\n\u003cp>“There’s clearly no single solution out there that will solve this rapidly rising spending,” said Dr. Peter Bach, who leads the lab. But, he added, “there’s not a lot of fundamental disagreement about the direction this needs to move.”\u003c/p>\n\u003cp>Trump drew new attention to the issue last month by tweeting that Merck’s chief executive, Kenneth Frazier, “will have more time to LOWER RIPOFF DRUG PRICES!” after Frazier quit the president’s manufacturing council to protest his remarks about white supremacists in Charlottesville, Va.\u003c/p>\n\u003cp>Those comments matched Trump’s \u003ca href=\"http://www.politico.com/story/2017/01/trump-press-conference-drug-industry-233475\" target=\"_blank\" rel=\"noopener\">characterization earlier this year of drug companies\u003c/a>as “getting away with murder.” That same January day, a dozen Republican senators, including Ted Cruz of Texas, John McCain of Arizona and Mike Lee of Utah, voted for the old liberal idea of letting Americans buy less-expensive drugs from Canada.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>The measure was attached to a budget resolution and \u003ca href=\"http://www.politifact.com/truth-o-meter/statements/2017/jan/18/other-98/viral-image-about-democratic-senators-and-big-phar/\" target=\"_blank\" rel=\"noopener\">wouldn’t, by itself,\u003c/a> have allowed importation. It failed 52 to 46 after 13 Democrats voted against it, with some citing safety concerns about foreign-sourced medicine — an idea promoted by American drugmakers.\u003c/p>\n\u003cp>Even so, the vote prompted speculation that a pharma price deal might be within reach.\u003c/p>\n\u003cp>Sen. Lee is one of the Republicans who favor importation as a way to increase competition. “When we’re talking about garden-variety, generic drugs that can be easily imported from another country that has regulatory procedures that make them safe?” he said in an interview. “I don’t see why not.”\u003c/p>\n\u003cp>In response to the new threats, the Pharmaceutical Research and Manufacturers of America, already one of Washington’s biggest-spending trade groups, \u003ca href=\"http://www.politico.com/story/2016/10/phrma-lobby-pricing-battle-230277\" target=\"_blank\" rel=\"noopener\">increased member dues by half\u003c/a> last year to prepare for battle.\u003c/p>\n\u003cp>The pharmaceutical and health products industries \u003ca href=\"https://www.opensecrets.org/lobby/indus.php?id=H&year=2017\" target=\"_blank\" rel=\"noopener\">spent $145 million\u003c/a> on lobbying for the first half of 2017, according to data from the Center for Responsive Politics.\u003c/p>\n\u003cp>Drug manufacturers gave $4.5 million to congressional campaigns in that period, including six-figure donations to House Speaker Paul Ryan; Rep. Greg Walden, head of the House Energy and Commerce Committee; and Sen. Orrin Hatch, head of the Senate Finance Committee, according to a Kaiser Health News analysis.\u003c/p>\n\u003cp>PhRMA’s “Go Boldly” campaign, showing heroic researchers seeking cures, has spent $28 million so far this year on six ads shown on about 4,600 national TV channels, according to iSpot.tv, an ad tracker.\u003c/p>\n\u003cp>The industry hired former FBI director Louis Freeh \u003ca href=\"https://storage.googleapis.com/m1738/20170605_Report%20on%20Counterfeit%20Drugs.pdf\" target=\"_blank\" rel=\"noopener\">to study\u003c/a> the impact of importation. He concluded that it would “leave the safety of the U.S. prescription drug supply vulnerable to criminals seeking to harm patients.” Import proponents argue the Food and Drug Administration could easily ensure safety by licensing and inspecting Canadian suppliers.\u003c/p>\n\u003cp>Drugmakers say that high prices reflect heavy investment in innovation and drug development. They reject the notion that the industry wields too much influence in Washington.\u003c/p>\n\u003cp>“These are important issues with significant ramifications,” Holly Campbell, a PhRMA spokeswoman, said. “So we will continue to be engaged with the administration to advance solutions that improve the marketplace and make it more responsive to the needs of patients.”\u003c/p>\n\u003cp>The top 10 publicly traded U.S. drug companies made $67.8 billion last year, after taxes, regulatory filings show.\u003c/p>\n\u003cp>Efforts to restrain prices have made little progress in the executive branch, either.\u003c/p>\n\u003cp>The White House has long been expected to issue an executive order on drug costs. But \u003ca href=\"https://www.nytimes.com/2017/06/20/health/draft-order-on-drug-prices-proposes-easing-regulations.html?_r=0\" target=\"_blank\" rel=\"noopener\">leaked documents\u003c/a> show that deliberations have focused on things the industry wants, such as \u003ca href=\"https://khn.org/news/exclusive-white-house-task-force-echoes-pharma-proposals/\" target=\"_blank\" rel=\"noopener\">extending overseas patents\u003c/a> and changing a drug-discount program for hospitals, and not so much on lowering prices.\u003c/p>\n\u003cp>Gerard Anderson, a health policy professor at Johns Hopkins University, said Trump’s draft order “did not talk at all about branded drugs or about specialty drugs,” including for rheumatoid arthritis and cancer, that have seen especially steep price increases. “If that represents the administration’s thinking, then my guess is there is not much effort.”\u003c/p>\n\u003cp>Trump’s ongoing feud with congressional Republicans, especially Senate Majority Leader Mitch McConnell, means “you’re not going to get any strong direction or leadership out of the White House” on drug prices, said Vishnu Lekraj, who follows pharma stocks for Morningstar, an investment research firm.