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Her science radio stories appear on KQED and NPR.\r\n\r\nEmail her at astanden@kqed.org","avatar":"https://secure.gravatar.com/avatar/3d021b72de685a788b0487b059d0a6a1?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"news","roles":["subscriber"]},{"site":"futureofyou","roles":["subscriber"]},{"site":"stateofhealth","roles":["subscriber"]},{"site":"science","roles":["editor"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Amy Standen | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/3d021b72de685a788b0487b059d0a6a1?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/3d021b72de685a788b0487b059d0a6a1?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/amystanden"},"laurensommer":{"type":"authors","id":"239","meta":{"index":"authors_1591205172","id":"239","found":true},"name":"Lauren Sommer","firstName":"Lauren","lastName":"Sommer","slug":"laurensommer","email":"lsommer@kqed.org","display_author_email":false,"staff_mastheads":[],"title":"KQED Contributor","bio":"Lauren is a radio reporter formerly covering environment, water, and energy for KQED Science. 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You can find her on Twitter at \u003ca href=\"https://twitter.com/lesommer\">@lesommer\u003c/a>.","avatar":"https://secure.gravatar.com/avatar/33aa3772bb86c6ad45b8aca6a238bbdf?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"news","roles":["author"]},{"site":"science","roles":["editor","manage_content_types","manage_taxonomies"]},{"site":"quest","roles":["editor"]}],"headData":{"title":"Lauren Sommer | KQED","description":"KQED Contributor","ogImgSrc":"https://secure.gravatar.com/avatar/33aa3772bb86c6ad45b8aca6a238bbdf?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/33aa3772bb86c6ad45b8aca6a238bbdf?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/laurensommer"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_19241":{"type":"posts","id":"quest_19241","meta":{"index":"posts_1591205157","site":"quest","id":"19241","score":null,"sort":[1307730030000]},"guestAuthors":[],"slug":"the-search-for-alcoholisms-miracle-drug","title":"The Search for Alcoholism's Miracle Drug","publishDate":1307730030,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/spirits300.jpg\" alt=\"\">\u003c/a>\u003cem>By one estimate, there are 10 million alcoholics in the US. Photo Credit: \u003ca href=\"http://commons.wikimedia.org/wiki/File:Spirituosen-im-supermarkt.jpg\">Ralf Roletschek \u003c/a>\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Joseph McHugh is an artist who lives in San Francisco. Like his father before him, Joe had always been a drinker. But recently, it started to pick up. \u003c/p>\n\u003cp>“It sort of got out of control,” he says. “It wasn’t starting at five o’clock, it was starting at noon, when I’d have a couple shots and so forth.” \u003c/p>\n\u003cp>He was having blackouts, he says. He remembered nothing, but people would tell him stories of what he’d done. “Like what?” I ask him. \u003c/p>\n\u003cp>“Things I don’t want to even mention, ok?” \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>What brought McHugh \u003ca href=\"http://www.sanfrancisco.va.gov/\">VA Medical Center\u003c/a> in San Francisco was a heart attack. It literally terrified him into sobriety. He's been dry a month now, slogging through recovery with other men whose lives have also become simply untenable. \u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>[jwplayer config=\"QUEST Audio Player\" skin=\"http://ww2.kqed.org/quest/wp-content/themes/quest/glow.zip\" file=\"http://www.kqed.org/.stream/anon/radio/quest/2011/06/2011-06-13-quest.mp3\" ]\u003cbr>\n\u003c/p>\n\u003cp>\u003cem>Listen to the QUEST radio story \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/audio/the-search-for-alcoholisms-miracle-drug\">The Search for Alcoholism's Miracle Drug\u003c/a>\u003c/strong>\u003c/em>\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>McHugh’s story is a familiar one to doctors who treat alcoholism, like Peter Banys, Director of Substance Abuse Programs at the VA.\u003c/p>\n\u003cp>“It's always a crisis,” Banys says. “And it can be a marital crisis, a family crisis, or job termination.”\u003c/p>\n\u003cp>Alcoholism is a very treatable disease, says Banys. Because of all the recent research, people like McHugh have more options than ever, including AA, therapy, and medication, which can be effective in preventing relapse.