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She was a 2013 recipient of the NYU Reporting Award, a 2013 Dennis Hunt Health Journalism fellow and a 2015 USC Data Journalism fellow.\r\n\r\nRead her \u003ca href=\"http://science.kqed.org/quest/author/lizagross/\">previous contributions\u003c/a> to \u003ca href=\"science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/1f7d36efc78088d63466cef5f10c4c7a?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"stateofhealth","roles":["author"]},{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Liza Gross | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/1f7d36efc78088d63466cef5f10c4c7a?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/1f7d36efc78088d63466cef5f10c4c7a?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/lizagross"},"dannastaaf":{"type":"authors","id":"6324","meta":{"index":"authors_1591205172","id":"6324","found":true},"name":"Danna Staaf","firstName":"Danna","lastName":"Staaf","slug":"dannastaaf","email":"dannajoy@gmail.com","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Danna Staaf is a marine biologist, science writer, novelist, artist, and educator. She holds a PhD in Squid Babies from Stanford and a BA in Biology from the College of Creative Studies at the University of California, Santa Barbara. She helped found the outreach program \u003ca href=\"http://gilly.stanford.edu/outreach.html\">Squids4Kids\u003c/a>, illustrated \u003ca href=\"https://www.thegamecrafter.com/games/the-game-of-science\">The Game of Science\u003c/a>, and blogs at \u003ca href=\"http://www.science20.com/squid_day\">Science 2.0\u003c/a>. She lives in San Jose with her husband, daughter, and cats.","avatar":"https://secure.gravatar.com/avatar/62085c2562a0b91949bfd6ff7548082e?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Danna Staaf | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/62085c2562a0b91949bfd6ff7548082e?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/62085c2562a0b91949bfd6ff7548082e?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dannastaaf"},"jenniferhuber":{"type":"authors","id":"6360","meta":{"index":"authors_1591205172","id":"6360","found":true},"name":"Jennifer Huber","firstName":"Jennifer","lastName":"Huber","slug":"jenniferhuber","email":"jshuber@lbl.gov","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Jennifer Huber is a medical imaging scientist at the Lawrence Berkeley National Laboratory with more than 20 years of experience in academic science writing. 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Jennifer has lived in the San Francisco Bay Area most of her life and she frequently enjoys the eclectic cultural, culinary and outdoor activities available in the area.\r\n\r\nRead her \u003ca href=\"http://science.kqed.org/quest/author/jenniferhuber/\">previous contributions\u003c/a> to \u003ci>QUEST\u003c/i>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/ca897c62a710c0bf8c5f429c89331765?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Jennifer Huber | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/ca897c62a710c0bf8c5f429c89331765?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/ca897c62a710c0bf8c5f429c89331765?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/jenniferhuber"},"darya-pino":{"type":"authors","id":"10218","meta":{"index":"authors_1591205172","id":"10218","found":true},"name":"Darya Pino","firstName":"Darya","lastName":"Pino","slug":"darya-pino","email":"darya@summertomato.com","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Darya Pino is a Ph.D trained scientist, San Francisco foodie, food and health writer and advocate of local, seasonal foods. She shares her unique scientific perspective on health and enthusiasm for delicious foods at her website Summer Tomato. Follow her on Twitter @summertomato.","avatar":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twitter":null,"facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Darya Pino | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/b5303fe7938a19bb9d4baa7837fb8390?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/darya-pino"},"rmcclure":{"type":"authors","id":"10505","meta":{"index":"authors_1591205172","id":"10505","found":true},"name":"Robert McClure","firstName":"Robert","lastName":"McClure","slug":"rmcclure","email":"rmcclure@invw.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Robert McClure is executive director of \u003ca href=\"http://www.invw.org\">InvestigateWest\u003c/a>, a nonprofit newsroom in Seattle specializing in the environment, public health and government accountability for the Pacific Northwest and British Columbia. A veteran newspaper reporter with a quarter of a century on the environment beat, he is a winner of the John B. Oakes Award for Distinguished Environmental Journalism and serves on the board of the Society of Environmental Journalists. 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Thousands are suctioned onto the walls of 19 outdoor aquaculture tanks behind his office in Port Hueneme, California, south of Santa Barbara.\u003c/p>\n\u003cp>Shaped like oblong cinnamon rolls, the black, tan, and striped snails may live up to 60 years, although their population may be dwindling.\u003c/p>\n\u003cp>“This fragile California resource could be the basis of multiple life-saving drugs,” said Oakes, who is the CEO of \u003ca href=\"http://www.stellarbiotechnologies.com/\">Stellar Biotechnologies Inc.\u003c/a>, a biomedical company.\u003c/p>\n\u003cp>Giant keyhole limpets contain a valuable protein called KLH, or \u003ca href=\"http://en.wikipedia.org/wiki/Keyhole_limpet_hemocyanin\">keyhole limpet hemocyanin\u003c/a>, which is being tested in more than 20 different types of cancer vaccines and on autoimmune diseases like Alzheimer’s.\u003c/p>\n\u003cfigure id=\"attachment_72272\" class=\"wp-caption alignleft\" style=\"max-width: 365px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1.jpg\">\u003cimg class=\" wp-image-72272\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1-379x253.jpg\" alt=\"Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and automimmune diseases. Photo: Stellar Biotechnologies, Inc.\" width=\"365\" height=\"244\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and autoimmune diseases. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>The copper-based blood protein carries oxygen through the snail’s body, as hemoglobin does in humans.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In the 1950s, immunologists found that inserting KLH into patients triggered a powerful immune response. Such responses are critical in helping the body fight cancer and other diseases.\u003c/p>\n\u003cp>“There are lots of situations where we wish we could elicit an immune response,” said \u003ca href=\"http://www.oxy.edu/\">Occidental College\u003c/a> biology professor \u003ca href=\"https://www.oxy.edu/faculty/gary-martin\">Gary Martin\u003c/a>. “Cancer, for example, doesn’t stimulate a strong response.”\u003c/p>\n\u003cp>So researchers have figured out how to take markers for a specific type of cancer and attach KLH before inserting them into a vaccine.\u003c/p>\n\u003cp>Once administered, KLH wakes up the immune system and the patient’s antibodies see the markers. Like a signpost, the markers point toward the patient’s cancer. This process trains the immune system to fight the patient’s specific type of cancer.\u003c/p>\n\u003cp>“The hope with the cancer vaccines that contain KLH is that one day they will be preventative, much like the vaccines for measles and polio are today,” said \u003ca href=\"http://www.stellarbiotechnologies.com/about-stellar/leadership/management-team\">Catherine Brisson\u003c/a>, chief operating officer of Stellar Biotechnologies.\u003c/p>\n\u003cp>\u003cspan style=\"color: #ff8000\">\u003c/span>\u003c/p>\n\u003caside class=\"pullquote alignleft\">\"This fragile California resource could be the basis of multiple life-saving drugs\" -- Frank Oakes, CEO Stellar Biotechnologies, Inc.\u003c/aside>\n\u003cp>KLH-based vaccines are in phase III clinical trials, the last stage before a drug receives commercial approval from the \u003ca href=\"http://www.fda.gov/\">Food and Drug Administration\u003c/a>.\u003c/p>\n\u003cp>Other countries, including South Korea, China, and the Netherlands, have already approved KLH-based cancer vaccines. Stellar sells the purified blood protein to international companies for $50,000 per gram.\u003c/p>\n\u003cp>But generating a steady supply of KLH is tricky.\u003c/p>\n\u003cp>Giant keyhole limpets only live off the California coast and no one knows how many exist in the wild.\u003c/p>\n\u003cp>Most international pharmaceutical companies collect mollusks from the ocean, which are frozen and shipped overseas or bled to death and thrown back into the water.\u003c/p>\n\u003cfigure id=\"attachment_72274\" class=\"wp-caption alignleft\" style=\"max-width: 225px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1.jpg\">\u003cimg class=\" wp-image-72274\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1-168x253.jpg\" alt=\"One gram of the snails' purified blood protein is $50,000. Photo: Stellar Biotechnologies, Inc.\" width=\"225\" height=\"339\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">One gram of the snails' purified blood protein is sold to pharmaceutical companies for $50,000. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>“I have been working in our kelp forest since 1970 and have seen [them] become much more rare over the years,” \u003ca href=\"http://daytonlab.ucsd.edu/\">Paul Dayton\u003c/a>, a marine ecologist at \u003ca href=\"https://scripps.ucsd.edu/\">Scripps Institution of Oceanography\u003c/a>, said in an email.\u003c/p>\n\u003cp>Because of the market value for the blood protein, Dayton said, “it makes sense that they might be disappearing.”\u003c/p>\n\u003cp>What’s important, he said, is preserving a marine habitat that is vastly under studied.\u003c/p>\n\u003cp>“I do not think it is appropriate to have a commercial harvest…without first doing some research on the population biology.”\u003c/p>\n\u003cp>Dayton argued for restrictions on the number of snails that can be removed, since there are no catch limits.\u003c/p>\n\u003cp>And while Stellar is no longer taking limpets from the wild, it is relying on a supply that may not last if KLH-based treatments are approved.\u003c/p>\n\u003cp>“Should any of these clinical trials hit the jackpot, we don’t have a huge reservoir of these animals to supply the need for further clinical trials and treatments,” said Martin.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>\u003cem>This story was made possible, in part, by support from the \u003ca href=\"http://www.ijnr.org/\">Institute for Journalism & Natural Resources\u003c/a>.\u003c/em>\u003c/strong>\u003c/p>\n\n","blocks":[],"excerpt":"A marine mollusk with a coveted blood protein is shaping the way researchers treat cancer and autoimmune diseases.","status":"publish","parent":0,"modified":1457553692,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":26,"wordCount":676},"headData":{"title":"In Rare Sea Snail, Scientists Find Compound That Could Help Cancer Patients | KQED","description":"A marine mollusk with a coveted blood protein is shaping the way researchers treat cancer and autoimmune diseases.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"70177 http://science.kqed.org/quest/?p=70177","disqusUrl":"https://ww2.kqed.org/quest/2014/10/16/in-rare-sea-snail-scientists-find-compound-that-could-help-cancer-patients/","disqusTitle":"In Rare Sea Snail, Scientists Find Compound That Could Help Cancer Patients","videoEmbed":"https://www.youtube.com/watch?v=5wSMe9hh66M","path":"/quest/70177/in-rare-sea-snail-scientists-find-compound-that-could-help-cancer-patients","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>PORT HUENEME -- Frank Oakes is betting his future on a snail. Thousands are suctioned onto the walls of 19 outdoor aquaculture tanks behind his office in Port Hueneme, California, south of Santa Barbara.\u003c/p>\n\u003cp>Shaped like oblong cinnamon rolls, the black, tan, and striped snails may live up to 60 years, although their population may be dwindling.\u003c/p>\n\u003cp>“This fragile California resource could be the basis of multiple life-saving drugs,” said Oakes, who is the CEO of \u003ca href=\"http://www.stellarbiotechnologies.com/\">Stellar Biotechnologies Inc.\u003c/a>, a biomedical company.\u003c/p>\n\u003cp>Giant keyhole limpets contain a valuable protein called KLH, or \u003ca href=\"http://en.wikipedia.org/wiki/Keyhole_limpet_hemocyanin\">keyhole limpet hemocyanin\u003c/a>, which is being tested in more than 20 different types of cancer vaccines and on autoimmune diseases like Alzheimer’s.\u003c/p>\n\u003cfigure id=\"attachment_72272\" class=\"wp-caption alignleft\" style=\"max-width: 365px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1.jpg\">\u003cimg class=\" wp-image-72272\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_GKL-AQJuveniles-18-1-379x253.jpg\" alt=\"Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and automimmune diseases. Photo: Stellar Biotechnologies, Inc.\" width=\"365\" height=\"244\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Since the 1990s, limpets have been raised in captivity and their blood is being tested in treatments for cancer and autoimmune diseases. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>The copper-based blood protein carries oxygen through the snail’s body, as hemoglobin does in humans.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In the 1950s, immunologists found that inserting KLH into patients triggered a powerful immune response. Such responses are critical in helping the body fight cancer and other diseases.\u003c/p>\n\u003cp>“There are lots of situations where we wish we could elicit an immune response,” said \u003ca href=\"http://www.oxy.edu/\">Occidental College\u003c/a> biology professor \u003ca href=\"https://www.oxy.edu/faculty/gary-martin\">Gary Martin\u003c/a>. “Cancer, for example, doesn’t stimulate a strong response.”\u003c/p>\n\u003cp>So researchers have figured out how to take markers for a specific type of cancer and attach KLH before inserting them into a vaccine.\u003c/p>\n\u003cp>Once administered, KLH wakes up the immune system and the patient’s antibodies see the markers. Like a signpost, the markers point toward the patient’s cancer. This process trains the immune system to fight the patient’s specific type of cancer.\u003c/p>\n\u003cp>“The hope with the cancer vaccines that contain KLH is that one day they will be preventative, much like the vaccines for measles and polio are today,” said \u003ca href=\"http://www.stellarbiotechnologies.com/about-stellar/leadership/management-team\">Catherine Brisson\u003c/a>, chief operating officer of Stellar Biotechnologies.\u003c/p>\n\u003cp>\u003cspan style=\"color: #ff8000\">\u003c/span>\u003c/p>\n\u003caside class=\"pullquote alignleft\">\"This fragile California resource could be the basis of multiple life-saving drugs\" -- Frank Oakes, CEO Stellar Biotechnologies, Inc.\u003c/aside>\n\u003cp>KLH-based vaccines are in phase III clinical trials, the last stage before a drug receives commercial approval from the \u003ca href=\"http://www.fda.gov/\">Food and Drug Administration\u003c/a>.\u003c/p>\n\u003cp>Other countries, including South Korea, China, and the Netherlands, have already approved KLH-based cancer vaccines. Stellar sells the purified blood protein to international companies for $50,000 per gram.\u003c/p>\n\u003cp>But generating a steady supply of KLH is tricky.\u003c/p>\n\u003cp>Giant keyhole limpets only live off the California coast and no one knows how many exist in the wild.\u003c/p>\n\u003cp>Most international pharmaceutical companies collect mollusks from the ocean, which are frozen and shipped overseas or bled to death and thrown back into the water.\u003c/p>\n\u003cfigure id=\"attachment_72274\" class=\"wp-caption alignleft\" style=\"max-width: 225px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1.jpg\">\u003cimg class=\" wp-image-72274\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/04/Stellar-2014-copyright_KLH-IMG_8554-1-168x253.jpg\" alt=\"One gram of the snails' purified blood protein is $50,000. Photo: Stellar Biotechnologies, Inc.\" width=\"225\" height=\"339\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">One gram of the snails' purified blood protein is sold to pharmaceutical companies for $50,000. Photo: Stellar Biotechnologies, Inc.\u003c/figcaption>\u003c/figure>\n\u003cp>“I have been working in our kelp forest since 1970 and have seen [them] become much more rare over the years,” \u003ca href=\"http://daytonlab.ucsd.edu/\">Paul Dayton\u003c/a>, a marine ecologist at \u003ca href=\"https://scripps.ucsd.edu/\">Scripps Institution of Oceanography\u003c/a>, said in an email.\u003c/p>\n\u003cp>Because of the market value for the blood protein, Dayton said, “it makes sense that they might be disappearing.”\u003c/p>\n\u003cp>What’s important, he said, is preserving a marine habitat that is vastly under studied.\u003c/p>\n\u003cp>“I do not think it is appropriate to have a commercial harvest…without first doing some research on the population biology.”\u003c/p>\n\u003cp>Dayton argued for restrictions on the number of snails that can be removed, since there are no catch limits.\u003c/p>\n\u003cp>And while Stellar is no longer taking limpets from the wild, it is relying on a supply that may not last if KLH-based treatments are approved.\u003c/p>\n\u003cp>“Should any of these clinical trials hit the jackpot, we don’t have a huge reservoir of these animals to supply the need for further clinical trials and treatments,” said Martin.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>\u003cem>This story was made possible, in part, by support from the \u003ca href=\"http://www.ijnr.org/\">Institute for Journalism & Natural Resources\u003c/a>.\u003c/em>\u003c/strong>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/70177/in-rare-sea-snail-scientists-find-compound-that-could-help-cancer-patients","authors":["5432"],"categories":["quest_4","quest_9","quest_12"],"tags":["quest_12994","quest_326","quest_475","quest_12269","quest_12996","quest_2034","quest_12995","quest_13","quest_12997","quest_12992","quest_12993","quest_13365","quest_3056","quest_3071"],"featImg":"quest_72198","label":"quest"},"quest_63103":{"type":"posts","id":"quest_63103","meta":{"index":"posts_1591205157","site":"quest","id":"63103","score":null,"sort":[1390489217000]},"guestAuthors":[],"slug":"could-your-driveway-be-poisoning-your-kids","title":"Could your driveway be poisoning your kids?","publishDate":1390489217,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>Every year about 85 million gallons of a toxic waste that is known to promote cancer is carefully painted across about 170 square miles of American cities and suburbs, a swath as big as the city of New Orleans.