\u003c/p>\n\u003cp>Trump isn’t the only one in his administration criticizing drug companies. Scott Gottlieb, the FDA commissioner, has accused the industry of \u003ca href=\"https://blogs.fda.gov/fdavoice/index.php/2017/06/fda-working-to-lift-barriers-to-generic-drug-competition/\" target=\"_blank\" rel=\"noopener\">“gaming” the system\u003c/a> to delay the appearance of cheap generics after patents expire. He has pledged to speed applications for generics when there is little competition as part of a \u003ca href=\"https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm564725.htm\" target=\"_blank\" rel=\"noopener\">“drug competition action plan”\u003c/a>while opposing stronger measures like allowing importation.\u003c/p>\n\u003cp>But promoting generics is “reasonably small potatoes” compared with the money that could be saved by putting direct pressure on brand-drug prices, Anderson said. Gottlieb has served on the boards of \u003ca href=\"https://www.opensecrets.org/news/2017/04/fda-nominee-gottlieb/\" target=\"_blank\" rel=\"noopener\">several pharmaceutical companies\u003c/a> and reaped large consulting and speaking fees from the industry.\u003c/p>\n\u003cp>Yet even small potatoes might be a long shot — despite widespread agreement that change is needed.\u003c/p>\n\u003cp>“It is sort of remarkable to see just how far the system can bend before meaningful reform is taken,” said Sarpatwari of Harvard. “If there ever was a time to strike while it’s hot, it’s now.”\u003c/p>\n\u003cp>\u003cem>Elizabeth Lucas and Sydney Lupkin contributed to this report.\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cem>KHN’s coverage of prescription drug development, costs and pricing is supported in part by the \u003ca href=\"http://www.arnoldfoundation.org/\" target=\"_blank\" rel=\"noopener\">Laura and John Arnold Foundation\u003c/a>.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/435763/most-americans-want-drug-prices-controlled-why-wont-congress-act","authors":["byline_futureofyou_435763"],"categories":["futureofyou_1"],"tags":["futureofyou_302","futureofyou_948","futureofyou_137","futureofyou_442"],"featImg":"futureofyou_435772","label":"futureofyou"},"futureofyou_435626":{"type":"posts","id":"futureofyou_435626","meta":{"index":"posts_1591205157","site":"futureofyou","id":"435626","score":null,"sort":[1506533332000]},"guestAuthors":[],"slug":"youve-heard-about-precision-medicine-now-get-ready-for-precision-drug-ads","title":"You've Heard About Precision Medicine. Now Get Ready for Precision Drug Ads","publishDate":1506533332,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{"site":"futureofyou"},"content":"\u003caside class=\"pullquote alignright\">Drug makers have long steered clear of targeted ads, for fear of violating patient privacy law. That’s changing now.\u003c/aside>\n\u003cp>The drug industry spends billions each year to promote its medicines to the masses, blanketing \u003ca href=\"https://www.statnews.com/2017/08/29/tv-shows-drug-advertising/\">popular TV shows\u003c/a> and magazines with ads. Now, digital companies are increasingly trying to pry away a share of that money for ads that target specific patients, rather than broad demographics.\u003c/p>\n\u003cp>Targeted ads are nothing new in retail; anyone who uses the internet has had the eerie feeling that the ads popping up on page after page appear to be aimed directly at them. But drug makers have long steered clear of many such tools, for fear of violating patient privacy law.\u003c/p>\n\u003cp>That’s changing now. Facebook and the music streaming service Pandora are aggressively vying for pharma dollars by promising to help drug makers identify and reach the users most likely to have certain diseases or conditions — without violating the privacy law known as HIPAA.\u003c/p>\n\u003cp>Other companies looking to get in on the action are rushing to strike deals giving them access to vast troves of anonymized medical records. The databases strip out names — but can tell them, for instance, how many times women in a certain age bracket fill prescriptions for Drug X, or go to the doctor with complaints about Condition Y, or use their supermarket loyalty card to buy over-the-counter meds touted as a quick fix for Complaint Z.\u003c/p>\n\u003cp>[contextly_sidebar id=\"2Wegz0n5Tdi5RqBqCSz5CQGpP2SO8KCr\"]Combine that with the personal information that consumers enter when they set up accounts with social media sites, and you have a powerful tool for predicting which individuals may be most likely to be interested in certain medications.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>And marketers say they can use those analytics to send ads only to the most receptive patients as they browse online, scroll through Twitter, stream music — or even as they watch TV, thanks to a service that will deliver an ad to the airwaves only in a specifically targeted “micro-neighborhood” as small as a few residential blocks.\u003c/p>\n\u003cp>“It’s a matter of economics: Good targeting saves money. Good targeting improves the effectiveness of the spend. And … the ads don’t go to folks that don’t need them,” said John Kamp, executive director of the Coalition for Healthcare Communication, a trade group for pharmaceutical marketing companies and medical publishers.\u003c/p>\n\u003cp>STAT requested interviews with more than a dozen of the largest drug makers about the ad targeting tools they’re using. None agreed to talk about how they’re promoting specific products. Merck, Pfizer, and Eli Lilly did, however, share some information about how they reach out to patients to fill clinical trials or promote financial assistance programs — revealing some of the work they’re doing to target patients more precisely.\u003c/p>\n\u003cp>Pfizer, for instance, this summer took the first steps toward using geographic targeting for digital ads promoting RxPathways, its service that connects low-income patients with free prescriptions and help with copays.