Newly Discovered Stem Cells Cause Clogged Arteries
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(Zoey Huang photo.)","credit":null,"description":"Zhenyu Tang (seated at microscope) examines vascular stem cells in culture along with Aijun Wang (left) and Song Li (right). 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(Zoey Huang photo.)\u003c/figcaption>\u003c/figure>\n\u003cp>Odds are that you know someone who’s had a heart attack. One American suffers a coronary event \u003ca href=\"http://circ.ahajournals.org/content/125/1/e2.full.pdf\" title=\"prevalence of atherosclerosis\">every 25 seconds and about every minute\u003c/a> someone dies from one. \u003c/p>\n\u003cp>Doctors thought they understood artery-hardening diseases, such as \u003ca href=\"http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/\" title=\"about atherosclerosis\">atherosclerosis\u003c/a>, that lead to heart attacks, strokes and death. But these generally accepted theories are contradicted by new research performed at the University of California, Berkeley. According to a \u003ca href=\"http://www.nature.com/ncomms/journal/v3/n6/full/ncomms1867.html\" title=\"Song Li journal article in Nature Communications\">new study\u003c/a> published in \u003cem>Nature Communications\u003c/em>, a previously unknown type of stem cell is actually the underlying cause for clogged arteries.\u003c/p>\n\u003cp>For decades, scientists believed that heart disease was caused by the smooth muscle cells that line artery walls. It was thought that bad (LDL) cholesterol damaged the arteries and triggered smooth muscle cells to rapidly reproduce. This led to a build up of fibrous scar tissue that narrowed and hardened the arteries, restricting blood flow. As a result, most therapies focus on physically widening the inside of the blood vessels or replacing the damaged area with a graft.\u003c/p>\n\u003cp>These beliefs are challenged by new research performed by principle investigator Song Li, a professor of bioengineering and researcher at the Berkeley Stem Cell Center, and his colleagues.\u003c/p>\n\u003cp>“For the first time, we are showing evidence that vascular diseases are actually a kind of stem cell disease,” said Song Li in a university news release. “This work should revolutionize therapies for vascular diseases because we now know that stem cells rather than smooth muscle cells are the correct therapeutic target.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Analyzing cells from arteries and veins of transgenic mice, the researchers were able to trace the lineage of the cells that rapidly reproduced in the vessel walls to prove that they were not smooth muscle cells as current theory predicted. Further experiments discovered that they are actually multipotent vascular stem cells, meaning that they can become various specialized cells – smooth muscle, nerve, cartilage, bone and fat cells. The same type of stem cells were also identified in human blood vessels.\u003c/p>\n\u003cp>This explains why previous studies mistook the multipotent vascular stem cells as smooth muscle cells. It also explains how a soft artery can calcify and harden, since the multipotent stem cells can also form bone and cartilage.\u003c/p>\n\u003cfigure id=\"attachment_42124\" class=\"wp-caption alignleft\" style=\"max-width: 319px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350-319x253.jpg\" alt=\"Within walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle cells, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries.\" title=\"stemcell-schematic350\" width=\"319\" height=\"253\" class=\"size-medium wp-image-42124\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Within the walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries. (Song Li illustration)\u003c/figcaption>\u003c/figure>\n\u003cp>When new research dramatically challenges existing scientific beliefs, often people resist the new ideas. Dr. Jill Helms, a professor in the Department of Surgery at Stanford School of Medicine and co-author of the study, explained in an \u003ca href=\"http://www.npr.org/2012/06/08/154587990/identifying-the-real-culprit-behind-killer-vascular-diseases\" title=\"Jill Helms NPR Science Friday interview\">NPR interview\u003c/a>, “There is resistance oftentimes, but there can be moments where there’s great clarity and I think Song’s work certainly falls within that category.