Gene Editing: Coming to a Kitchen Counter Near You
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Designer babies? What about new fuel sources or drought-tolerant crops? Gene editing with a technique known as CRISPR/Cas9, hailed as a scientific \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">breakthrough\u003c/a>, could mean all those things.\u003c/p>\n\u003cp>There's a possibility, of course, that CRISPR/Cas9 may not live up to expectations. That's happened before. Twenty-five years ago, recombinant DNA was supposed to transform society in a way that, well, didn't happen. But any past biotech disappointments are not stopping a slew of Bay Area CRISPR startups from taking the leap into the new world of DNA tinkering and synthetic biology. They are, in fact, everywhere, from biotech labs in Emeryville to kitchen counters in Burlingame.\u003c/p>\n\u003cp>\"It's something that people read about, it's something people see that's cutting edge,\" says Josiah Zayner, a former synthetic biologist at NASA. \"Yet it's so accessible, it's something that you can do in your home, on your kitchen table.\"\u003c/p>\n\u003cp>Zayner has considered himself a \"biohacker\" for a long time. Now it's his full-time job.\u003c/p>\n\u003cfigure id=\"attachment_114669\" class=\"wp-caption alignleft\" style=\"max-width: 360px\">\u003cimg class=\"size-full wp-image-114669\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/crispr-featureimage-e1455913319463.jpg\" alt='Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists.' width=\"360\" height=\"540\">\u003cfigcaption class=\"wp-caption-text\">Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>He's started a company called The Open Discovery Institute, or The ODIN (not coincidentally, the name of the Norse god connected with healing, knowledge and ... death). The point, he says, is to make science more accessible by providing low-cost supplies for people to practice gene editing at home. The first shipments from his \u003ca href=\"https://www.indiegogo.com/projects/diy-crispr-kits-learn-modern-science-by-doing#/\" target=\"_blank\">Indiegogo crowdfunding campaign\u003c/a> are expected this spring.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"You can learn about cutting-edge science by actually doing it,\" Zayner says. \"When I started experimenting with CRISPR I thought, 'That's pretty crazy!' I would definitely want that opportunity.\"\u003c/p>\n\u003cp>In Zayner's kitchen I get a crash course in how this new kind of gene editing works. Zayner's kits have three major parts: the Cas9 protein (other forms can use other proteins), the \"guide\" RNA and the donor DNA. The Cas9 protein makes precise cuts in the sections of the DNA to which it's led by the guide RNA. Sensing the cut, the cell's own repair mechanisms will try to repair it, by inserting a new piece of DNA. If all goes well, it will add a section of the donated DNA containing the desired gene or genes.\u003c/p>\n\u003cp>\"So you kind of trick the cell into using your new piece of DNA instead of some other piece of DNA it finds, or the original piece of DNA,\" says Zayner.\u003c/p>\n\u003cfigure id=\"attachment_115245\" class=\"wp-caption alignnone\" style=\"max-width: 1280px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\">\u003cimg class=\"wp-image-115245 size-full\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\" alt=\"CRISPR is Here\" width=\"1280\" height=\"850\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here.jpg 1280w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-400x266.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-800x531.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-768x510.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-1180x784.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-960x638.jpg 960w\" sizes=\"(max-width: 1280px) 100vw, 1280px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\u003cem>Click on the image for a larger version\u003c/em>\u003c/figcaption>\u003c/figure>\n\u003cp>To see the process in action, we insert a yeast mutation that will change its color from milky white to rusty red. We mix a chemical solution called a buffer (which helps the cell accept the DNA into its wall), the Cas9 protein, the guide RNA and the donor DNA together in a small plastic test tube.\u003c/p>\n\u003cp>\"So we're going to try to get this inside the yeast cells,\" Zayner says, holding up the clear fluid.\u003c/p>\n\u003cp>Zayner has some yeast growing on an agar-filled culture plate in his fridge. We transfer the yeast with a thin plastic loop. We heat up the cells by putting the test tube in a warm bowl of water, then let them cool again and rest before spreading them on a plate to let them grow. The yeast only needs to grow a day or two to see if the experiment was successful. A few days later, Zayner says it was.