Career Spotlight: Developmental and Stem Cell Biology Graduate Student
Science on the SPOT: New Hope for Heart Repair
Reporter's Notes: California Takes the Lead on Stem Cell Research
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Stream or download it on \u003ca href=\"http://www.pbslearningmedia.org/resource/c7e42f18-46b1-4cb8-8588-1c628a3e5b18/developmental-stem-cell-biology-graduate-student/\"> PBS LearningMedia\u003c/a>.\u003c/em>\u003cbr>\n \u003cbr>\nElijah Martin is a second-year graduate student in the \u003ca href=\"https://dscb.ucsf.edu/\">Developmental and Stem Cell Biology \u003c/a>program at University of California, San Francisco. He works in the laboratory of \u003ca href=\"http://gladstoneinstitutes.org/u/dsrivastava/SrivastavaLab.htm\">Dr. Deepak Srivastava \u003c/a>at the Gladstone Institutes. Martin studies how the heart forms to try to understand the causes of heart disease in order to develop therapies. In the lab, he grows heart cells in petri dishes, which involves mixing together different chemicals and nutrients to get the cells to grow and develop into a heart. He uses microscopes to track the growth of the cells. Since he was a young child, Martin has wanted to study the heart and he says attending graduate school will help turn his dream into a career.\u003c/p>\n\u003cp>This video is featured in our \u003cb>\u003ca href=\"http://foldscope.woop.ie/\" target=\"_blank\">Engineering Is: Diagnosing Diseases with Origami Microscopes\u003c/a>\u003c/b>e-book. You can find our other e-books at \u003ca href=\"http://blogs.kqed.org/education/e-books/\">kqed.org/ebooks\u003c/a>.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n","blocks":[],"excerpt":"Elijah Martin is a graduate student in Dr. Deepak Srivastava's Lab at Gladstone Institutes where he studies how the heart develops. ","status":"publish","parent":0,"modified":1450483280,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":4,"wordCount":160},"headData":{"title":"Career Spotlight: Developmental and Stem Cell Biology Graduate Student | KQED","description":"Elijah Martin is a graduate student in Dr. Deepak Srivastava's Lab at Gladstone Institutes where he studies how the heart develops. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"74092 http://science.kqed.org/quest/?p=74092","disqusUrl":"https://ww2.kqed.org/quest/2015/05/14/career-spotlight-developmental-and-stem-cell-biology-graduate-student/","disqusTitle":"Career Spotlight: Developmental and Stem Cell Biology Graduate Student","videoEmbed":"http://www.youtube.com/watch?v=g8a6jFrc7F4","source":"Biology","sourceUrl":"https://ww2.kqed.org/quest/category/biology/","path":"/quest/74092/career-spotlight-developmental-and-stem-cell-biology-graduate-student","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>Trouble viewing the video? Stream or download it on \u003ca href=\"http://www.pbslearningmedia.org/resource/c7e42f18-46b1-4cb8-8588-1c628a3e5b18/developmental-stem-cell-biology-graduate-student/\"> PBS LearningMedia\u003c/a>.\u003c/em>\u003cbr>\n \u003cbr>\nElijah Martin is a second-year graduate student in the \u003ca href=\"https://dscb.ucsf.edu/\">Developmental and Stem Cell Biology \u003c/a>program at University of California, San Francisco. He works in the laboratory of \u003ca href=\"http://gladstoneinstitutes.org/u/dsrivastava/SrivastavaLab.htm\">Dr. Deepak Srivastava \u003c/a>at the Gladstone Institutes. Martin studies how the heart forms to try to understand the causes of heart disease in order to develop therapies. In the lab, he grows heart cells in petri dishes, which involves mixing together different chemicals and nutrients to get the cells to grow and develop into a heart. He uses microscopes to track the growth of the cells. Since he was a young child, Martin has wanted to study the heart and he says attending graduate school will help turn his dream into a career.\u003c/p>\n\u003cp>This video is featured in our \u003cb>\u003ca href=\"http://foldscope.woop.ie/\" target=\"_blank\">Engineering Is: Diagnosing Diseases with Origami Microscopes\u003c/a>\u003c/b>e-book. You can find our other e-books at \u003ca href=\"http://blogs.kqed.org/education/e-books/\">kqed.org/ebooks\u003c/a>.