Test Of Experimental Alzheimer's Drug Finds Progress Against Brain Plaques
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also be able to slow the loss of memory and thinking.\u003c/p>\n\u003cp>\"If that hint of a clinical benefit is confirmed, it would be a game changer in the fight against Alzheimer's disease,\" says \u003ca href=\"http://banneralz.org/about-us/our-leadership.aspx\">Dr. Eric Reiman\u003c/a>, executive director of the Banner Alzheimer's Institute in Phoenix. Reiman wrote a commentary that accompanies the study in \u003cem>Nature\u003c/em>.\u003c/p>\n\u003cp>But it will take much larger studies to show for sure whether aducanumab really does slow down Alzheimer's disease, Reiman says.\u003c/p>\n\u003cp>Officials of \u003ca href=\"https://www.biogen.com/en_us/research-pipeline/biogen-pipeline.html\">Biogen\u003c/a>, which is developing the drug, were also cautious about interpreting the results of the study, which included 165 patients in the early stages of Alzheimer's disease.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"We think we have something important here,\" says \u003ca href=\"https://www.biogen.com/en_us/about-biogen/leadership/leadership-detail.sandrock_alfred.html\">Dr. Alfred Sandrock\u003c/a>, chief medical officer for Biogen. \"We hope we're right because if it's true it would benefit millions of patients. But we don't know we're right yet.\"\u003c/p>\n\u003cp>The results are encouraging for pharmaceutical companies that have spent billions of dollars on efforts to come up with the first drug to treat the underlying cause of Alzheimer's. Those efforts have \u003ca href=\"http://www.npr.org/sections/health-shots/2012/08/24/159997459/failure-of-lilly-drug-is-latest-alzheimers-setback\">failed to produce a single approved drug\u003c/a> so far.\u003c/p>\n\u003cp>But last summer, Biogen began presenting its results with aducanumab at scientific meetings, including the \u003ca href=\"https://www.alz.org/\">Alzheimer's Association\u003c/a> International Conference in July. These early reports suggested the drug had a remarkable ability to remove plaques in the brain.\u003c/p>\n\u003cp>\"It was surprising, encouraging and thought-provoking to see such a striking reduction of existing plaques,\" Reiman says.\u003c/p>\n\u003cp>The \u003ca href=\"http://dx.doi.org/10.1038/nature19323\">publication\u003c/a> in \u003cem>Nature \u003c/em>Wednesday provides details about those early reports.\u003c/p>\n\u003cp>Biogen has already begun two much larger studies of aducanumab. They will include a total of 2,700 patients, and results are still several years off.\u003c/p>\n\u003cp>But there are reasons to think aducanumab may succeed where other drugs have failed.\u003c/p>\n\u003cp>One is that the drug appears to ignore benign forms of amyloid protein while attacking the toxic forms thought to damage brain cells. Another is that aducanumab seems to enhance the ability of existing immune cells in the brain to devour toxins, including amyloid.\u003c/p>\n\u003cp>But there's a downside. The process of removing plaque sometimes causes fluid to build up in the brain. In rare cases, it can also cause bleeding. These side effects are known as amyloid-related imaging abnormalities, or ARIA.\u003c/p>\n\u003cp>\"We were actually anticipating that we would see it,\" Sandrock says. And the researchers did. Twenty patients dropped out of the trial because of adverse effects.\u003c/p>\n\u003cp>If aducanumab works in larger studies, it could help settle a long-running debate about whether amyloid is really the root cause of Alzheimer's. This idea is known as the \u003ca href=\"https://www.alz.org/documents/national/topicsheet_betaamyloid.pdf\">amyloid hypothesis\u003c/a>.\u003c/p>\n\u003cp>And large studies showing that removing amyloid can preserve memory and thinking \"would go a long way toward validating the amyloid hypothesis,\" Sandrock says.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Results like those could also lead to the first approved drug to treat the underlying cause of Alzheimer's rather than just the symptoms.\u003c/p>\n\u003cdiv class=\"fullattribution\">\u003cem>Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Test+Of+Experimental+Alzheimer%27s+Drug+Finds+Progress+Against+Brain+Plaques+++&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/em>\u003c/div>\n\n","blocks":[],"excerpt":"Researchers have failed repeatedly in their efforts to slow or halt Alzheimer's disease. But there are hints that an experimental drug can do what previous medicines could not.","status":"publish","parent":0,"modified":1472671256,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":20,"wordCount":548},"headData":{"title":"Test Of Experimental Alzheimer's Drug Finds Progress Against Brain Plaques | KQED","description":"Researchers have failed repeatedly in their efforts to slow or halt Alzheimer's disease. But there are hints that an experimental drug can do what previous medicines could not.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"231480 http://ww2.kqed.org/stateofhealth/?p=231480","disqusUrl":"https://ww2.kqed.org/stateofhealth/2016/08/31/test-of-experimental-alzheimers-drug-finds-progress-against-brain-plaques/","disqusTitle":"Test Of Experimental Alzheimer's Drug Finds Progress Against Brain Plaques","nprImageCredit":"Science Photo Library/Pasieka","nprByline":"\u003cstrong> Jon Hamilton \u003c/br> NPR \u003c/strong>","nprImageAgency":"Getty Images","nprStoryId":"491941518","nprApiLink":"http://api.npr.org/query?id=491941518&apiKey=MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004","nprHtmlLink":"http://www.npr.org/sections/health-shots/2016/08/31/491941518/test-of-experimental-alzheimers-drug-finds-progress-against-brain-plaques?ft=nprml&f=491941518","nprRetrievedStory":"1","nprPubDate":"Wed, 31 Aug 2016 13:54:00 -0400","nprStoryDate":"Wed, 31 Aug 2016 13:10:00 -0400","nprLastModifiedDate":"Wed, 31 Aug 2016 13:54:20 -0400","path":"/stateofhealth/231480/test-of-experimental-alzheimers-drug-finds-progress-against-brain-plaques","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>An experimental drug dramatically reduced the toxic plaques found in the brains of patients with Alzheimer's disease, a team \u003ca href=\"http://nature.com/articles/doi:10.1038/nature19323\">reports\u003c/a> in the journal \u003cem>Nature\u003c/em>.