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Why should we limit ourselves to what evolution has told us we should have based on natural selection?'\u003ccite>Josiah Zayner, The ODIN\u003c/cite>\u003c/aside>\n\u003cp>This is fairly simple stuff. Zayner's editing kits are more about fostering an interest in science than creating a new breed of super-humans -- not that he necessarily would have a problem with that.\u003c/p>\n\u003cp>\"Gene editing is the next step for humanity,\" Zayner says. \"Why should we limit ourselves to what evolution has told us we should have based on natural selection? When we can decide what works best for humanity?\"\u003c/p>\n\u003cp>Gene editing technology has made great strides in the three years since CRISPR/Cas9 burst onto the scientific scene. Despite the rapid pace of advances, many scientists are urging caution as the technology becomes easier to use and the experiments become more ambitious.\u003c/p>\n\u003cp>\"We haven't really had the conversation about humans and what's ethically appropriate or inappropriate,\" says \u003ca href=\"https://med.stanford.edu/profiles/mildred-cho\" target=\"_blank\">Mildred Cho, \u003c/a>a bioethicist at Stanford University. She sees a huge potential for breakthroughs in gene editing, but also the possibility of misuse. \"And we haven't really had the conversation about widespread release of organisms that we won't be able to get back once they're released into the environment.\" Cho, however, says it's not up to scientists to decide such things. \"So far, those discussions have not been very widespread outside of the expert communities.\"\u003c/p>\n\u003cfigure id=\"attachment_114670\" class=\"wp-caption alignright\" style=\"max-width: 240px\">\u003cimg class=\"size-full wp-image-114670\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/RS18524_IMG_8357-sfi.jpg\" alt=\"Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \" width=\"240\" height=\"360\">\u003cfigcaption class=\"wp-caption-text\">Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Yet Silicon Valley and the local biotech community are forging ahead. In San Francisco's Mission Bay neighborhood, \u003ca href=\"https://www.twistbioscience.com/\" target=\"_blank\">Twist Bioscience\u003c/a> is making the components of DNA and RNA that companies and academic researchers can use in their synthetic biology experiments.\u003c/p>\n\u003cp>\"We started Twist to disrupt the DNA-writing market,\" says Emily Leproust, one of the co-founders. \"There is a massive demand. A huge demand.\"\u003c/p>\n\u003cp>Leproust says many drugs, antibiotics and vaccines begin from DNA, with engineered microbes used to make them. And in the area of industrial chemicals, many researchers and companies are modifying algae, yeast and E. coli to turn them into bio-factories that make specialty chemicals.\u003c/p>\n\u003cp>Twist doesn't disclose the names of its clients. And in the interest of safety, Twist executives say, they restrict what sequences of DNA they'll sell, and to whom. But there are lots of local labs and companies using DNA in this way, and they're raising boatloads of money.\u003c/p>\n\u003cp>According to CrunchBase.com, \u003ca href=\"http://www.zymergen.com/\" target=\"_blank\">Zymergen\u003c/a> in Emeryville has raised $44 million, \u003ca href=\"http://cariboubio.com/\" target=\"_blank\">Caribou Bioscience\u003c/a> in Berkeley $14 million, \u003ca href=\"http://www.sangamo.com/index.html\" target=\"_blank\">Sangamo BioSciences\u003c/a> in Richmond about $74 million, and Twist itself more than $130 million.\u003c/p>\n\u003cp>That's why, Leproust says, it's good, today, to be in bio.\u003c/p>\n\u003cp>\"If you were in the '50s, you wanted to be in space and aeronautics and in the '90s you wanted to be in computers. And nowadays you want to be in biology because that's where the next big economic growth is going to come from.\"\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>Time will tell. But local startups are betting and betting big on the new generation of gene editing.\u003c/p>\n\n","blocks":[],"excerpt":"A slew of Bay Area startups and even individuals are taking the leap into the new world of DNA tinkering and synthetic biology. ","status":"publish","parent":0,"modified":1456166199,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":25,"wordCount":1153},"headData":{"title":"Gene Editing: Coming to a Kitchen Counter Near You | KQED","description":"A slew of Bay Area startups and even individuals are taking the leap into the new world of DNA tinkering and synthetic biology. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"114619 http://ww2.kqed.org/futureofyou/?p=114619","disqusUrl":"https://ww2.kqed.org/futureofyou/2016/02/22/gene-editing-coming-to-a-kitchen-counter-near-you/","disqusTitle":"Gene Editing: Coming to a Kitchen Counter Near You","audioUrl":"http://www.kqed.org/.stream/anon/radio/science/2016/02/WEBCRISPRSilValVenton160222.mp3","path":"/futureofyou/114619/gene-editing-coming-to-a-kitchen-counter-near-you","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>When you hear \"gene editing,\" do you think cancer cures? Designer babies? What about new fuel sources or drought-tolerant crops? Gene editing with a technique known as CRISPR/Cas9, hailed as a scientific \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">breakthrough\u003c/a>, could mean all those things.