Therapy Made From Patient's Immune System Shows Promise For Advanced Breast Cancer
New Immune Treatment Eliminated Tumors in 97 Percent of Mice
Bay Area Scientists Say Computers Can Develop Cancer Drugs 6 Times Faster
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She is a 2013 graduate of Brooklyn Law School and is currently researching war on terror prosecutions for an upcoming book.","avatar":"https://secure.gravatar.com/avatar/c8b48ebc98e770640f3013c470d23f3e?s=600&d=blank&r=g","twitter":"amelscript","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"futureofyou","roles":["editor"]},{"site":"science","roles":["editor"]}],"headData":{"title":"Amel Ahmed | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/c8b48ebc98e770640f3013c470d23f3e?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/c8b48ebc98e770640f3013c470d23f3e?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/aahmed"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"futureofyou_442273":{"type":"posts","id":"futureofyou_442273","meta":{"index":"posts_1591205157","site":"futureofyou","id":"442273","score":null,"sort":[1528131660000]},"guestAuthors":[],"slug":"therapy-made-from-patients-immune-system-shows-promise-for-advanced-breast-cancer","title":"Therapy Made From Patient's Immune System Shows Promise For Advanced Breast Cancer","publishDate":1528131660,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>Doctors at the National Institutes of Health say they've apparently completely eradicated cancer from a patient who had untreatable, advanced breast cancer.[contextly_sidebar id=\"XBqZwaw0YLkXChOC5E9p7x7LlwjI87h0\"]\u003c/p>\n\u003cp>The case is raising hopes about a new way to harness the immune system to fight some of the most common cancers. The methods and the patient's experience are described Monday in a \u003ca href=\"https://www.nature.com/articles/s41591-018-0040-8\">paper\u003c/a> published in the journal \u003cem>Nature Medicine\u003c/em>.\u003c/p>\n\u003cp>\"We're looking for a treatment — an immunotherapy — that can be broadly used in patients with common cancers,\" says \u003ca href=\"https://ccr.cancer.gov/Surgery-Branch/steven-a-rosenberg\">Dr. Steven Rosenberg\u003c/a>, an oncologist and immunologist at the National Cancer Institute, who has been developing the approach.\u003c/p>\n\u003cp>Rosenberg's team painstakingly analyzes the DNA in a sample of each patient's cancer for mutations specific to their malignancies. Next, scientists sift through tumor tissue for immune system cells known as \u003ca href=\"https://www.cancer.gov/publications/dictionaries/cancer-terms/def/t-cell\">T cells\u003c/a> that appear programmed to home in on those mutations.\u003c/p>\n\u003cp>But Rosenberg and others caution that the approach doesn't work for everyone. In fact, it failed for two other breast cancer patients. Many more patients will have to be treated — and followed for much longer — to fully evaluate the treatment's effectiveness, the scientists say.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Still, the treatment has helped seven of 45 patients with a variety of cancers, Rosenberg says. That's a response rate of about 15 percent, and included patients with advanced cases of colon cancer, liver cancer and cervical cancer.\u003c/p>\n\u003cp>\"Is it ready for prime time today? No,\" Rosenberg says.\"Can we do it in most patients today? No.\"\u003c/p>\n\u003cp>But the treatment continues to be improved. \"I think it's the most promising treatment now being explored for solving the problem of the treatment of metastatic, common cancers,\" he says.\u003c/p>\n\u003cp>The breast cancer patient helped by the treatment says it transformed her life.\u003c/p>\n\u003cp>\"It's amazing,\" says Judy Perkins, 52, a retired engineer who lives in Port St. Lucie, Fla.[contextly_sidebar id=\"LBQmSDLCPJe4N0too3CcLvpq1h2WnS7o\"]\u003c/p>\n\u003cp>When Perkins was first diagnosed and treated for breast cancer in 2003, she thought she'd beaten the disease. \"I thought I was done with it,\" she says.\u003c/p>\n\u003cp>But about a decade later, she felt a new lump. Doctors discovered the cancer had already spread throughout her chest. Her prognosis was grim.\u003c/p>\n\u003cp>\"I became a metastatic cancer patient,\" says Perkins. \"That was hard.\"\u003c/p>\n\u003cp>Perkins went through round after round of chemotherapy. She tried every experimental treatment she could find. But the cancer kept spreading. Some of her tumors grew to the size of tennis balls.\u003c/p>\n\u003cp>\"I had sort of essentially run out of arrows in my quiver,\" she says. \"While I would say I had some hope, I was also kind of like ready to quit, too.\"\u003c/p>\n\u003cp>Then she heard about the experimental treatment at the NIH. It was designed to fight some of the most common cancers, including breast cancer.\u003c/p>\n\u003cp>\"The excitement here is that we're attacking the very mutations that are unique to that cancer — in that patient's cancer and not in anybody else's cancer. So it's about as personalized a treatment as you can imagine,\" Rosenberg says.\u003c/p>\n\u003cp>His team identified and then grew billions of T cells for Perkins in the lab and then infused them back into her body. They also gave her two drugs to help the cells do their job.[contextly_sidebar id=\"7hRhhF6kMzZu5JjMty7K1k5yrQUh2pfA\"]\u003c/p>\n\u003cp>The treatment was grueling. Perkins says the hardest part was the side effects of a drug known as interleukin, which she received to help boost the effectiveness of the immune system cells. Interleukin causes severe flu-like symptoms, such as a high fever, intense malaise and uncontrollable shivering.\u003c/p>\n\u003cp>But the treatment apparently worked, Rosenberg reports. Perkins' tumors soon disappeared. And, more than two years later, she remains cancer-free.