\u003c/p>\n\u003cp>Results from a small number of patients who received a high dose of the drug, called \u003ca href=\"https://www.biogen.com/en_us/research-pipeline/biogen-pipeline.html\">aducanumab\u003c/a>, hint that it may also be able to slow the loss of memory and thinking.\u003c/p>\n\u003cp>\"If that hint of a clinical benefit is confirmed, it would be a game changer in the fight against Alzheimer's disease,\" says \u003ca href=\"http://banneralz.org/about-us/our-leadership.aspx\">Dr. Eric Reiman\u003c/a>, executive director of the Banner Alzheimer's Institute in Phoenix. Reiman wrote a commentary that accompanies the study in \u003cem>Nature\u003c/em>.\u003c/p>\n\u003cp>But it will take much larger studies to show for sure whether aducanumab really does slow down Alzheimer's disease, Reiman says.\u003c/p>\n\u003cp>Officials of \u003ca href=\"https://www.biogen.com/en_us/research-pipeline/biogen-pipeline.html\">Biogen\u003c/a>, which is developing the drug, were also cautious about interpreting the results of the study, which included 165 patients in the early stages of Alzheimer's disease.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"We think we have something important here,\" says \u003ca href=\"https://www.biogen.com/en_us/about-biogen/leadership/leadership-detail.sandrock_alfred.html\">Dr. Alfred Sandrock\u003c/a>, chief medical officer for Biogen. \"We hope we're right because if it's true it would benefit millions of patients. But we don't know we're right yet.\"\u003c/p>\n\u003cp>The results are encouraging for pharmaceutical companies that have spent billions of dollars on efforts to come up with the first drug to treat the underlying cause of Alzheimer's. Those efforts have \u003ca href=\"http://www.npr.org/sections/health-shots/2012/08/24/159997459/failure-of-lilly-drug-is-latest-alzheimers-setback\">failed to produce a single approved drug\u003c/a> so far.\u003c/p>\n\u003cp>But last summer, Biogen began presenting its results with aducanumab at scientific meetings, including the \u003ca href=\"https://www.alz.org/\">Alzheimer's Association\u003c/a> International Conference in July. These early reports suggested the drug had a remarkable ability to remove plaques in the brain.\u003c/p>\n\u003cp>\"It was surprising, encouraging and thought-provoking to see such a striking reduction of existing plaques,\" Reiman says.\u003c/p>\n\u003cp>The \u003ca href=\"http://dx.doi.org/10.1038/nature19323\">publication\u003c/a> in \u003cem>Nature \u003c/em>Wednesday provides details about those early reports.\u003c/p>\n\u003cp>Biogen has already begun two much larger studies of aducanumab. They will include a total of 2,700 patients, and results are still several years off.\u003c/p>\n\u003cp>But there are reasons to think aducanumab may succeed where other drugs have failed.\u003c/p>\n\u003cp>One is that the drug appears to ignore benign forms of amyloid protein while attacking the toxic forms thought to damage brain cells. Another is that aducanumab seems to enhance the ability of existing immune cells in the brain to devour toxins, including amyloid.\u003c/p>\n\u003cp>But there's a downside. The process of removing plaque sometimes causes fluid to build up in the brain. In rare cases, it can also cause bleeding. These side effects are known as amyloid-related imaging abnormalities, or ARIA.\u003c/p>\n\u003cp>\"We were actually anticipating that we would see it,\" Sandrock says. And the researchers did. Twenty patients dropped out of the trial because of adverse effects.\u003c/p>\n\u003cp>If aducanumab works in larger studies, it could help settle a long-running debate about whether amyloid is really the root cause of Alzheimer's. This idea is known as the \u003ca href=\"https://www.alz.org/documents/national/topicsheet_betaamyloid.pdf\">amyloid hypothesis\u003c/a>.\u003c/p>\n\u003cp>And large studies showing that removing amyloid can preserve memory and thinking \"would go a long way toward validating the amyloid hypothesis,\" Sandrock says.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Results like those could also lead to the first approved drug to treat the underlying cause of Alzheimer's rather than just the symptoms.\u003c/p>\n\u003cdiv class=\"fullattribution\">\u003cem>Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Test+Of+Experimental+Alzheimer%27s+Drug+Finds+Progress+Against+Brain+Plaques+++&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/em>\u003c/div>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/stateofhealth/231480/test-of-experimental-alzheimers-drug-finds-progress-against-brain-plaques","authors":["byline_stateofhealth_231480"],"categories":["stateofhealth_13"],"tags":["stateofhealth_2875"],"featImg":"stateofhealth_231483","label":"stateofhealth"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg","imageAlt":"On Our Watch from NPR and KQED","officialWebsiteLink":"/podcasts/onourwatch","meta":{"site":"news","source":"kqed","order":"1"},"link":"/podcasts/onourwatch","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1567098962","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw","npr":"https://rpb3r.app.goo.gl/onourwatch","spotify":"https://open.spotify.com/show/0OLWoyizopu6tY1XiuX70x","tuneIn":"https://tunein.com/radio/On-Our-Watch-p1436229/","stitcher":"https://www.stitcher.com/show/on-our-watch","rss":"https://feeds.npr.org/510360/podcast.xml"}},"on-the-media":{"id":"on-the-media","title":"On The Media","info":"Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. 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