\u003c/p>\n\u003cp>There's a possibility, of course, that CRISPR/Cas9 may not live up to expectations. That's happened before. Twenty-five years ago, recombinant DNA was supposed to transform society in a way that, well, didn't happen. But any past biotech disappointments are not stopping a slew of Bay Area CRISPR startups from taking the leap into the new world of DNA tinkering and synthetic biology. They are, in fact, everywhere, from biotech labs in Emeryville to kitchen counters in Burlingame.\u003c/p>\n\u003cp>\"It's something that people read about, it's something people see that's cutting edge,\" says Josiah Zayner, a former synthetic biologist at NASA. \"Yet it's so accessible, it's something that you can do in your home, on your kitchen table.\"\u003c/p>\n\u003cp>Zayner has considered himself a \"biohacker\" for a long time. Now it's his full-time job.\u003c/p>\n\u003cfigure id=\"attachment_114669\" class=\"wp-caption alignleft\" style=\"max-width: 360px\">\u003cimg class=\"size-full wp-image-114669\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/crispr-featureimage-e1455913319463.jpg\" alt='Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists.' width=\"360\" height=\"540\">\u003cfigcaption class=\"wp-caption-text\">Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>He's started a company called The Open Discovery Institute, or The ODIN (not coincidentally, the name of the Norse god connected with healing, knowledge and ... death). The point, he says, is to make science more accessible by providing low-cost supplies for people to practice gene editing at home. The first shipments from his \u003ca href=\"https://www.indiegogo.com/projects/diy-crispr-kits-learn-modern-science-by-doing#/\" target=\"_blank\">Indiegogo crowdfunding campaign\u003c/a> are expected this spring.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"You can learn about cutting-edge science by actually doing it,\" Zayner says. \"When I started experimenting with CRISPR I thought, 'That's pretty crazy!' I would definitely want that opportunity.\"\u003c/p>\n\u003cp>In Zayner's kitchen I get a crash course in how this new kind of gene editing works. Zayner's kits have three major parts: the Cas9 protein (other forms can use other proteins), the \"guide\" RNA and the donor DNA. The Cas9 protein makes precise cuts in the sections of the DNA to which it's led by the guide RNA. Sensing the cut, the cell's own repair mechanisms will try to repair it, by inserting a new piece of DNA. If all goes well, it will add a section of the donated DNA containing the desired gene or genes.\u003c/p>\n\u003cp>\"So you kind of trick the cell into using your new piece of DNA instead of some other piece of DNA it finds, or the original piece of DNA,\" says Zayner.\u003c/p>\n\u003cfigure id=\"attachment_115245\" class=\"wp-caption alignnone\" style=\"max-width: 1280px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\">\u003cimg class=\"wp-image-115245 size-full\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\" alt=\"CRISPR is Here\" width=\"1280\" height=\"850\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here.jpg 1280w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-400x266.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-800x531.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-768x510.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-1180x784.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-960x638.jpg 960w\" sizes=\"(max-width: 1280px) 100vw, 1280px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\u003cem>Click on the image for a larger version\u003c/em>\u003c/figcaption>\u003c/figure>\n\u003cp>To see the process in action, we insert a yeast mutation that will change its color from milky white to rusty red. We mix a chemical solution called a buffer (which helps the cell accept the DNA into its wall), the Cas9 protein, the guide RNA and the donor DNA together in a small plastic test tube.\u003c/p>\n\u003cp>\"So we're going to try to get this inside the yeast cells,\" Zayner says, holding up the clear fluid.\u003c/p>\n\u003cp>Zayner has some yeast growing on an agar-filled culture plate in his fridge. We transfer the yeast with a thin plastic loop. We heat up the cells by putting the test tube in a warm bowl of water, then let them cool again and rest before spreading them on a plate to let them grow. The yeast only needs to grow a day or two to see if the experiment was successful. A few days later, Zayner says it was.