Why no Y? Gender-bending Transcaucasian mole voles
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The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_3737":{"type":"posts","id":"quest_3737","meta":{"index":"posts_1591205157","site":"quest","id":"3737","score":null,"sort":[1254172690000]},"guestAuthors":[],"slug":"genetic-tests-when-no-means-maybe-part-2","title":"Genetic Tests: When No Means Maybe (Part 2)","publishDate":1254172690,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/SamBelleStarr.jpg\">\u003cem>Are they related to me? I still don't know...\u003c/em>\u003c/span>When last I left you, I was searching for my great-great grandmother’s DNA in my own DNA. Remember, legend has it she was Cherokee and I wanted to confirm the legend with a genetic test from a company called 23andMe.\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2009/09/14/genetic-tests-when-no-means-maybe-part-1/\">In my last blog post\u003c/a>, I showed how the two most powerful ancestry tests, mitochondrial DNA (mtDNA) and Y chromosome, were useless to me in my hunt. Now I want look at the rest of my DNA. So here we go!\u003c/p>\n\u003cp>The Y chromosome and mtDNA are a small fraction of my DNA—something like 0.8% of the total DNA in one of my cells. But they are incredibly useful because they change very little from generation to generation. The mtDNA I got from my mom is probably exactly like hers. Same with most of the Y I got from my dad.\u003c/p>\n\u003cp>The other 99.2% of my DNA is a lot trickier to look at from an ancestry perspective because it has changed a lot from generation to generation over time. For example, the chromosomes I inherited from my parents are not the same as the ones they have. I got a \u003ca href=\"http://ww2.kqed.org/quest/2009/08/03/why-we-will-never-see-another-einstein/\">mix of their chromosomes\u003c/a>\u003c/p>\n\u003cp>For example, my mom had two copies of chromosome 1 (and two copies of her other 22 chromosomes too). As you know, she passed one chromosome 1 to me (my dad gave me my other one). But, through a process called recombination, her two copies of chromosome 1 swapped DNA so that I got a hybrid of her two copies. I inherited a unique chromosome never before seen.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>This is all well and good from a survival of the species point of view, but it is a problem for ancestry testing. Imagine that instead of my mom, we look at my Cherokee great-great grandmother. She has just had a child who inherited a mix of her chromosome 1’s. This chromosome will look Native American and the child would appear half Native American.\u003c/p>\n\u003cp>Actually, the test isn’t perfect yet and so there isn’t yet a “Native American” set \u003cem>per se\u003c/em>. Instead, here is how 23andMe describes Native American DNA in their tests:\u003c/p>\n\u003cp>\u003cem>“…people who identify themselves as Native American exhibit fairly consistent Ancestry Painting proportions of about 75% Asian and 25% European, plus or minus 10%.” \u003c/em>\u003c/p>\n\u003cp>This means the chromosomes the child got from his or her mom won’t look Native American but instead will look 75% Asian and 25% European. (See \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=41\">a realted post of mine elsewhere\u003c/a> for why it looks like this.) Now imagine that this half Native American child grows up and has my grandfather as his or her son.\u003c/p>\n\u003cp>My grandpa will inherit a mix of his parents’ DNA too. In this case the Native American DNA will mix with the European DNA to create a hybrid. On average, you would now see something along the lines of 37.5% Asian (this is a simplification but it gets us into the ballpark of the number we might expect).\u003c/p>\n\u003cp>Each generation would see, on average, a continued dilution of this Asian part. My dad would have 18% Asian, I would have 9%, etc. Here are my ancestry results (click the image to enlarge):\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/2009/09/AncestryPainting.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/AncestryPainting.jpg\" alt=\"AncestryPainting\" title=\"AncestryPainting\" width=\"600\" class=\"alignleft size-full wp-image-3738\">\u003c/a>\u003c/p>\n\u003cp>Not a hint of Asian. Looks like my great-great grandma wasn't Cherokee. Or was she?\u003c/p>\n\u003cp>There are lots of ways she could still be Cherokee. First off, I don’t know how solid the 75% number is for all Native Americans. I don’t know how many Native Americans are in their database. I also don’t know how much variation there will be tribe to tribe.