\u003c/p>\n\u003cp>Still, there are some challenges. First of all, the meds are a tough sell, Banys says. He says his patients often think of their alcoholism as a moral weakness. \u003c/p>\n\u003cp>“One of the things we hear a lot,” he says, “is I don’t want to depend on a drug. They’ve been depending on a drug for 25 years, they don’t want to depend on ours.”\u003c/p>\n\u003cp>Another problem is that drugs that once seemed promising have often fallen short. \u003c/p>\n\u003cp>Take \u003ca href=\"http://www.drugs.com/pro/naltrexone.html\">Naltrexone\u003c/a>, which was approved in 1995. Naltrexone blocks the brain’s opioid receptors, which make alcohol feel good.\u003c/p>\n\u003cp>“That was the great hope,” says Banys. “It kind of crumbled in our hands.” \u003c/p>\n\u003cp>On many people, Natrexone has no effect all. They’re just wired differently.\u003c/p>\n\u003cp>And that’s proven to be a useful insight. \u003c/p>\n\u003cp>“One of the things that we have to make clear is that alcoholism is almost certainly not a single disease or disorder. I believe that in the near future, we will be talking about “the alcoholisms.”\u003c/p>\n\u003cp>The fact of these “alcoholisms” means that researchers are now targeting specific kinds aspects of brain chemistry that might be involved in alcoholism.\u003c/p>\n\u003cp>Howard Fields directs Human Clinical Research at the \u003ca href=\"http://www.galloresearch.org/\">Gallo Center in Emeryville,\u003c/a> an institute devoted to alcoholism and addiction, affiliated with The University of California, San Francisco.\u003c/p>\n\u003cp>What interests him is something familiar to many of us: Impulsivity. Different people are impulsive to different degrees, just like rats, and other animals. From an evolutionary standpoint, this makes sense. \u003c/p>\n\u003cp>“You want someone who would throw themselves on the hand grenade and save the lives of other people,” says Fields. “The same people who wind up in prison might be completely different in a battlefield situation. They might be the heroes.” \u003c/p>\n\u003cp>But in regular life, impulsivity can be a dangerous trait to have, says Fields. “If you score high for impulsivity, you are at greater risk to actually become an abuser or an addict. There’s no question about that.”\u003c/p>\n\u003cp>Fields says that in some people, impulsivity \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/18160646\">can be traced back\u003c/a> to a specific gene. If you have it, you’re more likely to be impulsive. And it turns out, there is already a drug on the market that targets a function of this gene. It’s called tolcapone, and it’s prescribed to people with Parkinson’s disease. \u003c/p>\n\u003cp>So what Fields aims to find out is whether tolcapone might actually make people less impulsive. And if that’s true, whether it can help people limit their drinking. \u003ca href=\"http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01158950\">This research\u003c/a> is now in human clinical trials. \u003c/p>\n\u003cp>Of course, even if the drug works for some people, it won’t work for everyone. The fact that there are “alcoholisms,” as Peter Banys put it, means that there may never be a single miracle drug. \u003c/p>\n\u003cp>But whatever the future holds, the goal of treatment will always look more or less the same: More people like Joseph McHugh, who have made the life-changing decision to get and stay sober. \u003c/p>\n\u003cp>McHugh says it’s hard to know what things will be like, once he’s out of rehab and back with his family. But he’s optimistic.\u003c/p>\n\u003cp>“I’m sort of glad that everything is where it is now. Because it is a change. It’s a necessary change.\" \u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7813092 -122.5032109\u003c/p>\n\n","blocks":[],"excerpt":"Alcoholism is a very treatable disease, but still, there are some challenges.","status":"publish","parent":0,"modified":1371060682,"stats":{"hasAudio":true,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":34,"wordCount":885},"headData":{"title":"The Search for Alcoholism's Miracle Drug | KQED","description":"","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"The Search for Alcoholism's Miracle Drug","datePublished":"2011-06-10T18:20:30.000Z","dateModified":"2013-06-12T18:11:22.