\u003c/p>\n\u003cp>\"All of her detectable disease has disappeared. It's remarkable,\" Rosenberg says.\u003c/p>\n\u003cp>Perkins is thrilled.\u003c/p>\n\u003cp>\"I'm one of the lucky ones,\" Perkins says. \"We got the right T cells in the right place at the right time. And they went in and ate up all my cancer. And I'm cured. It's freaking unreal.\"\u003c/p>\n\u003cp>In an \u003ca href=\"https://doi.org/10.1038/s41591-018-0065-z\">article\u003c/a> accompanying the new paper, \u003ca href=\"https://news.oicr.on.ca/2018/03/oicr-names-dr-laszlo-radvanyi-as-new-president-and-scientific-director/\">Laszlo Radvanyi\u003c/a>, president and scientific director of the Ontario Institute for Cancer Research, calls the results \"remarkable.\"\u003c/p>\n\u003cp>The approach and other recent advances suggest scientists may be \"at the cusp of a major revolution in finally realizing the elusive goal of being able to target the plethora of mutations in cancer through immunotherapy,\" Radvanyi writes.\u003c/p>\n\u003cp>Other cancer researchers agree.\u003c/p>\n\u003cp>\"When I saw this paper I thought: \"Whoa! I mean, it's very impressive,\" says \u003ca href=\"https://www.systemsbiology.org/bio/james-r-heath/\">James Heath\u003c/a>, president of the Institute for Systems Biology in Seattle.\u003c/p>\n\u003cp>\"One of the most exciting breakthroughs in biomedicine over the past decade has been activating the immune system against various cancers. But they have not been successful in breast cancer. Metastatic breast cancer is basically a death sentence,\" Heath says. \"And this shows that you can reverse it. It's a big deal.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>One key challenge will be to make the treatment easier, faster, and affordable, Rosenberg says. \"We're working literally around the clock to try to improve the treatment.\"\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2018 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"https://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Therapy+Made+From+Patient%27s+Immune+System+Shows+Promise+For+Advanced+Breast+Cancer&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n","blocks":[],"excerpt":"An experimental therapy seems to have eradicated cancer in a patient with metastatic breast cancer who had failed every other treatment. The goal is to reliably repeat that success in more people.","status":"publish","parent":0,"modified":1528135229,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":31,"wordCount":865},"headData":{"title":"Therapy Made From Patient's Immune System Shows Promise For Advanced Breast Cancer | KQED","description":"An experimental therapy seems to have eradicated cancer in a patient with metastatic breast cancer who had failed every other treatment. The goal is to reliably repeat that success in more people.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Therapy Made From Patient's Immune System Shows Promise For Advanced Breast Cancer","datePublished":"2018-06-04T17:01:00.000Z","dateModified":"2018-06-04T18:00:29.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"442273 https://ww2.kqed.org/futureofyou/?p=442273","disqusUrl":"https://ww2.kqed.org/futureofyou/2018/06/04/therapy-made-from-patients-immune-system-shows-promise-for-advanced-breast-cancer/","disqusTitle":"Therapy Made From Patient's Immune System Shows Promise For Advanced Breast Cancer","source":"Health","nprByline":"Rob Stein, NPR","nprImageAgency":"Courtesy of Judy Perkins","nprStoryId":"615673436","nprApiLink":"http://api.npr.org/query?id=615673436&apiKey=MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004","nprHtmlLink":"https://www.npr.org/sections/health-shots/2018/06/04/615673436/therapy-made-from-patients-immune-system-shows-promise-for-advanced-breast-cance?ft=nprml&f=615673436","nprRetrievedStory":"1","nprPubDate":"Mon, 04 Jun 2018 12:10:00 -0400","nprStoryDate":"Mon, 04 Jun 2018 11:02:00 -0400","nprLastModifiedDate":"Mon, 04 Jun 2018 12:10:02 -0400","path":"/futureofyou/442273/therapy-made-from-patients-immune-system-shows-promise-for-advanced-breast-cancer","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Doctors at the National Institutes of Health say they've apparently completely eradicated cancer from a patient who had untreatable, advanced breast cancer.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>The case is raising hopes about a new way to harness the immune system to fight some of the most common cancers. The methods and the patient's experience are described Monday in a \u003ca href=\"https://www.nature.com/articles/s41591-018-0040-8\">paper\u003c/a> published in the journal \u003cem>Nature Medicine\u003c/em>.\u003c/p>\n\u003cp>\"We're looking for a treatment — an immunotherapy — that can be broadly used in patients with common cancers,\" says \u003ca href=\"https://ccr.cancer.gov/Surgery-Branch/steven-a-rosenberg\">Dr. Steven Rosenberg\u003c/a>, an oncologist and immunologist at the National Cancer Institute, who has been developing the approach.\u003c/p>\n\u003cp>Rosenberg's team painstakingly analyzes the DNA in a sample of each patient's cancer for mutations specific to their malignancies. Next, scientists sift through tumor tissue for immune system cells known as \u003ca href=\"https://www.cancer.gov/publications/dictionaries/cancer-terms/def/t-cell\">T cells\u003c/a> that appear programmed to home in on those mutations.\u003c/p>\n\u003cp>But Rosenberg and others caution that the approach doesn't work for everyone. In fact, it failed for two other breast cancer patients. Many more patients will have to be treated — and followed for much longer — to fully evaluate the treatment's effectiveness, the scientists say.