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>However, the research still needs to be repeated by other research groups, as well as verified in other animals and humans. Song Li’s collaboration is already studying human cells from healthy and diseased arteries. They are also developing techniques to rapidly screen drugs that specifically target these stem cells without affecting the normal (endothelial) cells that line a blood vessel, which could ultimately lead to new therapies.\u003c/p>\n\n","blocks":[],"excerpt":"Scientists thought they understood how arteries hardened and clogged, but they may have been wrong. New research indicates that a previously unknown type of stem cell is actually the underlying cause of clogged arteries. If confirmed, it could lead to new therapies.","status":"publish","parent":0,"modified":1346781910,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":11,"wordCount":582},"headData":{"title":"Newly Discovered Stem Cells Cause Clogged Arteries | KQED","description":"Scientists thought they understood how arteries hardened and clogged, but they may have been wrong. New research indicates that a previously unknown type of stem cell is actually the underlying cause of clogged arteries. If confirmed, it could lead to new therapies.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Newly Discovered Stem Cells Cause Clogged Arteries","datePublished":"2012-08-06T15:00:41.000Z","dateModified":"2012-09-04T18:05:10.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"42114 http://science.kqed.org/quest/?p=42114","disqusUrl":"https://ww2.kqed.org/quest/2012/08/06/newly-discovered-stem-cells-cause-clogged-arteries/","disqusTitle":"Newly Discovered Stem Cells Cause Clogged Arteries","path":"/quest/42114/newly-discovered-stem-cells-cause-clogged-arteries","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_42120\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-researchers640x360.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-researchers640x360.jpg\" alt=\"UCB researchers exam vascular stem cells in the microscope\" title=\"stemcell-researchers640x360\" width=\"640\" height=\"360\" class=\"size-full wp-image-42120\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/08/stemcell-researchers640x360.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/08/stemcell-researchers640x360-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Zhenyu Tang (seated at microscope) examines vascular stem cells in culture along with Aijun Wang (left) and Song Li (right). (Zoey Huang photo.)\u003c/figcaption>\u003c/figure>\n\u003cp>Odds are that you know someone who’s had a heart attack. One American suffers a coronary event \u003ca href=\"http://circ.ahajournals.org/content/125/1/e2.full.pdf\" title=\"prevalence of atherosclerosis\">every 25 seconds and about every minute\u003c/a> someone dies from one. \u003c/p>\n\u003cp>Doctors thought they understood artery-hardening diseases, such as \u003ca href=\"http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/\" title=\"about atherosclerosis\">atherosclerosis\u003c/a>, that lead to heart attacks, strokes and death. But these generally accepted theories are contradicted by new research performed at the University of California, Berkeley. According to a \u003ca href=\"http://www.nature.com/ncomms/journal/v3/n6/full/ncomms1867.html\" title=\"Song Li journal article in Nature Communications\">new study\u003c/a> published in \u003cem>Nature Communications\u003c/em>, a previously unknown type of stem cell is actually the underlying cause for clogged arteries.\u003c/p>\n\u003cp>For decades, scientists believed that heart disease was caused by the smooth muscle cells that line artery walls. It was thought that bad (LDL) cholesterol damaged the arteries and triggered smooth muscle cells to rapidly reproduce. This led to a build up of fibrous scar tissue that narrowed and hardened the arteries, restricting blood flow. As a result, most therapies focus on physically widening the inside of the blood vessels or replacing the damaged area with a graft.\u003c/p>\n\u003cp>These beliefs are challenged by new research performed by principle investigator Song Li, a professor of bioengineering and researcher at the Berkeley Stem Cell Center, and his colleagues.