\u003c/p>\n\u003cp>Gary Pelletier, who runs the program for Pfizer, said his team compiled a list of the 16 states with the highest rates of uninsured patients and identified the ZIP codes in those states where the most patients have used Pfizer’s finance assistance program in the past.\u003c/p>\n\u003cp>Pelletier’s team then targeted everyone on certain social media sites in those ZIP codes with a \u003ca href=\"https://www.youtube.com/watch?v=rzZSn4YgHeE\" target=\"_blank\" rel=\"noopener noreferrer\">video ad\u003c/a>, featuring a couple navigating a labyrinth rising up out of the street. The off-screen narrator urged patients to “get the help you need to get the prescriptions you need.” They also blasted a \u003ca href=\"https://www.youtube.com/watch?v=bMAueAuI7EA\" target=\"_blank\" rel=\"noopener noreferrer\">Spanish language version\u003c/a> of the ad to people in those ZIP codes with a Spanish language setting on their social media account.\u003c/p>\n\u003cp>In another first, Pelletier’s team in the past few weeks promoted \u003ca href=\"https://twitter.com/pfizer/status/906252557789655041\" target=\"_blank\" rel=\"noopener noreferrer\">tweets\u003c/a> and \u003ca href=\"https://www.facebook.com/Pfizer/photos/a.390855402242.168464.314499212242/10155627232737243/?type=3&theater\" target=\"_blank\" rel=\"noopener noreferrer\">Facebook posts\u003c/a> publicizing Pfizer’s financial assistance hotline and website to people in parts of Texas and Florida ravaged by the recent hurricanes.\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=rzZSn4YgHeE\u003c/p>\n\u003cp>\u003cstrong>Following mom through her day\u003c/strong>\u003cbr>\nSpending on drug ads on TV, in print, and other traditional channels last year reached \u003ca href=\"https://www.statnews.com/2017/03/08/drug-ads-spending-single-drug/\">an estimated $5.7 billion\u003c/a>. And that’s not even counting the growing category of digital ads, which one research firm \u003ca href=\"https://www.emarketer.com/Article/Health-Pharma-Marketers-Split-Digital-Spend-Between-Search-Display/1014123\" target=\"_blank\" rel=\"noopener noreferrer\">estimated at $1.9 billion\u003c/a> last year.\u003c/p>\n\u003cp>Pandora is going hard after those pharma dollars.\u003c/p>\n\u003cp>Pandora now has more than 16 million individual monthly listeners over age 55 — and its fastest growing segments of new users are people in that bracket. Not surprisingly, over the past two years, the company has seen a rapid rise in interest from drug advertisers, according to Lee Ann Longinotti, who runs Pandora’s business with health care advertisers.\u003c/p>\n\u003cp>Pandora now counts 20 drug makers among its recent advertisers, including Pfizer, Merck, and Johnson & Johnson. They’ve promoted 40 different prescription and over-the-counter drugs, for conditions ranging from diabetes to erectile dysfunction to a \u003ca href=\"https://www.statnews.com/2016/05/04/sleep-drug-blind-advertising/\">circadian rhythm disorder\u003c/a> common in the blind.\u003c/p>\n\u003cp>To target users more precisely, Pandora struck a partnership a year ago with Crossix, a company which \u003ca href=\"http://www.crossix.com/commitment-to-privacy.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">mines anonymized patient data\u003c/a> from electronic health records, insurance claims, and pharmacy transactions.\u003c/p>\n\u003cp>That’s allowed Pandora to create profiles of the types of people who are most likely to be interested in drugs for a certain condition. Then it helps the pharma company follow those users around as they listen to music on different devices throughout the day.\u003c/p>\n\u003cp>[contextly_sidebar id=\"9wQwYT5PuC75fZS0QytUg2XHdt1VSUxc\"]A mom who is a prime target for a given drug company, for instance, might hear ads for the same product as she listens to the Adele playlist on her computer at work, rocks out to the “Frozen” playlist with her kids in the car, and relaxes to jazz at home in the evening. Other listeners streaming the same general playlists at the same time would hear very different ads.\u003c/p>\n\u003cp>The marketing company 4INFO uses a similar strategy, drawing on \u003ca href=\"https://4info.com/Resources/Press-Releases/4INFO-and-Crossix-Partnership-Enables-Pharma-Brand\" target=\"_blank\" rel=\"noopener noreferrer\">its own partnership with Crossix\u003c/a> to help drug companies target mobile ads to consumers.\u003c/p>\n\u003cp>Another key player in the new landscape is Facebook, which earlier this month \u003ca href=\"https://www.cnbc.com/2017/09/07/facebook-held-a-breakfast-to-promote-clinical-trials-strategy.html\" target=\"_blank\" rel=\"noopener noreferrer\">hosted a breakfast\u003c/a> to pitch drug advertisers on using its tools to recruit patients for clinical trials. Drug marketers, like other advertisers on Facebook, can pay to send ads to users based on their location, likes, and search history.\u003c/p>\n\u003cp>Danielle Salowski, industry manager for Facebook’s health team, said in a written statement that drug makers are showing an “increasing interest” in advertising on Facebook in general. She wouldn’t say how many are making use of precision targeting tools.\u003c/p>\n\u003cp>\u003cstrong>Hitting only certain TVs\u003c/strong>\u003cbr>\nThe pitch at Medicx Media Solutions: We can help “pharmaceutical and health brands reach the right audience, every time.”\u003c/p>\n\u003cp>Michael Joachim, Medicx’s vice president of sales, said his team has worked with about 18 of the top 20 drug companies on precision marketing campaigns, such as online ads. Medicx also pitches targeted TV ads, though Joachim said so far just a handful of companies in the broad health, pharmaceutical, and wellness space have tried it.