\u003c/p>\n\u003cp>As incredible as that may sound, that’s the conclusion squarely presented by a growing body of research that looks at a gooey black \u003ca href=\"http://en.wikipedia.org/wiki/Pitch_(resin)\">pitch\u003c/a> made from a substance known as coal tar. It’s a kind of creosote, the stuff used to weatherproof telephone poles and railroad ties.\u003c/p>\n\u003cp>It’s also one of the two main ways Americans use to “seal” asphalt parking lots and driveways. It makes the asphalt look blacker and is intended to keep the pavement from wearing away so fast. Researchers are most interested in a class of chemicals contained in asphalt sealers known as “\u003ca href=\"http://www.epa.gov/osw/hazard/wastemin/minimize/factshts/pahs.pdf\">polycyclic aromatic hydrocarbons\u003c/a>,” or PAHs. And coal tar-based sealers are dangerous enough in the opinion of some local and state governments that they have been banned. In 2011 Washington \u003ca href=\"http://www.invw.org/content/washington-is-first-state-in-nation-to-ban-toxic-pavement-sealants\">became the first state to forbid\u003c/a> the use of this kind of sealant, followed by Minnesota \u003ca href=\"https://www.revisor.mn.gov/statutes/?id=116.202\"> last year\u003c/a>.\u003c/p>\n\u003cfigure id=\"attachment_65749\" class=\"wp-caption alignleft\" style=\"max-width: 393px\">\u003cimg class=\" wp-image-65749 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/10/Man-spraying-e1389131931776.jpg\" alt=\"Man spraying\" width=\"393\" height=\"382\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776.jpg 1135w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-400x389.jpg 400w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-800x779.jpg 800w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-960x935.jpg 960w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-32x32.jpg 32w\" sizes=\"(max-width: 393px) 100vw, 393px\">\u003cfigcaption class=\"wp-caption-text\">Man 'seals' pavement with spray. Photo courtesy of USGS.\u003c/figcaption>\u003c/figure>\n\u003cp>If you’ve ever walked by a parking lot or driveway that’s recently been sealed with coal tar, your nose most likely told you so. The “aromatic” part of PAHs means that you can smell the chemicals emanating from the recently sealed pavement , especially when it bakes in the sun. \u003ca href=\"http://www.sciencedirect.com/science/article/pii/S135223101200057X\">Recent research\u003c/a> shows that large and potentially dangerous amounts of these harmful chemicals are released into the air in the days, weeks, and even months after the pavement is sealed – more, in fact, than what is put out by all the cars in the country.\u003c/p>\n\u003cp>Scientists also looked at what happens to the toxic coal tar sealants after they have sat on the asphalt for a few months or years and start to peel off in tiny bits. Car tires, rain, foot traffic, snowplows, and the freeze/thaw cycle all cause tiny bits of the sealant to “abrade,” as scientists say. Little bits of the black stuff flake off.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003ca href=\"http://pubs.acs.org/doi/abs/10.1021/es902533r\">Research shows\u003c/a> some of it gets tracked off the parking lots and driveways and into people’s homes. Scientists at the U.S. Geological Survey (USGS) found that the most dangerous coal tar component , a PAH chemical called benzo[\u003cem>a\u003c/em>]pyrene, was in driveway dust at two suburban single-family homes at thousands of times the level that would trigger a cleanup at a toxic-waste site.\u003c/p>\n\u003cp>The United States has no standard for benzo[\u003cem>a\u003c/em>]pyrene in house dust, but Germany does: an official guideline of 10 parts of the chemical for every 1 million parts of dust. In the USGS’s tests of apartments near parking lots sealed with coal tar, more than one-third of the apartments showed levels of the toxic chemical exceeding that standard. House dust levels were much lower in apartments located next to parking lots coated with other kinds of sealants, which are based on asphalt and contain thousands of times less PAHs. \u003c/p>\n\u003cfigure id=\"attachment_66042\" class=\"wp-caption alignright\" style=\"max-width: 398px\">\u003cimg class=\"wp-image-66042 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/01/Converse-shoe.jpg\" alt=\"Converse shoe\" width=\"398\" height=\"265\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe.jpg 1536w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-400x267.jpg 400w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-800x533.jpg 800w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-1440x960.jpg 1440w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-1180x787.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-960x640.jpg 960w\" sizes=\"(max-width: 398px) 100vw, 398px\">\u003cfigcaption class=\"wp-caption-text\">Photo courtesy of \u003ca href=\"http://www.flickr.com/photos/werewolvesbaby/2863909864/\">brittany fucci\u003c/a>.\u003c/figcaption>\u003c/figure>\n\u003cp>\u003ca href=\"http://pubs.acs.org/doi/abs/10.1021/es303371t\">Further research\u003c/a> revealed that growing up with toxic dust from a coal tar-sealed parking lot next door could cause a child to face a 38-fold increase in lifetime cancer risk. It’s especially toxic to kids under age 6. The levels measured exceed those the EPA considers worthy of cleanup at toxic waste sites, because they are likely to cause cancer in more than 1 person out of every 1,000 people exposed, researchers reported.\u003c/p>\n\u003cp>Other studies have shown that the runoff from the coal tar-sealed lots harms critters in freshwater streams where it ends up, affecting their development and reproduction and reducing the populations and the number of species able to live in affected streams.\u003c/p>\n\u003cp>The growing body of research around asphalt sealants was \u003ca href=\"http://tx.usgs.gov/coring/pubs/parking%20lot%20sealants.pdf\">pioneered by\u003c/a> Barbara Mahler and Peter van Metre, a husband-and-wife team of researchers for the USGS in Austin, Texas. Many other researchers from more than a dozen other governments and universities also investigated.\u003c/p>\n\u003cp>The sealant industry questioned their findings. In reaction to the work by these government and university researchers, the trade group of asphalt sealers, the \u003ca href=\"http://www.pavementcouncil.org/\">Pavement Coatings Technology Council\u003c/a>, has sponsored \u003ca href=\"http://www.pavementcouncil.org/scientific-journals\">its own body of research\u003c/a>. \u003ca href=\"http://www.pavementcouncil.org/pavementcouncil/PAH%20volatilization%20critique.pdf\">One industry-sponsored critique\u003c/a> went after the USGS researchers, saying,in general, that in their work, “effects have been exaggerated and uncertainties have been minimized.”\u003c/p>\n\u003cfigure id=\"attachment_66066\" class=\"wp-caption alignleft\" style=\"max-width: 419px\">\u003ca href=\"http://ww2.kqed.org/quest/2014/01/23/could-your-driveway-be-poisoning-your-kids/walking-the-line/\" rel=\"attachment wp-att-66066\">\u003cimg class=\" wp-image-66066 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/01/Walking-the-line.jpg\" alt=\"Walking the line\" width=\"419\" height=\"279\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line.jpg 1539w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-400x266.jpg 400w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-800x532.jpg 800w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-1440x957.jpg 1440w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-1180x784.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-960x638.jpg 960w\" sizes=\"(max-width: 419px) 100vw, 419px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Photo courtesy of \u003ca href=\"http://www.flickr.com/photos/angelinawb/1085267480/\">Angelina 🙂\u003c/a>.\u003c/figcaption>\u003c/figure>\n\u003cp>PAHs are produced by many sources, the industry pointed out. Any \u003ca href=\"http://en.wikipedia.org/wiki/Organic_matter\">organic matter\u003c/a> that is burned – gasoline, for example – puts out PAHs. But the USGS team and its collaborators said the chemical “fingerprint” they are finding in, for example, sediments at the bottom of lakes near coal tar-sealed pavement, looks very similar to the PAH “fingerprint” in sealants made with coal tar.\u003c/p>\n\u003cp>Although only two states have banned coal tar sealants, \u003ca href=\"http://coaltarfreeamerica.blogspot.com/p/bans.html\">more than 40 local and state governments\u003c/a> forbid application of the coal tar-based sealants, according to the blog \u003ca href=\"http://coaltarfreeamerica.blogspot.com/\">coaltarfreeamerica.com\u003c/a>, which tracks the bans and is crusading to have the sealants outlawed nationwide. Some of the first local governments to ban the coal tar sealants were Austin, TX, Washington, DC, and Madison, WI, and surrounding Dane County.\u003c/p>\n\u003cp>In a recent webinar for researchers and others interested the topic, Mahler, the USGS researcher, reviewed the findings to date. Other scientists on the call suggested further work, such as looking into how the sealants are affecting creatures in salt water, and analysis of \u003ca href=\"http://en.wikipedia.org/wiki/Isotope\">isotopes\u003c/a> of the chemicals involved.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Mahler agreed, telling the other researchers, “There’s a lot of really fruitful areas for research that have to do with this subject.”\u003c/p>\n\n","blocks":[],"excerpt":"Parking lots coated with coal tar, a gooey black waste product of steel manufacturing, shed the coatings at a high rate. This toxic residue is showing up in dust on nearby apartment surfaces.","status":"publish","parent":0,"modified":1443823502,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":17,"wordCount":983},"headData":{"title":"Could your driveway be poisoning your kids? | KQED","description":"Parking lots coated with coal tar, a gooey black waste product of steel manufacturing, shed the coatings at a high rate. This toxic residue is showing up in dust on nearby apartment surfaces.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"63103 http://science.kqed.org/quest/?p=63103","disqusUrl":"https://ww2.kqed.org/quest/2014/01/23/could-your-driveway-be-poisoning-your-kids/","disqusTitle":"Could your driveway be poisoning your kids?","path":"/quest/63103/could-your-driveway-be-poisoning-your-kids","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Every year about 85 million gallons of a toxic waste that is known to promote cancer is carefully painted across about 170 square miles of American cities and suburbs, a swath as big as the city of New Orleans.\u003c/p>\n\u003cp>As incredible as that may sound, that’s the conclusion squarely presented by a growing body of research that looks at a gooey black \u003ca href=\"http://en.wikipedia.org/wiki/Pitch_(resin)\">pitch\u003c/a> made from a substance known as coal tar. It’s a kind of creosote, the stuff used to weatherproof telephone poles and railroad ties.\u003c/p>\n\u003cp>It’s also one of the two main ways Americans use to “seal” asphalt parking lots and driveways. It makes the asphalt look blacker and is intended to keep the pavement from wearing away so fast. Researchers are most interested in a class of chemicals contained in asphalt sealers known as “\u003ca href=\"http://www.epa.gov/osw/hazard/wastemin/minimize/factshts/pahs.pdf\">polycyclic aromatic hydrocarbons\u003c/a>,” or PAHs. And coal tar-based sealers are dangerous enough in the opinion of some local and state governments that they have been banned. In 2011 Washington \u003ca href=\"http://www.invw.org/content/washington-is-first-state-in-nation-to-ban-toxic-pavement-sealants\">became the first state to forbid\u003c/a> the use of this kind of sealant, followed by Minnesota \u003ca href=\"https://www.revisor.mn.gov/statutes/?id=116.202\"> last year\u003c/a>.\u003c/p>\n\u003cfigure id=\"attachment_65749\" class=\"wp-caption alignleft\" style=\"max-width: 393px\">\u003cimg class=\" wp-image-65749 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/10/Man-spraying-e1389131931776.jpg\" alt=\"Man spraying\" width=\"393\" height=\"382\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776.jpg 1135w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-400x389.jpg 400w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-800x779.jpg 800w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-960x935.jpg 960w, https://ww2.kqed.org/app/uploads/sites/39/2013/10/Man-spraying-e1389131931776-32x32.jpg 32w\" sizes=\"(max-width: 393px) 100vw, 393px\">\u003cfigcaption class=\"wp-caption-text\">Man 'seals' pavement with spray. Photo courtesy of USGS.\u003c/figcaption>\u003c/figure>\n\u003cp>If you’ve ever walked by a parking lot or driveway that’s recently been sealed with coal tar, your nose most likely told you so. The “aromatic” part of PAHs means that you can smell the chemicals emanating from the recently sealed pavement , especially when it bakes in the sun. \u003ca href=\"http://www.sciencedirect.com/science/article/pii/S135223101200057X\">Recent research\u003c/a> shows that large and potentially dangerous amounts of these harmful chemicals are released into the air in the days, weeks, and even months after the pavement is sealed – more, in fact, than what is put out by all the cars in the country.\u003c/p>\n\u003cp>Scientists also looked at what happens to the toxic coal tar sealants after they have sat on the asphalt for a few months or years and start to peel off in tiny bits. Car tires, rain, foot traffic, snowplows, and the freeze/thaw cycle all cause tiny bits of the sealant to “abrade,” as scientists say. Little bits of the black stuff flake off.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://pubs.acs.org/doi/abs/10.1021/es902533r\">Research shows\u003c/a> some of it gets tracked off the parking lots and driveways and into people’s homes. Scientists at the U.S. Geological Survey (USGS) found that the most dangerous coal tar component , a PAH chemical called benzo[\u003cem>a\u003c/em>]pyrene, was in driveway dust at two suburban single-family homes at thousands of times the level that would trigger a cleanup at a toxic-waste site.\u003c/p>\n\u003cp>The United States has no standard for benzo[\u003cem>a\u003c/em>]pyrene in house dust, but Germany does: an official guideline of 10 parts of the chemical for every 1 million parts of dust. In the USGS’s tests of apartments near parking lots sealed with coal tar, more than one-third of the apartments showed levels of the toxic chemical exceeding that standard. House dust levels were much lower in apartments located next to parking lots coated with other kinds of sealants, which are based on asphalt and contain thousands of times less PAHs. \u003c/p>\n\u003cfigure id=\"attachment_66042\" class=\"wp-caption alignright\" style=\"max-width: 398px\">\u003cimg class=\"wp-image-66042 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/01/Converse-shoe.jpg\" alt=\"Converse shoe\" width=\"398\" height=\"265\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe.jpg 1536w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-400x267.jpg 400w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-800x533.jpg 800w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-1440x960.jpg 1440w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-1180x787.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Converse-shoe-960x640.jpg 960w\" sizes=\"(max-width: 398px) 100vw, 398px\">\u003cfigcaption class=\"wp-caption-text\">Photo courtesy of \u003ca href=\"http://www.flickr.com/photos/werewolvesbaby/2863909864/\">brittany fucci\u003c/a>.\u003c/figcaption>\u003c/figure>\n\u003cp>\u003ca href=\"http://pubs.acs.org/doi/abs/10.1021/es303371t\">Further research\u003c/a> revealed that growing up with toxic dust from a coal tar-sealed parking lot next door could cause a child to face a 38-fold increase in lifetime cancer risk. It’s especially toxic to kids under age 6. The levels measured exceed those the EPA considers worthy of cleanup at toxic waste sites, because they are likely to cause cancer in more than 1 person out of every 1,000 people exposed, researchers reported.\u003c/p>\n\u003cp>Other studies have shown that the runoff from the coal tar-sealed lots harms critters in freshwater streams where it ends up, affecting their development and reproduction and reducing the populations and the number of species able to live in affected streams.\u003c/p>\n\u003cp>The growing body of research around asphalt sealants was \u003ca href=\"http://tx.usgs.gov/coring/pubs/parking%20lot%20sealants.pdf\">pioneered by\u003c/a> Barbara Mahler and Peter van Metre, a husband-and-wife team of researchers for the USGS in Austin, Texas. Many other researchers from more than a dozen other governments and universities also investigated.\u003c/p>\n\u003cp>The sealant industry questioned their findings. In reaction to the work by these government and university researchers, the trade group of asphalt sealers, the \u003ca href=\"http://www.pavementcouncil.org/\">Pavement Coatings Technology Council\u003c/a>, has sponsored \u003ca href=\"http://www.pavementcouncil.org/scientific-journals\">its own body of research\u003c/a>. \u003ca href=\"http://www.pavementcouncil.org/pavementcouncil/PAH%20volatilization%20critique.pdf\">One industry-sponsored critique\u003c/a> went after the USGS researchers, saying,in general, that in their work, “effects have been exaggerated and uncertainties have been minimized.”\u003c/p>\n\u003cfigure id=\"attachment_66066\" class=\"wp-caption alignleft\" style=\"max-width: 419px\">\u003ca href=\"http://ww2.kqed.org/quest/2014/01/23/could-your-driveway-be-poisoning-your-kids/walking-the-line/\" rel=\"attachment wp-att-66066\">\u003cimg class=\" wp-image-66066 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/01/Walking-the-line.jpg\" alt=\"Walking the line\" width=\"419\" height=\"279\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line.jpg 1539w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-400x266.jpg 400w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-800x532.jpg 800w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-1440x957.jpg 1440w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-1180x784.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/39/2014/01/Walking-the-line-960x638.jpg 960w\" sizes=\"(max-width: 419px) 100vw, 419px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Photo courtesy of \u003ca href=\"http://www.flickr.com/photos/angelinawb/1085267480/\">Angelina 🙂\u003c/a>.\u003c/figcaption>\u003c/figure>\n\u003cp>PAHs are produced by many sources, the industry pointed out. Any \u003ca href=\"http://en.wikipedia.org/wiki/Organic_matter\">organic matter\u003c/a> that is burned – gasoline, for example – puts out PAHs. But the USGS team and its collaborators said the chemical “fingerprint” they are finding in, for example, sediments at the bottom of lakes near coal tar-sealed pavement, looks very similar to the PAH “fingerprint” in sealants made with coal tar.