\u003c/p>\n\u003cp>“For the first time, we are showing evidence that vascular diseases are actually a kind of stem cell disease,” said Song Li in a university news release. “This work should revolutionize therapies for vascular diseases because we now know that stem cells rather than smooth muscle cells are the correct therapeutic target.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Analyzing cells from arteries and veins of transgenic mice, the researchers were able to trace the lineage of the cells that rapidly reproduced in the vessel walls to prove that they were not smooth muscle cells as current theory predicted. Further experiments discovered that they are actually multipotent vascular stem cells, meaning that they can become various specialized cells – smooth muscle, nerve, cartilage, bone and fat cells. The same type of stem cells were also identified in human blood vessels.\u003c/p>\n\u003cp>This explains why previous studies mistook the multipotent vascular stem cells as smooth muscle cells. It also explains how a soft artery can calcify and harden, since the multipotent stem cells can also form bone and cartilage.\u003c/p>\n\u003cfigure id=\"attachment_42124\" class=\"wp-caption alignleft\" style=\"max-width: 319px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350-319x253.jpg\" alt=\"Within walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle cells, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries.\" title=\"stemcell-schematic350\" width=\"319\" height=\"253\" class=\"size-medium wp-image-42124\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Within the walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries. (Song Li illustration)\u003c/figcaption>\u003c/figure>\n\u003cp>When new research dramatically challenges existing scientific beliefs, often people resist the new ideas. Dr. Jill Helms, a professor in the Department of Surgery at Stanford School of Medicine and co-author of the study, explained in an \u003ca href=\"http://www.npr.org/2012/06/08/154587990/identifying-the-real-culprit-behind-killer-vascular-diseases\" title=\"Jill Helms NPR Science Friday interview\">NPR interview\u003c/a>, “There is resistance oftentimes, but there can be moments where there’s great clarity and I think Song’s work certainly falls within that category.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>However, the research still needs to be repeated by other research groups, as well as verified in other animals and humans. Song Li’s collaboration is already studying human cells from healthy and diseased arteries. They are also developing techniques to rapidly screen drugs that specifically target these stem cells without affecting the normal (endothelial) cells that line a blood vessel, which could ultimately lead to new therapies.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/42114/newly-discovered-stem-cells-cause-clogged-arteries","authors":["6360"],"categories":["quest_4","quest_12"],"tags":["quest_3467","quest_11334","quest_10997","quest_13202","quest_2791","quest_10452"],"featImg":"quest_42120","label":"quest"},"quest_27324":{"type":"posts","id":"quest_27324","meta":{"index":"posts_1591205157","site":"quest","id":"27324","score":null,"sort":[1321387430000]},"guestAuthors":[],"slug":"exoskeletons-walk-forward","title":"Exoskeletons Walk Forward","publishDate":1321387430,"format":"video","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>How do you see the world? \u003ca href=\"http://www.exploratorium.edu/seeing/\">Visual perspective\u003c/a> - the way things appear to our eye- things like shapes, dimensions, colors- those are set. But some \u003ca href=\"http://www.exploratorium.edu/snacks/iconperception.html\">perspectives\u003c/a> can be manipulated; proximity or angles can be changed. For example, you might be sitting at your computer now. Stand up and see how the room looks different from that other angle. While there are optical illusions and tricks to the eye, most visual variables are not going to be physically altered. (standing up isn’t going to change the color of the curtains) But a different view can change perceptions. And how we perceive the information we take in is very much a choice.