Personalized Medicine: A Potential Tool for Predicting Disease?
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Barry Starr","firstName":"Dr. Barry","lastName":"Starr","slug":"dr-barry-starr","email":"bstarr@thetech.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Dr. Barry Starr (\u003ca href=\"https://twitter.com/geneticsboy\">@geneticsboy\u003c/a>) is a Geneticist-in-Residence at The Tech Museum of Innovation in San Jose, CA and runs their Stanford at The Tech program. The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"},"darya-pino":{"type":"authors","id":"10218","meta":{"index":"authors_1591205172","id":"10218","found":true},"name":"Darya Pino","firstName":"Darya","lastName":"Pino","slug":"darya-pino","email":"darya@summertomato.com","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Darya Pino is a Ph.D trained scientist, San Francisco foodie, food and health writer and advocate of local, seasonal foods. She shares her unique scientific perspective on health and enthusiasm for delicious foods at her website Summer Tomato. Follow her on Twitter @summertomato.","avatar":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Darya Pino | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/darya-pino"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_37476":{"type":"posts","id":"quest_37476","meta":{"index":"posts_1591205157","site":"quest","id":"37476","score":null,"sort":[1337007653000]},"guestAuthors":[],"slug":"personalized-medicine","title":"Personalized Medicine: A Potential Tool for Predicting Disease?","publishDate":1337007653,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_37481\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/14/personalized-medicine/pills/\" rel=\"attachment wp-att-37481\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/Pills.jpg\" alt=\"\" title=\"Pills\" width=\"640\" height=\"361\" class=\"size-full wp-image-37481\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/05/Pills.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/05/Pills-400x226.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">We've taken another baby step away from the current one size fits all health care system.\u003c/figcaption>\u003c/figure>\n\u003cp>We may finally be at the threshold of the age of personalized medicine. In a recent \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/22424236\">study\u003c/a>, scientists were able to predict that a man was at a higher risk for developing Type 2 diabetes and over a two-year period tracked his health as he developed the disease. And even better, because they caught it so early, they were able to stave off the diabetes with lifestyle changes. This man’s glucose levels have returned to normal.\u003c/p>\n\u003cp>Wow. This story highlights the promise of at least one aspect of personalized medicine. By looking at someone’s DNA, you can predict what might go wrong with someone and so keep an eye out for early symptoms. Or maybe even start out with the right lifestyle changes that will keep the disease from developing in the first place.\u003c/p>\n\u003cp>This study also showed that intensely studying a single person can yield potential benefits for lots of other people. The researchers saw that just before the test subject’s glucose levels spiked, he had a viral infection. No one was really looking for viruses that trigger Type 2 diabetes in people. Now they will. (Keep in mind we don’t yet know if the two are connected or if it was just a coincidence.)\u003c/p>\n\u003cp>The study also points to the obstacles we still need to overcome to realize the full potential of personalized medicine. The top ones I could think of off the top of my head are our own ignorance, the inconvenience, the expense, and our lack of willpower.\u003c/p>\n\u003cp>The researchers were able to predict an increased risk for diabetes as well as an increased risk for high triglycerides but very little else. There is certainly more information lurking in his DNA…we just don’t understand our DNA well enough to tease it out yet.\u003c/p>\n\u003cfigure id=\"attachment_37488\" class=\"wp-caption alignright\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/14/personalized-medicine/personalpill/\" rel=\"attachment wp-att-37488\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/PersonalPill.jpg\" alt=\"\" title=\"PersonalPill\" width=\"250\" height=\"302\" class=\"size-full wp-image-37488\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Soon your treatments will be tailored for you based on at least partly on what's in your DNA.\u003c/figcaption>\u003c/figure>\n\u003cp>Another related issue is whether we actually do know enough to make good predictions or if we just got lucky here. In other words, was his developing Type 2 diabetes a coincidence or was he really at a higher risk for getting it? He didn’t have any classic risk factors but given that so many people in the U.S. have the disease, it could have been chance. Doing many more studies on lots of different people should give us some idea about how predictive our DNA really is right now.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Besides our still sketchy knowledge, we also have to deal with the expense and inconvenience of this form of personalized medicine. The test subject had over twenty blood draws over a two year period that each looked at tens of thousands of different things. Not many people would put up with so many blood draws. And the expense of looking at all those different molecules is prohibitively expensive.