\u003c/p>\n\u003cp>Although only two states have banned coal tar sealants, \u003ca href=\"http://coaltarfreeamerica.blogspot.com/p/bans.html\">more than 40 local and state governments\u003c/a> forbid application of the coal tar-based sealants, according to the blog \u003ca href=\"http://coaltarfreeamerica.blogspot.com/\">coaltarfreeamerica.com\u003c/a>, which tracks the bans and is crusading to have the sealants outlawed nationwide. Some of the first local governments to ban the coal tar sealants were Austin, TX, Washington, DC, and Madison, WI, and surrounding Dane County.\u003c/p>\n\u003cp>In a recent webinar for researchers and others interested the topic, Mahler, the USGS researcher, reviewed the findings to date. Other scientists on the call suggested further work, such as looking into how the sealants are affecting creatures in salt water, and analysis of \u003ca href=\"http://en.wikipedia.org/wiki/Isotope\">isotopes\u003c/a> of the chemicals involved.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Mahler agreed, telling the other researchers, “There’s a lot of really fruitful areas for research that have to do with this subject.”\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/63103/could-your-driveway-be-poisoning-your-kids","authors":["10505"],"categories":["quest_5","quest_8","quest_9","quest_12"],"tags":["quest_12556","quest_475","quest_530","quest_12555","quest_12558","quest_12557","quest_12269","quest_12386","quest_12684","quest_12683","quest_12146","quest_12682","quest_13365"],"featImg":"quest_65744","label":"quest"},"quest_52297":{"type":"posts","id":"quest_52297","meta":{"index":"posts_1591205157","site":"quest","id":"52297","score":null,"sort":[1365802017000]},"guestAuthors":[],"slug":"bay-area-biotech-industry-braces-for-gene-patenting-court-case","title":"Bay Area Biotech Industry Braces for Gene Patenting Court Case","publishDate":1365802017,"format":"audio","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>http://www.kqed.org/.stream/anon/radio/quest/2013/04/20130415science.mp3\u003c/p>\n\u003cp>Bay Area biotechnology companies are keeping an eye on the nation’s highest court. On Monday, the Supreme Court will hear a case on a key question: can you patent a human gene?\u003c/p>\n\u003cp>A recent study estimates that close to half of human genes identified so far are already patented. The court’s ruling could put millions of dollars at stake for Bay Area universities and biotech companies. \u003c/p>\n\u003cp>At issue are two genes related to breast and ovarian cancer, \u003ca href=\"http://blogs.kqed.org/stateofhealth/2013/04/12/breast-cancer-gene-mutations-at-heart-of-supreme-court-case/#more-12082\">BRCA 1 and BRCA 2\u003c/a>. Women with mutations in these genes are five to eight times more likely to develop breast cancer. To gauge that risk, patients often get a genetic test. It’s one of the most common tests that genetic counselors handle, like Julie Mak at\u003ca href=\"http://cancer.ucsf.edu/\"> UCSF’s Cancer Center\u003c/a>in San Francisco.\u003c/p>\n\u003cfigure id=\"attachment_52321\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/sequencing.jpg\">\u003cimg class=\"size-thumbnail wp-image-52321 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/sequencing-300x169.jpg\" alt=\"Preparation for DNA sequencing (Maggie Bartlett, NHGRI)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Preparation for DNA sequencing (Maggie Bartlett, NHGRI)\u003c/figcaption>\u003c/figure>\n\u003cp>“I do think it opens up a very loaded set of questions for people who are sometimes very young,” says Mak. “As you can imagine, the things we talk about with people are very serious and sometimes stressful and upsetting.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>A blood or saliva sample can tell a woman if she has those mutations, but that test isn’t run at UCSF. “For most BRCA 1 and 2 testing, the lab in Utah is the only one that does this testing,” Mak says, referring to Myriad Genetics.\u003c/p>\n\u003cp>\u003ca href=\"http://www.myriad.com/\">Myriad Genetics\u003c/a> holds patents on not only the test, but the actual genes themselves. That means one company has a monopoly on those genes and theoretically controls what can be done with them. That’s what’s being challenged by the American Civil Liberties Union.\u003c/p>\n\u003cp>\u003cstrong>Natural or Not?\u003c/strong>\u003c/p>\n\u003cp>“A lot of people wonder: how can you patent a gene?” says Mildred Cho, associate director of the \u003ca href=\"http://bioethics.stanford.edu/\">Stanford Center for Biomedical Ethics\u003c/a>.\u003c/p>\n\u003cp>In the case, the ACLU is arguing that genes aren’t patentable because they’re naturally occurring -- they’re found inside our bodies. According to patent law, “products of nature are not patentable,” Cho says.\u003c/p>\n\u003cp>Myriad Genetics argues that by extracting a specific gene and isolating it, it turns into a man-made invention, which makes it patentable. “In order to analyze to DNA, you have to break open the cells and break the DNA up in to little pieces,” Cho explains.\u003c/p>\n\u003cp>Legal complexities aside, Cho says it has real effects on our healthcare decision, like getting a second opinion. “No laboratory has 100 percent accuracy and so you would ideally want to have a lab result that’s really important confirmed by another lab,” she says. “You can’t do that if there are patents on that lab test.”\u003c/p>\n\u003cp>\u003cstrong>Questions of Open Access\u003c/strong>\u003c/p>\n\u003cp>Patents can also affect genetic research, according to UCSF professor Dr. Robert Nusssbaum. When I meet him in his office, he’s wearing a button pinned to his shirt.\u003c/p>\n\u003cp>“So my button says ‘free the data,'” he points out.\u003c/p>\n\u003cp>Since DNA doesn’t come with an instruction manual that reveals if a genetic mutation is harmful or not, the only way to find out is to compare it to thousands of other genetic tests.\u003c/p>\n\u003cp>“The only way to make that happen faster is for all the laboratories to pool all their information in one place and all have access to it,” Nussbaum says.\u003c/p>\n\u003cp>But not everyone is sharing. “There are a couple of laboratories, and Myriad is one of them, that have decided that since they had the patent on testing, that they would keep their data locked up as intellectual property,” he says.\u003c/p>\n\u003cp>In response, Nussbaum has organized an \u003ca href=\"http://www.sharingclinicalreports.org/\">open source database\u003c/a> that holds genetic data about breast cancer mutations, free for researchers to use.\u003c/p>\n\u003cp>“In terms of gene testing, I think patents are of no value, period,” says Nussbaum.\u003c/p>\n\u003cp>\u003cstrong>Basis of Biotech\u003c/strong>\u003c/p>\n\u003cp>“Patents are a very important, fundamental part of the foundation on which the biotechnology, biopharmaceutical industry has been built,” says Sean Johnston, general counsel at \u003ca href=\"http://www.gene.com/\">Genentech\u003c/a> in South San Francisco, one of the largest biotech companies in the world.\u003c/p>\n\u003cp>Companies like Genentech use genetic information to develop drugs and treatments, in addition to genetic diagnostic tests.\u003c/p>\n\u003cp>“Biotech and biopharmaceutical companies have relied upon patent protection to justify the significant investment, the risk-taking and the innovation that is necessary to develop new drugs,” Johnston says.\u003c/p>\n\u003cp>Johnston says it often takes a billion dollars to bring a drug to market, an investment that could be tougher to make without the protection of gene patents.\u003c/p>\n\u003cp>“It’s not a matter that if the court were to rule broadly our business would be destroyed,” Johnston says. “But in theory I think it has the potential to be very disruptive to the industry.”\u003c/p>\n\u003cp>\u003cstrong>Universities in the Middle\u003c/strong>\u003c/p>\n\u003cp>Biotech companies here aren’t the only ones watching this case. The University of California as a whole is one of the top ten gene patent holders in the country.\u003c/p>\n\u003cp>“Universities are often accused of patenting solely for the purpose of getting financial gain,” says Karin Immergluck of UCSF’s Office of Technology Management. The office handles several hundred gene patents.\u003c/p>\n\u003cp>“UCSF’s first goal is to translate our really exciting, cutting-edge technologies into products and services that will benefit the public,” she says.\u003c/p>\n\u003cp>The university walks a fine line. Companies pay millions of dollars a year to use its patents, like the one related to human growth hormone. But the court case brings up issue in licensing patents that universities already grappling with.\u003c/p>\n\u003cp>“For example, making sure the rights aren’t completely locked up in one company so that underinsured patients don’t have access,” says Immergluck.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Patient access, biotech industry profits and innovation could all be affected by the Supreme Court’s ruling. It’s expected in June.\u003c/p>\n\n","blocks":[],"excerpt":"The Supreme Court is hearing a case on a key question: can you patent a human gene? ","status":"publish","parent":0,"modified":1366389328,"stats":{"hasAudio":true,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":34,"wordCount":1025},"headData":{"title":"Bay Area Biotech Industry Braces for Gene Patenting Court Case | KQED","description":"The Supreme Court is hearing a case on a key question: can you patent a human gene? ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"52297 http://science.kqed.org/quest/?post_type=audio_reports&p=52297","disqusUrl":"https://ww2.kqed.org/quest/2013/04/12/bay-area-biotech-industry-braces-for-gene-patenting-court-case/","disqusTitle":"Bay Area Biotech Industry Braces for Gene Patenting Court Case","WpOldSlug":"west-coast-a-test-bed-for-ocean-acidification-2","path":"/quest/52297/bay-area-biotech-industry-braces-for-gene-patenting-court-case","audioUrl":"http://www.kqed.org/.stream/anon/radio/quest/2013/04/20130415science.mp3","audioDuration":null,"audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"audioLink","attributes":{"named":{"src":"http://www.kqed.org/.stream/anon/radio/quest/2013/04/20130415science.mp3"},"numeric":[]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Bay Area biotechnology companies are keeping an eye on the nation’s highest court. On Monday, the Supreme Court will hear a case on a key question: can you patent a human gene?\u003c/p>\n\u003cp>A recent study estimates that close to half of human genes identified so far are already patented. The court’s ruling could put millions of dollars at stake for Bay Area universities and biotech companies. \u003c/p>\n\u003cp>At issue are two genes related to breast and ovarian cancer, \u003ca href=\"http://blogs.kqed.org/stateofhealth/2013/04/12/breast-cancer-gene-mutations-at-heart-of-supreme-court-case/#more-12082\">BRCA 1 and BRCA 2\u003c/a>. Women with mutations in these genes are five to eight times more likely to develop breast cancer. To gauge that risk, patients often get a genetic test. It’s one of the most common tests that genetic counselors handle, like Julie Mak at\u003ca href=\"http://cancer.ucsf.edu/\"> UCSF’s Cancer Center\u003c/a>in San Francisco.\u003c/p>\n\u003cfigure id=\"attachment_52321\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/sequencing.jpg\">\u003cimg class=\"size-thumbnail wp-image-52321 \" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/sequencing-300x169.jpg\" alt=\"Preparation for DNA sequencing (Maggie Bartlett, NHGRI)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Preparation for DNA sequencing (Maggie Bartlett, NHGRI)\u003c/figcaption>\u003c/figure>\n\u003cp>“I do think it opens up a very loaded set of questions for people who are sometimes very young,” says Mak. “As you can imagine, the things we talk about with people are very serious and sometimes stressful and upsetting.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>A blood or saliva sample can tell a woman if she has those mutations, but that test isn’t run at UCSF. “For most BRCA 1 and 2 testing, the lab in Utah is the only one that does this testing,” Mak says, referring to Myriad Genetics.\u003c/p>\n\u003cp>\u003ca href=\"http://www.myriad.com/\">Myriad Genetics\u003c/a> holds patents on not only the test, but the actual genes themselves. That means one company has a monopoly on those genes and theoretically controls what can be done with them. That’s what’s being challenged by the American Civil Liberties Union.\u003c/p>\n\u003cp>\u003cstrong>Natural or Not?\u003c/strong>\u003c/p>\n\u003cp>“A lot of people wonder: how can you patent a gene?” says Mildred Cho, associate director of the \u003ca href=\"http://bioethics.stanford.edu/\">Stanford Center for Biomedical Ethics\u003c/a>.\u003c/p>\n\u003cp>In the case, the ACLU is arguing that genes aren’t patentable because they’re naturally occurring -- they’re found inside our bodies. According to patent law, “products of nature are not patentable,” Cho says.\u003c/p>\n\u003cp>Myriad Genetics argues that by extracting a specific gene and isolating it, it turns into a man-made invention, which makes it patentable. “In order to analyze to DNA, you have to break open the cells and break the DNA up in to little pieces,” Cho explains.\u003c/p>\n\u003cp>Legal complexities aside, Cho says it has real effects on our healthcare decision, like getting a second opinion. “No laboratory has 100 percent accuracy and so you would ideally want to have a lab result that’s really important confirmed by another lab,” she says. “You can’t do that if there are patents on that lab test.”\u003c/p>\n\u003cp>\u003cstrong>Questions of Open Access\u003c/strong>\u003c/p>\n\u003cp>Patents can also affect genetic research, according to UCSF professor Dr. Robert Nusssbaum. When I meet him in his office, he’s wearing a button pinned to his shirt.\u003c/p>\n\u003cp>“So my button says ‘free the data,'” he points out.\u003c/p>\n\u003cp>Since DNA doesn’t come with an instruction manual that reveals if a genetic mutation is harmful or not, the only way to find out is to compare it to thousands of other genetic tests.\u003c/p>\n\u003cp>“The only way to make that happen faster is for all the laboratories to pool all their information in one place and all have access to it,” Nussbaum says.\u003c/p>\n\u003cp>But not everyone is sharing. “There are a couple of laboratories, and Myriad is one of them, that have decided that since they had the patent on testing, that they would keep their data locked up as intellectual property,” he says.\u003c/p>\n\u003cp>In response, Nussbaum has organized an \u003ca href=\"http://www.sharingclinicalreports.org/\">open source database\u003c/a> that holds genetic data about breast cancer mutations, free for researchers to use.\u003c/p>\n\u003cp>“In terms of gene testing, I think patents are of no value, period,” says Nussbaum.\u003c/p>\n\u003cp>\u003cstrong>Basis of Biotech\u003c/strong>\u003c/p>\n\u003cp>“Patents are a very important, fundamental part of the foundation on which the biotechnology, biopharmaceutical industry has been built,” says Sean Johnston, general counsel at \u003ca href=\"http://www.gene.com/\">Genentech\u003c/a> in South San Francisco, one of the largest biotech companies in the world.\u003c/p>\n\u003cp>Companies like Genentech use genetic information to develop drugs and treatments, in addition to genetic diagnostic tests.\u003c/p>\n\u003cp>“Biotech and biopharmaceutical companies have relied upon patent protection to justify the significant investment, the risk-taking and the innovation that is necessary to develop new drugs,” Johnston says.\u003c/p>\n\u003cp>Johnston says it often takes a billion dollars to bring a drug to market, an investment that could be tougher to make without the protection of gene patents.\u003c/p>\n\u003cp>“It’s not a matter that if the court were to rule broadly our business would be destroyed,” Johnston says. “But in theory I think it has the potential to be very disruptive to the industry.”\u003c/p>\n\u003cp>\u003cstrong>Universities in the Middle\u003c/strong>\u003c/p>\n\u003cp>Biotech companies here aren’t the only ones watching this case. The University of California as a whole is one of the top ten gene patent holders in the country.\u003c/p>\n\u003cp>“Universities are often accused of patenting solely for the purpose of getting financial gain,” says Karin Immergluck of UCSF’s Office of Technology Management. The office handles several hundred gene patents.\u003c/p>\n\u003cp>“UCSF’s first goal is to translate our really exciting, cutting-edge technologies into products and services that will benefit the public,” she says.\u003c/p>\n\u003cp>The university walks a fine line. Companies pay millions of dollars a year to use its patents, like the one related to human growth hormone. But the court case brings up issue in licensing patents that universities already grappling with.\u003c/p>\n\u003cp>“For example, making sure the rights aren’t completely locked up in one company so that underinsured patients don’t have access,” says Immergluck.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Patient access, biotech industry profits and innovation could all be affected by the Supreme Court’s ruling. It’s expected in June.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/52297/bay-area-biotech-industry-braces-for-gene-patenting-court-case","authors":["239"],"categories":["quest_5","quest_12"],"tags":["quest_252","quest_9951","quest_475","quest_13194","quest_848","quest_11907","quest_1192","quest_1197","quest_13201","quest_11518","quest_13203","quest_11908","quest_2841"],"featImg":"quest_52321","label":"quest"},"quest_51910":{"type":"posts","id":"quest_51910","meta":{"index":"posts_1591205157","site":"quest","id":"51910","score":null,"sort":[1364997634000]},"guestAuthors":[],"slug":"misrachs-cancer-alley-documenting-the-poisoning-of-americas-wetland","title":"Richard Misrach’s Cancer Alley: Documenting the Poisoning of America’s Wetland","publishDate":1364997634,"format":"aside","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_51912\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919.jpg\">\u003cimg class=\"size-full wp-image-51912\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919.jpg\" alt='\"Cypress Swamp, Alligator Bayou, Prairieville, Louisiana\" (negative 1998, print 2012) Injet print by Richard Misrach. High Museum of Art, Atlanta. ' width=\"640\" height=\"360\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\"Cypress Swamp, Alligator Bayou, Prairieville, Louisiana\" (negative 1998, print 2012) Injet print by Richard Misrach. High Museum of Art, Atlanta.\u003c/figcaption>\u003c/figure>\n\u003cp>In February 1970, in a \u003ca href=\"http://www.presidency.ucsb.edu/ws/?pid=2757\">special message to Congress\u003c/a>, President Nixon served notice that American corporations had laid waste to the country’s land, air and water resources long enough. “We in this century have too casually and too long abused our natural environment. The time has come when we can wait no longer to repair the damage already done.”