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"19241 http://www.kqed.org/quest/blog/2011/06/10/the-search-for-alcoholisms-miracle-drug/","disqusUrl":"https://ww2.kqed.org/quest/2011/06/10/the-search-for-alcoholisms-miracle-drug/","disqusTitle":"The Search for Alcoholism's Miracle Drug","path":"/quest/19241/the-search-for-alcoholisms-miracle-drug","audioUrl":"http://www.kqed.org/.stream/anon/radio/quest/2011/06/2011-06-13-quest.mp3","audioDuration":null,"audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/spirits300.jpg\" alt=\"\">\u003c/a>\u003cem>By one estimate, there are 10 million alcoholics in the US. Photo Credit: \u003ca href=\"http://commons.wikimedia.org/wiki/File:Spirituosen-im-supermarkt.jpg\">Ralf Roletschek \u003c/a>\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Joseph McHugh is an artist who lives in San Francisco. Like his father before him, Joe had always been a drinker. But recently, it started to pick up. \u003c/p>\n\u003cp>“It sort of got out of control,” he says. “It wasn’t starting at five o’clock, it was starting at noon, when I’d have a couple shots and so forth.” \u003c/p>\n\u003cp>He was having blackouts, he says. He remembered nothing, but people would tell him stories of what he’d done. “Like what?” I ask him. \u003c/p>\n\u003cp>“Things I don’t want to even mention, ok?” \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>What brought McHugh \u003ca href=\"http://www.sanfrancisco.va.gov/\">VA Medical Center\u003c/a> in San Francisco was a heart attack. It literally terrified him into sobriety. He's been dry a month now, slogging through recovery with other men whose lives have also become simply untenable. \u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>[jwplayer config=\"QUEST Audio Player\" skin=\"http://ww2.kqed.org/quest/wp-content/themes/quest/glow.zip\" file=\"http://www.kqed.org/.stream/anon/radio/quest/2011/06/2011-06-13-quest.mp3\" ]\u003cbr>\n\u003c/p>\n\u003cp>\u003cem>Listen to the QUEST radio story \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/audio/the-search-for-alcoholisms-miracle-drug\">The Search for Alcoholism's Miracle Drug\u003c/a>\u003c/strong>\u003c/em>\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>McHugh’s story is a familiar one to doctors who treat alcoholism, like Peter Banys, Director of Substance Abuse Programs at the VA.\u003c/p>\n\u003cp>“It's always a crisis,” Banys says. “And it can be a marital crisis, a family crisis, or job termination.”\u003c/p>\n\u003cp>Alcoholism is a very treatable disease, says Banys. Because of all the recent research, people like McHugh have more options than ever, including AA, therapy, and medication, which can be effective in preventing relapse.\u003c/p>\n\u003cp>Still, there are some challenges. First of all, the meds are a tough sell, Banys says. He says his patients often think of their alcoholism as a moral weakness. \u003c/p>\n\u003cp>“One of the things we hear a lot,” he says, “is I don’t want to depend on a drug. They’ve been depending on a drug for 25 years, they don’t want to depend on ours.”\u003c/p>\n\u003cp>Another problem is that drugs that once seemed promising have often fallen short. \u003c/p>\n\u003cp>Take \u003ca href=\"http://www.drugs.com/pro/naltrexone.html\">Naltrexone\u003c/a>, which was approved in 1995. Naltrexone blocks the brain’s opioid receptors, which make alcohol feel good.\u003c/p>\n\u003cp>“That was the great hope,” says Banys. “It kind of crumbled in our hands.” \u003c/p>\n\u003cp>On many people, Natrexone has no effect all. They’re just wired differently.\u003c/p>\n\u003cp>And that’s proven to be a useful insight. \u003c/p>\n\u003cp>“One of the things that we have to make clear is that alcoholism is almost certainly not a single disease or disorder. I believe that in the near future, we will be talking about “the alcoholisms.”\u003c/p>\n\u003cp>The fact of these “alcoholisms” means that researchers are now targeting specific kinds aspects of brain chemistry that might be involved in alcoholism.\u003c/p>\n\u003cp>Howard Fields directs Human Clinical Research at the \u003ca href=\"http://www.galloresearch.org/\">Gallo Center in Emeryville,\u003c/a> an institute devoted to alcoholism and addiction, affiliated with The University of California, San Francisco.