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Still, the treatment has helped seven of 45 patients with a variety of cancers, Rosenberg says. That's a response rate of about 15 percent, and included patients with advanced cases of colon cancer, liver cancer and cervical cancer.\u003c/p>\n\u003cp>\"Is it ready for prime time today? No,\" Rosenberg says.\"Can we do it in most patients today? No.\"\u003c/p>\n\u003cp>But the treatment continues to be improved. \"I think it's the most promising treatment now being explored for solving the problem of the treatment of metastatic, common cancers,\" he says.\u003c/p>\n\u003cp>The breast cancer patient helped by the treatment says it transformed her life.\u003c/p>\n\u003cp>\"It's amazing,\" says Judy Perkins, 52, a retired engineer who lives in Port St. Lucie, Fla.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>When Perkins was first diagnosed and treated for breast cancer in 2003, she thought she'd beaten the disease. \"I thought I was done with it,\" she says.\u003c/p>\n\u003cp>But about a decade later, she felt a new lump. Doctors discovered the cancer had already spread throughout her chest. Her prognosis was grim.\u003c/p>\n\u003cp>\"I became a metastatic cancer patient,\" says Perkins. \"That was hard.\"\u003c/p>\n\u003cp>Perkins went through round after round of chemotherapy. She tried every experimental treatment she could find. But the cancer kept spreading. Some of her tumors grew to the size of tennis balls.\u003c/p>\n\u003cp>\"I had sort of essentially run out of arrows in my quiver,\" she says. \"While I would say I had some hope, I was also kind of like ready to quit, too.\"\u003c/p>\n\u003cp>Then she heard about the experimental treatment at the NIH. It was designed to fight some of the most common cancers, including breast cancer.\u003c/p>\n\u003cp>\"The excitement here is that we're attacking the very mutations that are unique to that cancer — in that patient's cancer and not in anybody else's cancer. So it's about as personalized a treatment as you can imagine,\" Rosenberg says.\u003c/p>\n\u003cp>His team identified and then grew billions of T cells for Perkins in the lab and then infused them back into her body. They also gave her two drugs to help the cells do their job.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>The treatment was grueling. Perkins says the hardest part was the side effects of a drug known as interleukin, which she received to help boost the effectiveness of the immune system cells. Interleukin causes severe flu-like symptoms, such as a high fever, intense malaise and uncontrollable shivering.\u003c/p>\n\u003cp>But the treatment apparently worked, Rosenberg reports. Perkins' tumors soon disappeared. And, more than two years later, she remains cancer-free.\u003c/p>\n\u003cp>\"All of her detectable disease has disappeared. It's remarkable,\" Rosenberg says.\u003c/p>\n\u003cp>Perkins is thrilled.\u003c/p>\n\u003cp>\"I'm one of the lucky ones,\" Perkins says. \"We got the right T cells in the right place at the right time. And they went in and ate up all my cancer. And I'm cured. It's freaking unreal.\"\u003c/p>\n\u003cp>In an \u003ca href=\"https://doi.org/10.1038/s41591-018-0065-z\">article\u003c/a> accompanying the new paper, \u003ca href=\"https://news.oicr.on.ca/2018/03/oicr-names-dr-laszlo-radvanyi-as-new-president-and-scientific-director/\">Laszlo Radvanyi\u003c/a>, president and scientific director of the Ontario Institute for Cancer Research, calls the results \"remarkable.\"\u003c/p>\n\u003cp>The approach and other recent advances suggest scientists may be \"at the cusp of a major revolution in finally realizing the elusive goal of being able to target the plethora of mutations in cancer through immunotherapy,\" Radvanyi writes.\u003c/p>\n\u003cp>Other cancer researchers agree.\u003c/p>\n\u003cp>\"When I saw this paper I thought: \"Whoa! I mean, it's very impressive,\" says \u003ca href=\"https://www.systemsbiology.org/bio/james-r-heath/\">James Heath\u003c/a>, president of the Institute for Systems Biology in Seattle.\u003c/p>\n\u003cp>\"One of the most exciting breakthroughs in biomedicine over the past decade has been activating the immune system against various cancers. But they have not been successful in breast cancer. Metastatic breast cancer is basically a death sentence,\" Heath says. \"And this shows that you can reverse it. It's a big deal.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>One key challenge will be to make the treatment easier, faster, and affordable, Rosenberg says. \"We're working literally around the clock to try to improve the treatment.\"\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2018 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"https://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Therapy+Made+From+Patient%27s+Immune+System+Shows+Promise+For+Advanced+Breast+Cancer&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/442273/therapy-made-from-patients-immune-system-shows-promise-for-advanced-breast-cancer","authors":["byline_futureofyou_442273"],"categories":["futureofyou_1060","futureofyou_1062","futureofyou_1"],"tags":["futureofyou_264","futureofyou_1403","futureofyou_141","futureofyou_61","futureofyou_215"],"collections":["futureofyou_1093"],"featImg":"futureofyou_442274","label":"source_futureofyou_442273"},"futureofyou_440520":{"type":"posts","id":"futureofyou_440520","meta":{"index":"posts_1591205157","site":"futureofyou","id":"440520","score":null,"sort":[1522357217000]},"guestAuthors":[],"slug":"new-immune-treatment-eliminated-tumors-in-97-percent-of-mice","title":"New Immune Treatment Eliminated Tumors in 97 Percent of Mice","publishDate":1522357217,"format":"standard","headTitle":"Future of You | KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp class=\"p1\">A cutting-edge immune system treatment cured certain cancers in 97 percent of mice, and it didn’t require chemotherapy. The treatment is now headed for a human trial at the \u003ca href=\"http://med.stanford.edu/\" target=\"_blank\" rel=\"noopener\">Stanford University School of Medicine.