\u003c/p>\n\u003cp>Before the year was out, Congress authorized the Environmental Protection Agency to establish and enforce standards to protect the environment. Forty-three years later, it’s hard to think of a place where that mission has failed more miserably than Louisiana’s Cancer Alley.\u003c/p>\n\u003cp>For the 85 miles between Baton Rouge and New Orleans, the haunting swamplands of the Mississippi River corridor—called America’s wetland for its biological value to the nation—bump up against the sprawling refineries and paraphernalia of the petrochemical industry. Industry leaders call this stretch of the Mississippi, sandwiched between 150-plus oil and gas plants on both sides of its devastated banks, Chemical Corridor. But locals—who blame the millions of pounds of toxic chemicals pouring out of industry smokestacks every year for high rates of miscarriages, cancer, respiratory ailments and other serious diseases—have another name for it. They call it \u003ca href=\"http://envstudies.brown.edu/theses/AngelaHackelmasterthesispdf.pdf\">Cancer Alley.\u003c/a>\u003c/p>\n\u003cp>In 1998, Richard Misrach went to Cancer Alley to produce a series of photographs for an exhibition commissioned by Atlanta’s High Museum called “Picturing the South.” Misrach, known for penetrating portraits of human disturbances of the natural landscape, returned last year at the High Museum’s request. The museum displayed his new photos alongside the old series last year.\u003c/p>\n\u003cfigure id=\"attachment_51915\" class=\"wp-caption alignleft\" style=\"max-width: 321px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/SwampandPipeline1.jpg\">\u003cimg class=\"size-medium wp-image-51915\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/SwampandPipeline1-321x253.jpg\" alt='\"Swamp and Pipeline, Geismar, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta. ' width=\"321\" height=\"253\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\"Swamp and Pipeline, Geismar, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta.\u003c/figcaption>\u003c/figure>\n\u003cp>Now you can see what’s changed—or not—in \u003ca href=\"http://museum.stanford.edu/news_room/misrach.html\">“Revisiting the South: Richard Misrach’s Cancer Alley”\u003c/a> at Stanford University’s Cantor Arts Center.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Like any great artist, Misrach mines the troubles of his times—in this case, environmental devastation wrought by an petroleum-based economy—to raise broader questions of human existence. As you walk among the large-format photos, most measuring 6 feet by 5 feet, it’s hard not to get drawn into the destruction. Their imposing presence echoes the scale of the waste and brings us in intimate contact with it. Now that we see the consequences of our dependence on oil, what will we do to restore what’s been lost? If we do nothing to repair this ecological ruin, are we as guilty as the polluters?\u003c/p>\n\u003cp>I seemed to find my answer in “Holy Rosary Cemetery and Dow Chemical Corporation (Union Carbide Complex), Taft, Louisiana,” (1998): Dark clouds linger heavily over an industrial facility that serves as backdrop to a cemetery that once adjoined a church. But it is Jesus looming on the cross that catches your eye. Is he paying for our environmental sins? In the photo’s label, Misrach notes, “Dow (which now owns the complex) leaked 26,720 pounds of vaporized ethyl acrylate (EA), a Class II toxic air pollutant, into the atmosphere. No fine was levied, but Dow has pledged a $100,000 contribution to the Surpriya Jindal Foundation for Louisiana’s Children…).\u003c/p>\n\u003cfigure id=\"attachment_51917\" class=\"wp-caption alignright\" style=\"max-width: 319px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/NightFishing1.jpg\">\u003cimg class=\"size-medium wp-image-51917\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/NightFishing1-319x253.jpg\" alt='\"Night Fishing, Near Bonnet Carre Spillway, Norco, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta.' width=\"319\" height=\"253\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\"Night Fishing, Near Bonnet Carre Spillway, Norco, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta.\u003c/figcaption>\u003c/figure>\n\u003cp>Most residents of Cancer Alley are poor and African American. Misrach makes sure you don’t miss the legacy of racism that has long plagued these communities, with “Restored Slave Cabins, Evergreen Planation, Edgard, Louisiana” (1998) and “Tour Guide, Nottoway Plantation, White Castle, Louisiana” (1998), showing an African American woman peering through the window in the grand foyer of an old plantation. Here, plantations persist among the petrochemical plants, and the specter of past injustices hovers over modern human rights violations, where all communities do not receive equal protection from environmental hazards.\u003c/p>\n\u003cp>There is no doubt that Cancer Alley is one of the most polluted regions in the United States. Less clear is what explains the high rates of cancers afflicting the community. It’s notoriously difficult to link cancer clusters to any particular exposures. Misrach seems to capture that ambiguity in several photographs—a hazardous waste site, a parking lot and a pipeline above a murky river, all shrouded in a dense haze. Is the haze just fog or is it a toxic chemical cloud?\u003c/p>\n\u003cp>In some cases, labels remove any doubt what the haze is meant to imply. In “Hazardous Waste Containment Site, Dow Chemical Corporation, Mississippi River, Plaquemine, Louisiana” (1998), you’ll learn: “Between 1958 and 1973 Dow buried forty-six thousand tons of toxic waste in unlined pits that now cover more than thirty underground acres. The company attempts to pump the waste back to the surface before it reaches the drinking water aquifer for the city of Plaquemine.”\u003c/p>\n\u003cp>You’ll leave wondering how anything could survive a decades-long onslaught of toxic releases into the land, air and waterways in such a concentrated area—and how the EPA could allow the poisoning to continue for so long in such an ecologically sensitive area with a long history of racial injustice.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>Revisiting the South:\u003c/strong> Richard Misrach's Cancer Alley: Photographs. Through June 16. \u003ca href=\"http://www.museum.stanford.edu\" target=\"_blank\">Cantor Arts Center\u003c/a>, Stanford University, Stanford. (650) 723-4177.\u003c/p>\n\n","blocks":[],"excerpt":"In the new exhibition on display at Stanford's Cantor Arts Center, \"Revisiting the South: Richard Misrach's Cancer Alley,\" the Berkeley photographer takes a hard look at the environmental consequences of our dependence on petroleum.","status":"publish","parent":0,"modified":1367967469,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":14,"wordCount":948},"headData":{"title":"Richard Misrach’s Cancer Alley: Documenting the Poisoning of America’s Wetland | KQED","description":"In the new exhibition on display at Stanford's Cantor Arts Center, "Revisiting the South: Richard Misrach's Cancer Alley," the Berkeley photographer takes a hard look at the environmental consequences of our dependence on petroleum.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"51910 http://science.kqed.org/quest/?p=51910","disqusUrl":"https://ww2.kqed.org/quest/2013/04/03/misrachs-cancer-alley-documenting-the-poisoning-of-americas-wetland/","disqusTitle":"Richard Misrach’s Cancer Alley: Documenting the Poisoning of America’s Wetland","path":"/quest/51910/misrachs-cancer-alley-documenting-the-poisoning-of-americas-wetland","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_51912\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919.jpg\">\u003cimg class=\"size-full wp-image-51912\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919.jpg\" alt='\"Cypress Swamp, Alligator Bayou, Prairieville, Louisiana\" (negative 1998, print 2012) Injet print by Richard Misrach. High Museum of Art, Atlanta. ' width=\"640\" height=\"360\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2013/04/CypressSwamp1.resized-e1364970905919-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\"Cypress Swamp, Alligator Bayou, Prairieville, Louisiana\" (negative 1998, print 2012) Injet print by Richard Misrach. High Museum of Art, Atlanta.\u003c/figcaption>\u003c/figure>\n\u003cp>In February 1970, in a \u003ca href=\"http://www.presidency.ucsb.edu/ws/?pid=2757\">special message to Congress\u003c/a>, President Nixon served notice that American corporations had laid waste to the country’s land, air and water resources long enough. “We in this century have too casually and too long abused our natural environment. The time has come when we can wait no longer to repair the damage already done.”\u003c/p>\n\u003cp>Before the year was out, Congress authorized the Environmental Protection Agency to establish and enforce standards to protect the environment. Forty-three years later, it’s hard to think of a place where that mission has failed more miserably than Louisiana’s Cancer Alley.\u003c/p>\n\u003cp>For the 85 miles between Baton Rouge and New Orleans, the haunting swamplands of the Mississippi River corridor—called America’s wetland for its biological value to the nation—bump up against the sprawling refineries and paraphernalia of the petrochemical industry. Industry leaders call this stretch of the Mississippi, sandwiched between 150-plus oil and gas plants on both sides of its devastated banks, Chemical Corridor. But locals—who blame the millions of pounds of toxic chemicals pouring out of industry smokestacks every year for high rates of miscarriages, cancer, respiratory ailments and other serious diseases—have another name for it. They call it \u003ca href=\"http://envstudies.brown.edu/theses/AngelaHackelmasterthesispdf.pdf\">Cancer Alley.\u003c/a>\u003c/p>\n\u003cp>In 1998, Richard Misrach went to Cancer Alley to produce a series of photographs for an exhibition commissioned by Atlanta’s High Museum called “Picturing the South.” Misrach, known for penetrating portraits of human disturbances of the natural landscape, returned last year at the High Museum’s request. The museum displayed his new photos alongside the old series last year.\u003c/p>\n\u003cfigure id=\"attachment_51915\" class=\"wp-caption alignleft\" style=\"max-width: 321px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/SwampandPipeline1.jpg\">\u003cimg class=\"size-medium wp-image-51915\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/SwampandPipeline1-321x253.jpg\" alt='\"Swamp and Pipeline, Geismar, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta. ' width=\"321\" height=\"253\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\"Swamp and Pipeline, Geismar, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta.\u003c/figcaption>\u003c/figure>\n\u003cp>Now you can see what’s changed—or not—in \u003ca href=\"http://museum.stanford.edu/news_room/misrach.html\">“Revisiting the South: Richard Misrach’s Cancer Alley”\u003c/a> at Stanford University’s Cantor Arts Center.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Like any great artist, Misrach mines the troubles of his times—in this case, environmental devastation wrought by an petroleum-based economy—to raise broader questions of human existence. As you walk among the large-format photos, most measuring 6 feet by 5 feet, it’s hard not to get drawn into the destruction. Their imposing presence echoes the scale of the waste and brings us in intimate contact with it. Now that we see the consequences of our dependence on oil, what will we do to restore what’s been lost? If we do nothing to repair this ecological ruin, are we as guilty as the polluters?\u003c/p>\n\u003cp>I seemed to find my answer in “Holy Rosary Cemetery and Dow Chemical Corporation (Union Carbide Complex), Taft, Louisiana,” (1998): Dark clouds linger heavily over an industrial facility that serves as backdrop to a cemetery that once adjoined a church. But it is Jesus looming on the cross that catches your eye. Is he paying for our environmental sins? In the photo’s label, Misrach notes, “Dow (which now owns the complex) leaked 26,720 pounds of vaporized ethyl acrylate (EA), a Class II toxic air pollutant, into the atmosphere. No fine was levied, but Dow has pledged a $100,000 contribution to the Surpriya Jindal Foundation for Louisiana’s Children…).\u003c/p>\n\u003cfigure id=\"attachment_51917\" class=\"wp-caption alignright\" style=\"max-width: 319px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/NightFishing1.jpg\">\u003cimg class=\"size-medium wp-image-51917\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/04/NightFishing1-319x253.jpg\" alt='\"Night Fishing, Near Bonnet Carre Spillway, Norco, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta.' width=\"319\" height=\"253\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\"Night Fishing, Near Bonnet Carre Spillway, Norco, Louisiana\" (negative 1998, print 2012) Inkjet print by Richard Misrach. High Museum of Art, Atlanta.\u003c/figcaption>\u003c/figure>\n\u003cp>Most residents of Cancer Alley are poor and African American. Misrach makes sure you don’t miss the legacy of racism that has long plagued these communities, with “Restored Slave Cabins, Evergreen Planation, Edgard, Louisiana” (1998) and “Tour Guide, Nottoway Plantation, White Castle, Louisiana” (1998), showing an African American woman peering through the window in the grand foyer of an old plantation. Here, plantations persist among the petrochemical plants, and the specter of past injustices hovers over modern human rights violations, where all communities do not receive equal protection from environmental hazards.\u003c/p>\n\u003cp>There is no doubt that Cancer Alley is one of the most polluted regions in the United States. Less clear is what explains the high rates of cancers afflicting the community. It’s notoriously difficult to link cancer clusters to any particular exposures. Misrach seems to capture that ambiguity in several photographs—a hazardous waste site, a parking lot and a pipeline above a murky river, all shrouded in a dense haze. Is the haze just fog or is it a toxic chemical cloud?\u003c/p>\n\u003cp>In some cases, labels remove any doubt what the haze is meant to imply. In “Hazardous Waste Containment Site, Dow Chemical Corporation, Mississippi River, Plaquemine, Louisiana” (1998), you’ll learn: “Between 1958 and 1973 Dow buried forty-six thousand tons of toxic waste in unlined pits that now cover more than thirty underground acres. The company attempts to pump the waste back to the surface before it reaches the drinking water aquifer for the city of Plaquemine.”\u003c/p>\n\u003cp>You’ll leave wondering how anything could survive a decades-long onslaught of toxic releases into the land, air and waterways in such a concentrated area—and how the EPA could allow the poisoning to continue for so long in such an ecologically sensitive area with a long history of racial injustice.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>Revisiting the South:\u003c/strong> Richard Misrach's Cancer Alley: Photographs. Through June 16. \u003ca href=\"http://www.museum.stanford.edu\" target=\"_blank\">Cantor Arts Center\u003c/a>, Stanford University, Stanford. (650) 723-4177.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/51910/misrachs-cancer-alley-documenting-the-poisoning-of-americas-wetland","authors":["6322"],"categories":["quest_4","quest_12"],"tags":["quest_475","quest_11869","quest_11203","quest_13201","quest_11518","quest_2187","quest_11870","quest_13365"],"featImg":"quest_51912","label":"quest"},"quest_45500":{"type":"posts","id":"quest_45500","meta":{"index":"posts_1591205157","site":"quest","id":"45500","score":null,"sort":[1349191814000]},"guestAuthors":[],"slug":"illustrating-science-translating-knowledge-into-pictures","title":"Illustrating Science: Translating Knowledge Into Pictures","publishDate":1349191814,"format":"aside","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_45505\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/akb_eyes/\" rel=\"attachment wp-att-45505\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/AKB_eyes.jpg\" alt=\"Blood vessel growth in a healthy (left) and diseased (right) eye - Allison Bruce\" title=\"AKB_eyes\" width=\"640\" height=\"360\" class=\"size-full wp-image-45505\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/10/AKB_eyes.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/10/AKB_eyes-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Blood vessel growth in a healthy (left) and diseased (right) eye - Allison Bruce\u003c/figcaption>\u003c/figure>\n\u003cp>\u003ca href=\"http://www.scifx.com/\" title=\"Allison Bruce Portfolio\">Allison Bruce\u003c/a> has a wonderful job: she spends all day making pictures for scientists.\u003c/p>\n\u003cp>Bruce started out in science herself, earning a chemistry degree from UC Davis. After college, she worked in an environmental lab, but she didn't enjoy it and turned to art classes \"to keep from losing my mind,\" she says. She'd always drawn, but never pursued it as a career until a friend suggested she apply for a temporary position as an artist at \u003ca href=\"http://www.gene.com/gene/index.jsp\" title=\"Genentech, Inc.\">Genentech\u003c/a>, the bay area's biotech behemoth. \u003c/p>\n\u003cfigure id=\"attachment_45502\" class=\"wp-caption alignright\" style=\"max-width: 282px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/gdc-0941-illustration-nocallouts-mockup/\" rel=\"attachment wp-att-45502\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/AKB_CancerCellCover-282x360.jpg\" alt=\"Cancer Cell cover - cartoon cell\" title=\"GDC-0941 Illustration NoCallouts Mockup\" width=\"282\" height=\"360\" class=\"size-large wp-image-45502\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Cover illustration of breast-cancer drug trastuzumab - Allison Bruce\u003c/figcaption>\u003c/figure>\n\u003cp>That was 18 years ago, and now Bruce is a Senior Graphics Specialist at Genentech. \"It's a lot of fun,\" she says. \"It's really cutting-edge what they do here.\" She gets to learn about research before it's even published, translating brand-new knowledge about the world from words into pictures. \u003c/p>\n\u003cp>The detail can be exquisite, as in an illustration of the eye's blood vessel growth (above), which shuttled back and forth many times between Bruce and the researcher to make sure each line was accurate. The result is an eerily beautiful representation of sickness and health.\u003c/p>\n\u003cp>Bruce's favorite projects, though, are journal covers, because they offer more flexibility to play around. To \u003ca href=\"http://www.cell.com/cancer-cell/issue?pii=S1535-6108(09)X0005-X#\" title=\"Cancer Cell - Trastuzumab cover\">illustrate the action of trastuzumab\u003c/a>, a breast-cancer drug, she enlisted her nephew's help to cartoonify a cell, complete with classic ZAP! and POW!.