\u003c/p>\n\u003cp>In one instance, Joachim said, Medicx helped the maker of an eye care medication try to target TV ads to people who had previously been using the product but then stopped for some reason. The team identified micro-neighborhoods across the country where residents were deemed more likely to have used the product, based on Census data, survey results, and the patterns deduced from analyzing huge quantities of anonymized health records. For eight weeks, Medicx helped deliver TV ads for the product to hundreds of thousands of these micro-neighborhoods, distributed across urban, rural, and suburban areas.\u003c/p>\n\u003cp>“Generalization in geography works more for selling potato chips than health,” Joachim said.\u003c/p>\n\u003cp>It’s not clear that many pharmaceutical companies have yet tried out such granular targeting of TV ads. Several industry experts said they thought the uptake, so far, is probably close to negligible among prescription drug makers.\u003c/p>\n\u003cp>Joe Kim, Eli Lilly’s senior adviser on clinical trial innovation, said he wouldn’t use the tactic to recruit patients for a trial, calling it “a little bit overkill.” In general, he said, he’s a bit wary of some of the precision targeting tools being pitched.\u003c/p>\n\u003cp>“I get called a lot from people who say: ‘Hey, I have a great new way to reach patients for research,'” Kim said. “And what I tell them is: ‘Everything works. To what degree is always the question.'”\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003ci>\u003cspan style=\"font-weight: 400\">This \u003ca href=\"https://www.statnews.com/2017/09/26/drug-ads-precision-targeting/\" target=\"_blank\" rel=\"noopener noreferrer\">story\u003c/a> was originally published by STAT, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery.\u003c/span>\u003c/i>\u003c/p>\n\n","blocks":[],"excerpt":"The drug industry is adopting tools that let it directly target individual patients on platforms such as Facebook, Pandora, and Twitter.","status":"publish","parent":0,"modified":1506536227,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":32,"wordCount":1495},"headData":{"title":"You've Heard About Precision Medicine. Now Get Ready for Precision Drug Ads | KQED","description":"The drug industry is adopting tools that let it directly target individual patients on platforms such as Facebook, Pandora, and Twitter.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"You've Heard About Precision Medicine. Now Get Ready for Precision Drug Ads","datePublished":"2017-09-27T17:28:52.000Z","dateModified":"2017-09-27T18:17:07.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"435626 https://ww2.kqed.org/futureofyou/?p=435626","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/09/27/youve-heard-about-precision-medicine-now-get-ready-for-precision-drug-ads/","disqusTitle":"You've Heard About Precision Medicine. Now Get Ready for Precision Drug Ads","nprByline":"Rebecca Robbins\u003c/br>\u003ca href=\"https://www.statnews.com\">STAT\u003c/a>","path":"/futureofyou/435626/youve-heard-about-precision-medicine-now-get-ready-for-precision-drug-ads","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003caside class=\"pullquote alignright\">Drug makers have long steered clear of targeted ads, for fear of violating patient privacy law. That’s changing now.\u003c/aside>\n\u003cp>The drug industry spends billions each year to promote its medicines to the masses, blanketing \u003ca href=\"https://www.statnews.com/2017/08/29/tv-shows-drug-advertising/\">popular TV shows\u003c/a> and magazines with ads. Now, digital companies are increasingly trying to pry away a share of that money for ads that target specific patients, rather than broad demographics.\u003c/p>\n\u003cp>Targeted ads are nothing new in retail; anyone who uses the internet has had the eerie feeling that the ads popping up on page after page appear to be aimed directly at them. But drug makers have long steered clear of many such tools, for fear of violating patient privacy law.\u003c/p>\n\u003cp>That’s changing now. Facebook and the music streaming service Pandora are aggressively vying for pharma dollars by promising to help drug makers identify and reach the users most likely to have certain diseases or conditions — without violating the privacy law known as HIPAA.\u003c/p>\n\u003cp>Other companies looking to get in on the action are rushing to strike deals giving them access to vast troves of anonymized medical records. The databases strip out names — but can tell them, for instance, how many times women in a certain age bracket fill prescriptions for Drug X, or go to the doctor with complaints about Condition Y, or use their supermarket loyalty card to buy over-the-counter meds touted as a quick fix for Complaint Z.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>Combine that with the personal information that consumers enter when they set up accounts with social media sites, and you have a powerful tool for predicting which individuals may be most likely to be interested in certain medications.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>And marketers say they can use those analytics to send ads only to the most receptive patients as they browse online, scroll through Twitter, stream music — or even as they watch TV, thanks to a service that will deliver an ad to the airwaves only in a specifically targeted “micro-neighborhood” as small as a few residential blocks.\u003c/p>\n\u003cp>“It’s a matter of economics: Good targeting saves money. Good targeting improves the effectiveness of the spend. And … the ads don’t go to folks that don’t need them,” said John Kamp, executive director of the Coalition for Healthcare Communication, a trade group for pharmaceutical marketing companies and medical publishers.\u003c/p>\n\u003cp>STAT requested interviews with more than a dozen of the largest drug makers about the ad targeting tools they’re using. None agreed to talk about how they’re promoting specific products. Merck, Pfizer, and Eli Lilly did, however, share some information about how they reach out to patients to fill clinical trials or promote financial assistance programs — revealing some of the work they’re doing to target patients more precisely.