\u003c/p>\n\u003cp>Secondly, you may have noticed that I was very careful to always say, “on average.” This is because the recombinations don’t have to be a 50-50 swap. It is true that if you look at a large number of recombination events, the average will be 50%. But individual recombination events can be biased towards one or more chromosomes. Occasionally you’ll get mostly one chromosome and sometimes mostly the other.\u003c/p>\n\u003cp>Sort of like flipping a coin—do it enough and you’ll get pretty close to half heads and half tails. But if you flip a coin twice, you might get one head and one tail. And you might not. Half the time you’ll get two heads or two tails.\u003c/p>\n\u003cp>This is less a problem than you might think with our chromosomes since the recombination is spread over 23 pairs with each pair being independent of the others. But it can still throw a monkey wrench into the works. 23andMe actually has a nice chart that hints at this by giving the most likely range of possibilities. Unfortunately, this chart didn’t come up with my results and I had to stumble on it while I was playing around.\u003c/p>\n\u003cp>Using the chart, I can see that the bottom end of my expected results in 0.24% “Native American” (if I am reading the chart correctly). That is pretty low and it seems like a pretty minor mistaken assumption at the beginning might knock this down to zero.\u003c/p>\n\u003cp>So where am I after this? Still in the dark. This is actually how many genetic tests end up.\u003c/p>\n\u003cp>The positive result tells you a lot. Had there been Native American DNA, that would have been a slam dunk. (This isn’t always the case with genetic tests but it would be here.) But there wasn’t. Which means, given that I was on the edge of detection, that she may or may not have been Cherokee.\u003c/p>\n\u003cp>Now, this isn’t 23andMe’s fault. The test itself couldn’t be conclusive given how far back we need to go and the DNA tests that 23andMe offers. In fact, 23andMe does an excellent job of presenting the data. There are pretty chromosome paintings, graphs superimposed on world maps, etc. All very nice.\u003c/p>\n\u003cp>I am still worried that the explanations that go along with these images assume an awful lot of knowledge that most people might not have. Without that knowledge, it can be hard to assess the significance of a certain result. Next blog that’ll become even more important as I tackle health conditions.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp> 37.33161018170129 -121.89019918441772\u003c/p>\n\n","blocks":[],"excerpt":"In my last blog post, I showed how the two most powerful ancestry tests, mitochondrial DNA (mtDNA) and Y chromosome, were useless to me in my hunt. Now I want look at the rest of my DNA. So here we go!","status":"publish","parent":0,"modified":1316920939,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":25,"wordCount":1139},"headData":{"title":"Genetic Tests: When No Means Maybe (Part 2) | KQED","description":"In my last blog post, I showed how the two most powerful ancestry tests, mitochondrial DNA (mtDNA) and Y chromosome, were useless to me in my hunt. Now I want look at the rest of my DNA. So here we go!","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Genetic Tests: When No Means Maybe (Part 2)","datePublished":"2009-09-28T21:18:10.000Z","dateModified":"2011-09-25T03:22:19.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"3737 http://www.kqed.org/quest/blog/?p=3737","disqusUrl":"https://ww2.kqed.org/quest/2009/09/28/genetic-tests-when-no-means-maybe-part-2/","disqusTitle":"Genetic Tests: When No Means Maybe (Part 2)","path":"/quest/3737/genetic-tests-when-no-means-maybe-part-2","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/SamBelleStarr.jpg\">\u003cem>Are they related to me? I still don't know...\u003c/em>\u003c/span>When last I left you, I was searching for my great-great grandmother’s DNA in my own DNA. Remember, legend has it she was Cherokee and I wanted to confirm the legend with a genetic test from a company called 23andMe.\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2009/09/14/genetic-tests-when-no-means-maybe-part-1/\">In my last blog post\u003c/a>, I showed how the two most powerful ancestry tests, mitochondrial DNA (mtDNA) and Y chromosome, were useless to me in my hunt. Now I want look at the rest of my DNA. So here we go!\u003c/p>\n\u003cp>The Y chromosome and mtDNA are a small fraction of my DNA—something like 0.8% of the total DNA in one of my cells. But they are incredibly useful because they change very little from generation to generation. The mtDNA I got from my mom is probably exactly like hers. Same with most of the Y I got from my dad.