\u003c/p>\n\u003cp>A better knowledge of our risks can help with the second point. Once we understand our DNA better and so know what are most likely risks are, we’ll be able to test for fewer molecules which should make the whole thing more affordable. This may also solve the first problem too.\u003c/p>\n\u003cp>Maybe in the future we’ll look at few enough molecules or the tests will be sensitive enough to get the information we need from a simple finger prick. Then we’d all be like folks with diabetes, self testing our blood on a regular basis. And hopefully in the more distant future, we’ll have some sort of implant that reads the information for us automatically without the need for a blood draw.\u003c/p>\n\u003cp>All of these are technical hurdles that will almost certainly be overcome at some point. The last obstacle, though, is much more difficult. It deals with human nature.\u003c/p>\n\u003cp>One reason this is such a powerful story is that the test subject was able to get his glucose under control without the use of medicines. This is not only good for him but it suggests that this form of personalized medicine may prove to be cost effective sooner rather than later. Keeping his Type 2 diabetes at bay will probably save tons of money over his life time. Perhaps even enough to justify the cost of his testing.\u003c/p>\n\u003cp>But to control his glucose levels, he had to make radical changes to his diet and exercise regime. He had to eat a whole lot less sugar and fat and exercise a lot more. Sound familiar?\u003c/p>\n\u003cp>Everyone should be doing this stuff anyway but most of us don’t. Will we have the willpower to realize the full potential of personalized medicine? Or will things pretty much stay the same except with more frequent scolding from our doctors? \u003c/p>\n\u003cp>Of course, catching a disease early and getting patients their medications early when it could do the most good is obviously wonderful too. Just not as cost effective.\u003c/p>\n\u003cp>[youtube=http://www.youtube.com/watch?v=xbjqHj_J0is]\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>What a visit to the doctor in the near future might look like.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"We may finally be at the threshold of the age of personalized medicine. In a recent study, scientists were able to predict that a man was at a higher risk for developing Type 2 diabetes and over a two-year period tracked his health as he developed the disease.","status":"publish","parent":0,"modified":1336926394,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":874},"headData":{"title":"Personalized Medicine: A Potential Tool for Predicting Disease? | KQED","description":"We may finally be at the threshold of the age of personalized medicine. In a recent study, scientists were able to predict that a man was at a higher risk for developing Type 2 diabetes and over a two-year period tracked his health as he developed the disease.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Personalized Medicine: A Potential Tool for Predicting Disease?","datePublished":"2012-05-14T15:00:53.000Z","dateModified":"2012-05-13T16:26:34.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"37476 http://science.kqed.org/quest/?p=37476","disqusUrl":"https://ww2.kqed.org/quest/2012/05/14/personalized-medicine/","disqusTitle":"Personalized Medicine: A Potential Tool for Predicting Disease?","path":"/quest/37476/personalized-medicine","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_37481\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/14/personalized-medicine/pills/\" rel=\"attachment wp-att-37481\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/Pills.jpg\" alt=\"\" title=\"Pills\" width=\"640\" height=\"361\" class=\"size-full wp-image-37481\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/05/Pills.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/05/Pills-400x226.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">We've taken another baby step away from the current one size fits all health care system.\u003c/figcaption>\u003c/figure>\n\u003cp>We may finally be at the threshold of the age of personalized medicine. In a recent \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/22424236\">study\u003c/a>, scientists were able to predict that a man was at a higher risk for developing Type 2 diabetes and over a two-year period tracked his health as he developed the disease. And even better, because they caught it so early, they were able to stave off the diabetes with lifestyle changes. This man’s glucose levels have returned to normal.\u003c/p>\n\u003cp>Wow. This story highlights the promise of at least one aspect of personalized medicine. By looking at someone’s DNA, you can predict what might go wrong with someone and so keep an eye out for early symptoms. Or maybe even start out with the right lifestyle changes that will keep the disease from developing in the first place.