Newly Discovered Stem Cells Cause Clogged Arteries
Scientists Understand Heart Disease Better, Still Give Bad Advice
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(Zoey Huang photo.)","credit":null,"description":"Zhenyu Tang (seated at microscope) examines vascular stem cells in culture along with Aijun Wang (left) and Song Li (right). 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(Zoey Huang photo.)\u003c/figcaption>\u003c/figure>\n\u003cp>Odds are that you know someone who’s had a heart attack. One American suffers a coronary event \u003ca href=\"http://circ.ahajournals.org/content/125/1/e2.full.pdf\" title=\"prevalence of atherosclerosis\">every 25 seconds and about every minute\u003c/a> someone dies from one. \u003c/p>\n\u003cp>Doctors thought they understood artery-hardening diseases, such as \u003ca href=\"http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/\" title=\"about atherosclerosis\">atherosclerosis\u003c/a>, that lead to heart attacks, strokes and death. But these generally accepted theories are contradicted by new research performed at the University of California, Berkeley. According to a \u003ca href=\"http://www.nature.com/ncomms/journal/v3/n6/full/ncomms1867.html\" title=\"Song Li journal article in Nature Communications\">new study\u003c/a> published in \u003cem>Nature Communications\u003c/em>, a previously unknown type of stem cell is actually the underlying cause for clogged arteries.\u003c/p>\n\u003cp>For decades, scientists believed that heart disease was caused by the smooth muscle cells that line artery walls. It was thought that bad (LDL) cholesterol damaged the arteries and triggered smooth muscle cells to rapidly reproduce. This led to a build up of fibrous scar tissue that narrowed and hardened the arteries, restricting blood flow. As a result, most therapies focus on physically widening the inside of the blood vessels or replacing the damaged area with a graft.\u003c/p>\n\u003cp>These beliefs are challenged by new research performed by principle investigator Song Li, a professor of bioengineering and researcher at the Berkeley Stem Cell Center, and his colleagues.\u003c/p>\n\u003cp>“For the first time, we are showing evidence that vascular diseases are actually a kind of stem cell disease,” said Song Li in a university news release. “This work should revolutionize therapies for vascular diseases because we now know that stem cells rather than smooth muscle cells are the correct therapeutic target.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Analyzing cells from arteries and veins of transgenic mice, the researchers were able to trace the lineage of the cells that rapidly reproduced in the vessel walls to prove that they were not smooth muscle cells as current theory predicted. Further experiments discovered that they are actually multipotent vascular stem cells, meaning that they can become various specialized cells – smooth muscle, nerve, cartilage, bone and fat cells. The same type of stem cells were also identified in human blood vessels.\u003c/p>\n\u003cp>This explains why previous studies mistook the multipotent vascular stem cells as smooth muscle cells. It also explains how a soft artery can calcify and harden, since the multipotent stem cells can also form bone and cartilage.\u003c/p>\n\u003cfigure id=\"attachment_42124\" class=\"wp-caption alignleft\" style=\"max-width: 319px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350-319x253.jpg\" alt=\"Within walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle cells, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries.\" title=\"stemcell-schematic350\" width=\"319\" height=\"253\" class=\"size-medium wp-image-42124\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Within the walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries. (Song Li illustration)\u003c/figcaption>\u003c/figure>\n\u003cp>When new research dramatically challenges existing scientific beliefs, often people resist the new ideas. Dr. Jill Helms, a professor in the Department of Surgery at Stanford School of Medicine and co-author of the study, explained in an \u003ca href=\"http://www.npr.org/2012/06/08/154587990/identifying-the-real-culprit-behind-killer-vascular-diseases\" title=\"Jill Helms NPR Science Friday interview\">NPR interview\u003c/a>, “There is resistance oftentimes, but there can be moments where there’s great clarity and I think Song’s work certainly falls within that category.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>However, the research still needs to be repeated by other research groups, as well as verified in other animals and humans. Song Li’s collaboration is already studying human cells from healthy and diseased arteries. They are also developing techniques to rapidly screen drugs that specifically target these stem cells without affecting the normal (endothelial) cells that line a blood vessel, which could ultimately lead to new therapies.\u003c/p>\n\n","blocks":[],"excerpt":"Scientists thought they understood how arteries hardened and clogged, but they may have been wrong. New research indicates that a previously unknown type of stem cell is actually the underlying cause of clogged arteries. If confirmed, it could lead to new therapies.","status":"publish","parent":0,"modified":1346781910,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":11,"wordCount":582},"headData":{"title":"Newly Discovered Stem Cells Cause Clogged Arteries | KQED","description":"Scientists thought they understood how arteries hardened and clogged, but they may have been wrong. New research indicates that a previously unknown type of stem cell is actually the underlying cause of clogged arteries. If confirmed, it could lead to new therapies.