\u003c/p>\n\u003cp>The other 99.2% of my DNA is a lot trickier to look at from an ancestry perspective because it has changed a lot from generation to generation over time. For example, the chromosomes I inherited from my parents are not the same as the ones they have. I got a \u003ca href=\"http://ww2.kqed.org/quest/2009/08/03/why-we-will-never-see-another-einstein/\">mix of their chromosomes\u003c/a>\u003c/p>\n\u003cp>For example, my mom had two copies of chromosome 1 (and two copies of her other 22 chromosomes too). As you know, she passed one chromosome 1 to me (my dad gave me my other one). But, through a process called recombination, her two copies of chromosome 1 swapped DNA so that I got a hybrid of her two copies. I inherited a unique chromosome never before seen.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>This is all well and good from a survival of the species point of view, but it is a problem for ancestry testing. Imagine that instead of my mom, we look at my Cherokee great-great grandmother. She has just had a child who inherited a mix of her chromosome 1’s. This chromosome will look Native American and the child would appear half Native American.\u003c/p>\n\u003cp>Actually, the test isn’t perfect yet and so there isn’t yet a “Native American” set \u003cem>per se\u003c/em>. Instead, here is how 23andMe describes Native American DNA in their tests:\u003c/p>\n\u003cp>\u003cem>“…people who identify themselves as Native American exhibit fairly consistent Ancestry Painting proportions of about 75% Asian and 25% European, plus or minus 10%.” \u003c/em>\u003c/p>\n\u003cp>This means the chromosomes the child got from his or her mom won’t look Native American but instead will look 75% Asian and 25% European. (See \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=41\">a realted post of mine elsewhere\u003c/a> for why it looks like this.) Now imagine that this half Native American child grows up and has my grandfather as his or her son.\u003c/p>\n\u003cp>My grandpa will inherit a mix of his parents’ DNA too. In this case the Native American DNA will mix with the European DNA to create a hybrid. On average, you would now see something along the lines of 37.5% Asian (this is a simplification but it gets us into the ballpark of the number we might expect).\u003c/p>\n\u003cp>Each generation would see, on average, a continued dilution of this Asian part. My dad would have 18% Asian, I would have 9%, etc. Here are my ancestry results (click the image to enlarge):\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/2009/09/AncestryPainting.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/AncestryPainting.jpg\" alt=\"AncestryPainting\" title=\"AncestryPainting\" width=\"600\" class=\"alignleft size-full wp-image-3738\">\u003c/a>\u003c/p>\n\u003cp>Not a hint of Asian. Looks like my great-great grandma wasn't Cherokee. Or was she?\u003c/p>\n\u003cp>There are lots of ways she could still be Cherokee. First off, I don’t know how solid the 75% number is for all Native Americans. I don’t know how many Native Americans are in their database. I also don’t know how much variation there will be tribe to tribe.\u003c/p>\n\u003cp>Secondly, you may have noticed that I was very careful to always say, “on average.” This is because the recombinations don’t have to be a 50-50 swap. It is true that if you look at a large number of recombination events, the average will be 50%. But individual recombination events can be biased towards one or more chromosomes. Occasionally you’ll get mostly one chromosome and sometimes mostly the other.\u003c/p>\n\u003cp>Sort of like flipping a coin—do it enough and you’ll get pretty close to half heads and half tails. But if you flip a coin twice, you might get one head and one tail. And you might not. Half the time you’ll get two heads or two tails.\u003c/p>\n\u003cp>This is less a problem than you might think with our chromosomes since the recombination is spread over 23 pairs with each pair being independent of the others. But it can still throw a monkey wrench into the works. 23andMe actually has a nice chart that hints at this by giving the most likely range of possibilities. Unfortunately, this chart didn’t come up with my results and I had to stumble on it while I was playing around.\u003c/p>\n\u003cp>Using the chart, I can see that the bottom end of my expected results in 0.24% “Native American” (if I am reading the chart correctly). That is pretty low and it seems like a pretty minor mistaken assumption at the beginning might knock this down to zero.\u003c/p>\n\u003cp>So where am I after this? Still in the dark. This is actually how many genetic tests end up.\u003c/p>\n\u003cp>The positive result tells you a lot. Had there been Native American DNA, that would have been a slam dunk. (This isn’t always the case with genetic tests but it would be here.) But there wasn’t. Which means, given that I was on the edge of detection, that she may or may not have been Cherokee.