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2016","publishDate":1484072779,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp class=\"p1\">\u003cspan class=\"s1\">Two thousand and sixteen was a big year for genetics, and there was no bigger story than everyone’s favorite gene-editing tool, \u003ca href=\"http://genetics.thetech.org/ask-a-geneticist/why-crispr-revolutionary-and-how-it-works\">CRISPR-Cas9\u003c/a>. But that wasn’t the only story: A “three-parent baby” was born in Mexico, the minimum number of genes needed for bacterial life was determined, gene drives were tentatively approved for dealing with the Zika virus, and four species of giraffes were identified based on DNA alone. And there were many more.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Here's the rundown of our top stories.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">\u003cb>The Many Tales of CRISPR-Cas9\u003c/b>\u003c/span>\u003c/p>\n\u003cp class=\"p1\">For the last couple of years, there's been a lot of news about tweaking genes using the CRISPR-Cas9 system. In 2016, scientists began to use this cutting-edge gene-editing tool in earnest.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Last year was the first time that CRISPR-Cas9 was \u003ca href=\"http://www.nature.com/news/crispr-gene-editing-tested-in-a-person-for-the-first-time-1.20988\">\u003cspan class=\"s2\">directly used to treat a disease\u003c/span>\u003c/a> in a patient. In late October, Dr. Lu You of Sichuan University in Chengdu, China used CRISPR-Cas9 to change the DNA in a patient’s immune cells so that these cells would attack the patient’s cancer. This approach is called immunotherapy--a \u003ca href=\"http://www.cnn.com/2016/10/26/health/immunotherapy-cancer-treatments/\">\u003cspan class=\"s2\">big story all on its own\u003c/span>\u003c/a>.\u003c/span>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp class=\"p1\">What these researchers did was to remove immune cells from the patient and knock out their PD-1 gene, which can incorrectly determine that cancer cells are not a threat. Removing the gene should theoretically help the immune cells recognize and destroy cancer cells. The researchers grew the modified cells in the lab and then injected them back into the patient. While it is too soon to know if the treatment is effective, we do know that -- so far at least-- the patient hasn't experienced any negative effects.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Last year, for only the second time, \u003ca href=\"http://www.nature.com/news/second-chinese-team-reports-gene-editing-in-human-embryos-1.19718\">\u003cspan class=\"s2\">researchers “successfully” changed DNA in human embryos\u003c/span>\u003c/a> using CRISPR-Cas9. (The first time was way back in 2015.) The researchers purposely used nonviable embryos, which were not transferred into a womb.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">The reason I included the quotation marks is that gene editing human embryos is still very much a work in progress. Only four of the 26 embryos were successfully edited. And the results were not identical even in these four; some had additional mutations in the targeted gene. \u003c/span>\u003cspan class=\"s1\">These mixed results emphasize how much more work needs to be done before editing human embryos can become routine.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">And of course, the \u003ca href=\"https://ww2.kqed.org/futureofyou/2016/01/15/crispr-patent-war-billions-at-stake-for-uc-berkeley/\">\u003cspan class=\"s2\">CRISPR-Cas9 patent war\u003c/span>\u003c/a> between UC Berkeley and the Broad Institute of Harvard and MIT continued to rage on. Whoever wins stands to make a whole lot of money, which makes this a very nasty, ongoing battle unlikely to end soon. \u003c/span>\u003c/p>\n\u003cp>CRISPR-Cas9 even became a player in the GMO field. The \u003ca href=\"https://www.washingtonpost.com/news/speaking-of-science/wp/2016/04/18/why-this-genetically-modified-mushroom-is-bypassing-usda-regulation/?utm_term=.1af905912360\">\u003cspan class=\"s2\">FDA ruled\u003c/span>\u003c/a> that a mushroom with a gene that had been modified with CRISPR-Cas9 didn’t need to jump through the usual regulatory hoops that a genetically modified organism has to.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Another big story last year, gene drives, owes its existence to CRISPR-Cas9:\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">\u003cb>Gene Drives, Mosquitoes and Zika\u003c/b>\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Last year, the Zika virus spread like wildfire across South and Central America, leaving over 1,000 babies with the birth defect microcephaly.