Stanford Pioneer in Brain Research Wins Prestigious Kyoto Prize
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The exact amount of the prize was 100 million yen.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Karl has created a revolutionary technology that has broadened our understanding of brain disorders and may one day yield treatments to the millions with these disorders.'\u003ccite>Lloyd Minor, Stanford School of Medicine\u003c/cite>\u003c/aside>\n\u003cp>Deisseroth is receiving the 2018 \u003ca href=\"https://www.kyotoprize.org/en/\" target=\"_blank\" rel=\"noopener\">Kyoto Prize\u003c/a> for advanced technology. Awards are also granted for basic sciences, and arts and philosophy. Some of its recipients have gone on to win the Nobel Prize.\u003c/p>\n\u003cp>\u003ca href=\"https://web.stanford.edu/group/dlab/about_pi.html\" target=\"_blank\" rel=\"noopener\">Deisseroth,\u003c/a> the youngest person to ever receive the prize, is being honored for developing \u003ca href=\"http://web.stanford.edu/group/dlab/optogenetics/\">optogenetics\u003c/a>, a technology that uses light-sensitive proteins to manipulate brain cell activity. The method allows scientists to glean more information about brain disorders and to probe how the nervous system works.\u003c/p>\n\u003cp>\"It is humbling to see all the distinguished people who have won the Kyoto Prize, and to be listed with them. It is wonderful to see pure basic science discoveries recognized in this way,\" said Deisseroth.\u003c/p>\n\u003cp>The technique developed by Deisseroth and his team manipulates cellular activity by delivering a pulse of light to a particular cell through an optical fiber that has been implanted in the animal’s brain. The method yields information on how brain cells give rise to sensations, memories and actions.\u003c/p>\n\u003cfigure id=\"attachment_442697\" class=\"wp-caption alignright\" style=\"max-width: 480px\">\u003cimg class=\"size-full wp-image-442697\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2018/06/image01.jpg\" alt=\"\" width=\"480\" height=\"360\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01.jpg 480w, https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01-160x120.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01-240x180.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01-375x281.jpg 375w\" sizes=\"(max-width: 480px) 100vw, 480px\">\u003cfigcaption class=\"wp-caption-text\">The Kyoto prize medal. \u003ccite>(Inamori Foundation)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>“A brilliant and innovative investigator, Karl has created a revolutionary technology that has broadened our understanding of brain disorders and may one day yield treatments to the millions with these disorders,” said Dr. Lloyd Minor, dean of the \u003ca href=\"http://med.stanford.edu/\" target=\"_blank\" rel=\"noopener\">Stanford School of Medicine\u003c/a>, in a statement. “His receipt of the Kyoto Prize is inordinately well-deserved and the product of his unmatched scientific vision.\"\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Deisseroth has said his research\u003ca href=\"https://www.scientificamerican.com/article/optogenetics-controlling/\" target=\"_blank\" rel=\"noopener\"> was motivated by\u003c/a> a desire to better understand psychiatric disorders, the leading cause of years of life lost to death or disability.\u003c/p>\n\u003cp>Deisseroth’s research, developed between 2004 and 2009, is used by laboratories around the world.\u003c/p>\n\u003cp>\"Thousands of laboratories around the world have used optogenetics to satisfy their own curiosity about the natural world, and to test ideas in a broad range of systems and species,\" he said. \"Many people are also studying brain diseases, and optogenetics-guided clinical trials have already started with some success, bringing a new kind of hope to people affected by these diseases such as substance dependence and depression.\"\u003c/p>\n\u003cp>\u003ciframe width=\"640\" height=\"360\" src=\"https://www.youtube.com/embed/CE6uNFFZ0qc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen>\u003c/iframe>\u003c/p>\n\u003cp>What makes optogenetics so groundbreaking is its level of precision in controlling defined activity within specific cells, according to I-Han Chou, senior editor at the journal \"Nature\".