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/74092/career-spotlight-developmental-and-stem-cell-biology-graduate-student","authors":["6544"],"series":["quest_13374"],"categories":["quest_4","quest_12"],"tags":["quest_13128","quest_793","quest_12946","quest_13173","quest_12269","quest_1218","quest_13172","quest_1331","quest_1332","quest_3351","quest_2349","quest_2791","quest_3025","quest_3071"],"collections":["quest_13175"],"featImg":"quest_74094","label":"source_quest_74092"},"quest_35176":{"type":"posts","id":"quest_35176","meta":{"index":"posts_1591205157","site":"quest","id":"35176","score":null,"sort":[1334768406000]},"guestAuthors":[],"slug":"science-on-the-spot-new-hope-for-heart-repair","title":"Science on the SPOT: New Hope for Heart Repair","publishDate":1334768406,"format":"video","headTitle":"Science on the SPOT | QUEST | KQED Science","labelTerm":{"term":3296,"site":"quest"},"content":"\u003cp>More than 5 million people in the United States live with damaged hearts that make it difficult to walk and carry out other simple daily tasks. Pacemakers and drugs can help, but they don’t repair the heart muscle that has died as a result of a heart attack or clogged arteries.\u003c/p>\n\u003cp>Now, scientists in San Francisco say a more effective treatment might be on the way. \u003c/p>\n\u003cfigure id=\"attachment_35476\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized-300x169.jpg\" alt=\"Research mouse\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Three months after being injected with three genes, the hearts of mice that had suffered a heart attack pumped as much blood as a normal heart. Credit: Gabriela Quirós, QUEST \u003c/figcaption>\u003c/figure>\n\u003cp>The researchers from the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, affiliated with the University of California-San Francisco, reported today that using a new genetic technique, they have succeeded for the first time in repairing, from within, the hearts of mice weakened by heart attacks. \u003c/p>\n\u003cp>“There are a variety of approaches we use right now to help people who are left with damaged hearts,” said \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/srivastava/\" title=\"Dr. Deepak Srivastava\" target=\"_blank\">Dr. Deepak Srivastava\u003c/a>, senior author of the paper and director of cardiovascular research at the Gladstone Institutes, “but none of them actually get to the root of the problem, which is replacing that damaged heart muscle. And that’s where our focus has been.”\u003c/p>\n\u003cp>The scientists injected three genes into the hearts of research mice that had been given mild heart attacks. Within three months, the genes transformed non-beating cells in the heart into cells that looked and acted just like beating heart muscle cells. These new beating cells restored the heart’s ability to pump blood to the rest of the body. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Human hearts have billions of non-beating cells, which support the beating cells by forming the heart’s structure, Srivastava said. Mice have millions of these support cells too. When a heart attack happens, the support cells rush to the site of the damage and form scar tissue, which preserves the heart’s structure, but doesn’t help it pump blood. \u003c/p>\n\u003cp>“We’ve found a way to take these support cells that should normally never become muscle, and convert them into new muscle cells that actually integrate with the rest of the heart, contribute to the force that it generates, and allow us to regenerate the heart from within the organ itself,” said Srivastava.\u003c/p>\n\u003cfigure id=\"attachment_35482\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized-300x169.jpg\" alt=\"Mouse heart muscle cells created by Gladstone Institutes researchers.\" title=\"yellow induced muscle cells with sarcomere structure_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35482\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Non-beating heart cells became beating heart cells like these. Credit: Li Qian, Gladstone Institutes \u003c/figcaption>\u003c/figure>\n\u003cp>The new research appears in the April 18 online edition of the journal \u003ca href=\"http://www.nature.com/nature/index.html\" title=\"Journal Nature\" target=\"_blank\">Nature\u003c/a> and was led by \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/736\" title=\"Li Qian wins prestigious award\" target=\"_blank\">Li Qian\u003c/a>, also from the Gladstone Institutes.\u003c/p>\n\u003cp>Heart attacks and other heart disease kill 600,000 people each year. Many more survive, yet lead diminished lives. Some 5.7 million people live with damaged hearts that pump less blood, making it difficult for them to climb a flight of stairs or walk across a parking lot. \u003c/p>\n\u003cp>During a heart attack, clots block one or several coronary arteries and cut off blood flow. By rushing patients to the operating table and unclogging their arteries with catheters and stents, doctors are able to save all but 5 percent of victims who make it to the hospital. \u003c/p>\n\u003cp>“While we’ve been doing better at saving lives, each time we save a life the patient still loses some of their muscle,” Srivastava said. “So the number of people who are left with damaged hearts is actually growing, even though the number of people who die from heart attacks is getting smaller.”