\u003c/a>\u003c/p>\n\u003cp>[contextly_sidebar id=\"kQL3J5XDxpDn2B9MPaqB9jKa15YAzuFt\"]Stanford researchers looked at four types of tumors— breast cancer, colon cancer, lymphoma, and melanoma. The clinical trial will, however, be limited to individuals with low-grade lymphoma.\u003c/p>\n\u003cp>The \u003ca href=\"http://stm.sciencemag.org/content/10/426/eaan4488\" target=\"_blank\" rel=\"noopener\">study\u003c/a>, published in journal \u003ca href=\"http://stm.sciencemag.org/\" target=\"_blank\" rel=\"noopener\">Science Translational Medicine, \u003c/a>is part of a new wave of innovative cancer research focusing on the body's immune system. Recent developments in the field mark a watershed moment in cancer research, says Ronald Levy, a Stanford oncology professor and the study's senior author.\u003c/p>\n\u003cp>[contextly_sidebar id=\"bc7NJIwxkt2B4Cp42gfRjdCM1aSALuS5\"]The \u003ca href=\"http://med.stanford.edu/news/all-news/2018/01/cancer-vaccine-eliminates-tumors-in-mice.html\" target=\"_blank\" rel=\"noopener\">treatment\u003c/a> injects two immune stimulants directly into a tumor. The combination of stimulants activates the immune system's T-cells, the white blood cells responsible for fighting signs of infection in the body. In the successfully treated mice, the activated cells eliminated the entire tumor from the bodies of the mice.\u003c/p>\n\u003cp>\"It's really a very exciting time,\" says Levy. \"These successful therapies have come after decades of work in trying to make the immune system fight the cancer. And now that we know that it's possible, it has brought an enormous amount of interest and investment into the field.\"\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The side affects of the treatment are typically what you would expect from any injection — possible fever and soreness at the injection site.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>While the clinical trial has not yet started, Stanford Medical School researchers are currently accepting applications for volunteers and \u003ca href=\"http://med.stanford.edu/cancer/trials/vaccine.html\" target=\"_blank\" rel=\"noopener\">providing information\u003c/a> about the study.\u003c/p>\n\n","blocks":[],"excerpt":"Stanford prepares to launch a human trial with a promising new cancer treatment. ","status":"publish","parent":0,"modified":1522351892,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":8,"wordCount":281},"headData":{"title":"New Immune Treatment Eliminated Tumors in 97 Percent of Mice | KQED","description":"Stanford prepares to launch a human trial with a promising new cancer treatment. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"New Immune Treatment Eliminated Tumors in 97 Percent of Mice","datePublished":"2018-03-29T21:00:17.000Z","dateModified":"2018-03-29T19:31:32.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"440520 https://ww2.kqed.org/futureofyou/?p=440520","disqusUrl":"https://ww2.kqed.org/futureofyou/2018/03/29/new-immune-treatment-eliminated-tumors-in-97-percent-of-mice/","disqusTitle":"New Immune Treatment Eliminated Tumors in 97 Percent of Mice","source":"Hope/Hype","path":"/futureofyou/440520/new-immune-treatment-eliminated-tumors-in-97-percent-of-mice","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp class=\"p1\">A cutting-edge immune system treatment cured certain cancers in 97 percent of mice, and it didn’t require chemotherapy. The treatment is now headed for a human trial at the \u003ca href=\"http://med.stanford.edu/\" target=\"_blank\" rel=\"noopener\">Stanford University School of Medicine.\u003c/a>\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>Stanford researchers looked at four types of tumors— breast cancer, colon cancer, lymphoma, and melanoma. The clinical trial will, however, be limited to individuals with low-grade lymphoma.\u003c/p>\n\u003cp>The \u003ca href=\"http://stm.sciencemag.org/content/10/426/eaan4488\" target=\"_blank\" rel=\"noopener\">study\u003c/a>, published in journal \u003ca href=\"http://stm.sciencemag.org/\" target=\"_blank\" rel=\"noopener\">Science Translational Medicine, \u003c/a>is part of a new wave of innovative cancer research focusing on the body's immune system. Recent developments in the field mark a watershed moment in cancer research, says Ronald Levy, a Stanford oncology professor and the study's senior author.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>The \u003ca href=\"http://med.stanford.edu/news/all-news/2018/01/cancer-vaccine-eliminates-tumors-in-mice.html\" target=\"_blank\" rel=\"noopener\">treatment\u003c/a> injects two immune stimulants directly into a tumor. The combination of stimulants activates the immune system's T-cells, the white blood cells responsible for fighting signs of infection in the body. In the successfully treated mice, the activated cells eliminated the entire tumor from the bodies of the mice.\u003c/p>\n\u003cp>\"It's really a very exciting time,\" says Levy. \"These successful therapies have come after decades of work in trying to make the immune system fight the cancer. And now that we know that it's possible, it has brought an enormous amount of interest and investment into the field.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The side affects of the treatment are typically what you would expect from any injection — possible fever and soreness at the injection site.