\u003c/p>\n\u003cp>We all perceive the world through our own lens. (You might think those curtains are ugly) Our point of view, or cognitive perception, is largely shaped by our experiences, our beliefs, \u003ca href=\"http://www.wellsphere.com/mental-health-article/shapes-emotions-and-perception/551731\">emotions\u003c/a>, moods and the actions around us. In that way, you choose how you see. And how we traverse the world and how we interact with others is shaped by this perspective. For instance, does the world look different when you are happy or sad? Does the traffic you are in seem worse when you are late or \u003ca href=\"http://www.wellsphere.com/green-living-article/perception/1360527\">angry\u003c/a>? Doesn’t the sun shine brighter when you are in love? \u003c/p>\n\u003cp>Cognitive perception can be manipulated too. Perhaps you are feeling blue because you are being laid off and losing your job? You might be feeling embarrassed, hurt or concerned about the future. It might feel like it’s the end of the world. But with a small twist of your point of view, the perspective might change. How does it compare on scale to other people or events around you? For example, how does the pain of losing your job compare to the illness or loss of a loved one? How would losing your job feel compared to, say, losing your ability to walk? Pretty small concern then.\u003c/p>\n\u003cp>Most visual and cognitive perception is unconscious. It’s not something we focus on as we slog through our daily routines. But for people in wheelchairs, perspective is often in the forefront. When you navigate the world on wheels, you have to think about how you get in a building, get out of bed, make breakfast, get into your car to get to work -- how you do so many of the things able-bodied people take for granted. \u003c/p>\n\u003cp>The world looks different from a sitting position too. When you are in a wheelchair, you always have to look up to talk with your standing fiends and family. That shapes your perspective, both visual and cognitive. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>So thinking about perspectives, one of the things that struck me most was the inspiring attitudes of \u003ca href=\"http://tamaramena.com/\">Tamara Mena \u003c/a>and \u003ca href=\"http://www.austinwhitney.com/Home_Page.php\">Austin Whitney\u003c/a>, the two exoskeleton test pilots we featured in our story. These two young people were both dealt major blows while in the prime of their lives. Both were vibrant and active teenagers when each was involved in catastrophic automobile accidents. Both had to deal with painful rehabilitations. And both faced a future where they probably would never walk again. And through that, both remain courageous, upbeat and positive. Where many might have given up, these two are charging into the future. \u003c/p>\n\u003cp>So put yourself in their shoes and think about what it might mean to be able to stand up and change your perspective. What would it mean to be able to look your friends in the eye, to stand and fully embrace your family again? Think about how the room looked different when you stood up from your computer.\u003c/p>\n\u003cp>The future of exoskeleton technology is marching forward. We saw Austin Whitney \u003ca href=\"http://www.youtube.com/watch?v=pmTPXDwgcm4\">walk across the stage\u003c/a> to receive his college diploma. More is hopefully on the way. Maybe someday soon we’ll also see paraplegics walking down the aisle at their weddings and walking onto airplanes to fly off on their honeymoons. Or less dramatically, maybe soon paraplegics will be able to regain the mundane pleasure of standing at the kitchen counter, making peanut butter sandwiches for their kids. \u003c/p>\n\u003cp>Fantasy? Too much to hope for? It’s all in your perspective.\u003c/p>\n\u003cp>*****************************************************************************************************\u003c/p>\n\u003cp>\u003cstrong>Web Extra - Tamara Mena: Exoskeleton Test Pilot\u003c/strong>\u003c/p>\n\u003cp>When she was 19 years old, Tamara Mena suffered a debilitating spinal injury that left her paralyzed from the chest down. Today she is working as an exoskeleton \"test pilot\" at Ekso Bionics, putting this new technology through its paces. Someday exoskeletons like the one she is testing may give paraplegics the ability to stand up and walk. This is her story. \u003c/p>\n\u003cp>\u003ciframe width=\"560\" height=\"315\" src=\"https://www.youtube.com/embed/I4DdHGEucTE\" frameborder=\"0\" allowfullscreen>\u003c/iframe>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>Additional links:\u003c/strong>\u003cbr>\n\u003ca href=\"http://tamaramena.com/\" title=\"Tamara Mena\">Tamara Mena\u003c/a>\u003cbr>\n\u003ca href=\"http://www.austinwhitney.com/Home_Page.php\" title=\"Austin