[contextly_sidebar id=\"08EVHeybNXS0fTuglKI55A1KVy7EFUpl\"]\u003c/p>\n\u003cp>\"If you imagine the brain as this city, up until now we have been looking at it as if from space,\" Chou\u003ca href=\"https://www.weforum.org/agenda/2016/10/what-is-optogenetics/\" target=\"_blank\" rel=\"noopener\"> told the\u003c/a> World Economic Forum site. \"We haven't had the tools to do anything beyond seeing what the whole city block is doing. What you actually want to know is what the individual components of the city are, what the people are doing, and what's the information being transported from one part of the city to another.\"\u003c/p>\n\u003cp>The technique could transform how neurological disorders such as Parkinson's disease are treated.\u003c/p>\n\u003cp>\"When things go wrong with the brain it is just so devastating. One of the hopes for optogenetics is that if it can work in humans, it might be used as a tool for restoring brain function,\" Chou added.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n","blocks":[],"excerpt":"Karl Deisseroth, the Stanford University professor who developed a groundbreaking method for probing how brain cells behave and communicate, is the recipient of the 2018 Kyoto Prize for advanced technology. ","status":"publish","parent":0,"modified":1529091009,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":600},"headData":{"title":"Stanford Pioneer in Brain Research Wins Prestigious Kyoto Prize | KQED","description":"Karl Deisseroth, the Stanford University professor who developed a groundbreaking method for probing how brain cells behave and communicate, is the recipient of the 2018 Kyoto Prize for advanced technology. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Stanford Pioneer in Brain Research Wins Prestigious Kyoto Prize","datePublished":"2018-06-15T06:30:28.000Z","dateModified":"2018-06-15T19:30:09.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"442639 https://ww2.kqed.org/futureofyou/?p=442639","disqusUrl":"https://ww2.kqed.org/futureofyou/2018/06/14/stanford-optogenetics-pioneer-wins-kyoto-prize/","disqusTitle":"Stanford Pioneer in Brain Research Wins Prestigious Kyoto Prize","source":"Health","path":"/futureofyou/442639/stanford-optogenetics-pioneer-wins-kyoto-prize","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Karl Deisseroth, a Stanford University professor of bioengineering and psychiatry, has been awarded an international prize worth more than $900,000 for his work in illuminating brain activity with light. The exact amount of the prize was 100 million yen.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Karl has created a revolutionary technology that has broadened our understanding of brain disorders and may one day yield treatments to the millions with these disorders.'\u003ccite>Lloyd Minor, Stanford School of Medicine\u003c/cite>\u003c/aside>\n\u003cp>Deisseroth is receiving the 2018 \u003ca href=\"https://www.kyotoprize.org/en/\" target=\"_blank\" rel=\"noopener\">Kyoto Prize\u003c/a> for advanced technology. Awards are also granted for basic sciences, and arts and philosophy. Some of its recipients have gone on to win the Nobel Prize.\u003c/p>\n\u003cp>\u003ca href=\"https://web.stanford.edu/group/dlab/about_pi.html\" target=\"_blank\" rel=\"noopener\">Deisseroth,\u003c/a> the youngest person to ever receive the prize, is being honored for developing \u003ca href=\"http://web.stanford.edu/group/dlab/optogenetics/\">optogenetics\u003c/a>, a technology that uses light-sensitive proteins to manipulate brain cell activity. The method allows scientists to glean more information about brain disorders and to probe how the nervous system works.\u003c/p>\n\u003cp>\"It is humbling to see all the distinguished people who have won the Kyoto Prize, and to be listed with them. It is wonderful to see pure basic science discoveries recognized in this way,\" said Deisseroth.\u003c/p>\n\u003cp>The technique developed by Deisseroth and his team manipulates cellular activity by delivering a pulse of light to a particular cell through an optical fiber that has been implanted in the animal’s brain. The method yields information on how brain cells give rise to sensations, memories and actions.