\u003c/p>\n\u003cp>Treatments for humans could be six to seven years away, he added. The next step will be to test the treatment on pigs. Scientists still need to figure out if cell reprogramming is safe for humans; how to deliver the genes into the heart, and how to produce enough new beating heart cells to repair a human – rather than a mouse – heart.\u003c/p>\n\u003cp>\u003cstrong>More in our Series\u003c/strong>\u003c/p>\n\u003cul>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/pump-it-up-heart-health-special-report/\">Pump It Up: Heart Health Special Report\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/li>\n\u003c/ul>\n\u003cp>Nevertheless, the research is drawing the attention of other heart researchers.\u003c/p>\n\u003cp>“It’s a major discovery and certainly suggests a new approach to treat injury that previously had been thought to be irreversible,” said \u003ca href=\"http://www.cedars-sinai.edu/Bios---Physician/H-O/Eduardo-Marban-MD.aspx\" title=\"Dr. Eduardo Marban\" target=\"_blank\">Dr. Eduardo Marbán\u003c/a>, director of the \u003ca href=\"http://www.cedars-sinai.edu/Patients/Programs-and-Services/Heart-Institute/\" title=\"Cedars-Sinai Heart Institute\" target=\"_blank\">Cedars-Sinai Heart Institute\u003c/a> in Los Angeles.\u003c/p>\n\u003cp>Marbán said it’s been “a long-held dogma” that once scar tissue has formed in the heart, it can’t change into heart muscle. This finding in mice, and recent research by Marbán’s team on a small group of human patients, challenge that belief, he said.\u003c/p>\n\u003cp>Although the cell reprogramming research doesn’t involve stem cells, the Gladstone scientists used techniques that were discovered through stem cell research. \u003c/p>\n\u003cp>The scientists said their work was inspired by the discovery in 2007 that a few genes can transform an adult skin cell into a cell with the properties of a human embryonic stem cell. Researchers have been intensely interested in \u003ca href=\"http://ww2.kqed.org/quest/video/stem-cell-gold-rush/\" title=\"QUEST TV segment about stem cell research in California\" target=\"_blank\">embryonic stem cells\u003c/a> as a possible source of treatments for diseases like Parkinson’s because they can be coaxed to turn into virtually any type of cell in the body. But because embryonic stem cells are plucked from embryos left over from fertility treatments, and require the destruction of these embryos, their study has been controversial.\u003c/p>\n\u003cp>An alternative to embryonic stem cells came with the skin cell breakthrough five years ago. Then, \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/yamanaka/\" title=\"Dr. Shinya Yamanaka\" target=\"_blank\">Dr. Shinya Yamanaka\u003c/a>, of the Gladstone Institutes and Kyoto University in Japan, inserted four genes that are present in embryonic stem cells into adult skin cells. The four genes \u003ca href=\"http://ww2.kqed.org/quest/2007/06/11/turning-skin-cells-into-embryonic-stem-cells/\" title=\"QUEST blog post about induced pluripotent stem cells\" target=\"_blank\">reprogrammed the skin cells to become embryonic-like stem cells\u003c/a>. \u003c/p>\n\u003cp>That led scientists to look for a way to transform one type of adult cell into another type of adult cell without the need to create stem cells at all.\u003c/p>\n\u003cp>“Yamanaka opened up the idea that adult cells weren’t permanently fixed,” said Srivastava. “That led us to ask whether or not we could convert one of these heart support cells into a heart muscle cell.” \u003c/p>\n\u003cp>Bypassing the creation of stem cells has several advantages. Though stem cells are versatile, when they’re introduced into the body they can behave as cancer cells and form tumors. \u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>“It’s a dramatic and heady possibility that vindicates for the first time the idea that we might be able to harness truly regenerative medicine,” Marbán said. \u003c/p>\n\n","blocks":[],"excerpt":"Scientists in San Francisco have coaxed mouse hearts to repair themselves from within.The breakthrough could lead to treatments for 5 million people in the United States whose hearts were damaged after they survived heart attacks. ","status":"publish","parent":0,"modified":1457569468,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":25,"wordCount":1094},"headData":{"title":"Science on the SPOT: New Hope for Heart Repair | KQED","description":"Scientists in San Francisco have coaxed mouse hearts to repair themselves from within.The breakthrough could lead to treatments for 5 million people in the United States whose hearts were damaged after they survived heart attacks. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"35176 http://science.kqed.org/quest/?post_type=videos&p=35176","disqusUrl":"https://ww2.kqed.org/quest/2012/04/18/science-on-the-spot-new-hope-for-heart-repair/","disqusTitle":"Science on the SPOT: New Hope for Heart Repair","videoEmbed":"https://youtu.be/9EvI1hVq5Ys","path":"/quest/35176/science-on-the-spot-new-hope-for-heart-repair","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>More than 5 million people in the United States live with damaged hearts that make it difficult to walk and carry out other simple daily tasks. Pacemakers and drugs can help, but they don’t repair the heart muscle that has died as a result of a heart attack or clogged arteries.\u003c/p>\n\u003cp>Now, scientists in San Francisco say a more effective treatment might be on the way. \u003c/p>\n\u003cfigure id=\"attachment_35476\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/602B_Yu_Huang_holds_research_mouse_CU_resized-300x169.jpg\" alt=\"Research mouse\" title=\"602B_Yu_Huang_holds_research_mouse_CU_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Three months after being injected with three genes, the hearts of mice that had suffered a heart attack pumped as much blood as a normal heart. Credit: Gabriela Quirós, QUEST \u003c/figcaption>\u003c/figure>\n\u003cp>The researchers from the \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/gweb1/\" title=\"The Gladstone Institutes\" target=\"_blank\">Gladstone Institutes\u003c/a>, affiliated with the University of California-San Francisco, reported today that using a new genetic technique, they have succeeded for the first time in repairing, from within, the hearts of mice weakened by heart attacks. \u003c/p>\n\u003cp>“There are a variety of approaches we use right now to help people who are left with damaged hearts,” said \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/srivastava/\" title=\"Dr. Deepak Srivastava\" target=\"_blank\">Dr. Deepak Srivastava\u003c/a>, senior author of the paper and director of cardiovascular research at the Gladstone Institutes, “but none of them actually get to the root of the problem, which is replacing that damaged heart muscle. And that’s where our focus has been.”\u003c/p>\n\u003cp>The scientists injected three genes into the hearts of research mice that had been given mild heart attacks. Within three months, the genes transformed non-beating cells in the heart into cells that looked and acted just like beating heart muscle cells. These new beating cells restored the heart’s ability to pump blood to the rest of the body. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Human hearts have billions of non-beating cells, which support the beating cells by forming the heart’s structure, Srivastava said. Mice have millions of these support cells too. When a heart attack happens, the support cells rush to the site of the damage and form scar tissue, which preserves the heart’s structure, but doesn’t help it pump blood. \u003c/p>\n\u003cp>“We’ve found a way to take these support cells that should normally never become muscle, and convert them into new muscle cells that actually integrate with the rest of the heart, contribute to the force that it generates, and allow us to regenerate the heart from within the organ itself,” said Srivastava.\u003c/p>\n\u003cfigure id=\"attachment_35482\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/yellow-induced-muscle-cells-with-sarcomere-structure_resized-300x169.jpg\" alt=\"Mouse heart muscle cells created by Gladstone Institutes researchers.\" title=\"yellow induced muscle cells with sarcomere structure_resized\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-35482\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Non-beating heart cells became beating heart cells like these. Credit: Li Qian, Gladstone Institutes \u003c/figcaption>\u003c/figure>\n\u003cp>The new research appears in the April 18 online edition of the journal \u003ca href=\"http://www.nature.com/nature/index.html\" title=\"Journal Nature\" target=\"_blank\">Nature\u003c/a> and was led by \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/736\" title=\"Li Qian wins prestigious award\" target=\"_blank\">Li Qian\u003c/a>, also from the Gladstone Institutes.