\u003c/p>\n\u003cp>Now, this isn’t 23andMe’s fault. The test itself couldn’t be conclusive given how far back we need to go and the DNA tests that 23andMe offers. In fact, 23andMe does an excellent job of presenting the data. There are pretty chromosome paintings, graphs superimposed on world maps, etc. All very nice.\u003c/p>\n\u003cp>I am still worried that the explanations that go along with these images assume an awful lot of knowledge that most people might not have. Without that knowledge, it can be hard to assess the significance of a certain result. Next blog that’ll become even more important as I tackle health conditions.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp> 37.33161018170129 -121.89019918441772\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/3737/genetic-tests-when-no-means-maybe-part-2","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_43","quest_159","quest_563","quest_848","quest_1192","quest_1197","quest_1844","quest_1890","quest_2383","quest_3195"],"label":"quest"},"quest_3620":{"type":"posts","id":"quest_3620","meta":{"index":"posts_1591205157","site":"quest","id":"3620","score":null,"sort":[1252948244000]},"guestAuthors":[],"slug":"genetic-tests-when-no-means-maybe-part-1","title":"Genetic Tests: When No Means Maybe (Part 1)","publishDate":1252948244,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/23andMe-web.jpg\">\u003cem>Genetic tests often don’t give as much information as you might think.\u003c/em>\u003c/span>In a previous blog I talked about \u003ca href=\"http://ww2.kqed.org/quest/2009/07/20/taking-the-plunge-diving-into-my-dna/\">getting my DNA tested with 23andMe\u003c/a>. Well, I got the email the other day saying that my results were ready. So I logged on and up popped this screen pictured to the left.\u003c/p>\n\u003cp>All sorts of goodies to try out! I feel like a kid at Christmas.\u003c/p>\n\u003cp>The first thing I thought I’d do is check out my ancestry. My grandfather’s grandmother was supposedly Native American and so I wanted to find out if I could see that in my DNA. (This relates to my supposed relationship with the outlaw Sam Starr but that is a different story.)\u003c/p>\n\u003cp>\u003ca href=\"http://www.23andme.com\">23andMe\u003c/a> has this Native American testing app in their 23andMe Labs section. I clicked on my data and up popped this result:\u003c/p>\n\u003cp>\u003cstrong>\u003cem>Recent Native American ancestry is unlikely\u003c/em>\u003c/strong>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Has it all been lies? My great, great grandma wasn’t Native American? Not so fast...\u003c/p>\n\u003cp>A “no” answer on a genetics test doesn’t necessarily tell you a lot. (And sometimes, the “yes” answer isn’t so helpful either!) Now as a geneticist, I know the drawbacks of ancestry tests like these. What I wanted to see was if 23andMe did a good job of explaining them.\u003c/p>\n\u003cp>I first checked out my \u003ca href=\"http://en.wikipedia.org/wiki/Mitochondrial_DNA\">mitochondrial\u003c/a> DNA (mtDNA) and my Y chromosome data. These DNA don’t change a lot from generation to generation and so are really good at tracing ancestry many generations back. Their downside for me is how they are passed down.\u003c/p>\n\u003cp>The Y chromosome passes from father to sons. My great, great grandma didn’t have a Y to pass on so of course my Y chromosome data wouldn’t show that she was Native American.\u003c/p>\n\u003cp>mtDNA passes from mom to her children. At first this sounds promising since we are talking about my great, great grandma until we realize that I am related to this woman through my grandfather. His mtDNA died with him (except for his female relatives and their descendants) so that is lost to me as well.\u003c/p>\n\u003cp>Here is what 23andMe has written under interpretation of my mtDNA and Y chromosome results:\u003cbr>\n\u003cstrong>\u003cbr>\n\u003cem>This mitochondrial DNA haplogroup is inconsistent with Native American ancestry along the maternal (mother's mother's mother's ...) line. \u003c/em>\u003c/strong>\u003cbr>\n\u003cstrong>\u003cbr>\n\u003cem>This Y chromosome haplogroup is inconsistent with Native American ancestry along the paternal (father's father's father's ...) line.\u003c/em>\u003c/strong>\u003c/p>\n\u003cp>I suppose this says what I just said but I am not sure how many people would really appreciate the limitations of mtDNA and Y chromosome data from this explanation. There wasn’t a link to a more explicit discussion of the limitations of this sort of testing and there wasn’t anything I could see from a quick glance at the ancestry part of the site either. An explicit explanation would be good or maybe a figure like this one:\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/2009/09/gene-tree.