Puberty is no picnic, even in the best of circumstances. Once the sex hormones estrogen or testosterone kick in, there’s no turning back: Here come breasts and periods, Adam’s apples and acne. It’s a tough passage for many kids, but for some — transgender youth whose bodies don’t match their gender identity — puberty can be unbearable.

For one Oakland family, their daughter’s path was clear from the time she was three. Her birth certificate said “male,” but the child would always say she wanted to be a girl, and that soon became, “I AM a girl,” said the mother, who asked that her family’s name not be used to protect her daughter’s privacy. She recalled a day when the girl wept in frustration trying to fashion a skirt out of some t-shirts.

“Finally I just said, ‘Honey, do you want a dress?’’ and they went to a store and bought one. “I literally thought she was going to faint or hyperventilate,” said the mother. “She couldn’t sit still, she was so excited and so happy. It was a moment of pure joy for her, and also a turning point,” she said.

She was happy growing up and attended a progressive school in the San Francisco Bay Area as a girl. But when she was approaching puberty, she became very nervous, “worried about getting facial hair or watching her shoulders get broader. It was all very painful for her,” her mother said.

The child was experiencing what’s known as gender dysphoria, a DSM-5 diagnosis of significant ongoing distress, with the feeling of being assigned the wrong gender at birth. Researchers at Harvard recently found that transgender youth are at a much higher risk for mental disorders, including depression, anxiety, suicidal thoughts and self-harm. They are more than twice as likely as non-trans youth to be diagnosed with depression (50.6 percent vs. 20.6 percent) or suffer from anxiety (26.7 percent vs. 10 percent).

“These kids are saying to the world, ‘I was born in the wrong body, and there’s something just not right about living this way,’” said Scott Leibowitz, head child and adolescent psychiatrist at the Ann & Robert H. Lurie Children’s Hospital of Chicago.

Blockers ‘Safe and Effective’

Full-blown puberty is irreversible, but for transgender children, it’s no longer inevitable. By taking a gonadotropin-releasing hormone (GnRH) agonist, secretion of the sex hormones can be stopped and the onset of puberty suppressed, so that the body does not develop secondary sex characteristics. This has been done safely for decades to suppress sex hormones in children who develop too early, a condition known as precocious puberty. Suppressors have also been used to treat endometriosis, uterine fibroids and prostate cancer.

It was only in 2008 that the Endocrine Society approved puberty suppressors as a treatment for transgender adolescents as young as 12 years old. The Society, with members in more than 100 countries, has since declared that the intervention appears to be safe and effective.  In 2011 the World Professional Association for Transgender Health (WPATH), also issued Standards of Care for the treatment of patients with gender dysphoria, which include puberty suppression.

There are few reported side effects to this off-label use of sex hormone suppressors. Despite early concerns that blocking sex hormones might harm bone development, a recent study from the Netherlands found no evidence of long-term effects on bone mineral density. If the suppressors are halted, puberty resumes as if there had been no treatment.

Data on the use of puberty blockers is scarce, but in the past decade or so, it’s believed thousands of transgender youth and their families have chosen to suppress puberty to give adolescents a time-out while they figure out the next step in their development.

A St. Louis, Mo., child was classified as female at birth, one of a set of twin girls. But the parents had been discussing puberty blockers with him since he was seven years old, after he had begun dressing as a boy and showing more masculine traits.

“I remember watching a documentary where he learned what blockers were and we talked about it and he was sure that’s what he wanted when the time came,” said his mother, who also asked that the family’s names not be used to protect her child’s privacy.

“As soon as he got breast buds, it was like the panic button was hit,” the mother said. “He was quickly and very intensely uncomfortable and afraid. He would cry, knowing that this was the beginning of something that he didn’t want, that he knew wasn’t right for him,” she said.