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Scientists are working on a number of ways to prevent Zika infections. The most controversial is to wipe out the mosquito that carries the virus using \u003ca href=\"http://genetics.thetech.org/driving-genes-wild\">gene drives\u003c/a>. \u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Gene drives use CRISPR-Cas9 to quickly and easily spread a harmful gene through a population. In this case the idea would be to destroy the population of mosquitoes that carry the Zika virus. \u003c/span>\u003c/p>\n\u003cp class=\"p1\">This method was given \u003ca href=\"http://www.forbes.com/sites/robertglatter/2016/03/14/fda-grants-tentative-approval-for-gmo-mosquito-trial-in-florida-keys/\">\u003cspan class=\"s2\">tentative approval by the FDA\u003c/span>\u003c/a> back in March 2016, but it has not yet been used, as\u003ca href=\"http://blogs.plos.org/scicomm/2016/11/09/as-florida-voters-are-asked-to-weigh-in-on-a-gm-mosquito-field-trial-where-is-and-isnt-the-science-of-zika-virus-control/\"> many Florida residents strongly oppose it\u003c/a>.\u003c/p>\n\u003cp class=\"p1\">Gene drives were mostly theoretical until CRISPR-Cas9 came along to make them a relatively simple thing to make. In fact, so simple that a group of undergraduate students \u003ca href=\"http://gizmodo.com/college-students-show-how-easy-it-is-to-use-terrifying-1790526457\">\u003cspan class=\"s2\">nearly pulled it off\u003c/span>\u003c/a> at the end of 2016.\u003c/p>\n\u003cp class=\"p1\">\u003cb>Child With Three Parents\u003c/b>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">In 2015, a big controversy swirled around whether to \u003ca href=\"http://genetics.thetech.org/ask/ask70\">\u003cspan class=\"s2\">restart\u003c/span>\u003c/a> a genetic technique that allows some women who carry mitochondrial diseases to have children without passing them on to their kids. In 2016 \u003ca href=\"https://www.newscientist.com/article/2107219-exclusive-worlds-first-baby-born-with-new-3-parent-technique/\">\u003cspan class=\"s2\">a healthy baby boy was born\u003c/span>\u003c/a> in Mexico using this technique.\u003c/span>\u003c/p>\n\u003cp>The technique is controversial for a couple of reasons. First, any girls born will pass their genetically engineered DNA down to their children. This has always been an ethics no-fly zone, as the feeling is that whatever genetic modification we make in a person should stay in that person. Because the woman in Mexico had a son, the issue was sidestepped.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">The other controversy is that this boy has DNA from three people instead of the usual two. \u003c/span>\u003c/p>\n\u003cfigure id=\"attachment_316963\" class=\"wp-caption aligncenter\" style=\"max-width: 500px\">\u003cimg class=\"wp-image-316963 size-full\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/01/3parent.jpg\" alt=\"This egg is now fertilized with dad's sperm.\" width=\"500\" height=\"335\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent.jpg 500w, https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent-160x107.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent-240x161.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent-375x251.jpg 375w\" sizes=\"(max-width: 500px) 100vw, 500px\">\u003cfigcaption class=\"wp-caption-text\">This egg is now fertilized with dad's sperm. (Image by Barry Starr)\u003c/figcaption>\u003c/figure>\n\u003cp class=\"p1\">The child has mitochondria, and thus mitochondrial DNA, from the donor, along with DNA from his mom and dad. (Mitochondria are the organelles that supply our cells with energy; they have a bit of DNA all their own.) Although this is referred to as having three parents, that might be a bit of an overstatement. After all, s\u003cspan class=\"s1\">omething like 1/300,000\u003c/span>\u003cspan class=\"s3\">\u003csup>th\u003c/sup>\u003c/span>\u003cspan class=\"s1\"> of the child's DNA comes from the donor, with the rest coming from the mother and father. If the donor is a parent, she is a very minor one indeed.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cb>The Edge of Life\u003c/b>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">With the exception of viruses, most life has evolved with a thousand or more genes.Humans have somewhere around 22,000 genes; the humble yeast that gives beer and wine its alcohol has around 6,000; and the bacterium with the fewest known number of genes has 901.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">In 2016 a group of researchers was able to show that this last bacterium could get by \u003ca href=\"https://www.sciencenews.org/article/scientists-build-minimum-genome-bacterium\">\u003cspan class=\"s2\">with only 473 genes\u003c/span>\u003c/a>. This is the bare bones machinery needed to keep a bacterium going.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">What is cool is that we would not have been able to predict that these were the 473 a bacterium would need. We don’t even know what 143 of them do... .\u003c/span>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp class=\"p1\">Genetics is bound to be a hot topic in 2017 as well. Stay tuned.