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>While the clinical trial has not yet started, Stanford Medical School researchers are currently accepting applications for volunteers and \u003ca href=\"http://med.stanford.edu/cancer/trials/vaccine.html\" target=\"_blank\" rel=\"noopener\">providing information\u003c/a> about the study.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/440520/new-immune-treatment-eliminated-tumors-in-97-percent-of-mice","authors":["11428"],"programs":["futureofyou_54"],"categories":["futureofyou_452","futureofyou_1062","futureofyou_1","futureofyou_73"],"tags":["futureofyou_103","futureofyou_1403","futureofyou_1189","futureofyou_141","futureofyou_61","futureofyou_327"],"collections":["futureofyou_1097"],"featImg":"futureofyou_440531","label":"source_futureofyou_440520"},"futureofyou_436544":{"type":"posts","id":"futureofyou_436544","meta":{"index":"posts_1591205157","site":"futureofyou","id":"436544","score":null,"sort":[1511884835000]},"guestAuthors":[],"slug":"bay-area-scientists-say-computers-can-develop-cancer-drugs-6-times-faster","title":"Bay Area Scientists Say Computers Can Develop Cancer Drugs 6 Times Faster","publishDate":1511884835,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>The average time to \u003ca href=\"http://njms.rutgers.edu/gsbs/olc/fmtm/resources/improvepharmaNatureDrugDisc.pdf\" target=\"_blank\" rel=\"noopener\">identify a new cancer\u003c/a> drug is six years. Since \u003ca href=\"https://www.cdc.gov/cancer/dcpc/data/types.htm\" target=\"_blank\" rel=\"noopener\">one of every four deaths\u003c/a> in the U.S. is due to cancer, a lot of lives could be saved if that drug development time could be cut down to just a year.\u003c/p>\n\u003cp>Cancer researchers at UCSF and computer scientists at Lawrence Livermore National Laboratory are \u003ca href=\"https://www.llnl.gov/news/public-private-consortium-aims-cut-preclinical-cancer-drug-discovery-six-years-just-one\" target=\"_blank\" rel=\"noopener\">partnering\u003c/a> with researchers from the National Cancer Institute's Frederick National Laboratory and pharmaceutical giant GlaxoSmithKline (GSK) in an attempt to do just that. Members of the consortium hope to use supercomputing power to significantly slash the time needed to\u003cstrong> \u003c/strong>screen potential cancer drugs and bring them to human trials.\u003c/p>\n\u003caside class=\"pullquote alignright\">'These projects were completely and utterly just a pipe dream 10 years ago.'\u003ccite>Aedin Culhane,\u003cbr>\nDana-Farber Cancer Institute\u003c/cite>\u003c/aside>\n\u003cp>\"We're rolling on this, and it's really exciting,\" says \u003ca href=\"http://cancer.ucsf.edu/people/profiles/ashworth_alan\" target=\"_blank\" rel=\"noopener\">Alan Ashworth\u003c/a>, president of the Helen Diller Family Comprehensive Cancer Center at UCSF. The university is committing $750,000 annually plus researchers and lab space, Ashworth says.\u003c/p>\n\u003cp>GSK is contributing a vast store of data concerning 2 million molecules that could lead to cancer drugs. The data trove also includes 500 compounds that failed in the development process. The combination of the huge data set with information on failed drugs will be key to training the project's algorithms to understand how compounds interact with the human body.\u003c/p>\n\u003cp>\u003cstrong>A Long Process\u003c/strong>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Ashworth was one of the scientists who, in 1995, discovered the gene BRCA2, which increases the risk of developing inherited breast cancer. It took 10 years from discovery of the drug to the treatment of cancer related to that mutation, he said, and another 9 years before the drug was licensed.\u003c/p>\n\u003cp>The reason cancer drug development can take so long is that most testing is done with actual molecules — millions of them in order to find one that might become an effective drug in treating a particular type of cancer.\u003c/p>\n\u003caside class=\"pullquote alignright\">'I honestly don’t see how throwing lots of computers at the problem will speed up preclinical cancer-drug discovery.'\u003ccite>Steven Salzberg, Johns Hopkins University\u003c/cite>\u003c/aside>\n\u003cp>For each molecule, researchers create dozens of iterations in a process called \"optimization,\" altering the molecule to find the most effective form. Chemists have to create every modification in the lab, so researchers can test each one for toxic effects and efficacy. Just one toxicology study on one molecule takes 18 months, says Michelle Arkin, an associate professor in the UCSF School of Pharmacy. If the molecule fails, you start over.\u003c/p>\n\u003cp>But if you could test these same molecules in a supercomputer programmed to understand the relevant biological relationships, it would significantly streamline the process — a computer can do in seconds what may take days or weeks in a lab.\u003c/p>\n\u003cp>The consortium, called ATOM, for Accelerating Therapeutics for Opportunities in Medicine, believes computing power has finally reached the point where it can aid in the process.\u003c/p>\n\u003cp>\"There's been a revolution in machine learning,\" says Jim Brase, the deputy associate director for computation at Lawrence Livermore National Laboratory.\u003c/p>\n\u003cp>[contextly_sidebar id=\"YVRKeVHRwPaovC2VxmUgK3PIxKAyVlyu\"]In the past, Brase says, when scientists wanted to analyze a large set of data, they had to tell the computer what interactions to search for in determining how a drug molecule might affect a specific protein in a particular type of tumor.\u003c/p>\n\u003cp>But now, Brase says, scientists believe they can teach a computer the fundamentals of biology so it can learn to identify which relationships might be effective and which could be useless or toxic.\u003c/p>\n\u003cp>Success will depend on scientists' ability to push computer learning to new levels.