\u003c/p>\n\u003cp>What interests him is something familiar to many of us: Impulsivity. Different people are impulsive to different degrees, just like rats, and other animals. From an evolutionary standpoint, this makes sense. \u003c/p>\n\u003cp>“You want someone who would throw themselves on the hand grenade and save the lives of other people,” says Fields. “The same people who wind up in prison might be completely different in a battlefield situation. They might be the heroes.” \u003c/p>\n\u003cp>But in regular life, impulsivity can be a dangerous trait to have, says Fields. “If you score high for impulsivity, you are at greater risk to actually become an abuser or an addict. There’s no question about that.”\u003c/p>\n\u003cp>Fields says that in some people, impulsivity \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/18160646\">can be traced back\u003c/a> to a specific gene. If you have it, you’re more likely to be impulsive. And it turns out, there is already a drug on the market that targets a function of this gene. It’s called tolcapone, and it’s prescribed to people with Parkinson’s disease. \u003c/p>\n\u003cp>So what Fields aims to find out is whether tolcapone might actually make people less impulsive. And if that’s true, whether it can help people limit their drinking. \u003ca href=\"http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01158950\">This research\u003c/a> is now in human clinical trials. \u003c/p>\n\u003cp>Of course, even if the drug works for some people, it won’t work for everyone. The fact that there are “alcoholisms,” as Peter Banys put it, means that there may never be a single miracle drug. \u003c/p>\n\u003cp>But whatever the future holds, the goal of treatment will always look more or less the same: More people like Joseph McHugh, who have made the life-changing decision to get and stay sober. \u003c/p>\n\u003cp>McHugh says it’s hard to know what things will be like, once he’s out of rehab and back with his family. But he’s optimistic.\u003c/p>\n\u003cp>“I’m sort of glad that everything is where it is now. Because it is a change. It’s a necessary change.\" \u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7813092 -122.5032109\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/19241/the-search-for-alcoholisms-miracle-drug","authors":["210"],"categories":["quest_5","quest_12"],"tags":["quest_3447","quest_13201","quest_1783","quest_3674","quest_13203","quest_3692","quest_2771","quest_3021"],"featImg":"quest_15187","label":"quest"},"quest_19236":{"type":"posts","id":"quest_19236","meta":{"index":"posts_1591205157","site":"quest","id":"19236","score":null,"sort":[1307134812000]},"guestAuthors":[],"slug":"the-science-of-pain","title":"The Science of Pain","publishDate":1307134812,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/mole300.jpg\" alt=\"\">\u003c/a>\u003cem>The nose of the star-nosed mole is much more sensitive than the human hand. Credit: Dr. Ken Catania, Vanderbilt University\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Pain is the most common reason for trips to the doctor's office. So it makes sense that pain treatment is a huge part of our healthcare system, costing more than 100 billion dollars a year. But how exactly pain works is still a mystery in many ways.\u003c/p>\n\u003cp>Like any normal 9-year-old, Maddie Burkhardt was playing outside with her friends last summer, racing around in a pedal go-cart. \u003c/p>\n\u003cp>\"And my foot slipped and it went under the go-cart. Like it got bent backwards,\" she says.\u003c/p>\n\u003cp>Maddie broke a bone in her foot. So, her mom, Danielle, took her to see a podiatrist, who put her in a series of casts. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>\"And every time he took the cast off, he said 'ok, you should feel much better now.' And she was just like 'no, it's killing me,\" says Danielle.\u003c/p>\n\u003cp>As the weeks went by, it became clear that Maddie's pain wasn't normal. \"She would not allow anything to touch her foot at all. And we didn't really know what was going on,\" says Danielle.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>[jwplayer config=\"QUEST Audio Player\" skin=\"http://ww2.kqed.org/quest/wp-content/themes/quest/glow.zip\" file=\"http://www.kqed.org/.stream/anon/radio/quest/2011/06/2011-06-06-quest.mp3\" ]\u003cbr>\n\u003c/p>\n\u003cp>\u003cem>Listen to the QUEST radio story \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/audio/the-science-of-pain\">The Science of Pain \u003c/a>\u003c/strong>\u003c/em>\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>Even a light touch, like the wind blowing, was incredibly painful. \"It felt like there was knives in my foot. Like a big elephant smashing on your foot or something,\" says Maddie.