\u003c/p>\n\n","blocks":[],"excerpt":"From CRISPR to gene drives, 2016 was a very potent year in the field of genetics.","status":"publish","parent":0,"modified":1484086185,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":4,"wordCount":1046},"headData":{"title":"Most Important Genetics Stories 2016 | KQED","description":"From CRISPR to gene drives, 2016 was a very potent year in the field of genetics.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Most Important Genetics Stories 2016","datePublished":"2017-01-10T18:26:19.000Z","dateModified":"2017-01-10T22:09:45.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"315823 http://ww2.kqed.org/futureofyou/?p=315823","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/01/10/most-important-genetics-stories-2016/","disqusTitle":"Most Important Genetics Stories 2016","source":"KQED Future of You","nprByline":"Barry Starr","path":"/futureofyou/315823/most-important-genetics-stories-2016","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp class=\"p1\">\u003cspan class=\"s1\">Two thousand and sixteen was a big year for genetics, and there was no bigger story than everyone’s favorite gene-editing tool, \u003ca href=\"http://genetics.thetech.org/ask-a-geneticist/why-crispr-revolutionary-and-how-it-works\">CRISPR-Cas9\u003c/a>. But that wasn’t the only story: A “three-parent baby” was born in Mexico, the minimum number of genes needed for bacterial life was determined, gene drives were tentatively approved for dealing with the Zika virus, and four species of giraffes were identified based on DNA alone. And there were many more.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Here's the rundown of our top stories.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">\u003cb>The Many Tales of CRISPR-Cas9\u003c/b>\u003c/span>\u003c/p>\n\u003cp class=\"p1\">For the last couple of years, there's been a lot of news about tweaking genes using the CRISPR-Cas9 system. In 2016, scientists began to use this cutting-edge gene-editing tool in earnest.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Last year was the first time that CRISPR-Cas9 was \u003ca href=\"http://www.nature.com/news/crispr-gene-editing-tested-in-a-person-for-the-first-time-1.20988\">\u003cspan class=\"s2\">directly used to treat a disease\u003c/span>\u003c/a> in a patient. In late October, Dr. Lu You of Sichuan University in Chengdu, China used CRISPR-Cas9 to change the DNA in a patient’s immune cells so that these cells would attack the patient’s cancer. This approach is called immunotherapy--a \u003ca href=\"http://www.cnn.com/2016/10/26/health/immunotherapy-cancer-treatments/\">\u003cspan class=\"s2\">big story all on its own\u003c/span>\u003c/a>.\u003c/span>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp class=\"p1\">What these researchers did was to remove immune cells from the patient and knock out their PD-1 gene, which can incorrectly determine that cancer cells are not a threat. Removing the gene should theoretically help the immune cells recognize and destroy cancer cells. The researchers grew the modified cells in the lab and then injected them back into the patient. While it is too soon to know if the treatment is effective, we do know that -- so far at least-- the patient hasn't experienced any negative effects.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Last year, for only the second time, \u003ca href=\"http://www.nature.com/news/second-chinese-team-reports-gene-editing-in-human-embryos-1.19718\">\u003cspan class=\"s2\">researchers “successfully” changed DNA in human embryos\u003c/span>\u003c/a> using CRISPR-Cas9. (The first time was way back in 2015.) The researchers purposely used nonviable embryos, which were not transferred into a womb.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">The reason I included the quotation marks is that gene editing human embryos is still very much a work in progress. Only four of the 26 embryos were successfully edited. And the results were not identical even in these four; some had additional mutations in the targeted gene. \u003c/span>\u003cspan class=\"s1\">These mixed results emphasize how much more work needs to be done before editing human embryos can become routine.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">And of course, the \u003ca href=\"https://ww2.kqed.org/futureofyou/2016/01/15/crispr-patent-war-billions-at-stake-for-uc-berkeley/\">\u003cspan class=\"s2\">CRISPR-Cas9 patent war\u003c/span>\u003c/a> between UC Berkeley and the Broad Institute of Harvard and MIT continued to rage on. Whoever wins stands to make a whole lot of money, which makes this a very nasty, ongoing battle unlikely to end soon. \u003c/span>\u003c/p>\n\u003cp>CRISPR-Cas9 even became a player in the GMO field. The \u003ca href=\"https://www.washingtonpost.com/news/speaking-of-science/wp/2016/04/18/why-this-genetically-modified-mushroom-is-bypassing-usda-regulation/?utm_term=.1af905912360\">\u003cspan class=\"s2\">FDA ruled\u003c/span>\u003c/a> that a mushroom with a gene that had been modified with CRISPR-Cas9 didn’t need to jump through the usual regulatory hoops that a genetically modified organism has to.