\u003c/p>\n\u003cfigure id=\"attachment_442697\" class=\"wp-caption alignright\" style=\"max-width: 480px\">\u003cimg class=\"size-full wp-image-442697\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2018/06/image01.jpg\" alt=\"\" width=\"480\" height=\"360\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01.jpg 480w, https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01-160x120.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01-240x180.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2018/06/image01-375x281.jpg 375w\" sizes=\"(max-width: 480px) 100vw, 480px\">\u003cfigcaption class=\"wp-caption-text\">The Kyoto prize medal. \u003ccite>(Inamori Foundation)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>“A brilliant and innovative investigator, Karl has created a revolutionary technology that has broadened our understanding of brain disorders and may one day yield treatments to the millions with these disorders,” said Dr. Lloyd Minor, dean of the \u003ca href=\"http://med.stanford.edu/\" target=\"_blank\" rel=\"noopener\">Stanford School of Medicine\u003c/a>, in a statement. “His receipt of the Kyoto Prize is inordinately well-deserved and the product of his unmatched scientific vision.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Deisseroth has said his research\u003ca href=\"https://www.scientificamerican.com/article/optogenetics-controlling/\" target=\"_blank\" rel=\"noopener\"> was motivated by\u003c/a> a desire to better understand psychiatric disorders, the leading cause of years of life lost to death or disability.\u003c/p>\n\u003cp>Deisseroth’s research, developed between 2004 and 2009, is used by laboratories around the world.\u003c/p>\n\u003cp>\"Thousands of laboratories around the world have used optogenetics to satisfy their own curiosity about the natural world, and to test ideas in a broad range of systems and species,\" he said. \"Many people are also studying brain diseases, and optogenetics-guided clinical trials have already started with some success, bringing a new kind of hope to people affected by these diseases such as substance dependence and depression.\"\u003c/p>\n\u003cp>\u003ciframe width=\"640\" height=\"360\" src=\"https://www.youtube.com/embed/CE6uNFFZ0qc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen>\u003c/iframe>\u003c/p>\n\u003cp>What makes optogenetics so groundbreaking is its level of precision in controlling defined activity within specific cells, according to I-Han Chou, senior editor at the journal \"Nature\".\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>\"If you imagine the brain as this city, up until now we have been looking at it as if from space,\" Chou\u003ca href=\"https://www.weforum.org/agenda/2016/10/what-is-optogenetics/\" target=\"_blank\" rel=\"noopener\"> told the\u003c/a> World Economic Forum site. \"We haven't had the tools to do anything beyond seeing what the whole city block is doing. What you actually want to know is what the individual components of the city are, what the people are doing, and what's the information being transported from one part of the city to another.\"\u003c/p>\n\u003cp>The technique could transform how neurological disorders such as Parkinson's disease are treated.\u003c/p>\n\u003cp>\"When things go wrong with the brain it is just so devastating. One of the hopes for optogenetics is that if it can work in humans, it might be used as a tool for restoring brain function,\" Chou added.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/442639/stanford-optogenetics-pioneer-wins-kyoto-prize","authors":["11428"],"categories":["futureofyou_1062","futureofyou_1","futureofyou_73","futureofyou_1061","futureofyou_1064"],"tags":["futureofyou_56","futureofyou_155","futureofyou_80","futureofyou_1150","futureofyou_35"],"collections":["futureofyou_1093","futureofyou_1096","futureofyou_1094"],"featImg":"futureofyou_442681","label":"source_futureofyou_442639"},"futureofyou_439403":{"type":"posts","id":"futureofyou_439403","meta":{"index":"posts_1591205157","site":"futureofyou","id":"439403","score":null,"sort":[1518476368000]},"guestAuthors":[],"slug":"stunning-video-scientists-trap-a-cancer-cell-within-a-cage-of-light","title":"Watch This Cancer Cell Get Caged Within Walls of Light","publishDate":1518476368,"format":"aside","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>https://www.youtube.com/watch?v=cp8SlAZhGbk&ab_channel=UCSanFrancisco%28UCSF%29\u003c/p>\n\u003cp>Let there be light -- in the battle against cancer cells.