Whitney \">Austin Whitney\u003c/a>\u003cbr>\n\u003ca href=\"http://bleex.me.berkeley.edu/\" title=\"Berkeley Robotics and Human Engineering Laboratory \">Berkeley Robotics and Human Engineering Laboratory\u003c/a>\u003cbr>\n\u003ca href=\"http://www.eksobionics.com/\" title=\" Ekso Bionics\">Ekso Bionics\u003c/a>\u003cbr>\n\u003ca href=\"http://www.tibion.com/\" title=\"Tibion | Makers of the Tibion Bionic Leg\">Tibion | Makers of the Tibion Bionic Leg\u003cbr>\n\u003c/a>\u003ca href=\"http://www.youtube.com/watch?v=pmTPXDwgcm4\" title=\"The Austin Exoskeleton Project at the University of California, Berkeley \">The Austin Exoskeleton Project at the University of California, Berkeley \u003c/a>\u003cbr>\n\u003ca href=\"http://newscenter.berkeley.edu/2011/05/12/paraplegic-student-exoskeleton-graduation-walk/\" title=\"Engineers to help paraplegic student walk at graduation\">Engineers to help paraplegic student walk at graduation\u003c/a>\u003cbr>\n\u003ca href=\"http://www.berkeleyside.com/2010/10/07/berkeley-bionics-to-launch-elegs/\" title=\"Berkeley Bionics to launch eLEGS\">Berkeley Bionics to launch eLEGS\u003c/a>\u003c/p>\n\n","blocks":[],"excerpt":"An exoskeleton suit may seem like science fiction, turning ordinary humans into super heroes, but wearable robots are moving forward into reality. ","status":"publish","parent":0,"modified":1457569345,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":true,"iframeSrcs":["https://www.youtube.com/embed/I4DdHGEucTE"],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":809},"headData":{"title":"Exoskeletons Walk Forward | KQED","description":"An exoskeleton suit may seem like science fiction, turning ordinary humans into super heroes, but wearable robots are moving forward into reality. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Exoskeletons Walk Forward","datePublished":"2011-11-15T20:03:50.000Z","dateModified":"2016-03-10T00:22:25.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"27324 http://science.kqed.org/quest/?post_type=videos&p=27324","disqusUrl":"https://ww2.kqed.org/quest/2011/11/15/exoskeletons-walk-forward/","disqusTitle":"Exoskeletons Walk Forward","videoEmbed":"https://youtu.be/cc-5XO4gc4g","path":"/quest/27324/exoskeletons-walk-forward","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>How do you see the world? \u003ca href=\"http://www.exploratorium.edu/seeing/\">Visual perspective\u003c/a> - the way things appear to our eye- things like shapes, dimensions, colors- those are set. But some \u003ca href=\"http://www.exploratorium.edu/snacks/iconperception.html\">perspectives\u003c/a> can be manipulated; proximity or angles can be changed. For example, you might be sitting at your computer now. Stand up and see how the room looks different from that other angle. While there are optical illusions and tricks to the eye, most visual variables are not going to be physically altered. (standing up isn’t going to change the color of the curtains) But a different view can change perceptions. And how we perceive the information we take in is very much a choice.\u003c/p>\n\u003cp>We all perceive the world through our own lens. (You might think those curtains are ugly) Our point of view, or cognitive perception, is largely shaped by our experiences, our beliefs, \u003ca href=\"http://www.wellsphere.com/mental-health-article/shapes-emotions-and-perception/551731\">emotions\u003c/a>, moods and the actions around us. In that way, you choose how you see. And how we traverse the world and how we interact with others is shaped by this perspective. For instance, does the world look different when you are happy or sad? Does the traffic you are in seem worse when you are late or \u003ca href=\"http://www.wellsphere.com/green-living-article/perception/1360527\">angry\u003c/a>? Doesn’t the sun shine brighter when you are in love? \u003c/p>\n\u003cp>Cognitive perception can be manipulated too. Perhaps you are feeling blue because you are being laid off and losing your job? You might be feeling embarrassed, hurt or concerned about the future. It might feel like it’s the end of the world. But with a small twist of your point of view, the perspective might change. How does it compare on scale to other people or events around you? For example, how does the pain of losing your job compare to the illness or loss of a loved one? How would losing your job feel compared to, say, losing your ability to walk? Pretty small concern then.