\u003c/p>\n\u003cp>Maddie was diagnosed with \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004456/\">complex regional pain syndrome\u003c/a> and ended up in a special treatment program at \u003ca href=\"http://www.lpch.org/index.html\">Lucile Packard Children's Hospital\u003c/a> in Palo Alto.\u003c/p>\n\u003cp>Dr. Elliot Krane, who heads the program, says \"most of the time, pain is the signal that there's a problem and it's a useful sensation to have and a protective one.\"\u003c/p>\n\u003cp>But sometimes, our body's warning system goes haywire, like in Maddie's case. Nerve cells send out pain signals even when there's no reason to.\u003c/p>\n\u003cp>\"It's a terrible pain problem,\" says Dr. Krane. \"And it's one that we really don't understand the origins of. And because we understand so little about it, our therapy of it is also very rudimentary.\u003c/p>\n\u003cp>Krane says Maddie, like most patients, went through a slew of treatments, like physical therapy and pain medication. It took months to recover. \"I can't exactly run really yet, but I can walk faster and I can play with my friends and do a lot more,\" Maddie says.\u003c/p>\n\u003cp>For the most part, doctors rely on opiates like morphine to control pain. But those drugs aren't very targeted. The challenge is that pain is very difficult to study. \"There's other things and other processes in the body which are measurable in some objective fashion: heart rate, blood pressure, temperature. But how do you measure pain?\" asks Dr. Krane.\u003c/p>\n\u003cp>\u003cstrong>Looking to Nature for Solutions\u003c/strong>\u003c/p>\n\u003cp>In a lab at the University of California-Berkeley, Diana Bautista has the same questions about pain. \"Many people are trying to figure out how to do this. And we decided to look to nature to solve this problem.\"\u003c/p>\n\u003cp>Bautista is an assistant professor of biology at the University of California-Berkeley. She's peering into a large plastic tub filled with dirt.\u003c/p>\n\u003cp>\u003cspan class=\"right\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/Mole41.jpg\" alt=\"\">\u003cem>A star-nosed mole at UC Berkeley. Photo: Kristin Gerhold, Bautista Lab.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\"So, if you look here in the corner of the dirt, you can see that there's a star-nosed mole. Pretty interesting looking, right?\"\u003c/p>\n\u003cp>Star-nosed moles have a very unique look. Their large pink nose has 22 finger-like tentacles that they use to feel for food in the dark tunnels where the live.\u003c/p>\n\u003cp>\"What we don't see, that you need special high-speed video to see, is that they're actually tapping very rapidly the surface,\" says Bautista.\u003c/p>\n\u003cp>Compared to our fingertips, the mole's star has 10 times more nerve cells. \"It's much more sensitive than the human hand.\"\u003c/p>\n\u003cp>That lack of sensitivity in human skin makes it difficult to study pain, because our nerve endings are so spread out.\u003c/p>\n\u003cp>We also have about 20 different kinds of nerve cells. Some detect pain, some detect light touch. Others detect hot and cold. \"And so it's very difficult to study one in isolation or to separate the pain cells from the light touch cells.\"\u003c/p>\n\u003cp>That's where the star-nosed mole comes in. Its star is densely packed with light touch cells, but not a lot of pain cells. So Bautista says, studying tissue samples of the mole's star can reveal the differences between nerve cells.\u003c/p>\n\u003cp>\"How does one cell feel the prick of the pin and the other feel the feather? We don't know what happens in those nerve endings,\" says Bautista.\u003c/p>\n\u003cp>Bautista says knowing what happens in normal nerves can tell a lot about when nerves don't work normally – like when diabetes patients experience numbness or cancer patients have hypersensitivity. That comes down to the biochemistry inside the cells. For that, Bautista is also studying another organism.\u003c/p>\n\u003cp>\u003cstrong>Peppers Targeting Nerve Cells\u003c/strong>\u003c/p>\n\u003cp>\"These are \u003ca href=\"http://en.wikipedia.org/wiki/Sichuan_pepper\">Szechuan peppers\u003c/a> that are from the Chinese prickly ash,\" Bautista says, handing me the peppercorns.