\u003c/p>\n\u003cp>Pfizer, for instance, this summer took the first steps toward using geographic targeting for digital ads promoting RxPathways, its service that connects low-income patients with free prescriptions and help with copays.\u003c/p>\n\u003cp>Gary Pelletier, who runs the program for Pfizer, said his team compiled a list of the 16 states with the highest rates of uninsured patients and identified the ZIP codes in those states where the most patients have used Pfizer’s finance assistance program in the past.\u003c/p>\n\u003cp>Pelletier’s team then targeted everyone on certain social media sites in those ZIP codes with a \u003ca href=\"https://www.youtube.com/watch?v=rzZSn4YgHeE\" target=\"_blank\" rel=\"noopener noreferrer\">video ad\u003c/a>, featuring a couple navigating a labyrinth rising up out of the street. The off-screen narrator urged patients to “get the help you need to get the prescriptions you need.” They also blasted a \u003ca href=\"https://www.youtube.com/watch?v=bMAueAuI7EA\" target=\"_blank\" rel=\"noopener noreferrer\">Spanish language version\u003c/a> of the ad to people in those ZIP codes with a Spanish language setting on their social media account.\u003c/p>\n\u003cp>In another first, Pelletier’s team in the past few weeks promoted \u003ca href=\"https://twitter.com/pfizer/status/906252557789655041\" target=\"_blank\" rel=\"noopener noreferrer\">tweets\u003c/a> and \u003ca href=\"https://www.facebook.com/Pfizer/photos/a.390855402242.168464.314499212242/10155627232737243/?type=3&theater\" target=\"_blank\" rel=\"noopener noreferrer\">Facebook posts\u003c/a> publicizing Pfizer’s financial assistance hotline and website to people in parts of Texas and Florida ravaged by the recent hurricanes.\u003c/p>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/rzZSn4YgHeE'\n title='//www.youtube.com/embed/rzZSn4YgHeE'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>\u003cstrong>Following mom through her day\u003c/strong>\u003cbr>\nSpending on drug ads on TV, in print, and other traditional channels last year reached \u003ca href=\"https://www.statnews.com/2017/03/08/drug-ads-spending-single-drug/\">an estimated $5.7 billion\u003c/a>. And that’s not even counting the growing category of digital ads, which one research firm \u003ca href=\"https://www.emarketer.com/Article/Health-Pharma-Marketers-Split-Digital-Spend-Between-Search-Display/1014123\" target=\"_blank\" rel=\"noopener noreferrer\">estimated at $1.9 billion\u003c/a> last year.\u003c/p>\n\u003cp>Pandora is going hard after those pharma dollars.\u003c/p>\n\u003cp>Pandora now has more than 16 million individual monthly listeners over age 55 — and its fastest growing segments of new users are people in that bracket. Not surprisingly, over the past two years, the company has seen a rapid rise in interest from drug advertisers, according to Lee Ann Longinotti, who runs Pandora’s business with health care advertisers.\u003c/p>\n\u003cp>Pandora now counts 20 drug makers among its recent advertisers, including Pfizer, Merck, and Johnson & Johnson. They’ve promoted 40 different prescription and over-the-counter drugs, for conditions ranging from diabetes to erectile dysfunction to a \u003ca href=\"https://www.statnews.com/2016/05/04/sleep-drug-blind-advertising/\">circadian rhythm disorder\u003c/a> common in the blind.\u003c/p>\n\u003cp>To target users more precisely, Pandora struck a partnership a year ago with Crossix, a company which \u003ca href=\"http://www.crossix.com/commitment-to-privacy.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">mines anonymized patient data\u003c/a> from electronic health records, insurance claims, and pharmacy transactions.\u003c/p>\n\u003cp>That’s allowed Pandora to create profiles of the types of people who are most likely to be interested in drugs for a certain condition. Then it helps the pharma company follow those users around as they listen to music on different devices throughout the day.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>A mom who is a prime target for a given drug company, for instance, might hear ads for the same product as she listens to the Adele playlist on her computer at work, rocks out to the “Frozen” playlist with her kids in the car, and relaxes to jazz at home in the evening. Other listeners streaming the same general playlists at the same time would hear very different ads.\u003c/p>\n\u003cp>The marketing company 4INFO uses a similar strategy, drawing on \u003ca href=\"https://4info.com/Resources/Press-Releases/4INFO-and-Crossix-Partnership-Enables-Pharma-Brand\" target=\"_blank\" rel=\"noopener noreferrer\">its own partnership with Crossix\u003c/a> to help drug companies target mobile ads to consumers.\u003c/p>\n\u003cp>Another key player in the new landscape is Facebook, which earlier this month \u003ca href=\"https://www.cnbc.com/2017/09/07/facebook-held-a-breakfast-to-promote-clinical-trials-strategy.html\" target=\"_blank\" rel=\"noopener noreferrer\">hosted a breakfast\u003c/a> to pitch drug advertisers on using its tools to recruit patients for clinical trials. Drug marketers, like other advertisers on Facebook, can pay to send ads to users based on their location, likes, and search history.\u003c/p>\n\u003cp>Danielle Salowski, industry manager for Facebook’s health team, said in a written statement that drug makers are showing an “increasing interest” in advertising on Facebook in general. She wouldn’t say how many are making use of precision targeting tools.\u003c/p>\n\u003cp>\u003cstrong>Hitting only certain TVs\u003c/strong>\u003cbr>\nThe pitch at Medicx Media Solutions: We can help “pharmaceutical and health brands reach the right audience, every time.”