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/gene-tree.jpg\" alt=\"gene-tree\" title=\"gene-tree\" width=\"400\" height=\"150\" class=\"alignnone size-full wp-image-3621\">\u003c/a>\u003c/p>\n\u003cp>To me, this drives home the point that there is a whole lot of missing ancestry. It might help if they had some sort of family tree app where you could indicate as much as you know about family relationships. Once you’ve inputted the data, it would spit out what tests results would be useful to look at.\u003c/p>\n\u003cp>So the mtDNA and Y chromosome test results are of little use to me in this quest. (And of little use to me in general as it confirms my pasty whiteness.) Next blog I’ll deal with the rest of my DNA and what that can and can’t tell me about my great, great grandma.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.33161018170129 -121.89019918441772\u003c/p>\n\n","blocks":[],"excerpt":"Genetic tests often don’t give as much information as you might think.","status":"publish","parent":0,"modified":1316920901,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":649},"headData":{"title":"Genetic Tests: When No Means Maybe (Part 1) | KQED","description":"Genetic tests often don’t give as much information as you might think.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Genetic Tests: When No Means Maybe (Part 1)","datePublished":"2009-09-14T17:10:44.000Z","dateModified":"2011-09-25T03:21:41.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"3620 http://www.kqed.org/quest/blog/?p=3620","disqusUrl":"https://ww2.kqed.org/quest/2009/09/14/genetic-tests-when-no-means-maybe-part-1/","disqusTitle":"Genetic Tests: When No Means Maybe (Part 1)","path":"/quest/3620/genetic-tests-when-no-means-maybe-part-1","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/23andMe-web.jpg\">\u003cem>Genetic tests often don’t give as much information as you might think.\u003c/em>\u003c/span>In a previous blog I talked about \u003ca href=\"http://ww2.kqed.org/quest/2009/07/20/taking-the-plunge-diving-into-my-dna/\">getting my DNA tested with 23andMe\u003c/a>. Well, I got the email the other day saying that my results were ready. So I logged on and up popped this screen pictured to the left.\u003c/p>\n\u003cp>All sorts of goodies to try out! I feel like a kid at Christmas.\u003c/p>\n\u003cp>The first thing I thought I’d do is check out my ancestry. My grandfather’s grandmother was supposedly Native American and so I wanted to find out if I could see that in my DNA. (This relates to my supposed relationship with the outlaw Sam Starr but that is a different story.)\u003c/p>\n\u003cp>\u003ca href=\"http://www.23andme.com\">23andMe\u003c/a> has this Native American testing app in their 23andMe Labs section. I clicked on my data and up popped this result:\u003c/p>\n\u003cp>\u003cstrong>\u003cem>Recent Native American ancestry is unlikely\u003c/em>\u003c/strong>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Has it all been lies? My great, great grandma wasn’t Native American? Not so fast...\u003c/p>\n\u003cp>A “no” answer on a genetics test doesn’t necessarily tell you a lot. (And sometimes, the “yes” answer isn’t so helpful either!) Now as a geneticist, I know the drawbacks of ancestry tests like these. What I wanted to see was if 23andMe did a good job of explaining them.\u003c/p>\n\u003cp>I first checked out my \u003ca href=\"http://en.wikipedia.org/wiki/Mitochondrial_DNA\">mitochondrial\u003c/a> DNA (mtDNA) and my Y chromosome data. These DNA don’t change a lot from generation to generation and so are really good at tracing ancestry many generations back. Their downside for me is how they are passed down.\u003c/p>\n\u003cp>The Y chromosome passes from father to sons. My great, great grandma didn’t have a Y to pass on so of course my Y chromosome data wouldn’t show that she was Native American.\u003c/p>\n\u003cp>mtDNA passes from mom to her children. At first this sounds promising since we are talking about my great, great grandma until we realize that I am related to this woman through my grandfather. His mtDNA died with him (except for his female relatives and their descendants) so that is lost to me as well.\u003c/p>\n\u003cp>Here is what 23andMe has written under interpretation of my mtDNA and Y chromosome results:\u003cbr>\n\u003cstrong>\u003cbr>\n\u003cem>This mitochondrial DNA haplogroup is inconsistent with Native American ancestry along the maternal (mother's mother's mother's ...) line. \u003c/em>\u003c/strong>\u003cbr>\n\u003cstrong>\u003cbr>\n\u003cem>This Y chromosome haplogroup is inconsistent with Native American ancestry along the paternal (father's father's father's ...) line.