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Bruce also helps researchers with presentations, animations, and web design, and is constantly learning new tools. \"It's an unusual job, but there's a lot of demand for it,\" she says.\u003c/p>\n\u003cfigure id=\"attachment_45563\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/bonemarrow/\" rel=\"attachment wp-att-45563\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/bonemarrow-300x169.jpg\" alt=\"bone marrow image from Kevin Ang\" title=\"bonemarrow\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-45563\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Storyboard image of bone marrow - Kevin Ang\u003c/figcaption>\u003c/figure>\n\u003cp>In fact, there's enough demand that Genentech sometimes hires freelancers, such as self-described \"gun-for-hire\" \u003ca href=\"http://www.bingkoland.com/\" title=\"Kevin Ang Portfolio\">Kevin Ang\u003c/a> (\"Wacom-tablet-for-hire\" might be slightly more accurate). Ang has also worked for Bayer, Intuit, and Google, among others. \"Around here, it's all either pharma or tech,\" he says.\u003c/p>\n\u003cp>Ang's art jobs range from graphic recording (a bit like \u003ca href=\"http://www.thersa.org/events/rsaanimate\" title=\"RSAnimate\">RSAnimate\u003c/a>, but done in real time during a meeting) to commercial storyboarding. He particularly enjoys illustrating sequences that depict drug delivery because, he says, \"There's a very cinematic aspect to the things that happen at that scale in our bodies. I think of it as something from \u003ca href=\"http://www.imdb.com/title/tt0060397/\" title=\"IMDB - Fantastic Voyage\">Fantastic Voyage\u003c/a>.\" \u003c/p>\n\u003cfigure id=\"attachment_45511\" class=\"wp-caption alignright\" style=\"max-width: 282px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/akb_persephone-cell-cover/\" rel=\"attachment wp-att-45511\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/AKB_Persephone-Cell-Cover-282x360.jpg\" alt='Cover illustration by Allison Bruce. \"Much like Persephone, Greek goddess of spring growth and queen of the underworld, some glioblastoma cells possess the capability for self-renewal.\"' title=\"AKB_Persephone Cell Cover\" width=\"282\" height=\"360\" class=\"size-large wp-image-45511\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Cover illustration by Allison Bruce. \"Much like Persephone, Greek goddess of spring growth and queen of the underworld, some glioblastoma cells possess the capability for self-renewal.\"\u003c/figcaption>\u003c/figure>\n\u003cp>Unlike Bruce, Ang started out in art school. On his way to a BFA from UC Santa Cruz, his imagination was captured by a few natural science illustration courses. \"It was great to be surrounded by scientists,\" he says.\u003c/p>\n\u003cp>Bruce, too, loves working with and learning from scientists--perhaps in part because they often have their own idiosyncratic ideas. One of Bruce’s cover illustrations sprang from a researcher's suggestion that Persephone, Greek goddess of spring and the underworld, could \u003ca href=\"http://www.cell.com/cancer-cell/issue?pii=S1535-6108(10)X0005-8\" title=\"Cancer Cell - Persephone cover\">represent a self-renewing cell line\u003c/a>. \u003c/p>\n\u003cp>But even that wasn't Bruce's strangest project. Once she was asked to create a life-size Ronald McDonald bearing the face of a researcher, to welcome him back from sabbatical.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Drawing for scientists: never a dull moment.\u003c/p>\n\n","blocks":[],"excerpt":"Allison Bruce has a wonderful job: she spends all day making pictures for scientists. Bruce started out in science herself, earning a chemistry degree from UC Davis. After college, she worked in an environmental lab, but she didn't enjoy it and turned to art classes \"to keep from losing my mind,\" she says.","status":"publish","parent":0,"modified":1349809107,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":14,"wordCount":558},"headData":{"title":"Illustrating Science: Translating Knowledge Into Pictures | KQED","description":"Allison Bruce has a wonderful job: she spends all day making pictures for scientists. Bruce started out in science herself, earning a chemistry degree from UC Davis. After college, she worked in an environmental lab, but she didn't enjoy it and turned to art classes "to keep from losing my mind," she says.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"45500 http://science.kqed.org/quest/?p=45500","disqusUrl":"https://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/","disqusTitle":"Illustrating Science: Translating Knowledge Into Pictures","path":"/quest/45500/illustrating-science-translating-knowledge-into-pictures","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_45505\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/akb_eyes/\" rel=\"attachment wp-att-45505\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/AKB_eyes.jpg\" alt=\"Blood vessel growth in a healthy (left) and diseased (right) eye - Allison Bruce\" title=\"AKB_eyes\" width=\"640\" height=\"360\" class=\"size-full wp-image-45505\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/10/AKB_eyes.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/10/AKB_eyes-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Blood vessel growth in a healthy (left) and diseased (right) eye - Allison Bruce\u003c/figcaption>\u003c/figure>\n\u003cp>\u003ca href=\"http://www.scifx.com/\" title=\"Allison Bruce Portfolio\">Allison Bruce\u003c/a> has a wonderful job: she spends all day making pictures for scientists.\u003c/p>\n\u003cp>Bruce started out in science herself, earning a chemistry degree from UC Davis. After college, she worked in an environmental lab, but she didn't enjoy it and turned to art classes \"to keep from losing my mind,\" she says. She'd always drawn, but never pursued it as a career until a friend suggested she apply for a temporary position as an artist at \u003ca href=\"http://www.gene.com/gene/index.jsp\" title=\"Genentech, Inc.\">Genentech\u003c/a>, the bay area's biotech behemoth. \u003c/p>\n\u003cfigure id=\"attachment_45502\" class=\"wp-caption alignright\" style=\"max-width: 282px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/gdc-0941-illustration-nocallouts-mockup/\" rel=\"attachment wp-att-45502\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/AKB_CancerCellCover-282x360.jpg\" alt=\"Cancer Cell cover - cartoon cell\" title=\"GDC-0941 Illustration NoCallouts Mockup\" width=\"282\" height=\"360\" class=\"size-large wp-image-45502\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Cover illustration of breast-cancer drug trastuzumab - Allison Bruce\u003c/figcaption>\u003c/figure>\n\u003cp>That was 18 years ago, and now Bruce is a Senior Graphics Specialist at Genentech. \"It's a lot of fun,\" she says. \"It's really cutting-edge what they do here.\" She gets to learn about research before it's even published, translating brand-new knowledge about the world from words into pictures. \u003c/p>\n\u003cp>The detail can be exquisite, as in an illustration of the eye's blood vessel growth (above), which shuttled back and forth many times between Bruce and the researcher to make sure each line was accurate. The result is an eerily beautiful representation of sickness and health.\u003c/p>\n\u003cp>Bruce's favorite projects, though, are journal covers, because they offer more flexibility to play around. To \u003ca href=\"http://www.cell.com/cancer-cell/issue?pii=S1535-6108(09)X0005-X#\" title=\"Cancer Cell - Trastuzumab cover\">illustrate the action of trastuzumab\u003c/a>, a breast-cancer drug, she enlisted her nephew's help to cartoonify a cell, complete with classic ZAP! and POW!.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Bruce also helps researchers with presentations, animations, and web design, and is constantly learning new tools. \"It's an unusual job, but there's a lot of demand for it,\" she says.\u003c/p>\n\u003cfigure id=\"attachment_45563\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/bonemarrow/\" rel=\"attachment wp-att-45563\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/bonemarrow-300x169.jpg\" alt=\"bone marrow image from Kevin Ang\" title=\"bonemarrow\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-45563\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Storyboard image of bone marrow - Kevin Ang\u003c/figcaption>\u003c/figure>\n\u003cp>In fact, there's enough demand that Genentech sometimes hires freelancers, such as self-described \"gun-for-hire\" \u003ca href=\"http://www.bingkoland.com/\" title=\"Kevin Ang Portfolio\">Kevin Ang\u003c/a> (\"Wacom-tablet-for-hire\" might be slightly more accurate). Ang has also worked for Bayer, Intuit, and Google, among others. \"Around here, it's all either pharma or tech,\" he says.\u003c/p>\n\u003cp>Ang's art jobs range from graphic recording (a bit like \u003ca href=\"http://www.thersa.org/events/rsaanimate\" title=\"RSAnimate\">RSAnimate\u003c/a>, but done in real time during a meeting) to commercial storyboarding. He particularly enjoys illustrating sequences that depict drug delivery because, he says, \"There's a very cinematic aspect to the things that happen at that scale in our bodies. I think of it as something from \u003ca href=\"http://www.imdb.com/title/tt0060397/\" title=\"IMDB - Fantastic Voyage\">Fantastic Voyage\u003c/a>.\" \u003c/p>\n\u003cfigure id=\"attachment_45511\" class=\"wp-caption alignright\" style=\"max-width: 282px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/10/02/illustrating-science-translating-knowledge-into-pictures/akb_persephone-cell-cover/\" rel=\"attachment wp-att-45511\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/10/AKB_Persephone-Cell-Cover-282x360.jpg\" alt='Cover illustration by Allison Bruce. \"Much like Persephone, Greek goddess of spring growth and queen of the underworld, some glioblastoma cells possess the capability for self-renewal.\"' title=\"AKB_Persephone Cell Cover\" width=\"282\" height=\"360\" class=\"size-large wp-image-45511\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Cover illustration by Allison Bruce. \"Much like Persephone, Greek goddess of spring growth and queen of the underworld, some glioblastoma cells possess the capability for self-renewal.\"\u003c/figcaption>\u003c/figure>\n\u003cp>Unlike Bruce, Ang started out in art school. On his way to a BFA from UC Santa Cruz, his imagination was captured by a few natural science illustration courses. \"It was great to be surrounded by scientists,\" he says.\u003c/p>\n\u003cp>Bruce, too, loves working with and learning from scientists--perhaps in part because they often have their own idiosyncratic ideas. One of Bruce’s cover illustrations sprang from a researcher's suggestion that Persephone, Greek goddess of spring and the underworld, could \u003ca href=\"http://www.cell.com/cancer-cell/issue?pii=S1535-6108(10)X0005-8\" title=\"Cancer Cell - Persephone cover\">represent a self-renewing cell line\u003c/a>. \u003c/p>\n\u003cp>But even that wasn't Bruce's strangest project. Once she was asked to create a life-size Ronald McDonald bearing the face of a researcher, to welcome him back from sabbatical.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Drawing for scientists: never a dull moment.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/45500/illustrating-science-translating-knowledge-into-pictures","authors":["6324"],"categories":["quest_4","quest_12"],"tags":["quest_216","quest_475","quest_528","quest_888","quest_11515","quest_10412","quest_3351","quest_2349","quest_13202"],"featImg":"quest_45505","label":"quest"},"quest_40277":{"type":"posts","id":"quest_40277","meta":{"index":"posts_1591205157","site":"quest","id":"40277","score":null,"sort":[1347388245000]},"guestAuthors":[],"slug":"x-ray-microscope-seeing-cells-in-3-d","title":"X-ray Microscope: Seeing Cells in 3-D","publishDate":1347388245,"format":"video","headTitle":"QUEST | KQED Science","labelTerm":{},"content":"\u003cfigure id=\"attachment_40297\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1.jpg\" alt=\"\" title=\"XrayMicroscope_Day2_Scope_LeGros\" width=\"300\" height=\"169\" class=\"size-full wp-image-40297\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1-400x225.jpg 400w\" sizes=\"(max-width: 300px) 100vw, 300px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Physicist Mark LeGros spent three years building this microscope which uses x-rays to take 3-D images of biological cells. \u003c/figcaption>\u003c/figure>\n\u003cp>Mark LeGros, who spent three years building the world's first x-ray microscope dedicated to cell biology, greeted me at the \u003ca href=\"http://www.lbl.gov/\">Lawrence Berkeley National Laboratory \u003c/a>(LBNL) with a hearty handshake, effusive smile and an accent reminiscent of his New Zealand roots. \u003c/p>\n\u003cp>I spent an hour in April talking with him about the challenges and rewards of creating a powerful, state-of-the art microscope which can capture a truer, more accurate picture of a whole cell and its nucleus, mitochondria and other tiny, essential cellular structures. \u003c/p>\n\u003cp>I asked him to take me back to that moment in 2009 when he and the diverse team of researchers, including biologists, physicists, chemists and computer scientists, who comprise the \u003ca href=\"http://ncxt.lbl.gov\">National Center of X-ray Tomography\u003c/a> at LBNL, powered up the microscope and waited anxiously for the first x-ray images of a yeast cell, the biological specimen they chose to test the capabilities of their new imaging tool. \u003c/p>\n\u003cfigure id=\"attachment_40309\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_MarkLeGros1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_MarkLeGros1-300x169.jpg\" alt=\"\" title=\"XrayMicroscope_Day2_MarkLeGros\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40309\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Physicist Mark LeGros smiles for the camera while Bertrand Cinquin, a postdoctoral researcher, waits outside the lab containing the x-ray microscope. Photo by Sheraz Sadiq / QUEST.\u003c/figcaption>\u003c/figure>\n\u003cp>\"I wasn’t sure exactly just how well this was gonna work out. But it turned out that it was beautiful...and everybody associated with the project was stunned with the degree of detail that it revealed about the internal structure of a cell and the chromatin, which is the genetic material of the cell,\" he said. \u003c/p>\n\u003cp>It's important to note that this powerful device does not render obsolete other imaging techniques, including \u003ca href=\"http://en.wikipedia.org/wiki/Optical_microscope\">light microscopy\u003c/a> and \u003ca href=\"http://en.wikipedia.org/wiki/Electron_microscope\">electron microscopy\u003c/a>. For one thing, the cell sample is frozen to hold the structures in place and protect them from the x-rays which have much greater penetrating power than visible light because x-rays have shorter wavelengths than light rays. So it can't capture dynamic activity of cells moving in real-time, unlike an optical or light microscope. Also, while the resolution possible with the x-ray microscope is five times greater than a light microscope, an electron microscope, which uses electrons to penetrate ultra-thin sections of cells, provides better resolution than the x-ray microscope. \u003c/p>\n\u003cfigure id=\"attachment_40298\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Larabell_Scope1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Larabell_Scope1-300x169.jpg\" alt=\"\" title=\"XrayMicroscope_Day2_Larabell_Scope\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40298\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Carolyn Larabell looks at images taken with the x-ray microscope while Bertrand Cinquin loads a sample of cells into the microscope. Photo by Sheraz Sadiq / QUEST.\u003c/figcaption>\u003c/figure>\n\u003cp>Nonetheless, unlike an electron microscope, the x-ray microscope allows scientists to image a whole cell in its native state, with the only preparation being the freezing of the cell sample. Also, many of the classic textbook images of cells that were taken with electron microscopes which required the cells to be dehydrated and stained with heavy metals to bind the electrons to the cell and generate a rather grainy image. Since a cell is 70% water, dehydration and staining can degrade delicate cellular structures and thus make it hard to accurately visualize them. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In addition, the x-ray microscope uses the technique of tomography to faithfully reconstruct the volume of a cell in three dimensions, instead of a flat, 2-D image of it. \u003c/p>\n\u003cp>Here, a sample of cells is placed in the microscope and rotated 360 degrees. While it rotates, x-rays illuminate the carbon and nitrogen present in all biological cells and black and white images then display the absorption of the x-rays by the organic material in every part of the cell. All of this happens in about 30 seconds. Computer software then allows the team to process, in a mere five to ten minutes, the individual x-ray images and reconstruct a 3-D portrait of the cell which is possible since the cell has been imaged from every conceivable angle, allowing not only the shapes of its structures to be seen but also the amount of biological material such as the DNA packed into the cell's nucleus.\u003c/p>\n\u003cfigure id=\"attachment_40394\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/CLarabell_olfactory-neuron.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/CLarabell_olfactory-neuron-300x169.jpg\" alt=\"\" title=\"CLarabell_olfactory neuron\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40394\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A cross-section of stacked x-ray images taken of a mouse olfactory neuron, with the dark regions indicating the inactive genetic material and the light regions indicating the active genetic material within the nucleus. Image courtesy of Carolyn Larabell, PhD.\u003c/figcaption>\u003c/figure>\n\u003cp>This novel form of 3-D imaging is revealing new insight into the organization of the active genes - the euchromatin - and the silenced genes - the heterochromatin - in the nucleus. \u003c/p>\n\u003cp>\"So we can see now for the first time that the heterochromatin, or those silenced genes, are more crowded than the euchromatin regions. And we can actually quantify that and say that it’s 28% more crowded,\" said \u003ca href=\"http://www.lbl.gov/wonder/larabell.html\">Carolyn Larabell\u003c/a>, a microbiologist and the Director of the National Center for X-ray Tomography. \u003c/p>\n\u003cfigure id=\"attachment_40303\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/605B_CLarabell_mouse_olfactory_neuron.