\u003c/p>\n\u003cp>The stunning images above, captured using high-speed laser microscopy, shows a cancer cell isolated on a coverslip, trapped within \"walls\" of blue light. \u003c/p>\n\u003cp>Scientists created this cage by inserting a light-sensitive protein from plants into the cell, so that any contact with the light caused the protein to come apart, and the cell's structural \"scaffolding\" (the white lines within the cell) to collapse.\u003c/p>\n\u003cp>This makes it impossible for the cell to continue moving in the same direction. In response, the cell turns and tries a different route, with the same result. Thus, the cell is stopped dead in its tracks. The process of manipulating cells with light is called optogenetics.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>“Photo-inactivation lets us turn proteins off and back on in living cells in real time, and do so with much more spatial accuracy than has been possible before,” said Torsten Wittmann, a UCSF professor who led the study on the technique.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>While the technique is not going to be used in people any time soon, disrupting this isolated cell's ability to migrate is teaching researchers about new ways they might prevent metastatic cancer from spreading in patients. The same process can also be used to study a host of functions in other types of cells, as well.\u003c/p>\n\n","blocks":[],"excerpt":"The video, created using high-speed laser microscopy, shows a cancer cell genetically engineered to break down under four walls of blue light.\r\n\r\n","status":"publish","parent":0,"modified":1518480745,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":8,"wordCount":246},"headData":{"title":"Watch This Cancer Cell Get Caged Within Walls of Light | KQED","description":"The video, created using high-speed laser microscopy, shows a cancer cell genetically engineered to break down under four walls of blue light.\r\n\r\n","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Watch This Cancer Cell Get Caged Within Walls of Light","datePublished":"2018-02-12T22:59:28.000Z","dateModified":"2018-02-13T00:12:25.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"439403 https://ww2.kqed.org/futureofyou/?p=439403","disqusUrl":"https://ww2.kqed.org/futureofyou/2018/02/12/stunning-video-scientists-trap-a-cancer-cell-within-a-cage-of-light/","disqusTitle":"Watch This Cancer Cell Get Caged Within Walls of Light","source":"KQED Future of You","path":"/futureofyou/439403/stunning-video-scientists-trap-a-cancer-cell-within-a-cage-of-light","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>https://www.youtube.com/watch?v=cp8SlAZhGbk&ab_channel=UCSanFrancisco%28UCSF%29\u003c/p>\n\u003cp>Let there be light -- in the battle against cancer cells.\u003c/p>\n\u003cp>The stunning images above, captured using high-speed laser microscopy, shows a cancer cell isolated on a coverslip, trapped within \"walls\" of blue light. \u003c/p>\n\u003cp>Scientists created this cage by inserting a light-sensitive protein from plants into the cell, so that any contact with the light caused the protein to come apart, and the cell's structural \"scaffolding\" (the white lines within the cell) to collapse.\u003c/p>\n\u003cp>This makes it impossible for the cell to continue moving in the same direction. In response, the cell turns and tries a different route, with the same result. Thus, the cell is stopped dead in its tracks. The process of manipulating cells with light is called optogenetics.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“Photo-inactivation lets us turn proteins off and back on in living cells in real time, and do so with much more spatial accuracy than has been possible before,” said Torsten Wittmann, a UCSF professor who led the study on the technique.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>While the technique is not going to be used in people any time soon, disrupting this isolated cell's ability to migrate is teaching researchers about new ways they might prevent metastatic cancer from spreading in patients. The same process can also be used to study a host of functions in other types of cells, as well.