\u003c/em>\u003c/strong>\u003c/p>\n\u003cp>I suppose this says what I just said but I am not sure how many people would really appreciate the limitations of mtDNA and Y chromosome data from this explanation. There wasn’t a link to a more explicit discussion of the limitations of this sort of testing and there wasn’t anything I could see from a quick glance at the ancestry part of the site either. An explicit explanation would be good or maybe a figure like this one:\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/2009/09/gene-tree.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/09/gene-tree.jpg\" alt=\"gene-tree\" title=\"gene-tree\" width=\"400\" height=\"150\" class=\"alignnone size-full wp-image-3621\">\u003c/a>\u003c/p>\n\u003cp>To me, this drives home the point that there is a whole lot of missing ancestry. It might help if they had some sort of family tree app where you could indicate as much as you know about family relationships. Once you’ve inputted the data, it would spit out what tests results would be useful to look at.\u003c/p>\n\u003cp>So the mtDNA and Y chromosome test results are of little use to me in this quest. (And of little use to me in general as it confirms my pasty whiteness.) Next blog I’ll deal with the rest of my DNA and what that can and can’t tell me about my great, great grandma.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.33161018170129 -121.89019918441772\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/3620/genetic-tests-when-no-means-maybe-part-1","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_43","quest_159","quest_686","quest_848","quest_1197","quest_1890","quest_2907","quest_3195"],"label":"quest"},"quest_687":{"type":"posts","id":"quest_687","meta":{"index":"posts_1591205157","site":"quest","id":"687","score":null,"sort":[1215457434000]},"guestAuthors":[],"slug":"why-no-y-gender-bending-transcaucasian-mole-voles","title":"Why no Y? Gender-bending Transcaucasian mole voles","publishDate":1215457434,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>I've always been fascinated by weird animals. Especially those with out-of-the-ordinary genetics.\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/07/molevole1.jpg\">\u003cem>Transcaucasian mole vole. Image Courtesy of Heike Himmelreich\u003c/em>\u003c/span>One of my favorites is a little burrowing mammal called a Transcaucasian mole vole. These guys live in the Caucasus Mountains of Armenia, Iran, Turkey, and Azerbaijan. There they are born, live, have babies and die. All without a Y chromosome.\u003c/p>\n\u003cp>This is really bizarre. In most mammals, two X chromosomes usually means that the animal is female and an X and a Y means the animal is male. All mole voles have a single X chromosome. So technically, there shouldn’t be any males running around. And yet, clearly, there are. \u003c/p>\n\u003cp>So what distinguishes a boy mole vole from a girl mole vole genetically? No one really knows.\u003c/p>\n\u003cp>In most mammals, the Y chromosome causes a fertilized egg to turn into a male because of the \u003ca href=\"http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.156\">SRY\u003c/a> gene. This gene starts a cascade of events that eventually results in a male.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>One possibility would be if the SRY gene happened to move to another chromosome. There are certainly cases of this happening even in humans.\u003c/p>\n\u003cp>If this were the case, then maybe a different chromosome has the SRY gene in mole voles. Maybe there are versions of the gene that work and versions that don't. Now we have a gene no different than an eye or hair color gene.\u003c/p>\n\u003cp>Good model but it isn't true. Scientists have looked but it appears that these little guys don't have an SRY gene. They make the male/female decision in a completely different way.\u003c/p>\n\u003cp>Most likely somewhere along the way a gene mutated so that it could now determine the sex of these mammals. When this happened, the loss of the Y didn't matter much and so it was lost. The mole vole evolved into a Y-less mammal.\u003c/p>\n\u003cp>Of course, if any chromosome had to go it would be the Y. It has been under constant attack ever since it distinguished itself from the X chromosome 200 or 300 million years ago. It has gone from being one of the biggest chromosomes with 900-1400 genes to a bit of DNA with around 80 genes.\u003c/p>\n\u003cp>There are even active discussions about whether the Y is on a death spiral in all mammals. Soon we may all be mole voles. Or be gone. Some of my recent posts elsewhere on this topic:\u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/ask.php?id=51\">Males going extinct?