In March, after the boy turned 11, a pediatric endocrinologist prescribed the sex hormone suppressor Eligard, an injection that he receives every four months. According to his mother, because they intervened early, the unwanted breast buds receded quickly, along with her son’s depression and anxiety. “I don’t know what we would have done if we were not able to stop puberty so he doesn’t have to feel in constant conflict with his own body,” she said.

So far, according to the mother, the biggest problem their family has faced has been trying to get insurance coverage for her son’s treatment. She said they have been lucky to obtain the injections at cost — $500 per shot — rather than the $1,500 to $2,000 per shot that the therapy typically costs. Her husband’s employer, which self-funds its medical insurance plan, chose a clause that excludes transgender care.

That kind of exclusion could change, especially since the Obama Administration recently issued final regulations on Section 1557 of the Affordable Care Act that ban the denial of health care on the basis of gender identity in programs that receive federal funding. The rule could help people who feel they have been discriminated against to bring complaints or lawsuits, according to the Transgender Law Center in Oakland, Calif.

In 2014, Oregon became the first state to provide Medicaid coverage for adolescents receiving puberty blockers. Medicaid programs in other states, including New York and California, have also expanded transgender healthcare coverage, although that does not mean that puberty blockers always are covered.

How Early is Too Early?

Treatment with puberty blockers gives transgender children a breather so they can continue to mature and decide whether they will pursue treatment with cross-sex hormones or gender reassignment surgery. For many families, the question is not whether to intervene with blockers, but how early to start.

Because the onset of puberty varies so widely — as early as age 9 for some — suppression can begin at different ages. And that’s prompted some disagreement within the field — the “age versus stage” debate — about when to begin, according to Leibowitz. Most often blockers are initiated at the first visible signs of development as measured by the Tanner Stages, a scale of sexual maturation developed by pediatrician James Tanner. The trigger for suppression is usually Tanner stage 2, when pubic hair and breast buds appear.

“If you are able to suspend puberty as soon as it happens you’re optimizing the benefits that it can bring physically,” said Leibowitz. Starting early may alleviate the need for surgical breast removal or voice modification therapy later on. It also makes it far easier for transgender teens to fit in. “That ability to blend in and be perceived as the gender that they identify with is associated with long-term psychological benefits,” said Leibowitz.

But does that mean that 9- or 10-year-old transgender kids should be started on puberty blockers? Even though the treatment is reversible and is considered safe, Leibowitz said some clinicians argue the age issue is important because less is known about very early interventions. How long can puberty be safely suppressed? And if the next step is transitioning with cross-sex hormones, at what age should that begin?

Of course, there is no treatment at all unless the parents of transgender children agree. “For most of my clients [who are minors], the issue revolves around whether they can start hormones or puberty blockers without parental consent, and the short answer is ‘No,”’ said Danielle Castro, a psychotherapist and project director at the Center of Excellence for Transgender Health at the University of California, San Francisco.

Castro said families of some transgender youth refuse the intervention because they believe their children are “just going through a phase.”  A study in 2008 found that 43 percent of very young children who experienced gender dysphoria no longer felt that way after adolescence. The 27 percent who remained dysphoric were the ones who had felt that way most strongly when they were young.

Young children may indeed change their minds, but gender identity seems to be fixed by the time kids have reached puberty. The Endocrine Society finds that transgender adolescents grow up to be transgender adults “100 percent of the time.”  Dr. Stephen Rosenthal, director of the Child and Adolescent Gender Center at UCSF, agrees: “Children who meet the mental health criteria for gender dysphoria in adolescence are likely to be transgender for life.”

In a recent study of 70 participants  all the adolescents who had been given puberty blockers went through with sex reassignment.

The Standard of Care

Even though the Oakland family had agreed in advance that their daughter would start on blockers at the right time, “we had to reassure her constantly that we wouldn’t let it go too far,” she said.

When she turned 13, the girl started receiving monthly injections of Lupron, a widely prescribed sex hormone suppressor. “As soon as she started, you could just see the relief in her,” said the mother. “You could see it in her demeanor, in her mood; it was just a huge weight off her shoulders,” she said.