\u003c/p>\n\u003cp>Michael Joachim, Medicx’s vice president of sales, said his team has worked with about 18 of the top 20 drug companies on precision marketing campaigns, such as online ads. Medicx also pitches targeted TV ads, though Joachim said so far just a handful of companies in the broad health, pharmaceutical, and wellness space have tried it.\u003c/p>\n\u003cp>In one instance, Joachim said, Medicx helped the maker of an eye care medication try to target TV ads to people who had previously been using the product but then stopped for some reason. The team identified micro-neighborhoods across the country where residents were deemed more likely to have used the product, based on Census data, survey results, and the patterns deduced from analyzing huge quantities of anonymized health records. For eight weeks, Medicx helped deliver TV ads for the product to hundreds of thousands of these micro-neighborhoods, distributed across urban, rural, and suburban areas.\u003c/p>\n\u003cp>“Generalization in geography works more for selling potato chips than health,” Joachim said.\u003c/p>\n\u003cp>It’s not clear that many pharmaceutical companies have yet tried out such granular targeting of TV ads. Several industry experts said they thought the uptake, so far, is probably close to negligible among prescription drug makers.\u003c/p>\n\u003cp>Joe Kim, Eli Lilly’s senior adviser on clinical trial innovation, said he wouldn’t use the tactic to recruit patients for a trial, calling it “a little bit overkill.” In general, he said, he’s a bit wary of some of the precision targeting tools being pitched.\u003c/p>\n\u003cp>“I get called a lot from people who say: ‘Hey, I have a great new way to reach patients for research,'” Kim said. “And what I tell them is: ‘Everything works. To what degree is always the question.'”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003ci>\u003cspan style=\"font-weight: 400\">This \u003ca href=\"https://www.statnews.com/2017/09/26/drug-ads-precision-targeting/\" target=\"_blank\" rel=\"noopener noreferrer\">story\u003c/a> was originally published by STAT, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery.\u003c/span>\u003c/i>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/435626/youve-heard-about-precision-medicine-now-get-ready-for-precision-drug-ads","authors":["byline_futureofyou_435626"],"categories":["futureofyou_1"],"tags":["futureofyou_1361","futureofyou_1275","futureofyou_442"],"featImg":"futureofyou_435657","label":"futureofyou"},"futureofyou_4307":{"type":"posts","id":"futureofyou_4307","meta":{"index":"posts_1591205157","site":"futureofyou","id":"4307","score":null,"sort":[1434483945000]},"guestAuthors":[],"slug":"this-company-wants-to-mine-your-data-to-monitor-drug-safety-in-the-real-world","title":"This Company Wants to Mine Your Data to Monitor Drug Safety in the 'Real World'","publishDate":1434483945,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{"site":"futureofyou"},"content":"\u003cp>Each day, thousands of people turn to online discussion forums to share their health care experiences.\u003c/p>\n\u003cp>One site alone, \u003ca href=\"https://www.patientslikeme.com/\">PatientsLikeMe\u003c/a>, counts 350,000 patients worldwide who are using its service to compare symptoms, describe side effects to medications, and track the progress of their disease.\u003c/p>\n\u003cp>For PatientsLikeMe, all that personal health information is a potential gold-mine. It's not only attractive to large pharmaceutical vendors and clinical researchers, who will pay to eavesdrop on patient chats, but also government agencies.\u003c/p>\n\u003cp>This week, PatientsLikeMe signed a research agreement with the U.S. Food and Drug Administration, the government agency that is responsible for public health. The agency will assess whether the data will boost its drug safety surveillance efforts.\u003c/p>\n\u003cp>PatientsLikeMe has agreed to share the data with the FDA at no cost.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"\u003cspan class=\"s1\">FDA is interested in the patient's voice,\" said FDA spokeswoman Sandy Walsh in an email interview with KQED\u003cem>. \u003c/em>\u003c/span>\u003c/p>\n\u003cp>\"\u003cspan class=\"s1\">By design, this research collaboration agreement is intended to be exploratory,\" she explained. \"We have very little, if any, experience with data of this type.\"\u003cbr>\n\u003c/span>\u003c/p>\n\u003cp>\u003cspan class=\"s1\">This is the first time that \u003c/span>\u003cspan class=\"s1\">\u003ca href=\"http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/\">FDA's Center for Drug Evaluation and Research\u003c/a> has explored using a continuous source of patient data for drug safety, said Walsh. But going forward, the agency sees opportunities to tap into patient-generated health information on popular social media sites. \u003c/span>\u003c/p>\n\u003cp>That presents new opportunities for understanding the patient perspective -- but also raises privacy questions.\u003c/p>\n\u003cp>\u003cstrong>Should you be Concerned About Your Privacy?\u003c/strong>\u003c/p>\n\u003cp>Some privacy rights groups fear that patients have not been adequately informed that their intimate data could be shared with third parties.\u003c/p>\n\u003cp>The data that PatientsLikeMe collects won't include \"identifying\" information, like a patient's name and email, Heywood said. Partners and customers are \"contractually obligated\" to avoid \"re-identifying the data\" to connect symptoms to a specific patient.\u003c/p>\n\u003cp>The \u003ca href=\"https://www.eff.org/\">Electronic Frontier Foundation\u003c/a>'s Lee Tien said he still harbors concerns about the type of data that is being collected and that patients haven't been adequately informed about where it's going. Tien is a senior staff attorney for the San Francisco-based foundation, which specializes in protecting people's civil liberties.