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/439403/stunning-video-scientists-trap-a-cancer-cell-within-a-cage-of-light","authors":["11428"],"categories":["futureofyou_452","futureofyou_1","futureofyou_73"],"tags":["futureofyou_103","futureofyou_1275","futureofyou_80","futureofyou_1150"],"collections":["futureofyou_1093"],"featImg":"futureofyou_439411","label":"source_futureofyou_439403"},"futureofyou_304635":{"type":"posts","id":"futureofyou_304635","meta":{"index":"posts_1591205157","site":"futureofyou","id":"304635","score":null,"sort":[1482514537000]},"guestAuthors":[],"slug":"alzheimers-plaque-in-mice-cut-in-half-with-flashing-lights","title":"Alzheimer’s Plaque in Mice Cut in Half With Flashing Lights","publishDate":1482514537,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{"site":"futureofyou"},"content":"\u003cp>Radiolab, a frequent favorite among the public radio set, uncharacteristically covered a bit of breaking news on Dec. 8, \u003ca href=\"http://www.radiolab.org/story/bringing-gamma-back/\" target=\"_blank\">speaking to researchers\u003c/a> who'd just published their novel approach to treating Alzheimer's-infected lab mice.\u003c/p>\n\u003cp>They found that after a week of treatment using optogenetics, which allows researchers to switch specific neurons in the brain on and off, the amyloid plaque that's believed to contribute to Alzheimer's was \u003ca href=\"http://news.mit.edu/2016/visual-stimulation-treatment-alzheimer-1207\" target=\"_blank\">reduced by a startling 40 to 50 percent\u003c/a>.\u003cbr>\n\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe width=\"600\" height=\"50\" src=\"https://www.wnyc.org/widgets/ondemand_player/radiolab/#file=%2Faudio%2Fxspf%2F690533%2F\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\">\u003c/iframe>\u003c/p>\n\u003cp>The researchers at MIT's Picower Institute for Learning and Memory inundated the brains of mice with bright flashing lights at a specific frequency, in order to trigger the nonfunctioning cells that normally clean the plaque to do their job again.\u003c/p>\n\u003cp>Li-Huei Tsai, the research laboratory's director, told Radiolab the results were exciting, but she didn't want to get ahead of the research in predicting it would translate into success in humans. The failure rate in Alzheimer's research has been notoriously \u003ca href=\"https://www.insidescience.org/news/failure-upon-failure-alzheimers-drugs\" target=\"_blank\">high\u003c/a>.\u003c/p>\n\u003cp>[contextly_sidebar id=\"EEe6W1a2ZdfW3jWfCnS5bM2vzwgDkmbv\"]\u003c/p>\n\u003cp>One of the interesting things about the technique is that it not only worked using the maximally invasive procedure of drilling holes in the mice's skulls, but also by simply flashing lights into their eyes.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"Are you going to tell me you don't believe it, it's science fiction?\" Tsai giddily asks Radiolab's interviewer.\u003c/p>\n\u003cp>While the plaque only vanished if the neurons were exposed to the flashing lights every 24 hours, the group is looking at ways to make the disappearance permanent.\u003c/p>\n\u003cp>Tsai is planning to undertake human clinical trials through a medical technology startup she co-founded. The hope is to develop a non-invasive treatment that could slow the inevitable decline in Alzheimer's patients.\u003c/p>\n\u003cp>Groundbreaking research? TBD. Super-good radio? Definitely. Worth a \u003ca href=\"http://www.radiolab.org/story/bringing-gamma-back/\" target=\"_blank\">listen here\u003c/a> or above in the post.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ciframe width=\"640\" height=\"360\" src=\"https://www.youtube.com/embed/O_p4QWkE2Ls?feature=oembed\" frameborder=\"0\" allow=\"autoplay; encrypted-media\" allowfullscreen>\u003c/iframe>\u003c/p>\n\n","blocks":[],"excerpt":"Researchers inundated the brains of mice with bright lights flashing at a specific frequency, triggering a cleanup of the amyloid plaque believed to contribute to Alzheimer's.","status":"publish","parent":0,"modified":1483476808,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":13,"wordCount":321},"headData":{"title":"Alzheimer’s Plaque in Mice Cut in Half With Flashing Lights | KQED","description":"Researchers inundated the brains of mice with bright lights flashing at a specific frequency, triggering a cleanup of the amyloid plaque believed to contribute to Alzheimer's.