\u003c/p>\n\u003cp>Stacie Calad-Thomson, operations, planning and strategy director with GSK, says the consortium will take the first two years of the project to develop algorithms. After that, the goal is to identify an effective drug and take it to human trials -- all within one year.\u003c/p>\n\u003cp>The original data donated by GSK will remain private, says Mary Anne Rhyne, the company's director of corporate communications. But any resulting drug-testing tools will be made publicly available.\u003c/p>\n\u003cp>\u003cstrong>Reasons for Skepticism and Hope\u003c/strong>\u003c/p>\n\u003cp>The goals of computer-assisted drug development and personalized medicine have been around for a \u003ca href=\"https://web.archive.org/web/20080513083401/http://www.isgtw.org:80/?pid=1000993\" target=\"_blank\" rel=\"noopener\">long time, \u003c/a>and many of these efforts have disappointed.\u003c/p>\n\u003cp>Earlier this year \u003ca href=\"https://ww2.kqed.org/futureofyou/2017/09/06/ibm-pitched-its-watson-supercomputer-as-a-revolution-in-cancer-care-its-nowhere-close/\" target=\"_blank\" rel=\"noopener\">STAT\u003c/a>, as well as watchdog site\u003ca href=\"https://www.healthnewsreview.org/2017/02/md-anderson-cancer-centers-ibm-watson-project-fails-journalism-related/\" target=\"_blank\" rel=\"noopener\"> Health News Review, \u003c/a>reported on the failed collaboration between the M.D. Anderson Cancer Center and IBM's Watson, which sought to make personal cancer treatment recommendations and match patients to clinical trials. Behind the largely positive news coverage, the project did not work as hoped. (\u003ca href=\"https://medcitynews.com/2017/02/mayo-clinic-cio-ai-stuff-really-real/\" target=\"_blank\" rel=\"noopener\">Not everyone agrees\u003c/a> it's been a bust.)\u003c/p>\n\u003cp>Meanwhile, the company's \u003ca href=\"https://www.ibm.com/watson/health/life-sciences/drug-discovery/\" target=\"_blank\" rel=\"noopener\">Watson for Drug Discovery\u003c/a> program is hoping candidate drugs it identified as potential treatment for Parkinson's disease will prove to work. And IBM and Pfizer \u003ca href=\"https://www.forbes.com/sites/brucejapsen/2016/12/01/pfizer-partners-with-ibm-watson-to-advance-cancer-drug-discovery/#68904ce21b1e\" target=\"_blank\" rel=\"noopener\">announced a collaboration\u003c/a> in 2016 to use Watson to accelerate cancer drug discovery.\u003c/p>\n\u003cp>Dr. Steven Salzberg, director of the Center for Computational Biology at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins University, is skeptical of such supercomputing efforts.\u003c/p>\n\u003cp>\"I honestly don't see how throwing lots of computers at the problem will speed up preclinical cancer drug discovery,\" he says. \"It's the classic problem where when your only tool is a hammer, everything looks like a nail.\u003c/p>\n\u003cp>\"We all need computers for research, so that's good. But cutting drug discovery from 6 years down to 1? That sounds implausible to me.\"\u003c/p>\n\u003cp>But at the Dana-Farber Cancer Institute at Harvard, Aedin Culhane, who is also a researcher in the Department of Biostatistics, is more optimistic. Yes, the idea of computer-assisted drug discovery has been around for a long time, she says, but it's only now that it's finally matured.\u003c/p>\n\u003caside class=\"pullquote alignright\">'I think there are a confluence of things that give this a better shot now than we had in the past.'\u003ccite>John Baldoni, GlaxoSmithKline\u003c/cite>\u003c/aside>\n\u003cp>\"These projects were completely and utterly just a pipe dream 10 years ago,\" says Culhane. \"And now we have more and better data, and we're learning more day by day. Given good data, the machines can learn, and I'm very hopeful about it. Much more than I was 10 years ago.\"\u003c/p>\n\u003cp>She finds ATOM's intent to publish negative results especially interesting. \"Because that's something that is missing. Academics rarely publish negative results, and pharma even more so.\"\u003c/p>\n\u003cp>Re-examing old data in the light of new information, she says, can sometimes offer novel insights. Perhaps researchers misunderstood how a failed drug was working in the body the first time around; or maybe reviewing its off-target effects in light of new discoveries related to tumors will reveal a deeper understanding of biochemistry.\u003c/p>\n\u003cp>John Baldoni, senior vice president for computerized drug screening at GSK, says that not only are data more abundant, but the engineering required for computer-based analysis is more sophisticated.\u003c/p>\n\u003cp>He also believes researchers will be able to draw on software advancements in fields like facial recognition and dimensional analysis.\u003c/p>\n\u003cp>\"We have applications in other sectors that are analogous to the applications that we want to develop in the pharma sector,\" he said.\u003c/p>\n\u003cp>The technology is also starting to demonstrate results, according to Baldoni. He points to clinical testing of molecules discovered by computer algorithms from \u003ca href=\"http://www.nimbustx.com/\" target=\"_blank\" rel=\"noopener\">Nimbus Therapeutics\u003c/a>.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\"What I would say to a skeptic,\" he says, \"is 'You might be right.' But I hope they're not. I think there are a confluence of things that give this a better shot now than we had in the past.\"\u003c/p>\n\n","blocks":[],"excerpt":"Researchers at UCSF and Lawrence Livermore National Lab are partnering with GlaxoSmithKline in an attempt to use supercomputers to slash the screening time needed for potential cancer drugs.","status":"publish","parent":0,"modified":1512424181,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":34,"wordCount":1265},"headData":{"title":"Bay Area Scientists Say Computers Can Develop Cancer Drugs 6 Times Faster | KQED","description":"Researchers at UCSF and Lawrence Livermore National Lab are partnering with GlaxoSmithKline in an attempt to use supercomputers to slash the screening time needed for potential cancer drugs.