\u003c/p>\n\u003cp>In its privacy policy, PatientsLikeMe states that it will not share personal information as part of the registration process. But if a patient shares it in a \"free text\" field like their biography or as part of a survey, PatientsLikeMe may share this information with its partners.\u003c/p>\n\u003cp>The company's privacy policy also \"reserves the right\" for regulatory bodies, like the FDA, to contact patients for follow-up information at the agency's request.\u003c/p>\n\u003cp>\"PatientsLikeMe is fairly well known as a 'sharing' site, so it's not a place for those who are strongly concerned about their own medical privacy,\" said Tien.\u003c/p>\n\u003cp>\u003cstrong>Understanding How Patients Respond to Drugs in the Real World\u003c/strong>\u003c/p>\n\u003cp>Some people may delight in handing over their data to a government agency like the FDA. This massive store of information may help future generations of patients avoid drugs that do more harm than good.\u003c/p>\n\u003cp>\"Clinical trials help us understand the effects of drugs, but it's very difficult to keep track of that once the drug hits the market,\" said Ben Heywood, co-founder and president of PatientsLikeMe.\u003c/p>\n\u003cp>Drug makers are flocking to PatientsLikeMe for those real-world insights. The company's pharmaceutical customers include Janssen Pharmaceuticals and Roche-owned Genentech.\u003c/p>\n\u003cp>Pharma companies are well-aware of the limitations of clinical trials. These studies involve a very small number of patients -- in the hundreds or low thousands, depending on the research phase. They are also skewed to favor certain demographics: the majority of participants are male, for instance. This is problematic as men and women often respond to drugs differently.\u003c/p>\n\u003cp>But on sites like PatientsLikeMe, patients share information about their medication use with each other in ways that can be documented and tracked. This data is stored in a structured format, and includes rows and columns about treatment, side effects, outcomes and symptomology.\u003c/p>\n\u003cp>\"Unlike clinical trials, we tend to bias a little bit towards women and our average age is in the mid-40s,\" said Heywood. The most popular patient communities on PatientsLikeMe are dedicated to fibromyalgia and multiple sclerosis.\u003c/p>\n\u003cp>[\u003ca href=\"http://ww2.kqed.org/futureofyou/2015/05/15/womens-health-is-too-often-overlooked-will-digital-health-be-the-exception/\">Related: Women’s Health is Too Often Overlooked; Will Digital Health be the Exception.\u003c/a>]\u003c/p>\n\u003cp>In the future, PatientsLikeMe plans to supplement this database with data from mobile apps and sensors that patients use, such as an \u003ca href=\"http://www.alivecor.com/home\">AliveCor\u003c/a> heart health tracker.\u003c/p>\n\u003cp>Heywood has some ambitious plans for the research, which won't necessarily involve the FDA. He points out that not all side-effects are negative. He hopes that PatientsLikeMe can help uncover new uses for existing drugs. If\u003cspan style=\"line-height: 1.5\"> a large cohort of patients complain about an allergy medication that causes dry mouth, that same drug could help patients with ALS who routinely struggle with excess saliva. \u003c/span>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\"In general, we're not trying to get drugs off the market,\" he said. \"We're trying to help individual patients find the right intervention.\"\u003c/p>\n\n","blocks":[],"excerpt":"For the first time, the Food and Drug Administration's drug safety division is partnering with a startup to tap patient-generated health information. ","status":"publish","parent":0,"modified":1434575943,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":29,"wordCount":885},"headData":{"title":"This Company Wants to Mine Your Data to Monitor Drug Safety in the 'Real World' | KQED","description":"For the first time, the Food and Drug Administration's drug safety division is partnering with a startup to tap patient-generated health information. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"This Company Wants to Mine Your Data to Monitor Drug Safety in the 'Real World'","datePublished":"2015-06-16T19:45:45.000Z","dateModified":"2015-06-17T21:19:03.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"4307 http://ww2.kqed.org/futureofyou/?p=4307","disqusUrl":"https://ww2.kqed.org/futureofyou/2015/06/16/this-company-wants-to-mine-your-data-to-monitor-drug-safety-in-the-real-world/","disqusTitle":"This Company Wants to Mine Your Data to Monitor Drug Safety in the 'Real World'","path":"/futureofyou/4307/this-company-wants-to-mine-your-data-to-monitor-drug-safety-in-the-real-world","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Each day, thousands of people turn to online discussion forums to share their health care experiences.\u003c/p>\n\u003cp>One site alone, \u003ca href=\"https://www.patientslikeme.com/\">PatientsLikeMe\u003c/a>, counts 350,000 patients worldwide who are using its service to compare symptoms, describe side effects to medications, and track the progress of their disease.\u003c/p>\n\u003cp>For PatientsLikeMe, all that personal health information is a potential gold-mine. It's not only attractive to large pharmaceutical vendors and clinical researchers, who will pay to eavesdrop on patient chats, but also government agencies.\u003c/p>\n\u003cp>This week, PatientsLikeMe signed a research agreement with the U.S. Food and Drug Administration, the government agency that is responsible for public health. The agency will assess whether the data will boost its drug safety surveillance efforts.\u003c/p>\n\u003cp>PatientsLikeMe has agreed to share the data with the FDA at no cost.