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Why should we limit ourselves to what evolution has told us we should have based on natural selection?'\u003ccite>Josiah Zayner, The ODIN\u003c/cite>\u003c/aside>\n\u003cp>This is fairly simple stuff. Zayner's editing kits are more about fostering an interest in science than creating a new breed of super-humans -- not that he necessarily would have a problem with that.\u003c/p>\n\u003cp>\"Gene editing is the next step for humanity,\" Zayner says. \"Why should we limit ourselves to what evolution has told us we should have based on natural selection? When we can decide what works best for humanity?\"\u003c/p>\n\u003cp>Gene editing technology has made great strides in the three years since CRISPR/Cas9 burst onto the scientific scene. Despite the rapid pace of advances, many scientists are urging caution as the technology becomes easier to use and the experiments become more ambitious.\u003c/p>\n\u003cp>\"We haven't really had the conversation about humans and what's ethically appropriate or inappropriate,\" says \u003ca href=\"https://med.stanford.edu/profiles/mildred-cho\" target=\"_blank\">Mildred Cho, \u003c/a>a bioethicist at Stanford University. She sees a huge potential for breakthroughs in gene editing, but also the possibility of misuse. \"And we haven't really had the conversation about widespread release of organisms that we won't be able to get back once they're released into the environment.\" Cho, however, says it's not up to scientists to decide such things. \"So far, those discussions have not been very widespread outside of the expert communities.\"\u003c/p>\n\u003cfigure id=\"attachment_114670\" class=\"wp-caption alignright\" style=\"max-width: 240px\">\u003cimg class=\"size-full wp-image-114670\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/RS18524_IMG_8357-sfi.jpg\" alt=\"Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \" width=\"240\" height=\"360\">\u003cfigcaption class=\"wp-caption-text\">Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Yet Silicon Valley and the local biotech community are forging ahead. In San Francisco's Mission Bay neighborhood, \u003ca href=\"https://www.twistbioscience.com/\" target=\"_blank\">Twist Bioscience\u003c/a> is making the components of DNA and RNA that companies and academic researchers can use in their synthetic biology experiments.\u003c/p>\n\u003cp>\"We started Twist to disrupt the DNA-writing market,\" says Emily Leproust, one of the co-founders. \"There is a massive demand. A huge demand.\"\u003c/p>\n\u003cp>Leproust says many drugs, antibiotics and vaccines begin from DNA, with engineered microbes used to make them. And in the area of industrial chemicals, many researchers and companies are modifying algae, yeast and E. coli to turn them into bio-factories that make specialty chemicals.\u003c/p>\n\u003cp>Twist doesn't disclose the names of its clients. And in the interest of safety, Twist executives say, they restrict what sequences of DNA they'll sell, and to whom. But there are lots of local labs and companies using DNA in this way, and they're raising boatloads of money.\u003c/p>\n\u003cp>According to CrunchBase.com, \u003ca href=\"http://www.zymergen.com/\" target=\"_blank\">Zymergen\u003c/a> in Emeryville has raised $44 million, \u003ca href=\"http://cariboubio.com/\" target=\"_blank\">Caribou Bioscience\u003c/a> in Berkeley $14 million, \u003ca href=\"http://www.sangamo.com/index.html\" target=\"_blank\">Sangamo BioSciences\u003c/a> in Richmond about $74 million, and Twist itself more than $130 million.\u003c/p>\n\u003cp>That's why, Leproust says, it's good, today, to be in bio.\u003c/p>\n\u003cp>\"If you were in the '50s, you wanted to be in space and aeronautics and in the '90s you wanted to be in computers. And nowadays you want to be in biology because that's where the next big economic growth is going to come from.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Time will tell. But local startups are betting and betting big on the new generation of gene editing.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/114619/gene-editing-coming-to-a-kitchen-counter-near-you","authors":["11088"],"categories":["futureofyou_1","futureofyou_73"],"tags":["futureofyou_94","futureofyou_295","futureofyou_120","futureofyou_80","futureofyou_772"],"featImg":"futureofyou_114773","label":"futureofyou"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.","airtime":"THU 10pm, FRI 1am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.commonwealthclub.org/podcasts","meta":{"site":"news","source":"Commonwealth Club of California"},"link":"/radio/program/commonwealth-club","subscribe":{"apple":"https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2","google":"https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw","tuneIn":"https://tunein.com/radio/Commonwealth-Club-of-California-p1060/"}},"considerthis":{"id":"considerthis","title":"Consider This","tagline":"Make sense of the day","info":"Make sense of the day. Every weekday afternoon, Consider This helps you consider the major stories of the day in less than 15 minutes, featuring the reporting and storytelling resources of NPR. Plus, KQED’s Bianca Taylor brings you the local KQED news you need to know.