\u003c/p>\n\u003cp>Heart attacks and other heart disease kill 600,000 people each year. Many more survive, yet lead diminished lives. Some 5.7 million people live with damaged hearts that pump less blood, making it difficult for them to climb a flight of stairs or walk across a parking lot. \u003c/p>\n\u003cp>During a heart attack, clots block one or several coronary arteries and cut off blood flow. By rushing patients to the operating table and unclogging their arteries with catheters and stents, doctors are able to save all but 5 percent of victims who make it to the hospital. \u003c/p>\n\u003cp>“While we’ve been doing better at saving lives, each time we save a life the patient still loses some of their muscle,” Srivastava said. “So the number of people who are left with damaged hearts is actually growing, even though the number of people who die from heart attacks is getting smaller.”\u003c/p>\n\u003cp>Treatments for humans could be six to seven years away, he added. The next step will be to test the treatment on pigs. Scientists still need to figure out if cell reprogramming is safe for humans; how to deliver the genes into the heart, and how to produce enough new beating heart cells to repair a human – rather than a mouse – heart.\u003c/p>\n\u003cp>\u003cstrong>More in our Series\u003c/strong>\u003c/p>\n\u003cul>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/childhood-obesity-kids-fight-back/\">Childhood Obesity: Kids Fight Back\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/pump-it-up-heart-health-special-report/\">Pump It Up: Heart Health Special Report\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://ww2.kqed.org/quest/video/rushing-to-save-heart-attack-patients/\">Rushing to Save Heart Attack Patients\u003c/a>\u003c/li>\n\u003c/ul>\n\u003cp>Nevertheless, the research is drawing the attention of other heart researchers.\u003c/p>\n\u003cp>“It’s a major discovery and certainly suggests a new approach to treat injury that previously had been thought to be irreversible,” said \u003ca href=\"http://www.cedars-sinai.edu/Bios---Physician/H-O/Eduardo-Marban-MD.aspx\" title=\"Dr. Eduardo Marban\" target=\"_blank\">Dr. Eduardo Marbán\u003c/a>, director of the \u003ca href=\"http://www.cedars-sinai.edu/Patients/Programs-and-Services/Heart-Institute/\" title=\"Cedars-Sinai Heart Institute\" target=\"_blank\">Cedars-Sinai Heart Institute\u003c/a> in Los Angeles.\u003c/p>\n\u003cp>Marbán said it’s been “a long-held dogma” that once scar tissue has formed in the heart, it can’t change into heart muscle. This finding in mice, and recent research by Marbán’s team on a small group of human patients, challenge that belief, he said.\u003c/p>\n\u003cp>Although the cell reprogramming research doesn’t involve stem cells, the Gladstone scientists used techniques that were discovered through stem cell research. \u003c/p>\n\u003cp>The scientists said their work was inspired by the discovery in 2007 that a few genes can transform an adult skin cell into a cell with the properties of a human embryonic stem cell. Researchers have been intensely interested in \u003ca href=\"http://ww2.kqed.org/quest/video/stem-cell-gold-rush/\" title=\"QUEST TV segment about stem cell research in California\" target=\"_blank\">embryonic stem cells\u003c/a> as a possible source of treatments for diseases like Parkinson’s because they can be coaxed to turn into virtually any type of cell in the body. But because embryonic stem cells are plucked from embryos left over from fertility treatments, and require the destruction of these embryos, their study has been controversial.\u003c/p>\n\u003cp>An alternative to embryonic stem cells came with the skin cell breakthrough five years ago. Then, \u003ca href=\"http://www.gladstone.ucsf.edu/gladstone/site/yamanaka/\" title=\"Dr. Shinya Yamanaka\" target=\"_blank\">Dr. Shinya Yamanaka\u003c/a>, of the Gladstone Institutes and Kyoto University in Japan, inserted four genes that are present in embryonic stem cells into adult skin cells. The four genes \u003ca href=\"http://ww2.kqed.org/quest/2007/06/11/turning-skin-cells-into-embryonic-stem-cells/\" title=\"QUEST blog post about induced pluripotent stem cells\" target=\"_blank\">reprogrammed the skin cells to become embryonic-like stem cells\u003c/a>. \u003c/p>\n\u003cp>That led scientists to look for a way to transform one type of adult cell into another type of adult cell without the need to create stem cells at all.\u003c/p>\n\u003cp>“Yamanaka opened up the idea that adult cells weren’t permanently fixed,” said Srivastava. “That led us to ask whether or not we could convert one of these heart support cells into a heart muscle cell.” \u003c/p>\n\u003cp>Bypassing the creation of stem cells has several advantages. Though stem cells are versatile, when they’re introduced into the body they can behave as cancer cells and form tumors. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“It’s a dramatic and heady possibility that vindicates for the first time the idea that we might be able to harness truly regenerative medicine,” Marbán said. \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/35176/science-on-the-spot-new-hope-for-heart-repair","authors":["6186"],"series":["quest_3296"],"categories":["quest_4","quest_12","quest_3422","quest_3233"],"tags":["quest_10999","quest_793","quest_1218","quest_13201","quest_1331","quest_10997","quest_1332","quest_10998","quest_3351","quest_1783","quest_13203","quest_2349","quest_13","quest_2530","quest_2789","quest_3314","quest_3071"],"featImg":"quest_35485","label":"quest_3296"},"quest_8124":{"type":"posts","id":"quest_8124","meta":{"index":"posts_1591205157","site":"quest","id":"8124","score":null,"sort":[1284156010000]},"guestAuthors":[],"slug":"reporters-notes-california-takes-the-lead-on-stem-cell-research","title":"Reporter's Notes: California Takes the Lead on Stem Cell Research","publishDate":1284156010,"format":"audio","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/09/4-46StemCell_300.jpg\" alt=\"\">\u003c/a>\u003cem> Image courtesy of Jeff Miller, University of Wisconsin-Madison.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Deepak Srivastava – profiled in \u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">this week's radio story\u003c/a> – is no stranger to \u003ca href=\"http://www.kqed.org/quest/television/view/326\" target=\"_top\">QUEST\u003c/a>, or to \u003ca href=\"http://www.kqed.org/news/\" target=\"_top\">KQED News\u003c/a>. Just last month, \u003ca href=\"http://ww2.kqed.org/quest/2010/08/05/new-approach-to-creating-heart-cells-could-make-transplantation-unnecessary/\" target=\"_top\">Srivastava made headlines\u003c/a> when he announced that his lab had for the first time directly created beating heart cells from adult cells, without having to go through the stem cell stage.\u003cbr>\n\u003c!--more-->\u003c/p>\n\u003cp>But when I interviewed Srivastava for this story, I wanted to hear as well about his work with a type of stem cell called \u003ca href=\"http://www.nytimes.com/2007/12/11/science/11prof.html?_r=1\" target=\"_top\">induced pluripotent cells\u003c/a>. These are adult cells that have been coaxed into becoming like embryonic stem cells. Just like embryonic stem cells, these transformed cells are \"pluripotent,\" meaning that they have the ability to develop into any other kind of cell.\u003cbr>\nIf researchers like Srivastava can do pioneering work without requiring human embryonic stem cells, I wondered, then what to make of the \u003ca href=\"http://www.huffingtonpost.com/eli-y-adashi/the-halting-of-stem-cell-_b_711616.html\" target=\"_top\">recent ruling by US district court Judge Royce Lamberth?\u003c/a>\u003c/p>\n\u003cp>From a scientific standpoint, at least, was the debate over the \u003ca href=\"http://en.wikipedia.org/wiki/Dickey-Wicker_Amendment\" target=\"_top\">Dickey-Wicker Amendment\u003c/a> a moot point?\u003c/p>\n\u003cp>And finally, if human embryonic stem cells are no longer necessary, where does that leave \u003ca href=\"http://www.cirm.ca.gov/\" target=\"_top\">The California Institute For Regenerative Medicine\u003c/a>, \u003ca href=\"http://en.wikipedia.org/wiki/California_Proposition_71_(2004)\" target=\"_top\">the taxpayer-funded\u003c/a>, \u003ca href=\"http://www.cirm.ca.gov/GrantsSummary\" target=\"_top\">$3 billion\u003c/a> foundation created specifically to ensure that human embryonic stem cell research continues, regardless of federal support?\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Here's how The Institute – which funds \u003ca href=\"http://www.cirm.ca.gov/Grant_overview_charts\" target=\"_top\">research on induced pluripotent stem cells and other cells\u003c/a>, as well as embryonic stem cells, \u003ca href=\"http://www.cirm.ca.gov/StemCellBasics_Questions#6\" target=\"_top\">answers that question\u003c/a>.\u003c/p>\n\u003cp>And here's \u003ca href=\"http://www.isscr.org/ScienceStatementEndorsers.cfm\" target=\"_top\">a letter\u003c/a>, signed by 834 scientists in defense of continued support of research on both types of cells. An excerpt:\u003c/p>\n\u003cp>\"The basic tools for these discoveries will include the “gold standard” embryonic stem cells that remain the benchmark for assessment of pluripotency, or the ability to develop into all the fully functional cells of the body.\"\u003c/p>\n\u003cp>And that's exactly the term Srivastava used: \"gold standard.