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Newly Discovered Stem Cells Cause Clogged Arteries","datePublished":"2012-08-06T15:00:41.000Z","dateModified":"2012-09-04T18:05:10.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"42114 http://science.kqed.org/quest/?p=42114","disqusUrl":"https://ww2.kqed.org/quest/2012/08/06/newly-discovered-stem-cells-cause-clogged-arteries/","disqusTitle":"Newly Discovered Stem Cells Cause Clogged Arteries","path":"/quest/42114/newly-discovered-stem-cells-cause-clogged-arteries","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_42120\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-researchers640x360.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-researchers640x360.jpg\" alt=\"UCB researchers exam vascular stem cells in the microscope\" title=\"stemcell-researchers640x360\" width=\"640\" height=\"360\" class=\"size-full wp-image-42120\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/08/stemcell-researchers640x360.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/08/stemcell-researchers640x360-400x225.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Zhenyu Tang (seated at microscope) examines vascular stem cells in culture along with Aijun Wang (left) and Song Li (right). (Zoey Huang photo.)\u003c/figcaption>\u003c/figure>\n\u003cp>Odds are that you know someone who’s had a heart attack. One American suffers a coronary event \u003ca href=\"http://circ.ahajournals.org/content/125/1/e2.full.pdf\" title=\"prevalence of atherosclerosis\">every 25 seconds and about every minute\u003c/a> someone dies from one. \u003c/p>\n\u003cp>Doctors thought they understood artery-hardening diseases, such as \u003ca href=\"http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/\" title=\"about atherosclerosis\">atherosclerosis\u003c/a>, that lead to heart attacks, strokes and death. But these generally accepted theories are contradicted by new research performed at the University of California, Berkeley. According to a \u003ca href=\"http://www.nature.com/ncomms/journal/v3/n6/full/ncomms1867.html\" title=\"Song Li journal article in Nature Communications\">new study\u003c/a> published in \u003cem>Nature Communications\u003c/em>, a previously unknown type of stem cell is actually the underlying cause for clogged arteries.\u003c/p>\n\u003cp>For decades, scientists believed that heart disease was caused by the smooth muscle cells that line artery walls. It was thought that bad (LDL) cholesterol damaged the arteries and triggered smooth muscle cells to rapidly reproduce. This led to a build up of fibrous scar tissue that narrowed and hardened the arteries, restricting blood flow. As a result, most therapies focus on physically widening the inside of the blood vessels or replacing the damaged area with a graft.\u003c/p>\n\u003cp>These beliefs are challenged by new research performed by principle investigator Song Li, a professor of bioengineering and researcher at the Berkeley Stem Cell Center, and his colleagues.\u003c/p>\n\u003cp>“For the first time, we are showing evidence that vascular diseases are actually a kind of stem cell disease,” said Song Li in a university news release. “This work should revolutionize therapies for vascular diseases because we now know that stem cells rather than smooth muscle cells are the correct therapeutic target.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Analyzing cells from arteries and veins of transgenic mice, the researchers were able to trace the lineage of the cells that rapidly reproduced in the vessel walls to prove that they were not smooth muscle cells as current theory predicted. Further experiments discovered that they are actually multipotent vascular stem cells, meaning that they can become various specialized cells – smooth muscle, nerve, cartilage, bone and fat cells. The same type of stem cells were also identified in human blood vessels.\u003c/p>\n\u003cp>This explains why previous studies mistook the multipotent vascular stem cells as smooth muscle cells. It also explains how a soft artery can calcify and harden, since the multipotent stem cells can also form bone and cartilage.\u003c/p>\n\u003cfigure id=\"attachment_42124\" class=\"wp-caption alignleft\" style=\"max-width: 319px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350.jpg\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/08/stemcell-schematic350-319x253.jpg\" alt=\"Within walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle cells, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries.\" title=\"stemcell-schematic350\" width=\"319\" height=\"253\" class=\"size-medium wp-image-42124\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Within the walls of blood vessels are smooth muscle cells and newly discovered vascular stem cells. The stem cells are able to differentiate into smooth muscle, fat, cartilage and bone cells. UC Berkeley researchers provide evidence that these stem cells are contributing to clogged and hardened arteries. (Song Li illustration)\u003c/figcaption>\u003c/figure>\n\u003cp>When new research dramatically challenges existing scientific beliefs, often people resist the new ideas. Dr. Jill Helms, a professor in the Department of Surgery at Stanford School of Medicine and co-author of the study, explained in an \u003ca href=\"http://www.npr.org/2012/06/08/154587990/identifying-the-real-culprit-behind-killer-vascular-diseases\" title=\"Jill Helms NPR Science Friday interview\">NPR interview\u003c/a>, “There is resistance oftentimes, but there can be moments where there’s great clarity and I think Song’s work certainly falls within that category.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>However, the research still needs to be repeated by other research groups, as well as verified in other animals and humans. Song Li’s collaboration is already studying human cells from healthy and diseased arteries. They are also developing techniques to rapidly screen drugs that specifically target these stem cells without affecting the normal (endothelial) cells that line a blood vessel, which could ultimately lead to new therapies.