\u003c/p>\n\u003cp>Most visual and cognitive perception is unconscious. It’s not something we focus on as we slog through our daily routines. But for people in wheelchairs, perspective is often in the forefront. When you navigate the world on wheels, you have to think about how you get in a building, get out of bed, make breakfast, get into your car to get to work -- how you do so many of the things able-bodied people take for granted. \u003c/p>\n\u003cp>The world looks different from a sitting position too. When you are in a wheelchair, you always have to look up to talk with your standing fiends and family. That shapes your perspective, both visual and cognitive. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>So thinking about perspectives, one of the things that struck me most was the inspiring attitudes of \u003ca href=\"http://tamaramena.com/\">Tamara Mena \u003c/a>and \u003ca href=\"http://www.austinwhitney.com/Home_Page.php\">Austin Whitney\u003c/a>, the two exoskeleton test pilots we featured in our story. These two young people were both dealt major blows while in the prime of their lives. Both were vibrant and active teenagers when each was involved in catastrophic automobile accidents. Both had to deal with painful rehabilitations. And both faced a future where they probably would never walk again. And through that, both remain courageous, upbeat and positive. Where many might have given up, these two are charging into the future. \u003c/p>\n\u003cp>So put yourself in their shoes and think about what it might mean to be able to stand up and change your perspective. What would it mean to be able to look your friends in the eye, to stand and fully embrace your family again? Think about how the room looked different when you stood up from your computer.\u003c/p>\n\u003cp>The future of exoskeleton technology is marching forward. We saw Austin Whitney \u003ca href=\"http://www.youtube.com/watch?v=pmTPXDwgcm4\">walk across the stage\u003c/a> to receive his college diploma. More is hopefully on the way. Maybe someday soon we’ll also see paraplegics walking down the aisle at their weddings and walking onto airplanes to fly off on their honeymoons. Or less dramatically, maybe soon paraplegics will be able to regain the mundane pleasure of standing at the kitchen counter, making peanut butter sandwiches for their kids. \u003c/p>\n\u003cp>Fantasy? Too much to hope for? It’s all in your perspective.\u003c/p>\n\u003cp>*****************************************************************************************************\u003c/p>\n\u003cp>\u003cstrong>Web Extra - Tamara Mena: Exoskeleton Test Pilot\u003c/strong>\u003c/p>\n\u003cp>When she was 19 years old, Tamara Mena suffered a debilitating spinal injury that left her paralyzed from the chest down. Today she is working as an exoskeleton \"test pilot\" at Ekso Bionics, putting this new technology through its paces. Someday exoskeletons like the one she is testing may give paraplegics the ability to stand up and walk. This is her story. \u003c/p>\n\u003cp>\u003ciframe width=\"560\" height=\"315\" src=\"https://www.youtube.com/embed/I4DdHGEucTE\" frameborder=\"0\" allowfullscreen>\u003c/iframe>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>Additional links:\u003c/strong>\u003cbr>\n\u003ca href=\"http://tamaramena.com/\" title=\"Tamara Mena\">Tamara Mena\u003c/a>\u003cbr>\n\u003ca href=\"http://www.austinwhitney.com/Home_Page.php\" title=\"Austin Whitney \">Austin Whitney\u003c/a>\u003cbr>\n\u003ca href=\"http://bleex.me.berkeley.edu/\" title=\"Berkeley Robotics and Human Engineering Laboratory \">Berkeley Robotics and Human Engineering Laboratory\u003c/a>\u003cbr>\n\u003ca href=\"http://www.eksobionics.com/\" title=\" Ekso Bionics\">Ekso Bionics\u003c/a>\u003cbr>\n\u003ca href=\"http://www.tibion.com/\" title=\"Tibion | Makers of the Tibion Bionic Leg\">Tibion | Makers of the Tibion Bionic Leg\u003cbr>\n\u003c/a>\u003ca href=\"http://www.youtube.com/watch?v=pmTPXDwgcm4\" title=\"The Austin Exoskeleton Project at the University of California, Berkeley \">The Austin Exoskeleton Project at the University of California, Berkeley \u003c/a>\u003cbr>\n\u003ca href=\"http://newscenter.berkeley.edu/2011/05/12/paraplegic-student-exoskeleton-graduation-walk/\" title=\"Engineers to help paraplegic student walk at graduation\">Engineers to help paraplegic