\u003c/p>\n\u003cp>This study also showed that intensely studying a single person can yield potential benefits for lots of other people. The researchers saw that just before the test subject’s glucose levels spiked, he had a viral infection. No one was really looking for viruses that trigger Type 2 diabetes in people. Now they will. (Keep in mind we don’t yet know if the two are connected or if it was just a coincidence.)\u003c/p>\n\u003cp>The study also points to the obstacles we still need to overcome to realize the full potential of personalized medicine. The top ones I could think of off the top of my head are our own ignorance, the inconvenience, the expense, and our lack of willpower.\u003c/p>\n\u003cp>The researchers were able to predict an increased risk for diabetes as well as an increased risk for high triglycerides but very little else. There is certainly more information lurking in his DNA…we just don’t understand our DNA well enough to tease it out yet.\u003c/p>\n\u003cfigure id=\"attachment_37488\" class=\"wp-caption alignright\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/14/personalized-medicine/personalpill/\" rel=\"attachment wp-att-37488\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/PersonalPill.jpg\" alt=\"\" title=\"PersonalPill\" width=\"250\" height=\"302\" class=\"size-full wp-image-37488\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Soon your treatments will be tailored for you based on at least partly on what's in your DNA.\u003c/figcaption>\u003c/figure>\n\u003cp>Another related issue is whether we actually do know enough to make good predictions or if we just got lucky here. In other words, was his developing Type 2 diabetes a coincidence or was he really at a higher risk for getting it? He didn’t have any classic risk factors but given that so many people in the U.S. have the disease, it could have been chance. Doing many more studies on lots of different people should give us some idea about how predictive our DNA really is right now.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Besides our still sketchy knowledge, we also have to deal with the expense and inconvenience of this form of personalized medicine. The test subject had over twenty blood draws over a two year period that each looked at tens of thousands of different things. Not many people would put up with so many blood draws. And the expense of looking at all those different molecules is prohibitively expensive.\u003c/p>\n\u003cp>A better knowledge of our risks can help with the second point. Once we understand our DNA better and so know what are most likely risks are, we’ll be able to test for fewer molecules which should make the whole thing more affordable. This may also solve the first problem too.\u003c/p>\n\u003cp>Maybe in the future we’ll look at few enough molecules or the tests will be sensitive enough to get the information we need from a simple finger prick. Then we’d all be like folks with diabetes, self testing our blood on a regular basis. And hopefully in the more distant future, we’ll have some sort of implant that reads the information for us automatically without the need for a blood draw.\u003c/p>\n\u003cp>All of these are technical hurdles that will almost certainly be overcome at some point. The last obstacle, though, is much more difficult. It deals with human nature.\u003c/p>\n\u003cp>One reason this is such a powerful story is that the test subject was able to get his glucose under control without the use of medicines. This is not only good for him but it suggests that this form of personalized medicine may prove to be cost effective sooner rather than later. Keeping his Type 2 diabetes at bay will probably save tons of money over his life time. Perhaps even enough to justify the cost of his testing.\u003c/p>\n\u003cp>But to control his glucose levels, he had to make radical changes to his diet and exercise regime. He had to eat a whole lot less sugar and fat and exercise a lot more. Sound familiar?\u003c/p>\n\u003cp>Everyone should be doing this stuff anyway but most of us don’t. Will we have the willpower to realize the full potential of personalized medicine? Or will things pretty much stay the same except with more frequent scolding from our doctors? \u003c/p>\n\u003cp>Of course, catching a disease early and getting patients their medications early when it could do the most good is obviously wonderful too. Just not as cost effective.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/xbjqHj_J0is'\n title='//www.youtube.com/embed/xbjqHj_J0is'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>What a visit to the doctor in the near future might look like.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/37476/personalized-medicine","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_1197","quest_2162","quest_3974","quest_13202","quest_3319","quest_3018"],"featImg":"quest_37481","label":"quest"},"quest_12652":{"type":"posts","id":"quest_12652","meta":{"index":"posts_1591205157","site":"quest","id":"12652","score":null,"sort":[1299273617000]},"guestAuthors":[],"slug":"missing-gene-suggests-rodents-arent-the-best-model-for-diabetes-research","title":"Missing Gene Suggests Rodents Aren't The Best Model For Diabetes Research","publishDate":1299273617,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/03/mouse2.jpg\" alt=\"\">\u003cem>The gene CMAH is needed to induce human-like diabetes in mice. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/alicepopkorn/5254159199/\">AlicePopkorn\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003ca href=\"http://www.universityofcalifornia.edu/news/article/25049\">New research\u003c/a> suggests that rodents and other mammals might not be ideal for studying type 2 diabetes because of a gene that was deleted from the human genome millions of years ago.\u003c/p>\n\u003cp>Virtually all mammals produce specific sugar molecules that aid cells in interacting with their environment. That is, all except humans. Around 2 to 3 million years ago humans lost CMAH, a gene that codes for an enzyme that produces the sugar Neu5Gc.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>To test the role of this gene, researches compared two sets of mice. One group had a normal CMAH function and Neu5Gc production, the other group did not—just like humans. Both groups of mice were fed a diet that normally induces obesity and insulin resistance (metabolic syndrome), and both groups experienced these symptoms. However, only the mice missing the CMAH gene had lost the ability to produce insulin in the pancreas.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>These findings suggest that while normal mice can exhibit some of the symptoms of type 2 diabetes in the lab, they do not mimic the full effects of metabolic syndrome experienced by humans exposed to a similar diet.\u003c/p>\n\u003cp>Future diabetes research may be better served using mice with a genetic background more similar to humans and missing the CMAH gene.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 32.8774915 -117.2352765\u003c/p>\n\n","blocks":[],"excerpt":"Rodents and other mammals might not be ideal for studying type 2 diabetes because of a gene that was deleted from the human genome millions of years ago.","status":"publish","parent":0,"modified":1299273617,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":10,"wordCount":229},"headData":{"title":"Missing Gene Suggests Rodents Aren't The Best Model For Diabetes Research | KQED","description":"Rodents and other mammals might not be ideal for studying type 2 diabetes because of a gene that was deleted from the human genome millions of years ago.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Missing Gene Suggests Rodents Aren't The Best Model For Diabetes Research","datePublished":"2011-03-04T21:20:17.000Z","dateModified":"2011-03-04T21:20:17.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"12652 http://www.kqed.org/quest/blog/?p=12652","disqusUrl":"https://ww2.kqed.org/quest/2011/03/04/missing-gene-suggests-rodents-arent-the-best-model-for-diabetes-research/","disqusTitle":"Missing Gene Suggests Rodents Aren't The Best Model For Diabetes Research","path":"/quest/12652/missing-gene-suggests-rodents-arent-the-best-model-for-diabetes-research","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/03/mouse2.jpg\" alt=\"\">\u003cem>The gene CMAH is needed to induce human-like diabetes in mice. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/alicepopkorn/5254159199/\">AlicePopkorn\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003ca href=\"http://www.universityofcalifornia.edu/news/article/25049\">New research\u003c/a> suggests that rodents and other mammals might not be ideal for studying type 2 diabetes because of a gene that was deleted from the human genome millions of years ago.\u003c/p>\n\u003cp>Virtually all mammals produce specific sugar molecules that aid cells in interacting with their environment. That is, all except humans. Around 2 to 3 million years ago humans lost CMAH, a gene that codes for an enzyme that produces the sugar Neu5Gc.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>To test the role of this gene, researches compared two sets of mice. One group had a normal CMAH function and Neu5Gc production, the other group did not—just like humans. Both groups of mice were fed a diet that normally induces obesity and insulin resistance (metabolic syndrome), and both groups experienced these symptoms. However, only the mice missing the CMAH gene had lost the ability to produce insulin in the pancreas.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>These findings suggest that while normal mice can exhibit some of the symptoms of type 2 diabetes in the lab, they do not mimic the full effects of metabolic syndrome experienced by humans exposed to a similar diet.\u003c/p>\n\u003cp>Future diabetes research may be better served using mice with a genetic background more similar to humans and missing the CMAH gene.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 32.8774915 -117.2352765\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/12652/missing-gene-suggests-rodents-arent-the-best-model-for-diabetes-research","authors":["10218"],"categories":["quest_4","quest_12"],"tags":["quest_821","quest_1188","quest_1197","quest_3018"],"label":"quest"},"quest_4603":{"type":"posts","id":"quest_4603","meta":{"index":"posts_1591205157","site":"quest","id":"4603","score":null,"sort":[1261411257000]},"guestAuthors":[],"slug":"4603","title":"Don't Forget about Life Style Choices","publishDate":1261411257,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest/\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/12/blog_egg3001.jpg\" alt=\"\">\u003c/a>\u003cem>For most of us, avoiding these is just as important as the genes we inherit.