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Another big story last year, gene drives, owes its existence to CRISPR-Cas9:\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">\u003cb>Gene Drives, Mosquitoes and Zika\u003c/b>\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Last year, the Zika virus spread like wildfire across South and Central America, leaving over 1,000 babies with the birth defect microcephaly.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Scientists are working on a number of ways to prevent Zika infections. The most controversial is to wipe out the mosquito that carries the virus using \u003ca href=\"http://genetics.thetech.org/driving-genes-wild\">gene drives\u003c/a>. \u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">Gene drives use CRISPR-Cas9 to quickly and easily spread a harmful gene through a population. In this case the idea would be to destroy the population of mosquitoes that carry the Zika virus. \u003c/span>\u003c/p>\n\u003cp class=\"p1\">This method was given \u003ca href=\"http://www.forbes.com/sites/robertglatter/2016/03/14/fda-grants-tentative-approval-for-gmo-mosquito-trial-in-florida-keys/\">\u003cspan class=\"s2\">tentative approval by the FDA\u003c/span>\u003c/a> back in March 2016, but it has not yet been used, as\u003ca href=\"http://blogs.plos.org/scicomm/2016/11/09/as-florida-voters-are-asked-to-weigh-in-on-a-gm-mosquito-field-trial-where-is-and-isnt-the-science-of-zika-virus-control/\"> many Florida residents strongly oppose it\u003c/a>.\u003c/p>\n\u003cp class=\"p1\">Gene drives were mostly theoretical until CRISPR-Cas9 came along to make them a relatively simple thing to make. In fact, so simple that a group of undergraduate students \u003ca href=\"http://gizmodo.com/college-students-show-how-easy-it-is-to-use-terrifying-1790526457\">\u003cspan class=\"s2\">nearly pulled it off\u003c/span>\u003c/a> at the end of 2016.\u003c/p>\n\u003cp class=\"p1\">\u003cb>Child With Three Parents\u003c/b>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">In 2015, a big controversy swirled around whether to \u003ca href=\"http://genetics.thetech.org/ask/ask70\">\u003cspan class=\"s2\">restart\u003c/span>\u003c/a> a genetic technique that allows some women who carry mitochondrial diseases to have children without passing them on to their kids. In 2016 \u003ca href=\"https://www.newscientist.com/article/2107219-exclusive-worlds-first-baby-born-with-new-3-parent-technique/\">\u003cspan class=\"s2\">a healthy baby boy was born\u003c/span>\u003c/a> in Mexico using this technique.\u003c/span>\u003c/p>\n\u003cp>The technique is controversial for a couple of reasons. First, any girls born will pass their genetically engineered DNA down to their children. This has always been an ethics no-fly zone, as the feeling is that whatever genetic modification we make in a person should stay in that person. Because the woman in Mexico had a son, the issue was sidestepped.\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">The other controversy is that this boy has DNA from three people instead of the usual two. \u003c/span>\u003c/p>\n\u003cfigure id=\"attachment_316963\" class=\"wp-caption aligncenter\" style=\"max-width: 500px\">\u003cimg class=\"wp-image-316963 size-full\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/01/3parent.jpg\" alt=\"This egg is now fertilized with dad's sperm.\" width=\"500\" height=\"335\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent.jpg 500w, https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent-160x107.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent-240x161.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/01/3parent-375x251.jpg 375w\" sizes=\"(max-width: 500px) 100vw, 500px\">\u003cfigcaption class=\"wp-caption-text\">This egg is now fertilized with dad's sperm. (Image by Barry Starr)\u003c/figcaption>\u003c/figure>\n\u003cp class=\"p1\">The child has mitochondria, and thus mitochondrial DNA, from the donor, along with DNA from his mom and dad. (Mitochondria are the organelles that supply our cells with energy; they have a bit of DNA all their own.) Although this is referred to as having three parents, that might be a bit of an overstatement. After all, s\u003cspan class=\"s1\">omething like 1/300,000\u003c/span>\u003cspan class=\"s3\">\u003csup>th\u003c/sup>\u003c/span>\u003cspan class=\"s1\"> of the child's DNA comes from the donor, with the rest coming from the mother and father. If the donor is a parent, she is a very minor one indeed.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cb>The Edge of Life\u003c/b>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">With the exception of viruses, most life has evolved with a thousand or more genes.Humans have somewhere around 22,000 genes; the humble yeast that gives beer and wine its alcohol has around 6,000; and the bacterium with the fewest known number of genes has 901.