The family’s insurer, Kaiser Permanente, covered the treatment. Puberty blockers are considered “standard of care in the appropriate clinical circumstances,” said Erica Metz, medical director for Transgender Health at Kaiser Permanente Northern California. According to Metz, the treatment “gives patients and their families time to work with their mental health and medical providers to determine if it is appropriate to start transitioning.”

When the girl was 14, she started taking estrogen — the next step in her male-to-female transition. Instead of growing facial hair and a male physique, she developed breasts and some curves. Her voice didn’t deepen, and she doesn’t have an Adam’s apple.

The mother described her daughter as a social, outgoing and well-adjusted teenager. She knows the grim mental health statistics for transgender people — 41 percent have attempted suicide, nearly nine times the national average — and she doesn’t want to imagine a world where her daughter would be without puberty blockers, a medical intervention that she called a “lifesaver.”

“The thought of her having had to go through male puberty, I think it would have destroyed her mental health and well-being,” the mother said.

This story was produced by Kaiser Health News, which publishes California Healthline, a service of the California Health Care Foundation.

Transgender Youth Using Puberty Blockers 22 August,2016Jon Brooks
  • Queered

    This is pure unadulterated child abuse. Over 80% of children desist. This has got to be the most conservative movement i have ever witnessed in my life.

    • Hp440lisa

      There was a lot of way overly lgb biased gender identity research in the past.
      Most gender non- conforming kids who desists grow – up to be damaged heterosexuals. A lot of their damage is caused by people perceiving them as gay.
      The smallest portion of the kids are true transsexuals. Puberty is when they are easiest to spot because they are freaking out about it and they become more sensitive to the brain body mismatch.

    • Proud Amelekite

      Quite the opposite, actually. If the kid is just going through a phase, a puberty blocker is completely reversible and keeping them in an androgynous, in between state is preferable to letting puberty take its toll if it is not a phase.

      • Queered

        Absolutely not true. Doctors have spoken out on this because these blockers do cause irreversible damage when used over time. Facts over fiction, dude.

        • Proud Amelekite

          Which doctors? Do you have citations for that?

          Because I have citations for mine.

          The basic takeaway is that children who used hormone suppressors not only saw few side effects (none that would be considered terminal or serious) but the children on these blockers maintained a much better psychological status. The only real downside to the blockers is their cost, but that is a debate for another topic concerning healthcare and big pharma and not applicable to this.

          • Queered

            There are loads of studies on this which show the damage done by puberty blockers and the need for further studies:



            Plus many who have detransitioned have spoken out strongly against this practice. Remember over 80% of children desist. This is medical quackery and child abuse in one go.

          • Proud Amelekite

            The need for further studies is granted but the claim of puberty blocker use being quackery and child abuse are still not corroborated by any existing study or evidence that I have found or you have cited here.


            In the first paragraph he makes a bunch of claims about bone density issues, brain development problems, and permanent sterilization which are not actual certain effects of puberty blockers save for the first (and bone density quickly fixes once hormones are started at 16). He doesn’t bother citing any studies or medical information to corroborate these claims either so these are debunked on their head until he does.

            The rest is largely psychological supposition which is outside of the field of expertise for a physician and more in the wheelhouse of a psychiatrist or psychologist. Again, no citations and a lot of assumptions about things outside of his preview.


            The summary of the use of puberty blockers is there may be some negative impact on neurocognative development but, beyond this, there are no real dangers that aren’t fixed by the administration of hormones or removal of the blockers at 16. According to most comprehensive studies on the subject I have seen, the trans community suffers dramatically higher rates of mental illness and suicide if they don’t transition. Additionally, the cost of transition and the surgery and traumatic therapies required as well as the cost sky rocket once puberty has set in. In essence, the use of puberty blockers comes down to the danger we know is there versus the danger that may or may not be there.