\u003c/p>\n\u003cp>\"Chew them a little bit in the front of your mouth.\"\u003c/p>\n\u003cp>As I chew, my tongue becomes slightly numb. \"It feels like a little buzzing, tingling sensation,\" says Baustista.\u003c/p>\n\u003cp>The peppercorns aren't hot, but they do have chemicals that are working on my sense of touch. \"We know that they target special receptors and cause those nerves to be excited just as if somebody was tickling your tongue,\" says Bautista.\u003c/p>\n\u003cp>That's a trick that humans could copy. \"By indentifying the molecular mechanisms, we could really go in and design better drugs and come up with better therapies and alternatives for treating conditions like chronic pain,\" she says.\u003c/p>\n\u003cp>Bautista hopes the research will lead to more targeted pain drugs, so patients like Maddie Burkhardt will have an easier recovery.\u003c/p>\n\u003cp>\u003cstrong>Check out the star-nosed mole in action:\u003c/strong>\u003c/p>\n\u003cp>\u003ciframe width=\"480\" height=\"390\" src=\"http://www.youtube.com/embed/6m0PMcXK6XA?rel=0\" frameborder=\"0\">\u003c/iframe>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.8754404 -122.2455364\u003c/p>\n\n","blocks":[],"excerpt":"Pain is the most common reason for trips to the doctor's office. But how exactly pain works is still a mystery in many ways.","status":"publish","parent":0,"modified":1371060761,"stats":{"hasAudio":true,"hasVideo":true,"hasChartOrMap":true,"iframeSrcs":["http://www.youtube.com/embed/6m0PMcXK6XA"],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":43,"wordCount":1046},"headData":{"title":"The Science of Pain | KQED","description":"","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"The Science of Pain","datePublished":"2011-06-03T21:00:12.000Z","dateModified":"2013-06-12T18:12:41.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"19236 http://www.kqed.org/quest/blog/2011/06/03/the-science-of-pain/","disqusUrl":"https://ww2.kqed.org/quest/2011/06/03/the-science-of-pain/","disqusTitle":"The Science of Pain","path":"/quest/19236/the-science-of-pain","audioUrl":"http://www.kqed.org/.stream/anon/radio/quest/2011/06/2011-06-06-quest.mp3","audioDuration":null,"audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/mole300.jpg\" alt=\"\">\u003c/a>\u003cem>The nose of the star-nosed mole is much more sensitive than the human hand. Credit: Dr. Ken Catania, Vanderbilt University\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Pain is the most common reason for trips to the doctor's office. So it makes sense that pain treatment is a huge part of our healthcare system, costing more than 100 billion dollars a year. But how exactly pain works is still a mystery in many ways.\u003c/p>\n\u003cp>Like any normal 9-year-old, Maddie Burkhardt was playing outside with her friends last summer, racing around in a pedal go-cart. \u003c/p>\n\u003cp>\"And my foot slipped and it went under the go-cart. Like it got bent backwards,\" she says.\u003c/p>\n\u003cp>Maddie broke a bone in her foot. So, her mom, Danielle, took her to see a podiatrist, who put her in a series of casts. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>\"And every time he took the cast off, he said 'ok, you should feel much better now.' And she was just like 'no, it's killing me,\" says Danielle.\u003c/p>\n\u003cp>As the weeks went by, it became clear that Maddie's pain wasn't normal. \"She would not allow anything to touch her foot at all. And we didn't really know what was going on,\" says Danielle.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>[jwplayer config=\"QUEST Audio Player\" skin=\"http://ww2.kqed.org/quest/wp-content/themes/quest/glow.zip\" file=\"http://www.kqed.org/.stream/anon/radio/quest/2011/06/2011-06-06-quest.mp3\" ]\u003cbr>\n\u003c/p>\n\u003cp>\u003cem>Listen to the QUEST radio story \u003cstrong>\u003ca href=\"http://ww2.kqed.org/quest/audio/the-science-of-pain\">The Science of Pain \u003c/a>\u003c/strong>\u003c/em>\u003c/p>\n\u003cdiv style=\"border-bottom:1px dotted #cecece;height:20px;margin-bottom:10px\"> \u003c/div>\n\u003cp>Even a light touch, like the wind blowing, was incredibly painful. \"It felt like there was knives in my foot. Like a big elephant smashing on your foot or something,\" says Maddie.