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>As someone who studies genes, I tend to give the environment short shrift. I have to watch out for that because it can cause a blind spot in how I think about biology. And how I live my life.\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2009/10/12/do-these-genes-make-me-look-diabetic/\">As readers of this blog might remember\u003c/a>, I was recently diagnosed with \u003ca href=\"https://health.google.com/health/ref/Metabolic+syndrome\">metabolic syndrome\u003c/a> just as I was undergoing DNA testing. This was a wake up call in a couple of different ways.\u003c/p>\n\u003cp>First off, it confirmed my belief that we can’t get a lot out of genetic testing for complicated diseases right now. I couldn’t look at my DNA and predict that I would end up with high cholesterol, triglycerides and glucose levels. We just don’t know enough yet about our genes to be able to figure this out from any available DNA test.\u003c/p>\n\u003cp>But I could have guessed this might be a problem from my lifestyle and family history. All four of my grandparents developed \u003ca href=\"https://health.google.com/health/ref/Type+2+diabetes\">Type 2 diabetes\u003c/a> which put me at a pretty high risk. Of course I thought I could beat the odds and so lived a life filled with couch sitting, Haagen Dazs, and Double Western Bacon Cheeseburgers (cue Homer Simpson drool). Until my diagnosis.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Then I decided to see if all this talk of diet and exercise actually can have a significant impact on me. Or was I destined to high cholesterol, \u003ca href=\"http://www.americanheart.org/presenter.jhtml?identifier=4778\">triglycerides\u003c/a> and glucose levels because of the genes I got from my parents.\u003c/p>\n\u003cp>The doctor told me to lose weight, exercise more and eat better. So I did.\u003c/p>\n\u003cp>I lost 30 pounds by changing my diet and walking 30 minutes a day. This dropped my body mass index (BMI) from overweight (27.8) to normal (23.5).\u003c/p>\n\u003cp>I also stopped eating most sweets, and cut my saturated fats down to 15 grams per day. And the effects on my blood work have been amazing.\u003c/p>\n\u003cp>Here are a few of the stats:\u003c/p>\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n\u003ctbody>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">\u003c/td>\n\u003ctd width=\"72\" valign=\"top\">Desired\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">9/21/2009\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">11/16/2009\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Total Cholesterol\u003c/td>\n\u003ctd width=\"72\" valign=\"top\"><200\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">205(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">115\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Cholesterol/HDL\u003c/td>\n\u003ctd width=\"72\" valign=\"top\"><5\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">5.4(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">2.5\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Triglycerides\u003c/td>\n\u003ctd width=\"72\" valign=\"top\"><150\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">351(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">85\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Fasting Glucose\u003c/td>\n\u003ctd width=\"72\" valign=\"top\">70-100\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">122(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">104(H)\u003c/td>\n\u003c/tr>\n\u003c/tbody>\n\u003c/table>\n\u003cp>As you can see, everything is now in the normal range except for glucose which is still a bit worrisome. Now I just need to maintain this regimen which, in America, won’t be easy.\u003c/p>\n\u003cp>I probably panicked and went overboard anyway. I should have tried to just add exercise and see if that was good enough. If not, then cut back on sweets and saturated fats. I did bad science on myself by changing too many variables at once.\u003c/p>\n\u003cp>I think what I can conclude is that my set of genes makes me particularly susceptible to my lifestyle choices. Some lucky people are born with genes that let them get away with poor diet and no exercise.\u003c/p>\n\u003cp>I am not one of those lucky ones. Although perhaps more lucky than those people who make these changes and still have these health issues.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n","blocks":[],"excerpt":"As readers of this blog might remember, I was recently diagnosed with metabolic syndrome just as I was undergoing DNA testing. This was a wake up call in a couple of different ways.","status":"publish","parent":0,"modified":1261411257,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":17,"wordCount":526},"headData":{"title":"Don't Forget about Life Style Choices | KQED","description":"As readers of this blog might remember, I was recently diagnosed with metabolic syndrome just as I was undergoing DNA testing. This was a wake up call in a couple of different ways.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Don't Forget about Life Style Choices","datePublished":"2009-12-21T16:00:57.000Z","dateModified":"2009-12-21T16:00:57.