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/605B_CLarabell_mouse_olfactory_neuron-300x169.jpg\" alt=\"\" title=\"605B_CLarabell_mouse_olfactory_neuron\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40303\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The stack of x-ray images taken of the mouse olfactory neuron is then processed by computer software and turned into this striking 3-D illustration of the cell, with the nucleus shown in blue. Image courtesy of Carolyn Larabell, PhD.\u003c/figcaption>\u003c/figure>\n\u003cp>So why is it important to quantify the amount of active genes versus silenced genes in a cell's nucleus? For one thing, in certain diseases like cancer, previously silenced genes become active and the nucleus grows larger. So perhaps this new level of insight can shed light on the progression of cancer and perhaps even offer an early tool for its onset, well before symptoms appear. A three-dimensional window into cells may also lead to the development of better designed and consequently, more effective drug treatments. \u003c/p>\n\u003cfigure id=\"attachment_40325\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day1_Larabell1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day1_Larabell1-300x169.jpg\" alt=\"\" title=\"XrayMicroscope_Day1_Larabell\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40325\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Carolyn Larabell is a microbiologist and the Director of the National Center of X-ray Tomography at LBNL. Photo by Sheraz Sadiq / QUEST. \u003c/figcaption>\u003c/figure>\n\u003cp>\"It’s important to see these structures in 3-D (because) you want to test drugs on cells to see if they’re having the effect that you think they are,\" said Larabell. \"If you get a single section, you have just a very thin window on what might be happening to that cell. (So) you want to see what’s happening throughout the entire cell,\" she added. \u003c/p>\n\u003cp>Whether it's the life cycle of the deadly malaria parasite or the breakdown of sugars from plants in the production of biofuels, this exciting new imaging tool is providing a richer understanding of important biological processes. \u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>But as ingenious as this microscope is, it can't compare to the ingenuity and complexity of the microscopic world of cells which we've strained to bring into lucid focus for hundreds of years, ever since Robert Hooke's 17th-century descriptions of the tiny structures in a section of cork, which he likened to the modest chambers, or cells, of pious monks. \u003c/p>\n\n","blocks":[],"excerpt":"At the Lawrence Berkeley National Laboratory, scientists are using a cutting-edge microscope, the first of its kind in the world, to image whole cells in 3-D with the penetrating power of x-rays. The new images generated by the microscope are offering a deeper, more precise understanding of cellular structures and how they change with diseases. ","status":"publish","parent":0,"modified":1457566458,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":1115},"headData":{"title":"X-ray Microscope: Seeing Cells in 3-D | KQED","description":"At the Lawrence Berkeley National Laboratory, scientists are using a cutting-edge microscope, the first of its kind in the world, to image whole cells in 3-D with the penetrating power of x-rays. The new images generated by the microscope are offering a deeper, more precise understanding of cellular structures and how they change with diseases. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"40277 http://science.kqed.org/quest/?post_type=videos&p=40277","disqusUrl":"https://ww2.kqed.org/quest/2012/09/11/x-ray-microscope-seeing-cells-in-3-d/","disqusTitle":"X-ray Microscope: Seeing Cells in 3-D","videoEmbed":"https://www.youtube.com/watch?v=WcO7l2DdgEA","source":"Biology","sourceUrl":"https://ww2.kqed.org/quest/category/biology/","path":"/quest/40277/x-ray-microscope-seeing-cells-in-3-d","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_40297\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1.jpg\" alt=\"\" title=\"XrayMicroscope_Day2_Scope_LeGros\" width=\"300\" height=\"169\" class=\"size-full wp-image-40297\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/06/XrayMicroscope_Day2_Scope_LeGros1-400x225.jpg 400w\" sizes=\"(max-width: 300px) 100vw, 300px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Physicist Mark LeGros spent three years building this microscope which uses x-rays to take 3-D images of biological cells. \u003c/figcaption>\u003c/figure>\n\u003cp>Mark LeGros, who spent three years building the world's first x-ray microscope dedicated to cell biology, greeted me at the \u003ca href=\"http://www.lbl.gov/\">Lawrence Berkeley National Laboratory \u003c/a>(LBNL) with a hearty handshake, effusive smile and an accent reminiscent of his New Zealand roots. \u003c/p>\n\u003cp>I spent an hour in April talking with him about the challenges and rewards of creating a powerful, state-of-the art microscope which can capture a truer, more accurate picture of a whole cell and its nucleus, mitochondria and other tiny, essential cellular structures. \u003c/p>\n\u003cp>I asked him to take me back to that moment in 2009 when he and the diverse team of researchers, including biologists, physicists, chemists and computer scientists, who comprise the \u003ca href=\"http://ncxt.lbl.gov\">National Center of X-ray Tomography\u003c/a> at LBNL, powered up the microscope and waited anxiously for the first x-ray images of a yeast cell, the biological specimen they chose to test the capabilities of their new imaging tool. \u003c/p>\n\u003cfigure id=\"attachment_40309\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_MarkLeGros1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_MarkLeGros1-300x169.jpg\" alt=\"\" title=\"XrayMicroscope_Day2_MarkLeGros\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40309\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Physicist Mark LeGros smiles for the camera while Bertrand Cinquin, a postdoctoral researcher, waits outside the lab containing the x-ray microscope. Photo by Sheraz Sadiq / QUEST.\u003c/figcaption>\u003c/figure>\n\u003cp>\"I wasn’t sure exactly just how well this was gonna work out. But it turned out that it was beautiful...and everybody associated with the project was stunned with the degree of detail that it revealed about the internal structure of a cell and the chromatin, which is the genetic material of the cell,\" he said. \u003c/p>\n\u003cp>It's important to note that this powerful device does not render obsolete other imaging techniques, including \u003ca href=\"http://en.wikipedia.org/wiki/Optical_microscope\">light microscopy\u003c/a> and \u003ca href=\"http://en.wikipedia.org/wiki/Electron_microscope\">electron microscopy\u003c/a>. For one thing, the cell sample is frozen to hold the structures in place and protect them from the x-rays which have much greater penetrating power than visible light because x-rays have shorter wavelengths than light rays. So it can't capture dynamic activity of cells moving in real-time, unlike an optical or light microscope. Also, while the resolution possible with the x-ray microscope is five times greater than a light microscope, an electron microscope, which uses electrons to penetrate ultra-thin sections of cells, provides better resolution than the x-ray microscope. \u003c/p>\n\u003cfigure id=\"attachment_40298\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Larabell_Scope1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day2_Larabell_Scope1-300x169.jpg\" alt=\"\" title=\"XrayMicroscope_Day2_Larabell_Scope\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40298\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Carolyn Larabell looks at images taken with the x-ray microscope while Bertrand Cinquin loads a sample of cells into the microscope. Photo by Sheraz Sadiq / QUEST.\u003c/figcaption>\u003c/figure>\n\u003cp>Nonetheless, unlike an electron microscope, the x-ray microscope allows scientists to image a whole cell in its native state, with the only preparation being the freezing of the cell sample. Also, many of the classic textbook images of cells that were taken with electron microscopes which required the cells to be dehydrated and stained with heavy metals to bind the electrons to the cell and generate a rather grainy image. Since a cell is 70% water, dehydration and staining can degrade delicate cellular structures and thus make it hard to accurately visualize them. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In addition, the x-ray microscope uses the technique of tomography to faithfully reconstruct the volume of a cell in three dimensions, instead of a flat, 2-D image of it. \u003c/p>\n\u003cp>Here, a sample of cells is placed in the microscope and rotated 360 degrees. While it rotates, x-rays illuminate the carbon and nitrogen present in all biological cells and black and white images then display the absorption of the x-rays by the organic material in every part of the cell. All of this happens in about 30 seconds. Computer software then allows the team to process, in a mere five to ten minutes, the individual x-ray images and reconstruct a 3-D portrait of the cell which is possible since the cell has been imaged from every conceivable angle, allowing not only the shapes of its structures to be seen but also the amount of biological material such as the DNA packed into the cell's nucleus.\u003c/p>\n\u003cfigure id=\"attachment_40394\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/CLarabell_olfactory-neuron.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/CLarabell_olfactory-neuron-300x169.jpg\" alt=\"\" title=\"CLarabell_olfactory neuron\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40394\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A cross-section of stacked x-ray images taken of a mouse olfactory neuron, with the dark regions indicating the inactive genetic material and the light regions indicating the active genetic material within the nucleus. Image courtesy of Carolyn Larabell, PhD.\u003c/figcaption>\u003c/figure>\n\u003cp>This novel form of 3-D imaging is revealing new insight into the organization of the active genes - the euchromatin - and the silenced genes - the heterochromatin - in the nucleus. \u003c/p>\n\u003cp>\"So we can see now for the first time that the heterochromatin, or those silenced genes, are more crowded than the euchromatin regions. And we can actually quantify that and say that it’s 28% more crowded,\" said \u003ca href=\"http://www.lbl.gov/wonder/larabell.html\">Carolyn Larabell\u003c/a>, a microbiologist and the Director of the National Center for X-ray Tomography. \u003c/p>\n\u003cfigure id=\"attachment_40303\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/605B_CLarabell_mouse_olfactory_neuron.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/605B_CLarabell_mouse_olfactory_neuron-300x169.jpg\" alt=\"\" title=\"605B_CLarabell_mouse_olfactory_neuron\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40303\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The stack of x-ray images taken of the mouse olfactory neuron is then processed by computer software and turned into this striking 3-D illustration of the cell, with the nucleus shown in blue. Image courtesy of Carolyn Larabell, PhD.\u003c/figcaption>\u003c/figure>\n\u003cp>So why is it important to quantify the amount of active genes versus silenced genes in a cell's nucleus? For one thing, in certain diseases like cancer, previously silenced genes become active and the nucleus grows larger. So perhaps this new level of insight can shed light on the progression of cancer and perhaps even offer an early tool for its onset, well before symptoms appear. A three-dimensional window into cells may also lead to the development of better designed and consequently, more effective drug treatments. \u003c/p>\n\u003cfigure id=\"attachment_40325\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day1_Larabell1.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/XrayMicroscope_Day1_Larabell1-300x169.jpg\" alt=\"\" title=\"XrayMicroscope_Day1_Larabell\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-40325\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Carolyn Larabell is a microbiologist and the Director of the National Center of X-ray Tomography at LBNL. Photo by Sheraz Sadiq / QUEST. \u003c/figcaption>\u003c/figure>\n\u003cp>\"It’s important to see these structures in 3-D (because) you want to test drugs on cells to see if they’re having the effect that you think they are,\" said Larabell. \"If you get a single section, you have just a very thin window on what might be happening to that cell. (So) you want to see what’s happening throughout the entire cell,\" she added. \u003c/p>\n\u003cp>Whether it's the life cycle of the deadly malaria parasite or the breakdown of sugars from plants in the production of biofuels, this exciting new imaging tool is providing a richer understanding of important biological processes. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>But as ingenious as this microscope is, it can't compare to the ingenuity and complexity of the microscopic world of cells which we've strained to bring into lucid focus for hundreds of years, ever since Robert Hooke's 17th-century descriptions of the tiny structures in a section of cork, which he likened to the modest chambers, or cells, of pious monks. \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/40277/x-ray-microscope-seeing-cells-in-3-d","authors":["6176"],"categories":["quest_4","quest_12","quest_3422","quest_3233"],"tags":["quest_475","quest_1626","quest_11250","quest_1815","quest_13","quest_11251","quest_2893","quest_11248","quest_3071"],"featImg":"quest_40303","label":"source_quest_40277"},"quest_39215":{"type":"posts","id":"quest_39215","meta":{"index":"posts_1591205157","site":"quest","id":"39215","score":null,"sort":[1339426811000]},"guestAuthors":[],"slug":"screening-sunscreens","title":"Screening Sunscreens: Environmental Working Group's 2012 Report","publishDate":1339426811,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_39221\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature.jpg\">\u003cimg class=\"size-full wp-image-39221\" title=\"Sunscreens_JoeShlabotnik_feature\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature.jpg\" alt=\"colorful bottles of different brands of sunscreen\" width=\"640\" height=\"360\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Photograph courtesy of Joe Shlabotnik via Creative Commons\u003c/figcaption>\u003c/figure>\n\u003cp>I’m one of those grocery shoppers who flips a package around to check the ingredients on a label before buying it for the first time. Checking food packages is easy, because I expect to see only recognizable simple ingredients. What about sunscreen? How can you tell if it’s safe?\u003c/p>\n\u003cp>The \u003ca title=\"Environmental Working Group\" href=\"http://www.ewg.org/\">Environmental Working Group\u003c/a> (EWG) has done extensive research to evaluate the effectiveness and safety of over 1800 sunscreens on the market so you don’t have to. Their Sixth Annual \u003ca title=\"EWG 2012 Sunscreen Guide\" href=\"http://breakingnews.ewg.org/2012sunscreen/sunscreens-exposed/executive-summary/\">2012 Sunscreen Guide\u003c/a> lists the best and worst sunscreens. It’s worth a look to make sure your sunscreen isn’t in their “Hall of Shame.” The EWG also provides detailed information about potentially harmful sunscreen ingredients.\u003c/p>\n\u003cp>There is general concern over the large number of sunscreens with exaggerated SPF claims. The SPF (Sun Protection Factor) indicates the level of protection that a sunscreen offers against UVB -- the ultraviolet rays that cause sunburn. For instance, SPF 15 sunscreen protects against 93% of the sun’s UVB rays and SPF 50 protects against 98%. Users of high-SPF sunscreens often increase their risk of sun damage by staying out in the sun longer with a single application.\u003c/p>\n\u003cp>Many of these high-SPF sunscreens provide little protection from UVA rays, which are more deeply penetrating and 30-50 times more prevalent than UVB rays. Research shows that UVA radiation causes skin damage and increases the \u003ca title=\"research article on DNA damage from UVA exposure\" href=\"http://www.ncbi.nlm.nih.gov/pubmed/15140232\">risk of cancer\u003c/a>. It is important to use a sunscreen with zinc oxide, titanium oxide or 3% avobenzone so it protects against both UVA and UVB.\u003c/p>\n\u003cp>People also don’t use enough sunscreen to get the benefit of the SPF rating promised on the bottle. According to the EWG, people \u003ca title=\"article on typical SPF effectiveness\" href=\"http://breakingnews.ewg.org/2012sunscreen/sunscreens-exposed/whats-wrong-with-high-spf/\">typically use\u003c/a> 25% of the recommended amount so SPF 100 to 15 sunscreens actually perform like SPF 3.2 to 2.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The EWG is concerned about retinyl palmitate, a form of vitamin A found in one-fourth of sunscreens. It’s an anti-aging ingredient used as a stabilizer. Although research is not definitive, there is \u003ca title=\"research article on retinyl palmitate\" href=\"http://www.ewg.org/report/what-scientists-say-about-vitamin-sunscreen\">evidence\u003c/a> that retinyl palmitate may promote cancer when used on sun-exposed skin. The EWG recommends that you avoid sunscreens with vitamin A (any form of retinyl or retinol).\u003c/p>\n\u003cp>You also need to be careful of products with oxybenzone, found in more than half of beach and sport sunscreens. It penetrates the skin and has been linked to allergies, hormone disruption and cell damage. The U.S. Centers for Disease Control and Prevention found that \u003ca title=\"research article on benzophenone-3 exposure\" href=\"http://ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.11269\">97 percent of Americans tested had oxybenzone\u003c/a> in their bodies and additional research is underway to understand how this affects our health. The EWG advises against using sunscreens with oxybenzone, although the \u003ca title=\"Personal Care Products Council, a trade association\" href=\"http://www.ctfa.org/\">Personal Care Products Council\u003c/a> disputes these safety allegations.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Discouraged? All these troubling facts may tempt you to give up on sunscreen altogether. However, public health agencies still recommend using sunscreen, just not as your first line of defense. Hats, clothing and shade provide the most reliable sun protection. When that isn’t enough, use the Environmental Working Group’s Sunscreen Guide to help you select a relatively safe sunscreen.