\u003c/p>\n\u003cp>Maddie was diagnosed with \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004456/\">complex regional pain syndrome\u003c/a> and ended up in a special treatment program at \u003ca href=\"http://www.lpch.org/index.html\">Lucile Packard Children's Hospital\u003c/a> in Palo Alto.\u003c/p>\n\u003cp>Dr. Elliot Krane, who heads the program, says \"most of the time, pain is the signal that there's a problem and it's a useful sensation to have and a protective one.\"\u003c/p>\n\u003cp>But sometimes, our body's warning system goes haywire, like in Maddie's case. Nerve cells send out pain signals even when there's no reason to.\u003c/p>\n\u003cp>\"It's a terrible pain problem,\" says Dr. Krane. \"And it's one that we really don't understand the origins of. And because we understand so little about it, our therapy of it is also very rudimentary.\u003c/p>\n\u003cp>Krane says Maddie, like most patients, went through a slew of treatments, like physical therapy and pain medication. It took months to recover. \"I can't exactly run really yet, but I can walk faster and I can play with my friends and do a lot more,\" Maddie says.\u003c/p>\n\u003cp>For the most part, doctors rely on opiates like morphine to control pain. But those drugs aren't very targeted. The challenge is that pain is very difficult to study. \"There's other things and other processes in the body which are measurable in some objective fashion: heart rate, blood pressure, temperature. But how do you measure pain?\" asks Dr. Krane.\u003c/p>\n\u003cp>\u003cstrong>Looking to Nature for Solutions\u003c/strong>\u003c/p>\n\u003cp>In a lab at the University of California-Berkeley, Diana Bautista has the same questions about pain. \"Many people are trying to figure out how to do this. And we decided to look to nature to solve this problem.\"\u003c/p>\n\u003cp>Bautista is an assistant professor of biology at the University of California-Berkeley. She's peering into a large plastic tub filled with dirt.\u003c/p>\n\u003cp>\u003cspan class=\"right\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/Mole41.jpg\" alt=\"\">\u003cem>A star-nosed mole at UC Berkeley. Photo: Kristin Gerhold, Bautista Lab.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\"So, if you look here in the corner of the dirt, you can see that there's a star-nosed mole. Pretty interesting looking, right?\"\u003c/p>\n\u003cp>Star-nosed moles have a very unique look. Their large pink nose has 22 finger-like tentacles that they use to feel for food in the dark tunnels where the live.\u003c/p>\n\u003cp>\"What we don't see, that you need special high-speed video to see, is that they're actually tapping very rapidly the surface,\" says Bautista.\u003c/p>\n\u003cp>Compared to our fingertips, the mole's star has 10 times more nerve cells. \"It's much more sensitive than the human hand.\"\u003c/p>\n\u003cp>That lack of sensitivity in human skin makes it difficult to study pain, because our nerve endings are so spread out.\u003c/p>\n\u003cp>We also have about 20 different kinds of nerve cells. Some detect pain, some detect light touch. Others detect hot and cold. \"And so it's very difficult to study one in isolation or to separate the pain cells from the light touch cells.\"\u003c/p>\n\u003cp>That's where the star-nosed mole comes in. Its star is densely packed with light touch cells, but not a lot of pain cells. So Bautista says, studying tissue samples of the mole's star can reveal the differences between nerve cells.\u003c/p>\n\u003cp>\"How does one cell feel the prick of the pin and the other feel the feather? We don't know what happens in those nerve endings,\" says Bautista.\u003c/p>\n\u003cp>Bautista says knowing what happens in normal nerves can tell a lot about when nerves don't work normally – like when diabetes patients experience numbness or cancer patients have hypersensitivity. That comes down to the biochemistry inside the cells. For that, Bautista is also studying another organism.\u003c/p>\n\u003cp>\u003cstrong>Peppers Targeting Nerve Cells\u003c/strong>\u003c/p>\n\u003cp>\"These are \u003ca href=\"http://en.wikipedia.org/wiki/Sichuan_pepper\">Szechuan peppers\u003c/a> that are from the Chinese prickly ash,\" Bautista says, handing me the peppercorns.\u003c/p>\n\u003cp>\"Chew them a little bit in the front of your mouth.\"\u003c/p>\n\u003cp>As I chew, my tongue becomes slightly numb. \"It feels like a little buzzing, tingling sensation,\" says Baustista.