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">In 2016 a group of researchers was able to show that this last bacterium could get by \u003ca href=\"https://www.sciencenews.org/article/scientists-build-minimum-genome-bacterium\">\u003cspan class=\"s2\">with only 473 genes\u003c/span>\u003c/a>. This is the bare bones machinery needed to keep a bacterium going.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan class=\"s1\">What is cool is that we would not have been able to predict that these were the 473 a bacterium would need. We don’t even know what 143 of them do... .\u003c/span>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp class=\"p1\">Genetics is bound to be a hot topic in 2017 as well. Stay tuned.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/315823/most-important-genetics-stories-2016","authors":["byline_futureofyou_315823"],"categories":["futureofyou_452","futureofyou_1","futureofyou_73","futureofyou_1064"],"tags":["futureofyou_94","futureofyou_1158","futureofyou_120"],"featImg":"futureofyou_316957","label":"source_futureofyou_315823"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.","airtime":"THU 10pm, FRI 1am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.commonwealthclub.org/podcasts","meta":{"site":"news","source":"Commonwealth Club of California"},"link":"/radio/program/commonwealth-club","subscribe":{"apple":"https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2","google":"https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw","tuneIn":"https://tunein.com/radio/Commonwealth-Club-of-California-p1060/"}},"considerthis":{"id":"considerthis","title":"Consider This","tagline":"Make sense of the day","info":"Make sense of the day. Every weekday afternoon, Consider This helps you consider the major stories of the day in less than 15 minutes, featuring the reporting and storytelling resources of NPR. Plus, KQED’s Bianca Taylor brings you the local KQED news you need to know.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Consider-This-Podcast-Tile-703x703-1.jpg","imageAlt":"Consider This from NPR and KQED","officialWebsiteLink":"/podcasts/considerthis","meta":{"site":"news","source":"kqed","order":"7"},"link":"/podcasts/considerthis","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1503226625?mt=2&at=11l79Y&ct=nprdirectory","npr":"https://rpb3r.app.goo.gl/coronavirusdaily","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM1NS9wb2RjYXN0LnhtbA","spotify":"https://open.spotify.com/show/3Z6JdCS2d0eFEpXHKI6WqH"}},"forum":{"id":"forum","title":"Forum","tagline":"The conversation starts here","info":"KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.","airtime":"MON-FRI 9am-11am, 10pm-11pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED Forum with Mina Kim and Alexis Madrigal","officialWebsiteLink":"/forum","meta":{"site":"news","source":"kqed","order":"8"},"link":"/forum","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/kqeds-forum/id73329719","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz","npr":"https://www.npr.org/podcasts/432307980/forum","stitcher":"https://www.stitcher.com/podcast/kqedfm-kqeds-forum-podcast","rss":"https://feeds.megaphone.fm/KQINC9557381633"}},"freakonomics-radio":{"id":"freakonomics-radio","title":"Freakonomics Radio","info":"Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. It is produced in partnership with WNYC.","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/freakonomicsRadio.png","officialWebsiteLink":"http://freakonomics.com/","airtime":"SUN 1am-2am, SAT 3pm-4pm","meta":{"site":"radio","source":"WNYC"},"link":"/radio/program/freakonomics-radio","subscribe":{"npr":"https://rpb3r.app.goo.gl/4s8b","apple":"https://itunes.apple.com/us/podcast/freakonomics-radio/id354668519","tuneIn":"https://tunein.com/podcasts/WNYC-Podcasts/Freakonomics-Radio-p272293/","rss":"https://feeds.feedburner.com/freakonomicsradio"}},"fresh-air":{"id":"fresh-air","title":"Fresh Air","info":"Hosted by Terry Gross, \u003cem>Fresh Air from WHYY\u003c/em> is the Peabody Award-winning weekday magazine of contemporary arts and issues. One of public radio's most popular programs, Fresh Air features intimate conversations with today's biggest luminaries.","airtime":"MON-FRI 7pm-8pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Fresh-Air-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/fresh-air/","meta":{"site":"radio","source":"npr"},"link":"/radio/program/fresh-air","subscribe":{"npr":"https://rpb3r.app.goo.gl/4s8b","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=214089682&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/Fresh-Air-p17/","rss":"https://feeds.npr.org/381444908/podcast.xml"}},"here-and-now":{"id":"here-and-now","title":"Here & Now","info":"A live production of NPR and WBUR Boston, in collaboration with stations across the country, Here & Now reflects the fluid world of news as it's happening in the middle of the day, with timely, in-depth news, interviews and conversation. 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