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Alzheimer’s Plaque in Mice Cut in Half With Flashing Lights","datePublished":"2016-12-23T17:35:37.000Z","dateModified":"2017-01-03T20:53:28.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"304635 http://ww2.kqed.org/futureofyou/?p=304635","disqusUrl":"https://ww2.kqed.org/futureofyou/2016/12/23/alzheimers-plaque-in-mice-cut-in-half-with-flashing-lights/","disqusTitle":"Alzheimer’s Plaque in Mice Cut in Half With Flashing Lights","path":"/futureofyou/304635/alzheimers-plaque-in-mice-cut-in-half-with-flashing-lights","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Radiolab, a frequent favorite among the public radio set, uncharacteristically covered a bit of breaking news on Dec. 8, \u003ca href=\"http://www.radiolab.org/story/bringing-gamma-back/\" target=\"_blank\">speaking to researchers\u003c/a> who'd just published their novel approach to treating Alzheimer's-infected lab mice.\u003c/p>\n\u003cp>They found that after a week of treatment using optogenetics, which allows researchers to switch specific neurons in the brain on and off, the amyloid plaque that's believed to contribute to Alzheimer's was \u003ca href=\"http://news.mit.edu/2016/visual-stimulation-treatment-alzheimer-1207\" target=\"_blank\">reduced by a startling 40 to 50 percent\u003c/a>.\u003cbr>\n\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe width=\"600\" height=\"50\" src=\"https://www.wnyc.org/widgets/ondemand_player/radiolab/#file=%2Faudio%2Fxspf%2F690533%2F\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\">\u003c/iframe>\u003c/p>\n\u003cp>The researchers at MIT's Picower Institute for Learning and Memory inundated the brains of mice with bright flashing lights at a specific frequency, in order to trigger the nonfunctioning cells that normally clean the plaque to do their job again.\u003c/p>\n\u003cp>Li-Huei Tsai, the research laboratory's director, told Radiolab the results were exciting, but she didn't want to get ahead of the research in predicting it would translate into success in humans. The failure rate in Alzheimer's research has been notoriously \u003ca href=\"https://www.insidescience.org/news/failure-upon-failure-alzheimers-drugs\" target=\"_blank\">high\u003c/a>.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>One of the interesting things about the technique is that it not only worked using the maximally invasive procedure of drilling holes in the mice's skulls, but also by simply flashing lights into their eyes.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"Are you going to tell me you don't believe it, it's science fiction?\" Tsai giddily asks Radiolab's interviewer.\u003c/p>\n\u003cp>While the plaque only vanished if the neurons were exposed to the flashing lights every 24 hours, the group is looking at ways to make the disappearance permanent.\u003c/p>\n\u003cp>Tsai is planning to undertake human clinical trials through a medical technology startup she co-founded. The hope is to develop a non-invasive treatment that could slow the inevitable decline in Alzheimer's patients.\u003c/p>\n\u003cp>Groundbreaking research? TBD. Super-good radio? Definitely. Worth a \u003ca href=\"http://www.radiolab.org/story/bringing-gamma-back/\" target=\"_blank\">listen here\u003c/a> or above in the post.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ciframe width=\"640\" height=\"360\" src=\"https://www.youtube.com/embed/O_p4QWkE2Ls?feature=oembed\" frameborder=\"0\" allow=\"autoplay; encrypted-media\" allowfullscreen>\u003c/iframe>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/304635/alzheimers-plaque-in-mice-cut-in-half-with-flashing-lights","authors":["8654","80"],"categories":["futureofyou_452","futureofyou_1062","futureofyou_1"],"tags":["futureofyou_999","futureofyou_1033","futureofyou_80","futureofyou_1150"],"featImg":"futureofyou_313474","label":"futureofyou"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. 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Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. 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