\u003c/a>\u003cbr>\n\u003ca href=\"http://www.thetech.org/genetics/ask.php?id=28\">Fish that change gender\u003c/a> \u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n","blocks":[],"excerpt":null,"status":"publish","parent":0,"modified":1215457434,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":421},"headData":{"title":"Why no Y? Gender-bending Transcaucasian mole voles | KQED","description":"I've always been fascinated by weird animals. Especially those with out-of-the-ordinary genetics. Transcaucasian mole vole. Image Courtesy of Heike HimmelreichOne of my favorites is a little burrowing mammal called a Transcaucasian mole vole. These guys live in the Caucasus Mountains of Armenia, Iran, Turkey, and Azerbaijan. There they are born, live, have babies and die.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Why no Y? Gender-bending Transcaucasian mole voles","datePublished":"2008-07-07T19:03:54.000Z","dateModified":"2008-07-07T19:03:54.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"687 http://www.kqed.org/quest/blog/?p=687","disqusUrl":"https://ww2.kqed.org/quest/2008/07/07/why-no-y-gender-bending-transcaucasian-mole-voles/","disqusTitle":"Why no Y? Gender-bending Transcaucasian mole voles","path":"/quest/687/why-no-y-gender-bending-transcaucasian-mole-voles","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>I've always been fascinated by weird animals. Especially those with out-of-the-ordinary genetics.\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/07/molevole1.jpg\">\u003cem>Transcaucasian mole vole. Image Courtesy of Heike Himmelreich\u003c/em>\u003c/span>One of my favorites is a little burrowing mammal called a Transcaucasian mole vole. These guys live in the Caucasus Mountains of Armenia, Iran, Turkey, and Azerbaijan. There they are born, live, have babies and die. All without a Y chromosome.\u003c/p>\n\u003cp>This is really bizarre. In most mammals, two X chromosomes usually means that the animal is female and an X and a Y means the animal is male. All mole voles have a single X chromosome. So technically, there shouldn’t be any males running around. And yet, clearly, there are. \u003c/p>\n\u003cp>So what distinguishes a boy mole vole from a girl mole vole genetically? No one really knows.\u003c/p>\n\u003cp>In most mammals, the Y chromosome causes a fertilized egg to turn into a male because of the \u003ca href=\"http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.156\">SRY\u003c/a> gene. This gene starts a cascade of events that eventually results in a male.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>One possibility would be if the SRY gene happened to move to another chromosome. There are certainly cases of this happening even in humans.\u003c/p>\n\u003cp>If this were the case, then maybe a different chromosome has the SRY gene in mole voles. Maybe there are versions of the gene that work and versions that don't. Now we have a gene no different than an eye or hair color gene.\u003c/p>\n\u003cp>Good model but it isn't true. Scientists have looked but it appears that these little guys don't have an SRY gene. They make the male/female decision in a completely different way.\u003c/p>\n\u003cp>Most likely somewhere along the way a gene mutated so that it could now determine the sex of these mammals. When this happened, the loss of the Y didn't matter much and so it was lost. The mole vole evolved into a Y-less mammal.\u003c/p>\n\u003cp>Of course, if any chromosome had to go it would be the Y. It has been under constant attack ever since it distinguished itself from the X chromosome 200 or 300 million years ago. It has gone from being one of the biggest chromosomes with 900-1400 genes to a bit of DNA with around 80 genes.\u003c/p>\n\u003cp>There are even active discussions about whether the Y is on a death spiral in all mammals. Soon we may all be mole voles. Or be gone. Some of my recent posts elsewhere on this topic:\u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/ask.php?id=51\">Males going extinct?\u003c/a>\u003cbr>\n\u003ca href=\"http://www.thetech.org/genetics/ask.php?id=28\">Fish that change gender\u003c/a> \u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/687/why-no-y-gender-bending-transcaucasian-mole-voles","authors":["6177"],"categories":["quest_4","quest_16"],"tags":["quest_511","quest_596","quest_848","quest_1187","quest_1188","quest_1197","quest_3351","quest_1725","quest_2349","quest_2769","quest_2770","quest_3089","quest_3195"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. 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You ask the questions. You decide what Bay Curious investigates. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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