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"4603 http://www.kqed.org/quest/blog/?p=4603","disqusUrl":"https://ww2.kqed.org/quest/2009/12/21/4603/","disqusTitle":"Don't Forget about Life Style Choices","path":"/quest/4603/4603","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest/\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2009/12/blog_egg3001.jpg\" alt=\"\">\u003c/a>\u003cem>For most of us, avoiding these is just as important as the genes we inherit.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>As someone who studies genes, I tend to give the environment short shrift. I have to watch out for that because it can cause a blind spot in how I think about biology. And how I live my life.\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2009/10/12/do-these-genes-make-me-look-diabetic/\">As readers of this blog might remember\u003c/a>, I was recently diagnosed with \u003ca href=\"https://health.google.com/health/ref/Metabolic+syndrome\">metabolic syndrome\u003c/a> just as I was undergoing DNA testing. This was a wake up call in a couple of different ways.\u003c/p>\n\u003cp>First off, it confirmed my belief that we can’t get a lot out of genetic testing for complicated diseases right now. I couldn’t look at my DNA and predict that I would end up with high cholesterol, triglycerides and glucose levels. We just don’t know enough yet about our genes to be able to figure this out from any available DNA test.\u003c/p>\n\u003cp>But I could have guessed this might be a problem from my lifestyle and family history. All four of my grandparents developed \u003ca href=\"https://health.google.com/health/ref/Type+2+diabetes\">Type 2 diabetes\u003c/a> which put me at a pretty high risk. Of course I thought I could beat the odds and so lived a life filled with couch sitting, Haagen Dazs, and Double Western Bacon Cheeseburgers (cue Homer Simpson drool). Until my diagnosis.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Then I decided to see if all this talk of diet and exercise actually can have a significant impact on me. Or was I destined to high cholesterol, \u003ca href=\"http://www.americanheart.org/presenter.jhtml?identifier=4778\">triglycerides\u003c/a> and glucose levels because of the genes I got from my parents.\u003c/p>\n\u003cp>The doctor told me to lose weight, exercise more and eat better. So I did.\u003c/p>\n\u003cp>I lost 30 pounds by changing my diet and walking 30 minutes a day. This dropped my body mass index (BMI) from overweight (27.8) to normal (23.5).\u003c/p>\n\u003cp>I also stopped eating most sweets, and cut my saturated fats down to 15 grams per day. And the effects on my blood work have been amazing.\u003c/p>\n\u003cp>Here are a few of the stats:\u003c/p>\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n\u003ctbody>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">\u003c/td>\n\u003ctd width=\"72\" valign=\"top\">Desired\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">9/21/2009\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">11/16/2009\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Total Cholesterol\u003c/td>\n\u003ctd width=\"72\" valign=\"top\"><200\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">205(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">115\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Cholesterol/HDL\u003c/td>\n\u003ctd width=\"72\" valign=\"top\"><5\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">5.4(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">2.5\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Triglycerides\u003c/td>\n\u003ctd width=\"72\" valign=\"top\"><150\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">351(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">85\u003c/td>\n\u003c/tr>\n\u003ctr>\n\u003ctd width=\"115\" valign=\"top\">Fasting Glucose\u003c/td>\n\u003ctd width=\"72\" valign=\"top\">70-100\u003c/td>\n\u003ctd width=\"74\" valign=\"top\">122(H)\u003c/td>\n\u003ctd width=\"82\" valign=\"top\">104(H)\u003c/td>\n\u003c/tr>\n\u003c/tbody>\n\u003c/table>\n\u003cp>As you can see, everything is now in the normal range except for glucose which is still a bit worrisome. Now I just need to maintain this regimen which, in America, won’t be easy.\u003c/p>\n\u003cp>I probably panicked and went overboard anyway. I should have tried to just add exercise and see if that was good enough. If not, then cut back on sweets and saturated fats. I did bad science on myself by changing too many variables at once.\u003c/p>\n\u003cp>I think what I can conclude is that my set of genes makes me particularly susceptible to my lifestyle choices. Some lucky people are born with genes that let them get away with poor diet and no exercise.\u003c/p>\n\u003cp>I am not one of those lucky ones. Although perhaps more lucky than those people who make these changes and still have these health issues.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7749295 -122.4194155\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/4603/4603","authors":["6177"],"categories":["quest_12"],"tags":["quest_830","quest_848","quest_1035","quest_1195","quest_1226","quest_3018"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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You ask the questions. You decide what Bay Curious investigates. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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