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Consider-This-Podcast-Tile-703x703-1.jpg","imageAlt":"Consider This from NPR and KQED","officialWebsiteLink":"/podcasts/considerthis","meta":{"site":"news","source":"kqed","order":"7"},"link":"/podcasts/considerthis","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1503226625?mt=2&at=11l79Y&ct=nprdirectory","npr":"https://rpb3r.app.goo.gl/coronavirusdaily","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM1NS9wb2RjYXN0LnhtbA","spotify":"https://open.spotify.com/show/3Z6JdCS2d0eFEpXHKI6WqH"}},"forum":{"id":"forum","title":"Forum","tagline":"The conversation starts here","info":"KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.","airtime":"MON-FRI 9am-11am, 10pm-11pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED Forum with Mina Kim and Alexis Madrigal","officialWebsiteLink":"/forum","meta":{"site":"news","source":"kqed","order":"8"},"link":"/forum","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/kqeds-forum/id73329719","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz","npr":"https://www.npr.org/podcasts/432307980/forum","stitcher":"https://www.stitcher.com/podcast/kqedfm-kqeds-forum-podcast","rss":"https://feeds.megaphone.fm/KQINC9557381633"}},"freakonomics-radio":{"id":"freakonomics-radio","title":"Freakonomics Radio","info":"Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. It is produced in partnership with WNYC.","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/freakonomicsRadio.png","officialWebsiteLink":"http://freakonomics.com/","airtime":"SUN 1am-2am, SAT 3pm-4pm","meta":{"site":"radio","source":"WNYC"},"link":"/radio/program/freakonomics-radio","subscribe":{"npr":"https://rpb3r.app.goo.gl/4s8b","apple":"https://itunes.apple.com/us/podcast/freakonomics-radio/id354668519","tuneIn":"https://tunein.com/podcasts/WNYC-Podcasts/Freakonomics-Radio-p272293/","rss":"https://feeds.feedburner.com/freakonomicsradio"}},"fresh-air":{"id":"fresh-air","title":"Fresh Air","info":"Hosted by Terry Gross, \u003cem>Fresh Air from WHYY\u003c/em> is the Peabody Award-winning weekday magazine of contemporary arts and issues. One of public radio's most popular programs, Fresh Air features intimate conversations with today's biggest luminaries.","airtime":"MON-FRI 7pm-8pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Fresh-Air-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/fresh-air/","meta":{"site":"radio","source":"npr"},"link":"/radio/program/fresh-air","subscribe":{"npr":"https://rpb3r.app.goo.gl/4s8b","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=214089682&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/Fresh-Air-p17/","rss":"https://feeds.npr.org/381444908/podcast.xml"}},"here-and-now":{"id":"here-and-now","title":"Here & Now","info":"A live production of NPR and WBUR Boston, in collaboration with stations across the country, Here & Now reflects the fluid world of news as it's happening in the middle of the day, with timely, in-depth news, interviews and conversation. Hosted by Robin Young, Jeremy Hobson and Tonya Mosley.","airtime":"MON-THU 11am-12pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Here-And-Now-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"http://www.wbur.org/hereandnow","meta":{"site":"news","source":"npr"},"link":"/radio/program/here-and-now","subsdcribe":{"apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=426698661","tuneIn":"https://tunein.com/radio/Here--Now-p211/","rss":"https://feeds.npr.org/510051/podcast.xml"}},"how-i-built-this":{"id":"how-i-built-this","title":"How I Built This with Guy Raz","info":"Guy Raz dives into the stories behind some of the world's best known companies. How I Built This weaves a narrative journey about innovators, entrepreneurs and idealists—and the movements they built.","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/howIBuiltThis.png","officialWebsiteLink":"https://www.npr.org/podcasts/510313/how-i-built-this","airtime":"SUN 7:30pm-8pm","meta":{"site":"news","source":"npr"},"link":"/radio/program/how-i-built-this","subscribe":{"npr":"https://rpb3r.app.goo.gl/3zxy","apple":"https://itunes.apple.com/us/podcast/how-i-built-this-with-guy-raz/id1150510297?mt=2","tuneIn":"https://tunein.com/podcasts/Arts--Culture-Podcasts/How-I-Built-This-p910896/","rss":"https://feeds.npr.org/510313/podcast.xml"}},"inside-europe":{"id":"inside-europe","title":"Inside Europe","info":"Inside Europe, a one-hour weekly news magazine hosted by Helen Seeney and Keith Walker, explores the topical issues shaping the continent. 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