\" Adult cells that can be transformed into embryonic stem cell-like cells may well someday free researchers from the political roller coaster of embryonic stem cell support, he said. But first, scientists need to figure out exactly how well they work. And without human embryonic stem cells, there's just nothing to compare them to.\u003c/p>\n\u003cp>\u003cobject width=\"640\" height=\"385\">\u003cparam name=\"movie\" value=\"http://www.youtube.com/v/tOdyaiWr0oo&color1=0xb1b1b1&color2=0xd0d0d0&hl=en_US&feature=player_embedded&fs=1\">\u003cparam name=\"allowFullScreen\" value=\"true\">\u003cparam name=\"allowScriptAccess\" value=\"always\">\u003cembed src=\"http://www.youtube.com/v/tOdyaiWr0oo&color1=0xb1b1b1&color2=0xd0d0d0&hl=en_US&feature=player_embedded&fs=1\" type=\"application/x-shockwave-flash\" allowfullscreen=\"true\" allowscriptaccess=\"always\" width=\"640\" height=\"385\">\u003c/embed>\u003c/object>\u003c/p>\n\u003cp>\u003cem>Video of beating heart cell created from adult cells - Courtesy of the Gladstone Institute of Cardiovascular Disease\u003c/em>\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/09/radio_icon_light.gif\" alt=\"\">\u003c/a>\u003c/span>\u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">Listen to the California Takes the Lead on Stem Cell Research \u003c/a> radio report online.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7677229 -122.3942944\u003c/p>\n\n","blocks":[],"excerpt":"Deepak Srivastava – profiled in this week's radio story – is no stranger to QUEST. Just last month, Srivastava made headlines when he announced that his lab had successfully created beating heart cells from adult cells.","status":"publish","parent":0,"modified":1371076084,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":419},"headData":{"title":"Reporter's Notes: California Takes the Lead on Stem Cell Research | KQED","description":"Deepak Srivastava – profiled in this week's radio story – is no stranger to QUEST. Just last month, Srivastava made headlines when he announced that his lab had successfully created beating heart cells from adult cells.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"8124 http://science.kqed.org/quest/2010/09/10/reporters-notes-california-takes-the-lead-on-stem-cell-research/","disqusUrl":"https://ww2.kqed.org/quest/2010/09/10/reporters-notes-california-takes-the-lead-on-stem-cell-research/","disqusTitle":"Reporter's Notes: California Takes the Lead on Stem Cell Research","path":"/quest/8124/reporters-notes-california-takes-the-lead-on-stem-cell-research","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/09/4-46StemCell_300.jpg\" alt=\"\">\u003c/a>\u003cem> Image courtesy of Jeff Miller, University of Wisconsin-Madison.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Deepak Srivastava – profiled in \u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">this week's radio story\u003c/a> – is no stranger to \u003ca href=\"http://www.kqed.org/quest/television/view/326\" target=\"_top\">QUEST\u003c/a>, or to \u003ca href=\"http://www.kqed.org/news/\" target=\"_top\">KQED News\u003c/a>. Just last month, \u003ca href=\"http://ww2.kqed.org/quest/2010/08/05/new-approach-to-creating-heart-cells-could-make-transplantation-unnecessary/\" target=\"_top\">Srivastava made headlines\u003c/a> when he announced that his lab had for the first time directly created beating heart cells from adult cells, without having to go through the stem cell stage.\u003cbr>\n\u003c!--more-->\u003c/p>\n\u003cp>But when I interviewed Srivastava for this story, I wanted to hear as well about his work with a type of stem cell called \u003ca href=\"http://www.nytimes.com/2007/12/11/science/11prof.html?_r=1\" target=\"_top\">induced pluripotent cells\u003c/a>. These are adult cells that have been coaxed into becoming like embryonic stem cells. Just like embryonic stem cells, these transformed cells are \"pluripotent,\" meaning that they have the ability to develop into any other kind of cell.\u003cbr>\nIf researchers like Srivastava can do pioneering work without requiring human embryonic stem cells, I wondered, then what to make of the \u003ca href=\"http://www.huffingtonpost.com/eli-y-adashi/the-halting-of-stem-cell-_b_711616.html\" target=\"_top\">recent ruling by US district court Judge Royce Lamberth?\u003c/a>\u003c/p>\n\u003cp>From a scientific standpoint, at least, was the debate over the \u003ca href=\"http://en.wikipedia.org/wiki/Dickey-Wicker_Amendment\" target=\"_top\">Dickey-Wicker Amendment\u003c/a> a moot point?