\u003c/p>\n\n","blocks":[],"excerpt":"It’s time to grab your bottle of sunscreen and head outdoors, but how can you tell if your sunscreen is safe? Use the Environmental Working Group’s new sunscreen guide to make sure your sunscreen isn’t on their “Hall of Shame.”","status":"publish","parent":0,"modified":1366826269,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":10,"wordCount":539},"headData":{"title":"Screening Sunscreens: Environmental Working Group's 2012 Report | KQED","description":"It’s time to grab your bottle of sunscreen and head outdoors, but how can you tell if your sunscreen is safe? Use the Environmental Working Group’s new sunscreen guide to make sure your sunscreen isn’t on their “Hall of Shame.”","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"39215 http://science.kqed.org/quest/?p=39215","disqusUrl":"https://ww2.kqed.org/quest/2012/06/11/screening-sunscreens/","disqusTitle":"Screening Sunscreens: Environmental Working Group's 2012 Report","path":"/quest/39215/screening-sunscreens","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_39221\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature.jpg\">\u003cimg class=\"size-full wp-image-39221\" title=\"Sunscreens_JoeShlabotnik_feature\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature.jpg\" alt=\"colorful bottles of different brands of sunscreen\" width=\"640\" height=\"360\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/06/Sunscreens_JoeShlabotnik_feature-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Photograph courtesy of Joe Shlabotnik via Creative Commons\u003c/figcaption>\u003c/figure>\n\u003cp>I’m one of those grocery shoppers who flips a package around to check the ingredients on a label before buying it for the first time. Checking food packages is easy, because I expect to see only recognizable simple ingredients. What about sunscreen? How can you tell if it’s safe?\u003c/p>\n\u003cp>The \u003ca title=\"Environmental Working Group\" href=\"http://www.ewg.org/\">Environmental Working Group\u003c/a> (EWG) has done extensive research to evaluate the effectiveness and safety of over 1800 sunscreens on the market so you don’t have to. Their Sixth Annual \u003ca title=\"EWG 2012 Sunscreen Guide\" href=\"http://breakingnews.ewg.org/2012sunscreen/sunscreens-exposed/executive-summary/\">2012 Sunscreen Guide\u003c/a> lists the best and worst sunscreens. It’s worth a look to make sure your sunscreen isn’t in their “Hall of Shame.” The EWG also provides detailed information about potentially harmful sunscreen ingredients.\u003c/p>\n\u003cp>There is general concern over the large number of sunscreens with exaggerated SPF claims. The SPF (Sun Protection Factor) indicates the level of protection that a sunscreen offers against UVB -- the ultraviolet rays that cause sunburn. For instance, SPF 15 sunscreen protects against 93% of the sun’s UVB rays and SPF 50 protects against 98%. Users of high-SPF sunscreens often increase their risk of sun damage by staying out in the sun longer with a single application.\u003c/p>\n\u003cp>Many of these high-SPF sunscreens provide little protection from UVA rays, which are more deeply penetrating and 30-50 times more prevalent than UVB rays. Research shows that UVA radiation causes skin damage and increases the \u003ca title=\"research article on DNA damage from UVA exposure\" href=\"http://www.ncbi.nlm.nih.gov/pubmed/15140232\">risk of cancer\u003c/a>. It is important to use a sunscreen with zinc oxide, titanium oxide or 3% avobenzone so it protects against both UVA and UVB.\u003c/p>\n\u003cp>People also don’t use enough sunscreen to get the benefit of the SPF rating promised on the bottle. According to the EWG, people \u003ca title=\"article on typical SPF effectiveness\" href=\"http://breakingnews.ewg.org/2012sunscreen/sunscreens-exposed/whats-wrong-with-high-spf/\">typically use\u003c/a> 25% of the recommended amount so SPF 100 to 15 sunscreens actually perform like SPF 3.2 to 2.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The EWG is concerned about retinyl palmitate, a form of vitamin A found in one-fourth of sunscreens. It’s an anti-aging ingredient used as a stabilizer. Although research is not definitive, there is \u003ca title=\"research article on retinyl palmitate\" href=\"http://www.ewg.org/report/what-scientists-say-about-vitamin-sunscreen\">evidence\u003c/a> that retinyl palmitate may promote cancer when used on sun-exposed skin. The EWG recommends that you avoid sunscreens with vitamin A (any form of retinyl or retinol).\u003c/p>\n\u003cp>You also need to be careful of products with oxybenzone, found in more than half of beach and sport sunscreens. It penetrates the skin and has been linked to allergies, hormone disruption and cell damage. The U.S. Centers for Disease Control and Prevention found that \u003ca title=\"research article on benzophenone-3 exposure\" href=\"http://ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.11269\">97 percent of Americans tested had oxybenzone\u003c/a> in their bodies and additional research is underway to understand how this affects our health. The EWG advises against using sunscreens with oxybenzone, although the \u003ca title=\"Personal Care Products Council, a trade association\" href=\"http://www.ctfa.org/\">Personal Care Products Council\u003c/a> disputes these safety allegations.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Discouraged? All these troubling facts may tempt you to give up on sunscreen altogether. However, public health agencies still recommend using sunscreen, just not as your first line of defense. Hats, clothing and shade provide the most reliable sun protection. When that isn’t enough, use the Environmental Working Group’s Sunscreen Guide to help you select a relatively safe sunscreen.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/39215/screening-sunscreens","authors":["6360"],"categories":["quest_12"],"tags":["quest_475","quest_11187","quest_3307","quest_13202","quest_11188","quest_11186","quest_13365"],"featImg":"quest_39221","label":"quest"},"quest_38083":{"type":"posts","id":"quest_38083","meta":{"index":"posts_1591205157","site":"quest","id":"38083","score":null,"sort":[1337180449000]},"guestAuthors":[],"slug":"making-women-partners-in-breast-cancer-research","title":"Making Women Partners in Breast Cancer Research","publishDate":1337180449,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_38099\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/cancercellsi640/\" rel=\"attachment wp-att-38099\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/CancerCellsI640-300x169.jpg\" alt=\"breast cancer cells\" title=\"breast cancer cells\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-38099\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Cancer cells under a microscope. Colored stains mark different compartments in the cell. The nucleus is red and lysosomes (which break down waste) are purple. (Image: Carolin Zehetmeier, Morphosys AG, Germany)\u003c/figcaption>\u003c/figure>\n\u003cp>Dr. Susan Love thinks breast cancer researchers need to get over their addiction to rodents. \u003c/p>\n\u003cp>America’s most famous breast cancer surgeon started treating women some 30 years ago. “And we’re still doing the same thing we did when I started,” she told a crowd in San Francisco last month at the \u003ca href=\"http://sagecongress.org/\">Sage Bionetworks conference\u003c/a>, aimed at transforming biomedical research.\u003c/p>\n\u003cp>“Surgery radiation, chemotherapy, hormones, and now we’ve added a little bit of targeted therapies,” said Love, a clinical professor of surgery at UCLA. “We never subtract anything, mind you, we only add things on top. And our results are about the same.” \u003c/p>\n\u003cp>Although \u003ca href=\"http://www.cdc.gov/cancer/breast/statistics/trends.htm\">breast cancer incidence and mortality\u003c/a> have decreased since 1998, by 1.3% and 2% respectively, more than 200,000 women will be diagnosed with breast cancer this year and more than 40,000 will die from it. Nearly 110 women die from breast cancer every day.\u003c/p>\n\u003cp>Experts think earlier detection and better treatments account for the decline in deaths, but screening carries risks. With mass screening comes overdiagnosis—that is, diagnosing a condition that would not prove symptomatic or fatal—and \u003ca href=\"http://www.youtube.com/watch?feature=player_embedded&v=bRKc7YqFNps\">with overdiagnosis comes overtreatment\u003c/a> and other potential harms (see video below). Screening technology can’t distinguish between aggressive and harmless tumors, which can shrink or even disappear on their own. Overdiagnosis will likely just increase as imaging technology finds smaller and smaller tumors.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Medical experts acknowledged in an editorial in the \u003ca href=\"http://www.annals.org/content/156/7/536.full\">Annals of Internal Medicine\u003c/a> last month that it’s time to recognize overdiagnosis as a serious problem. Most patient-education materials don’t even mention overdiagnosis and most women aren’t aware of the possibility, the authors said. As they pointed out, and any woman knows, “the impact of a cancer diagnosis lasts a lifetime.”\u003c/p>\n\u003cp>It’s hard to think of a physician who’s done more to acknowledge the trauma of breast cancer than the author of the best-selling “Dr. Susan Love’s Breast Book,” now in its fifth edition. \u003c/p>\n\u003cp>That book, along with Love's early refusal to accept the oxymoronic (emphasis on moronic) “early detection is your best prevention” mantra of mainstream cancer and advocacy organizations, won her a place of honor among frustrated breast cancer activists, who know all too well that if you can diagnose cancer, you haven't prevented it. Detecting it, by definition, means it's there.\u003c/p>\n\u003cfigure id=\"attachment_38139\" class=\"wp-caption alignleft\" style=\"max-width: 245px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/louis-jacques_goussier_enzyklopadie_diderot_pl_xxix-3/\" rel=\"attachment wp-att-38139\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/Louis-Jacques_Goussier_Enzyklop%C3%A4die_Diderot_Pl_XXIX2-245x360.jpg\" alt=\"breast cancer surgery tools\" title=\"breast cancer surgery tools\" width=\"245\" height=\"360\" class=\"size-large wp-image-38139\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The surgical tools used on breast cancer patients in the 18th century look gruesome, but aren't really so far removed from the \"slash, burn and poison\" approach to breast cancer today. (Illustration: Louis-Jacques Goussier)\u003c/figcaption>\u003c/figure>\n\u003cp>Activists have long \u003ca href=\"http://bcaction.org/2007/02/21/from-the-executive-director-of-pills-prevention-and-politics/\">pushed researchers to shift their focus\u003c/a> from treatments and cures to true prevention. \u003c/p>\n\u003cp>Despite $4 billion spent on breast cancer research, researchers still don’t know what causes it or how to prevent it. Yet Love believes that the tools exist to “eradicate breast cancer within our lifetime” if we ask the right questions.\u003c/p>\n\u003cp>And for decades, Love has helped shine the spotlight on causes, not cures, to spare women from that dreaded diagnosis. But that goal will remain elusive, she believes, as long as researchers keep studying the disease in rodents. That’s because mice and rats don’t get breast cancer. Researchers have to give it to them.\u003c/p>\n\u003cp>So she’s been trying to wean researchers off rodents. “I can say this is a good study, you could do that in women, and they say, ‘Let me tell you about my rats.’ ” \u003c/p>\n\u003cp>Yet researchers can learn valuable insights into the origins of disease by comparing people with an illness to matched cohorts of healthy people, as the legendary \u003ca href=\"http://www.channing.harvard.edu/nhs/\">Nurses’ Health Study\u003c/a> has demonstrated for heart disease, diabetes and other conditions. \u003c/p>\n\u003cp>Finding the causes and, ultimately, how to prevent breast cancer requires a radical shift in thinking, Love said. And that means that at least some researchers have to give up their rats and mice and start working with the people who get the disease. \u003c/p>\n\u003cp>Researchers used to tell Love that even if they did want to study women, they didn’t know how to find them. But she knew that was the easy part. So for more than three years, the Dr. Susan Love Research Foundation has been recruiting an online \"army of women\" with a target of enrolling “one million women and a few good men.” \u003c/p>\n\u003cfigure id=\"attachment_38216\" class=\"wp-caption alignright\" style=\"max-width: 270px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/susan-love-unplugged/\" rel=\"attachment wp-att-38216\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/Susan-Love-Unplugged-270x360.jpg\" alt=\"susan love at sage bionetworks\" title=\"Susan Love at Sage Bionetworks\" width=\"270\" height=\"360\" class=\"size-large wp-image-38216\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Dr. Susan Love spoke at the Sage Bionetworks conference in San Francisco last month. The Seattle-based nonprofit is dedicated to “moving beyond the current medical information system and its rewards.” \u003c/figcaption>\u003c/figure>\n\u003cp>“Scientists come to us with studies that need people, and we e-blast them out to everybody in the army,” Love said.\u003c/p>\n\u003cp>So far, they’ve recruited 365,000 women for about 60 studies. Seven in 10 of the women don’t have breast cancer, but are \"altruistic,” Love said. They’re willing to undergo unpleasant procedures to help researchers figure out root causes. In one study, women in the control group had to endure a sigmoidoscopy and a biopsy. And Love got more enrollees than researchers could use.\u003c/p>\n\u003cp>By the end of this summer, the foundation will be launching its own \u003ca href=\"http://www.armyofwomen.org/how_splash/pdf/HOW_2012.pdf\">Health of Women Study.\u003c/a> The large online breast cancer cohort study will follow women with and without a diagnosis to identify new risk factors. It will also follow breast cancer survivors to identify factors that predict long-term survival and consequences of different therapies. \u003c/p>\n\u003cp>Any woman over 18 \u003ca href=\"https://www.armyofwomen.org/getinvolved\">can register online\u003c/a> or with a mobile phone. (Men are welcome, too.) \u003c/p>\n\u003cp>Love’s study will let participants suggest questions they’d like to see tested, because she thinks you don’t need a PhD to come up with a good idea.\u003c/p>\n\u003cp>She told her San Francisco audience that early theories about the cause of \u003ca href=\"http://www.cdc.gov/hpv/\">human papillomavirus\u003c/a> (HPV) came from observations of people who knew a man whose wife died of cervical cancer, and who then married a second woman who died of the same cancer. “They said, well maybe it’s the guy.”\u003c/p>\n\u003cp>“And then we figured out it was sexually transmitted, then we figured out it was a virus and now we have a vaccine.”\u003c/p>\n\u003cp>Potentially, Love reminds us, “Everybody is a patient.” She thinks eliminating disease is something we should all do together.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>“[youtube=http://www.youtube.com/watch?v=bRKc7YqFNps]”\u003c/p>\n\n","blocks":[],"excerpt":"Dr. Susan Love, breast cancer surgeon and women's health advocate, has long railed against cancer researchers' fixation on treatments and cures. After spending more than $4 billion on breast cancer research, we still don't know what causes the disease or how to prevent it. It's time to focus on looking for causes, she says. And she wants your help.","status":"publish","parent":0,"modified":1337112623,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":26,"wordCount":1138},"headData":{"title":"Making Women Partners in Breast Cancer Research | KQED","description":"Dr. Susan Love, breast cancer surgeon and women's health advocate, has long railed against cancer researchers' fixation on treatments and cures. After spending more than $4 billion on breast cancer research, we still don't know what causes the disease or how to prevent it. It's time to focus on looking for causes, she says. And she wants your help.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"38083 http://science.kqed.org/quest/?p=38083","disqusUrl":"https://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/","disqusTitle":"Making Women Partners in Breast Cancer Research","path":"/quest/38083/making-women-partners-in-breast-cancer-research","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_38099\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/cancercellsi640/\" rel=\"attachment wp-att-38099\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/CancerCellsI640-300x169.jpg\" alt=\"breast cancer cells\" title=\"breast cancer cells\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-38099\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Cancer cells under a microscope. Colored stains mark different compartments in the cell. The nucleus is red and lysosomes (which break down waste) are purple. (Image: Carolin Zehetmeier, Morphosys AG, Germany)\u003c/figcaption>\u003c/figure>\n\u003cp>Dr. Susan Love thinks breast cancer researchers need to get over their addiction to rodents. \u003c/p>\n\u003cp>America’s most famous breast cancer surgeon started treating women some 30 years ago. “And we’re still doing the same thing we did when I started,” she told a crowd in San Francisco last month at the \u003ca href=\"http://sagecongress.org/\">Sage Bionetworks conference\u003c/a>, aimed at transforming biomedical research.\u003c/p>\n\u003cp>“Surgery radiation, chemotherapy, hormones, and now we’ve added a little bit of targeted therapies,” said Love, a clinical professor of surgery at UCLA. “We never subtract anything, mind you, we only add things on top. And our results are about the same.” \u003c/p>\n\u003cp>Although \u003ca href=\"http://www.cdc.gov/cancer/breast/statistics/trends.htm\">breast cancer incidence and mortality\u003c/a> have decreased since 1998, by 1.3% and 2% respectively, more than 200,000 women will be diagnosed with breast cancer this year and more than 40,000 will die from it. Nearly 110 women die from breast cancer every day.\u003c/p>\n\u003cp>Experts think earlier detection and better treatments account for the decline in deaths, but screening carries risks. With mass screening comes overdiagnosis—that is, diagnosing a condition that would not prove symptomatic or fatal—and \u003ca href=\"http://www.youtube.com/watch?feature=player_embedded&v=bRKc7YqFNps\">with overdiagnosis comes overtreatment\u003c/a> and other potential harms (see video below). Screening technology can’t distinguish between aggressive and harmless tumors, which can shrink or even disappear on their own. Overdiagnosis will likely just increase as imaging technology finds smaller and smaller tumors.