student walk at graduation\u003c/a>\u003cbr>\n\u003ca href=\"http://www.berkeleyside.com/2010/10/07/berkeley-bionics-to-launch-elegs/\" title=\"Berkeley Bionics to launch eLEGS\">Berkeley Bionics to launch eLEGS\u003c/a>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/27324/exoskeletons-walk-forward","authors":["10169"],"categories":["quest_8","quest_12","quest_17","quest_3422"],"tags":["quest_10442","quest_10444","quest_10447","quest_10446","quest_10441","quest_10443","quest_10449","quest_10445","quest_10451","quest_13","quest_2443","quest_10452","quest_10448","quest_2893","quest_10450","quest_3021","quest_3071"],"featImg":"quest_27334","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us","airtime":"SUN 2pm-3pm, MON 12am-1am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png","officialWebsiteLink":"https://www.wnycstudios.org/shows/otm","meta":{"site":"news","source":"wnyc"},"link":"/radio/program/on-the-media","subscribe":{"apple":"https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2","tuneIn":"https://tunein.com/radio/On-the-Media-p69/","rss":"http://feeds.wnyc.org/onthemedia"}},"our-body-politic":{"id":"our-body-politic","title":"Our Body Politic","info":"Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.","airtime":"SAT 6pm-7pm, SUN 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://our-body-politic.simplecast.com/","meta":{"site":"news","source":"kcrw"},"link":"/radio/program/our-body-politic","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/our-body-politic/id1533069868","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw","spotify":"https://open.spotify.com/show/4ApAiLT1kV153TttWAmqmc","rss":"https://feeds.simplecast.com/_xaPhs1s","tuneIn":"https://tunein.com/podcasts/News--Politics-Podcasts/Our-Body-Politic-p1369211/"}},"pbs-newshour":{"id":"pbs-newshour","title":"PBS NewsHour","info":"Analysis, background reports and updates from the PBS NewsHour putting today's news in context.","airtime":"MON-FRI 3pm-4pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.pbs.org/newshour/","meta":{"site":"news","source":"pbs"},"link":"/radio/program/pbs-newshour","subscribe":{"apple":"https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2","tuneIn":"https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/","rss":"https://www.pbs.org/newshour/feeds/rss/podcasts/show"}},"perspectives":{"id":"perspectives","title":"Perspectives","tagline":"KQED's series of of daily listener commentaries since 1991","info":"KQED's series of of daily listener commentaries since 1991.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Perspectives-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/perspectives/","meta":{"site":"radio","source":"kqed","order":"15"},"link":"/perspectives","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/id73801135","npr":"https://www.npr.org/podcasts/432309616/perspectives","rss":"https://ww2.kqed.org/perspectives/category/perspectives/feed/","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"}},"planet-money":{"id":"planet-money","title":"Planet Money","info":"The economy explained. 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In the Radiolab world, information sounds like music and science and culture collide. Hosted by Jad Abumrad and Robert Krulwich, the show is designed for listeners who demand skepticism, but appreciate wonder. 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The result is stories that inform and inspire, arming our listeners with information to right injustices, hold the powerful accountable and improve lives.Reveal is hosted by Al Letson and showcases the award-winning work of CIR and newsrooms large and small across the nation. In a radio and podcast market crowded with choices, Reveal focuses on important and often surprising stories that illuminate the world for our listeners.","airtime":"SAT 4pm-5pm","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/reveal300px.png","officialWebsiteLink":"https://www.revealnews.org/episodes/","meta":{"site":"news","source":"npr"},"link":"/radio/program/reveal","subscribe":{"apple":"https://itunes.apple.com/us/podcast/reveal/id886009669","tuneIn":"https://tunein.com/radio/Reveal-p679597/","rss":"http://feeds.revealradio.org/revealpodcast"}},"says-you":{"id":"says-you","title":"Says You!","info":"Public radio's game show of bluff and bluster, words and whimsy. 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