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"\u003cspan class=\"s1\">FDA is interested in the patient's voice,\" said FDA spokeswoman Sandy Walsh in an email interview with KQED\u003cem>. \u003c/em>\u003c/span>\u003c/p>\n\u003cp>\"\u003cspan class=\"s1\">By design, this research collaboration agreement is intended to be exploratory,\" she explained. \"We have very little, if any, experience with data of this type.\"\u003cbr>\n\u003c/span>\u003c/p>\n\u003cp>\u003cspan class=\"s1\">This is the first time that \u003c/span>\u003cspan class=\"s1\">\u003ca href=\"http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/\">FDA's Center for Drug Evaluation and Research\u003c/a> has explored using a continuous source of patient data for drug safety, said Walsh. But going forward, the agency sees opportunities to tap into patient-generated health information on popular social media sites. \u003c/span>\u003c/p>\n\u003cp>That presents new opportunities for understanding the patient perspective -- but also raises privacy questions.\u003c/p>\n\u003cp>\u003cstrong>Should you be Concerned About Your Privacy?\u003c/strong>\u003c/p>\n\u003cp>Some privacy rights groups fear that patients have not been adequately informed that their intimate data could be shared with third parties.\u003c/p>\n\u003cp>The data that PatientsLikeMe collects won't include \"identifying\" information, like a patient's name and email, Heywood said. Partners and customers are \"contractually obligated\" to avoid \"re-identifying the data\" to connect symptoms to a specific patient.\u003c/p>\n\u003cp>The \u003ca href=\"https://www.eff.org/\">Electronic Frontier Foundation\u003c/a>'s Lee Tien said he still harbors concerns about the type of data that is being collected and that patients haven't been adequately informed about where it's going. Tien is a senior staff attorney for the San Francisco-based foundation, which specializes in protecting people's civil liberties.\u003c/p>\n\u003cp>In its privacy policy, PatientsLikeMe states that it will not share personal information as part of the registration process. But if a patient shares it in a \"free text\" field like their biography or as part of a survey, PatientsLikeMe may share this information with its partners.\u003c/p>\n\u003cp>The company's privacy policy also \"reserves the right\" for regulatory bodies, like the FDA, to contact patients for follow-up information at the agency's request.\u003c/p>\n\u003cp>\"PatientsLikeMe is fairly well known as a 'sharing' site, so it's not a place for those who are strongly concerned about their own medical privacy,\" said Tien.\u003c/p>\n\u003cp>\u003cstrong>Understanding How Patients Respond to Drugs in the Real World\u003c/strong>\u003c/p>\n\u003cp>Some people may delight in handing over their data to a government agency like the FDA. This massive store of information may help future generations of patients avoid drugs that do more harm than good.\u003c/p>\n\u003cp>\"Clinical trials help us understand the effects of drugs, but it's very difficult to keep track of that once the drug hits the market,\" said Ben Heywood, co-founder and president of PatientsLikeMe.\u003c/p>\n\u003cp>Drug makers are flocking to PatientsLikeMe for those real-world insights. The company's pharmaceutical customers include Janssen Pharmaceuticals and Roche-owned Genentech.\u003c/p>\n\u003cp>Pharma companies are well-aware of the limitations of clinical trials. These studies involve a very small number of patients -- in the hundreds or low thousands, depending on the research phase. They are also skewed to favor certain demographics: the majority of participants are male, for instance. This is problematic as men and women often respond to drugs differently.\u003c/p>\n\u003cp>But on sites like PatientsLikeMe, patients share information about their medication use with each other in ways that can be documented and tracked. This data is stored in a structured format, and includes rows and columns about treatment, side effects, outcomes and symptomology.\u003c/p>\n\u003cp>\"Unlike clinical trials, we tend to bias a little bit towards women and our average age is in the mid-40s,\" said Heywood. The most popular patient communities on PatientsLikeMe are dedicated to fibromyalgia and multiple sclerosis.\u003c/p>\n\u003cp>[\u003ca href=\"http://ww2.kqed.org/futureofyou/2015/05/15/womens-health-is-too-often-overlooked-will-digital-health-be-the-exception/\">Related: Women’s Health is Too Often Overlooked; Will Digital Health be the Exception.\u003c/a>]\u003c/p>\n\u003cp>In the future, PatientsLikeMe plans to supplement this database with data from mobile apps and sensors that patients use, such as an \u003ca href=\"http://www.alivecor.com/home\">AliveCor\u003c/a> heart health tracker.\u003c/p>\n\u003cp>Heywood has some ambitious plans for the research, which won't necessarily involve the FDA. He points out that not all side-effects are negative. He hopes that PatientsLikeMe can help uncover new uses for existing drugs. If\u003cspan style=\"line-height: 1.5\"> a large cohort of patients complain about an allergy medication that causes dry mouth, that same drug could help patients with ALS who routinely struggle with excess saliva. \u003c/span>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\"In general, we're not trying to get drugs off the market,\" he said. \"We're trying to help individual patients find the right intervention.\"\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/4307/this-company-wants-to-mine-your-data-to-monitor-drug-safety-in-the-real-world","authors":["3252"],"categories":["futureofyou_452"],"tags":["futureofyou_445","futureofyou_38","futureofyou_422","futureofyou_453","futureofyou_270","futureofyou_80","futureofyou_443","futureofyou_441","futureofyou_442","futureofyou_451","futureofyou_444","futureofyou_174"],"featImg":"futureofyou_4311","label":"futureofyou"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. 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