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Bay Area Scientists Say Computers Can Develop Cancer Drugs 6 Times Faster","datePublished":"2017-11-28T16:00:35.000Z","dateModified":"2017-12-04T21:49:41.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"436544 https://ww2.kqed.org/futureofyou/?p=436544","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/11/28/bay-area-scientists-say-computers-can-develop-cancer-drugs-6-times-faster/","disqusTitle":"Bay Area Scientists Say Computers Can Develop Cancer Drugs 6 Times Faster","source":"KQED Future of You","path":"/futureofyou/436544/bay-area-scientists-say-computers-can-develop-cancer-drugs-6-times-faster","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>The average time to \u003ca href=\"http://njms.rutgers.edu/gsbs/olc/fmtm/resources/improvepharmaNatureDrugDisc.pdf\" target=\"_blank\" rel=\"noopener\">identify a new cancer\u003c/a> drug is six years. Since \u003ca href=\"https://www.cdc.gov/cancer/dcpc/data/types.htm\" target=\"_blank\" rel=\"noopener\">one of every four deaths\u003c/a> in the U.S. is due to cancer, a lot of lives could be saved if that drug development time could be cut down to just a year.\u003c/p>\n\u003cp>Cancer researchers at UCSF and computer scientists at Lawrence Livermore National Laboratory are \u003ca href=\"https://www.llnl.gov/news/public-private-consortium-aims-cut-preclinical-cancer-drug-discovery-six-years-just-one\" target=\"_blank\" rel=\"noopener\">partnering\u003c/a> with researchers from the National Cancer Institute's Frederick National Laboratory and pharmaceutical giant GlaxoSmithKline (GSK) in an attempt to do just that. Members of the consortium hope to use supercomputing power to significantly slash the time needed to\u003cstrong> \u003c/strong>screen potential cancer drugs and bring them to human trials.\u003c/p>\n\u003caside class=\"pullquote alignright\">'These projects were completely and utterly just a pipe dream 10 years ago.'\u003ccite>Aedin Culhane,\u003cbr>\nDana-Farber Cancer Institute\u003c/cite>\u003c/aside>\n\u003cp>\"We're rolling on this, and it's really exciting,\" says \u003ca href=\"http://cancer.ucsf.edu/people/profiles/ashworth_alan\" target=\"_blank\" rel=\"noopener\">Alan Ashworth\u003c/a>, president of the Helen Diller Family Comprehensive Cancer Center at UCSF. The university is committing $750,000 annually plus researchers and lab space, Ashworth says.\u003c/p>\n\u003cp>GSK is contributing a vast store of data concerning 2 million molecules that could lead to cancer drugs. The data trove also includes 500 compounds that failed in the development process. The combination of the huge data set with information on failed drugs will be key to training the project's algorithms to understand how compounds interact with the human body.\u003c/p>\n\u003cp>\u003cstrong>A Long Process\u003c/strong>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Ashworth was one of the scientists who, in 1995, discovered the gene BRCA2, which increases the risk of developing inherited breast cancer. It took 10 years from discovery of the drug to the treatment of cancer related to that mutation, he said, and another 9 years before the drug was licensed.\u003c/p>\n\u003cp>The reason cancer drug development can take so long is that most testing is done with actual molecules — millions of them in order to find one that might become an effective drug in treating a particular type of cancer.\u003c/p>\n\u003caside class=\"pullquote alignright\">'I honestly don’t see how throwing lots of computers at the problem will speed up preclinical cancer-drug discovery.'\u003ccite>Steven Salzberg, Johns Hopkins University\u003c/cite>\u003c/aside>\n\u003cp>For each molecule, researchers create dozens of iterations in a process called \"optimization,\" altering the molecule to find the most effective form. Chemists have to create every modification in the lab, so researchers can test each one for toxic effects and efficacy. Just one toxicology study on one molecule takes 18 months, says Michelle Arkin, an associate professor in the UCSF School of Pharmacy. If the molecule fails, you start over.\u003c/p>\n\u003cp>But if you could test these same molecules in a supercomputer programmed to understand the relevant biological relationships, it would significantly streamline the process — a computer can do in seconds what may take days or weeks in a lab.\u003c/p>\n\u003cp>The consortium, called ATOM, for Accelerating Therapeutics for Opportunities in Medicine, believes computing power has finally reached the point where it can aid in the process.\u003c/p>\n\u003cp>\"There's been a revolution in machine learning,\" says Jim Brase, the deputy associate director for computation at Lawrence Livermore National Laboratory.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>In the past, Brase says, when scientists wanted to analyze a large set of data, they had to tell the computer what interactions to search for in determining how a drug molecule might affect a specific protein in a particular type of tumor.\u003c/p>\n\u003cp>But now, Brase says, scientists believe they can teach a computer the fundamentals of biology so it can learn to identify which relationships might be effective and which could be useless or toxic.\u003c/p>\n\u003cp>Success will depend on scientists' ability to push computer learning to new levels.\u003c/p>\n\u003cp>Stacie Calad-Thomson, operations, planning and strategy director with GSK, says the consortium will take the first two years of the project to develop algorithms. After that, the goal is to identify an effective drug and take it to human trials -- all within one year.