\u003c/p>\n\u003cp>The peppercorns aren't hot, but they do have chemicals that are working on my sense of touch. \"We know that they target special receptors and cause those nerves to be excited just as if somebody was tickling your tongue,\" says Bautista.\u003c/p>\n\u003cp>That's a trick that humans could copy. \"By indentifying the molecular mechanisms, we could really go in and design better drugs and come up with better therapies and alternatives for treating conditions like chronic pain,\" she says.\u003c/p>\n\u003cp>Bautista hopes the research will lead to more targeted pain drugs, so patients like Maddie Burkhardt will have an easier recovery.\u003c/p>\n\u003cp>\u003cstrong>Check out the star-nosed mole in action:\u003c/strong>\u003c/p>\n\u003cp>\u003ciframe width=\"480\" height=\"390\" src=\"http://www.youtube.com/embed/6m0PMcXK6XA?rel=0\" frameborder=\"0\">\u003c/iframe>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.8754404 -122.2455364\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/19236/the-science-of-pain","authors":["239"],"categories":["quest_5","quest_12"],"tags":["quest_13194","quest_13201","quest_1783","quest_3664","quest_13203","quest_3692","quest_2771","quest_3021"],"featImg":"quest_14987","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg","imageAlt":"On Our Watch from NPR and KQED","officialWebsiteLink":"/podcasts/onourwatch","meta":{"site":"news","source":"kqed","order":"1"},"link":"/podcasts/onourwatch","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1567098962","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw","npr":"https://rpb3r.app.goo.gl/onourwatch","spotify":"https://open.spotify.com/show/0OLWoyizopu6tY1XiuX70x","tuneIn":"https://tunein.com/radio/On-Our-Watch-p1436229/","stitcher":"https://www.stitcher.com/show/on-our-watch","rss":"https://feeds.npr.org/510360/podcast.xml"}},"on-the-media":{"id":"on-the-media","title":"On The Media","info":"Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us","airtime":"SUN 2pm-3pm, MON 12am-1am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png","officialWebsiteLink":"https://www.wnycstudios.org/shows/otm","meta":{"site":"news","source":"wnyc"},"link":"/radio/program/on-the-media","subscribe":{"apple":"https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2","tuneIn":"https://tunein.com/radio/On-the-Media-p69/","rss":"http://feeds.wnyc.org/onthemedia"}},"our-body-politic":{"id":"our-body-politic","title":"Our Body Politic","info":"Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.","airtime":"SAT 6pm-7pm, SUN 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://our-body-politic.simplecast.com/","meta":{"site":"news","source":"kcrw"},"link":"/radio/program/our-body-politic","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/our-body-politic/id1533069868","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw","spotify":"https://open.spotify.com/show/4ApAiLT1kV153TttWAmqmc","rss":"https://feeds.simplecast.com/_xaPhs1s","tuneIn":"https://tunein.com/podcasts/News--Politics-Podcasts/Our-Body-Politic-p1369211/"}},"pbs-newshour":{"id":"pbs-newshour","title":"PBS NewsHour","info":"Analysis, background reports and updates from the PBS NewsHour putting today's news in context.","airtime":"MON-FRI 3pm-4pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.pbs.org/newshour/","meta":{"site":"news","source":"pbs"},"link":"/radio/program/pbs-newshour","subscribe":{"apple":"https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2","tuneIn":"https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/","rss":"https://www.pbs.org/newshour/feeds/rss/podcasts/show"}},"perspectives":{"id":"perspectives","title":"Perspectives","tagline":"KQED's series of of daily listener commentaries since 1991","info":"KQED's series of of daily listener commentaries since 1991.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Perspectives-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/perspectives/","meta":{"site":"radio","source":"kqed","order":"15"},"link":"/perspectives","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/id73801135","npr":"https://www.npr.org/podcasts/432309616/perspectives","rss":"https://ww2.kqed.org/perspectives/category/perspectives/feed/","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"}},"planet-money":{"id":"planet-money","title":"Planet Money","info":"The economy explained. 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