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Medical experts acknowledged in an editorial in the \u003ca href=\"http://www.annals.org/content/156/7/536.full\">Annals of Internal Medicine\u003c/a> last month that it’s time to recognize overdiagnosis as a serious problem. Most patient-education materials don’t even mention overdiagnosis and most women aren’t aware of the possibility, the authors said. As they pointed out, and any woman knows, “the impact of a cancer diagnosis lasts a lifetime.”\u003c/p>\n\u003cp>It’s hard to think of a physician who’s done more to acknowledge the trauma of breast cancer than the author of the best-selling “Dr. Susan Love’s Breast Book,” now in its fifth edition. \u003c/p>\n\u003cp>That book, along with Love's early refusal to accept the oxymoronic (emphasis on moronic) “early detection is your best prevention” mantra of mainstream cancer and advocacy organizations, won her a place of honor among frustrated breast cancer activists, who know all too well that if you can diagnose cancer, you haven't prevented it. Detecting it, by definition, means it's there.\u003c/p>\n\u003cfigure id=\"attachment_38139\" class=\"wp-caption alignleft\" style=\"max-width: 245px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/louis-jacques_goussier_enzyklopadie_diderot_pl_xxix-3/\" rel=\"attachment wp-att-38139\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/Louis-Jacques_Goussier_Enzyklop%C3%A4die_Diderot_Pl_XXIX2-245x360.jpg\" alt=\"breast cancer surgery tools\" title=\"breast cancer surgery tools\" width=\"245\" height=\"360\" class=\"size-large wp-image-38139\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The surgical tools used on breast cancer patients in the 18th century look gruesome, but aren't really so far removed from the \"slash, burn and poison\" approach to breast cancer today. (Illustration: Louis-Jacques Goussier)\u003c/figcaption>\u003c/figure>\n\u003cp>Activists have long \u003ca href=\"http://bcaction.org/2007/02/21/from-the-executive-director-of-pills-prevention-and-politics/\">pushed researchers to shift their focus\u003c/a> from treatments and cures to true prevention. \u003c/p>\n\u003cp>Despite $4 billion spent on breast cancer research, researchers still don’t know what causes it or how to prevent it. Yet Love believes that the tools exist to “eradicate breast cancer within our lifetime” if we ask the right questions.\u003c/p>\n\u003cp>And for decades, Love has helped shine the spotlight on causes, not cures, to spare women from that dreaded diagnosis. But that goal will remain elusive, she believes, as long as researchers keep studying the disease in rodents. That’s because mice and rats don’t get breast cancer. Researchers have to give it to them.\u003c/p>\n\u003cp>So she’s been trying to wean researchers off rodents. “I can say this is a good study, you could do that in women, and they say, ‘Let me tell you about my rats.’ ” \u003c/p>\n\u003cp>Yet researchers can learn valuable insights into the origins of disease by comparing people with an illness to matched cohorts of healthy people, as the legendary \u003ca href=\"http://www.channing.harvard.edu/nhs/\">Nurses’ Health Study\u003c/a> has demonstrated for heart disease, diabetes and other conditions. \u003c/p>\n\u003cp>Finding the causes and, ultimately, how to prevent breast cancer requires a radical shift in thinking, Love said. And that means that at least some researchers have to give up their rats and mice and start working with the people who get the disease. \u003c/p>\n\u003cp>Researchers used to tell Love that even if they did want to study women, they didn’t know how to find them. But she knew that was the easy part. So for more than three years, the Dr. Susan Love Research Foundation has been recruiting an online \"army of women\" with a target of enrolling “one million women and a few good men.” \u003c/p>\n\u003cfigure id=\"attachment_38216\" class=\"wp-caption alignright\" style=\"max-width: 270px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/05/16/making-women-partners-in-breast-cancer-research/susan-love-unplugged/\" rel=\"attachment wp-att-38216\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/05/Susan-Love-Unplugged-270x360.jpg\" alt=\"susan love at sage bionetworks\" title=\"Susan Love at Sage Bionetworks\" width=\"270\" height=\"360\" class=\"size-large wp-image-38216\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Dr. Susan Love spoke at the Sage Bionetworks conference in San Francisco last month. The Seattle-based nonprofit is dedicated to “moving beyond the current medical information system and its rewards.” \u003c/figcaption>\u003c/figure>\n\u003cp>“Scientists come to us with studies that need people, and we e-blast them out to everybody in the army,” Love said.\u003c/p>\n\u003cp>So far, they’ve recruited 365,000 women for about 60 studies. Seven in 10 of the women don’t have breast cancer, but are \"altruistic,” Love said. They’re willing to undergo unpleasant procedures to help researchers figure out root causes. In one study, women in the control group had to endure a sigmoidoscopy and a biopsy. And Love got more enrollees than researchers could use.\u003c/p>\n\u003cp>By the end of this summer, the foundation will be launching its own \u003ca href=\"http://www.armyofwomen.org/how_splash/pdf/HOW_2012.pdf\">Health of Women Study.\u003c/a> The large online breast cancer cohort study will follow women with and without a diagnosis to identify new risk factors. It will also follow breast cancer survivors to identify factors that predict long-term survival and consequences of different therapies. \u003c/p>\n\u003cp>Any woman over 18 \u003ca href=\"https://www.armyofwomen.org/getinvolved\">can register online\u003c/a> or with a mobile phone. (Men are welcome, too.) \u003c/p>\n\u003cp>Love’s study will let participants suggest questions they’d like to see tested, because she thinks you don’t need a PhD to come up with a good idea.\u003c/p>\n\u003cp>She told her San Francisco audience that early theories about the cause of \u003ca href=\"http://www.cdc.gov/hpv/\">human papillomavirus\u003c/a> (HPV) came from observations of people who knew a man whose wife died of cervical cancer, and who then married a second woman who died of the same cancer. “They said, well maybe it’s the guy.”\u003c/p>\n\u003cp>“And then we figured out it was sexually transmitted, then we figured out it was a virus and now we have a vaccine.”\u003c/p>\n\u003cp>Potentially, Love reminds us, “Everybody is a patient.” She thinks eliminating disease is something we should all do together.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/bRKc7YqFNps'\n title='//www.youtube.com/embed/bRKc7YqFNps'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>”\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/38083/making-women-partners-in-breast-cancer-research","authors":["6322"],"categories":["quest_4","quest_12"],"tags":["quest_385","quest_475","quest_10934","quest_13202"],"featImg":"quest_38099","label":"quest"},"quest_25524":{"type":"posts","id":"quest_25524","meta":{"index":"posts_1591205157","site":"quest","id":"25524","score":null,"sort":[1317398402000]},"guestAuthors":[],"slug":"tobacco-industry-refused-to-reduce-radioactivity-in-cigarettes-in-order-to-maintain-addictive-potential","title":"Tobacco Industry Refused To Reduce Radioactivity In Cigarettes In Order To Maintain Addictive Potential ","publishDate":1317398402,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/09/smoking.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/09/smoking-300x169.jpg\" alt=\"\" title=\"smoking\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-25528\">\u003c/a>\u003c/p>\n\u003cp>While most of us probably never considered the tobacco industry to be particularly good people, the latest report based on 13 million documents released since a court-ordered legal settlement in 1998 should disturb even the most optimistic of industry supporters.\u003c/p>\n\u003cp>Scientists at UCLA have examined millions of previously secret internal records from the tobacco industry looking for clues as to how they handled potential health concerns regarding cigarette smoke. From these documents, two previous reports revealed that the presence of the radioactive isotope polonium 210 in tobacco and its associated increase in lung cancer risk from smoking was common knowledge among top industry executives as early as 1964. These reports showed that tobacco companies not only failed to inform consumers of the risk of smoking, but also refused to take action to reduce the radioactive potential.\u003c/p>\n\u003cp>The \u003ca href=\"http://www.universityofcalifornia.edu/news/article/26385\">latest study\u003c/a>, published this week in the journal \u003cem>Nicotine and Tobacco Research\u003c/em>, uncovered that the tobacco industry had detailed knowledge of the presence of radioactive substances as early as 1959.\u003c/p>\n\u003cp>According to the report, the authors were “surprised to discover the industry's scientists had actually made, as early as the 1960s, quantitative and realistic radiobiological calculations of the long-term radiation absorption dose of ionizing alpha particles and reached the conclusion that the alpha particles in cigarette smoke in promoting ‘cancerous growth’ in the lungs of smokers was ‘not an unlikely event’.” \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Amazingly, the tobacco industry was also aware of an acid washing process by which the radioactive potential of cigarette smoke could be dramatically reduced. Autopsies from smokers indicate that the majority of tumors occur where the alpha particles accumulate in the lungs. This acid wash technique is effective at removing the radioisotope from tobacco plants, and has the potential to significantly reduce cancer risk. \u003c/p>\n\u003cp>Though the industry frequently cited cost and environmental concerns for why they did not adopt the technique, the UCLA team found evidence that the industry was primarily worried that the technique would reduce the addictive potential of nicotine.\u003c/p>\n\u003cp>“The industry was concerned that the acid media would ionize the nicotine, making it more difficult to be absorbed into the brains of smokers and depriving them of that instant nicotine rush that fuels their addiction,” said Hrayr S. Karagueuzian, the first author of the study.\u003c/p>\n\u003cp>So not only was the industry aware that tobacco causes cancer, they intentionally hid this information from consumers and refused to take steps to reduce the danger because they wanted their customers to remain addicted to their product.\u003c/p>\n\u003cp>While this raises many frightening questions for consumers of any ingestible product (food industry, I’m looking in your direction), what bothers me most is the uncertainty over who will be held accountable for this crime.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>According to the report, polonium 210 is still present in all commercially available domestic and foreign cigarette brands.\u003c/p>\n\n","blocks":[],"excerpt":"Reducing radioactivity in tobacco would have also lowered the strength of nicotine, so the tobacco industry ignored it.","status":"publish","parent":0,"modified":1317331687,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":13,"wordCount":482},"headData":{"title":"Tobacco Industry Refused To Reduce Radioactivity In Cigarettes In Order To Maintain Addictive Potential | KQED","description":"Reducing radioactivity in tobacco would have also lowered the strength of nicotine, so the tobacco industry ignored it.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"25524 http://science.kqed.org/quest/?p=25524","disqusUrl":"https://ww2.kqed.org/quest/2011/09/30/tobacco-industry-refused-to-reduce-radioactivity-in-cigarettes-in-order-to-maintain-addictive-potential/","disqusTitle":"Tobacco Industry Refused To Reduce Radioactivity In Cigarettes In Order To Maintain Addictive Potential ","path":"/quest/25524/tobacco-industry-refused-to-reduce-radioactivity-in-cigarettes-in-order-to-maintain-addictive-potential","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/09/smoking.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/09/smoking-300x169.jpg\" alt=\"\" title=\"smoking\" width=\"300\" height=\"169\" class=\"size-thumbnail wp-image-25528\">\u003c/a>\u003c/p>\n\u003cp>While most of us probably never considered the tobacco industry to be particularly good people, the latest report based on 13 million documents released since a court-ordered legal settlement in 1998 should disturb even the most optimistic of industry supporters.\u003c/p>\n\u003cp>Scientists at UCLA have examined millions of previously secret internal records from the tobacco industry looking for clues as to how they handled potential health concerns regarding cigarette smoke. From these documents, two previous reports revealed that the presence of the radioactive isotope polonium 210 in tobacco and its associated increase in lung cancer risk from smoking was common knowledge among top industry executives as early as 1964. These reports showed that tobacco companies not only failed to inform consumers of the risk of smoking, but also refused to take action to reduce the radioactive potential.\u003c/p>\n\u003cp>The \u003ca href=\"http://www.universityofcalifornia.edu/news/article/26385\">latest study\u003c/a>, published this week in the journal \u003cem>Nicotine and Tobacco Research\u003c/em>, uncovered that the tobacco industry had detailed knowledge of the presence of radioactive substances as early as 1959.\u003c/p>\n\u003cp>According to the report, the authors were “surprised to discover the industry's scientists had actually made, as early as the 1960s, quantitative and realistic radiobiological calculations of the long-term radiation absorption dose of ionizing alpha particles and reached the conclusion that the alpha particles in cigarette smoke in promoting ‘cancerous growth’ in the lungs of smokers was ‘not an unlikely event’.” \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Amazingly, the tobacco industry was also aware of an acid washing process by which the radioactive potential of cigarette smoke could be dramatically reduced. Autopsies from smokers indicate that the majority of tumors occur where the alpha particles accumulate in the lungs. This acid wash technique is effective at removing the radioisotope from tobacco plants, and has the potential to significantly reduce cancer risk. \u003c/p>\n\u003cp>Though the industry frequently cited cost and environmental concerns for why they did not adopt the technique, the UCLA team found evidence that the industry was primarily worried that the technique would reduce the addictive potential of nicotine.\u003c/p>\n\u003cp>“The industry was concerned that the acid media would ionize the nicotine, making it more difficult to be absorbed into the brains of smokers and depriving them of that instant nicotine rush that fuels their addiction,” said Hrayr S. Karagueuzian, the first author of the study.\u003c/p>\n\u003cp>So not only was the industry aware that tobacco causes cancer, they intentionally hid this information from consumers and refused to take steps to reduce the danger because they wanted their customers to remain addicted to their product.\u003c/p>\n\u003cp>While this raises many frightening questions for consumers of any ingestible product (food industry, I’m looking in your direction), what bothers me most is the uncertainty over who will be held accountable for this crime.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>According to the report, polonium 210 is still present in all commercially available domestic and foreign cigarette brands.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/25524/tobacco-industry-refused-to-reduce-radioactivity-in-cigarettes-in-order-to-maintain-addictive-potential","authors":["10218"],"categories":["quest_12"],"tags":["quest_10246","quest_475","quest_10241","quest_10243","quest_10245","quest_13202","quest_10244","quest_10242","quest_10239","quest_10240"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg","imageAlt":"On Our Watch from NPR and KQED","officialWebsiteLink":"/podcasts/onourwatch","meta":{"site":"news","source":"kqed","order":"1"},"link":"/podcasts/onourwatch","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1567098962","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw","npr":"https://rpb3r.app.goo.gl/onourwatch","spotify":"https://open.spotify.com/show/0OLWoyizopu6tY1XiuX70x","tuneIn":"https://tunein.com/radio/On-Our-Watch-p1436229/","stitcher":"https://www.stitcher.com/show/on-our-watch","rss":"https://feeds.npr.org/510360/podcast.xml"}},"on-the-media":{"id":"on-the-media","title":"On The Media","info":"Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us","airtime":"SUN 2pm-3pm, MON 12am-1am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png","officialWebsiteLink":"https://www.wnycstudios.org/shows/otm","meta":{"site":"news","source":"wnyc"},"link":"/radio/program/on-the-media","subscribe":{"apple":"https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2","tuneIn":"https://tunein.com/radio/On-the-Media-p69/","rss":"http://feeds.wnyc.org/onthemedia"}},"our-body-politic":{"id":"our-body-politic","title":"Our Body Politic","info":"Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.","airtime":"SAT 6pm-7pm, SUN 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://our-body-politic.simplecast.com/","meta":{"site":"news","source":"kcrw"},"link":"/radio/program/our-body-politic","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/our-body-politic/id1533069868","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw","spotify":"https://open.spotify.com/show/4ApAiLT1kV153TttWAmqmc","rss":"https://feeds.simplecast.com/_xaPhs1s","tuneIn":"https://tunein.com/podcasts/News--Politics-Podcasts/Our-Body-Politic-p1369211/"}},"pbs-newshour":{"id":"pbs-newshour","title":"PBS NewsHour","info":"Analysis, background reports and updates from the PBS NewsHour putting today's news in context.","airtime":"MON-FRI 3pm-4pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.pbs.org/newshour/","meta":{"site":"news","source":"pbs"},"link":"/radio/program/pbs-newshour","subscribe":{"apple":"https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2","tuneIn":"https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/","rss":"https://www.pbs.org/newshour/feeds/rss/podcasts/show"}},"perspectives":{"id":"perspectives","title":"Perspectives","tagline":"KQED's series of of daily listener commentaries since 1991","info":"KQED's series of of daily listener commentaries since 1991.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Perspectives-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/perspectives/","meta":{"site":"radio","source":"kqed","order":"15"},"link":"/perspectives","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/id73801135","npr":"https://www.npr.org/podcasts/432309616/perspectives","rss":"https://ww2.kqed.org/perspectives/category/perspectives/feed/","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"}},"planet-money":{"id":"planet-money","title":"Planet Money","info":"The economy explained. 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