\u003c/p>\n\u003cp>And finally, if human embryonic stem cells are no longer necessary, where does that leave \u003ca href=\"http://www.cirm.ca.gov/\" target=\"_top\">The California Institute For Regenerative Medicine\u003c/a>, \u003ca href=\"http://en.wikipedia.org/wiki/California_Proposition_71_(2004)\" target=\"_top\">the taxpayer-funded\u003c/a>, \u003ca href=\"http://www.cirm.ca.gov/GrantsSummary\" target=\"_top\">$3 billion\u003c/a> foundation created specifically to ensure that human embryonic stem cell research continues, regardless of federal support?\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Here's how The Institute – which funds \u003ca href=\"http://www.cirm.ca.gov/Grant_overview_charts\" target=\"_top\">research on induced pluripotent stem cells and other cells\u003c/a>, as well as embryonic stem cells, \u003ca href=\"http://www.cirm.ca.gov/StemCellBasics_Questions#6\" target=\"_top\">answers that question\u003c/a>.\u003c/p>\n\u003cp>And here's \u003ca href=\"http://www.isscr.org/ScienceStatementEndorsers.cfm\" target=\"_top\">a letter\u003c/a>, signed by 834 scientists in defense of continued support of research on both types of cells. An excerpt:\u003c/p>\n\u003cp>\"The basic tools for these discoveries will include the “gold standard” embryonic stem cells that remain the benchmark for assessment of pluripotency, or the ability to develop into all the fully functional cells of the body.\"\u003c/p>\n\u003cp>And that's exactly the term Srivastava used: \"gold standard.\" Adult cells that can be transformed into embryonic stem cell-like cells may well someday free researchers from the political roller coaster of embryonic stem cell support, he said. But first, scientists need to figure out exactly how well they work. And without human embryonic stem cells, there's just nothing to compare them to.\u003c/p>\n\u003cp>\u003cobject width=\"640\" height=\"385\">\u003cparam name=\"movie\" value=\"http://www.youtube.com/v/tOdyaiWr0oo&color1=0xb1b1b1&color2=0xd0d0d0&hl=en_US&feature=player_embedded&fs=1\">\u003cparam name=\"allowFullScreen\" value=\"true\">\u003cparam name=\"allowScriptAccess\" value=\"always\">\u003cembed src=\"http://www.youtube.com/v/tOdyaiWr0oo&color1=0xb1b1b1&color2=0xd0d0d0&hl=en_US&feature=player_embedded&fs=1\" type=\"application/x-shockwave-flash\" allowfullscreen=\"true\" allowscriptaccess=\"always\" width=\"640\" height=\"385\">\u003c/embed>\u003c/object>\u003c/p>\n\u003cp>\u003cem>Video of beating heart cell created from adult cells - Courtesy of the Gladstone Institute of Cardiovascular Disease\u003c/em>\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/09/radio_icon_light.gif\" alt=\"\">\u003c/a>\u003c/span>\u003ca href=\"http://ww2.kqed.org/quest/audio/california-takes-the-lead-on-stem-cell-research\">Listen to the California Takes the Lead on Stem Cell Research \u003c/a> radio report online.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.7677229 -122.3942944\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/8124/reporters-notes-california-takes-the-lead-on-stem-cell-research","authors":["210"],"categories":["quest_12"],"tags":["quest_252","quest_313","quest_449","quest_606","quest_793","quest_1203","quest_1218","quest_1332","quest_1360","quest_1408","quest_1498","quest_1547","quest_2459"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. 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Plus, KQED’s Bianca Taylor brings you the local KQED news you need to know.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Consider-This-Podcast-Tile-703x703-1.jpg","imageAlt":"Consider This from NPR and KQED","officialWebsiteLink":"/podcasts/considerthis","meta":{"site":"news","source":"kqed","order":"7"},"link":"/podcasts/considerthis","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1503226625?mt=2&at=11l79Y&ct=nprdirectory","npr":"https://rpb3r.app.goo.gl/coronavirusdaily","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM1NS9wb2RjYXN0LnhtbA","spotify":"https://open.spotify.com/show/3Z6JdCS2d0eFEpXHKI6WqH"}},"forum":{"id":"forum","title":"Forum","tagline":"The conversation starts here","info":"KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.","airtime":"MON-FRI 9am-11am, 10pm-11pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED Forum with Mina Kim and Alexis Madrigal","officialWebsiteLink":"/forum","meta":{"site":"news","source":"kqed","order":"8"},"link":"/forum","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/kqeds-forum/id73329719","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz","npr":"https://www.npr.org/podcasts/432307980/forum","stitcher":"https://www.stitcher.com/podcast/kqedfm-kqeds-forum-podcast","rss":"https://feeds.megaphone.fm/KQINC9557381633"}},"freakonomics-radio":{"id":"freakonomics-radio","title":"Freakonomics Radio","info":"Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. 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