\u003c/p>\n\u003cp>The original data donated by GSK will remain private, says Mary Anne Rhyne, the company's director of corporate communications. But any resulting drug-testing tools will be made publicly available.\u003c/p>\n\u003cp>\u003cstrong>Reasons for Skepticism and Hope\u003c/strong>\u003c/p>\n\u003cp>The goals of computer-assisted drug development and personalized medicine have been around for a \u003ca href=\"https://web.archive.org/web/20080513083401/http://www.isgtw.org:80/?pid=1000993\" target=\"_blank\" rel=\"noopener\">long time, \u003c/a>and many of these efforts have disappointed.\u003c/p>\n\u003cp>Earlier this year \u003ca href=\"https://ww2.kqed.org/futureofyou/2017/09/06/ibm-pitched-its-watson-supercomputer-as-a-revolution-in-cancer-care-its-nowhere-close/\" target=\"_blank\" rel=\"noopener\">STAT\u003c/a>, as well as watchdog site\u003ca href=\"https://www.healthnewsreview.org/2017/02/md-anderson-cancer-centers-ibm-watson-project-fails-journalism-related/\" target=\"_blank\" rel=\"noopener\"> Health News Review, \u003c/a>reported on the failed collaboration between the M.D. Anderson Cancer Center and IBM's Watson, which sought to make personal cancer treatment recommendations and match patients to clinical trials. Behind the largely positive news coverage, the project did not work as hoped. (\u003ca href=\"https://medcitynews.com/2017/02/mayo-clinic-cio-ai-stuff-really-real/\" target=\"_blank\" rel=\"noopener\">Not everyone agrees\u003c/a> it's been a bust.)\u003c/p>\n\u003cp>Meanwhile, the company's \u003ca href=\"https://www.ibm.com/watson/health/life-sciences/drug-discovery/\" target=\"_blank\" rel=\"noopener\">Watson for Drug Discovery\u003c/a> program is hoping candidate drugs it identified as potential treatment for Parkinson's disease will prove to work. And IBM and Pfizer \u003ca href=\"https://www.forbes.com/sites/brucejapsen/2016/12/01/pfizer-partners-with-ibm-watson-to-advance-cancer-drug-discovery/#68904ce21b1e\" target=\"_blank\" rel=\"noopener\">announced a collaboration\u003c/a> in 2016 to use Watson to accelerate cancer drug discovery.\u003c/p>\n\u003cp>Dr. Steven Salzberg, director of the Center for Computational Biology at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins University, is skeptical of such supercomputing efforts.\u003c/p>\n\u003cp>\"I honestly don't see how throwing lots of computers at the problem will speed up preclinical cancer drug discovery,\" he says. \"It's the classic problem where when your only tool is a hammer, everything looks like a nail.\u003c/p>\n\u003cp>\"We all need computers for research, so that's good. But cutting drug discovery from 6 years down to 1? That sounds implausible to me.\"\u003c/p>\n\u003cp>But at the Dana-Farber Cancer Institute at Harvard, Aedin Culhane, who is also a researcher in the Department of Biostatistics, is more optimistic. Yes, the idea of computer-assisted drug discovery has been around for a long time, she says, but it's only now that it's finally matured.\u003c/p>\n\u003caside class=\"pullquote alignright\">'I think there are a confluence of things that give this a better shot now than we had in the past.'\u003ccite>John Baldoni, GlaxoSmithKline\u003c/cite>\u003c/aside>\n\u003cp>\"These projects were completely and utterly just a pipe dream 10 years ago,\" says Culhane. \"And now we have more and better data, and we're learning more day by day. Given good data, the machines can learn, and I'm very hopeful about it. Much more than I was 10 years ago.\"\u003c/p>\n\u003cp>She finds ATOM's intent to publish negative results especially interesting. \"Because that's something that is missing. Academics rarely publish negative results, and pharma even more so.\"\u003c/p>\n\u003cp>Re-examing old data in the light of new information, she says, can sometimes offer novel insights. Perhaps researchers misunderstood how a failed drug was working in the body the first time around; or maybe reviewing its off-target effects in light of new discoveries related to tumors will reveal a deeper understanding of biochemistry.\u003c/p>\n\u003cp>John Baldoni, senior vice president for computerized drug screening at GSK, says that not only are data more abundant, but the engineering required for computer-based analysis is more sophisticated.\u003c/p>\n\u003cp>He also believes researchers will be able to draw on software advancements in fields like facial recognition and dimensional analysis.\u003c/p>\n\u003cp>\"We have applications in other sectors that are analogous to the applications that we want to develop in the pharma sector,\" he said.\u003c/p>\n\u003cp>The technology is also starting to demonstrate results, according to Baldoni. He points to clinical testing of molecules discovered by computer algorithms from \u003ca href=\"http://www.nimbustx.com/\" target=\"_blank\" rel=\"noopener\">Nimbus Therapeutics\u003c/a>.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"What I would say to a skeptic,\" he says, \"is 'You might be right.' But I hope they're not. I think there are a confluence of things that give this a better shot now than we had in the past.\"\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/436544/bay-area-scientists-say-computers-can-develop-cancer-drugs-6-times-faster","authors":["235","11088"],"categories":["futureofyou_452","futureofyou_1062","futureofyou_1","futureofyou_73"],"tags":["futureofyou_29","futureofyou_103","futureofyou_1403","futureofyou_952","futureofyou_1275","futureofyou_377"],"featImg":"futureofyou_437052","label":"source_futureofyou_436544"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? 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