            I would posit it is child abuse to force a trans child to undergo puberty in the wrong natal sex when we have medical advances at our disposal that can pause this change until such a time that the child desists or proceeds because of what might go wrong.


            [Plus many who have detransitioned have spoken out strongly against this practice.]

            Against the use of puberty blockers, specifically? That is all I am arguing here. I have heard of trans kids “self treating” (e.g. male to female trans taking morning after pills without doctor oversight, for example) which is dangerous and all the more reason I prefer to have this done by endocrinologists.

            [Remember over 80% of children desist.}

            Which is fine. If they desist they are removed from the blockers, an endocrinologist takes blood work over the course of a few years to determine if supplemental hormone injections are required, and puberty continues as it would have.

          • Queered
          • Proud Amelekite

            That is a good link and I have heard of serious issues with Lupron. The problems with Lupron are under FDA review but, luckily, I have heard of better results from a combination of spiro and bicalamutide (these two are also much cheaper than Lupron). I think much of the problem with Lupron (and this is confirmed near the end of the story you linked) is that it was being used by normal doctors who didn’t do proper follow-up on it. Any time you mess with the endocrine system you need to be seeing a proper, dedicated endocrinologist because of the damage playing with hormone levels can cause if used off label or done by a normal MD.

      • Queered

        No, there are loads of articles saying that they are not irreversible–they can lead to sterilisation after used a few years. Let’s be honest about their effects and stop making up lies to suit a certain political narrative. Children do not deserve to be fed lies about their medical and psychological safety.

        Also we need to fight gender normativity, not medicalise it. Let’s fight to allow for boys and girls, men and women, to wear dresses, trousers, or whatever. Gender is the problem. Not the body.

        • Proud Amelekite

          [No, there are loads of articles saying that they are not irreversible–they can lead to sterilisation after used a few years.]

          You are mistaken. Puberty blockers, alone, do not lead to permanent sterilization. The administration of opposite natal sex hormones into a child after the administration of puberty blockers can, however. Which is why I agree with you that children shouldn’t be subject to such hormones until they have worked out what they are.

          “I wouldn’t use [puberty blockers] if I didn’t think that they were safe, or that the benefits didn’t outweigh the potential risks (…) But we always have this conversation with families before we start.” – Dr. Courtney Finlayson, Pediatric Endocrinologist from your second source in the other comment, actually.

          [Let’s be honest about their effects and stop making up lies to suit a certain political narrative. Children do not deserve to be fed lies about their medical and psychological safety.]

          Couldn’t have said it better myself.

          [Also we need to fight gender normativity, not medicalise it. Let’s fight to allow for boys and girls, men and women, to wear dresses, trousers, or whatever. Gender is the problem. Not the body.]

          I agree to a point but the fact is kids are hurting now and if these things can help I am for them. Today’s potentially trans kids don’t have time to wait for some golden age down the line where gender is no big deal any more and our brains have moved beyond it. They’re dying today.

  • Martha Bartha

    That’ll mess you the fuck up!

  • Richard Eisenman

    One thing for sure is that “she” will never have children and her genes will never be passed on to a future generation. So modern western technology is basically getting transexuals out of the gene pool by changing them from fertile males into unfertile ‘females’ and vs versa. Frankly, a lot of people spend a significant portion of their lifetime not feeling ‘comfortable’ (to various degrees) with their god-given bodies. But humans are adaptable and they find creative ways to adapt. It may not be easy, but who said life is easy (except the drug pushers who think life is about ‘being high’ all the time. Its a story as old as Odysseus in the land of the Lotus Eaters). So doctors are now telling kids that they can pick their bodies? Would the very fact that doctors can play god not have an effect on that child’s psychology? Are the doctors also telling them that they will never be real females? Never have children? And this dimension of sexuality is something a prepubescent child is supposed to understand? I doubt it: what an american prepubescent child understands is likely highly influenced by the distorted images of sex propagandized by popular culture.

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