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/42114/newly-discovered-stem-cells-cause-clogged-arteries","authors":["6360"],"categories":["quest_4","quest_12"],"tags":["quest_3467","quest_11334","quest_10997","quest_13202","quest_2791","quest_10452"],"featImg":"quest_42120","label":"quest"},"quest_12346":{"type":"posts","id":"quest_12346","meta":{"index":"posts_1591205157","site":"quest","id":"12346","score":null,"sort":[1298048441000]},"guestAuthors":[],"slug":"scientists-understand-heart-disease-better-still-give-bad-advice","title":"Scientists Understand Heart Disease Better, Still Give Bad Advice","publishDate":1298048441,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/02/fastfood12.jpg\" alt=\"\">\u003cem>Calling fast food \"high fat\" is true, but misleading. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/avlxyz/3861444749/\">avlxyz\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003ca href=\"http://ajpheart.physiology.org/content/early/2010/12/10/ajpheart.01036.2010.abstract\">New research\u003c/a> from UC Davis sheds light on how triglycerides induce atherosclerosis—the hardening of artery walls that causes heart disease—particularly in individuals with abdominal obesity. Unfortunately, however, the researchers credit the fat in the fast food meal they used to induce the triglyceride spike, while letting the more likely culprit, orange juice, completely off the hook.\u003c/p>\n\u003cp>In the study, researchers fed a fast food meal (two breakfast sandwiches, hash browns and orange juice, as noted in the \u003ca href=\"http://www.news.ucdavis.edu/search/news_detail.lasso?id=9767\">press release\u003c/a>) to people with either normal or elevated blood triglycerides. Triglycerides correlate strongly with risk of heart disease and are \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/19436658\">a better predictor of cardiovascular risk than total or LDL cholesterol\u003c/a>.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>After eating the horrible meal, triglycerides rose and LDL cholesterol was transported into cells in the artery wall, a process that leads to artery hardening and heart disease. This effect was worsened in the presence of cytokines, which are known to cause inflammation and correlate with a larger waist size.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The implication is that poor diet choices become more dangerous as a person's metabolic health declines, making good nutrition an even greater priority for people with abdominal obesity.\u003c/p>\n\u003cp>“The new study shows that eating a common fast food meal can affect inflammatory responses in the blood vessels,\" said the lead researcher, Anthony Passerini, and the effect seems to be worse in those with chronic inflammation and larger waists.\u003c/p>\n\u003cp>But why do they extrapolate and claim that this problem is caused by dietary fat?\u003c/p>\n\u003cp>The authors describe the fast food meal as “high-fat”, but neglect that it is also high in processed carbohydrates (two buns and hash browns) and fructose, the fruit sugar present in orange juice. Fructose is converted to triglycerides in the liver and is the \u003ca href=\"http://www.ajcn.org/content/20/2/131.long\">most effective way to increase triglyceride levels\u003c/a>.\u003c/p>\n\u003cp>Not only is fructose from the orange juice the most likely cause of the triglyceride effect, but it is particularly unlikely the fat had an impact. \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/5916038\">High-fat, low-carbohydrate diets have been used to \u003cem>treat\u003c/em> high triglycerides since the 1960s\u003c/a>, even at levels as high as 65% of calories from fat. In the current study the fat in the fast food meal represented only 47% of calories.\u003c/p>\n\u003cp>Though the fast food meal used by the researchers undoubtedly matches the “typical western diet,” it is unlikely that the fat content is responsible for elevating triglycerides and the risk of heart disease that comes with them.\u003c/p>\n\u003cp>A better message for people worried about triglycerides: watch your sugar.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 38.5397702 -121.7554965\u003c/p>\n\n","blocks":[],"excerpt":"High-fat, low-carbohydrate diets have been used to treat high triglycerides since the 1960s.","status":"publish","parent":0,"modified":1371061507,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":439},"headData":{"title":"Scientists Understand Heart Disease Better, Still Give Bad Advice | KQED","description":"High-fat, low-carbohydrate diets have been used to treat high triglycerides since the 1960s.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Scientists Understand Heart Disease Better, Still Give Bad Advice","datePublished":"2011-02-18T17:00:41.000Z","dateModified":"2013-06-12T18:25:07.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"12346 http://www.kqed.org/quest/blog/?p=12346","disqusUrl":"https://ww2.kqed.org/quest/2011/02/18/scientists-understand-heart-disease-better-still-give-bad-advice/","disqusTitle":"Scientists Understand Heart Disease Better, Still Give Bad Advice","path":"/quest/12346/scientists-understand-heart-disease-better-still-give-bad-advice","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/02/fastfood12.jpg\" alt=\"\">\u003cem>Calling fast food \"high fat\" is true, but misleading. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/avlxyz/3861444749/\">avlxyz\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003ca href=\"http://ajpheart.physiology.org/content/early/2010/12/10/ajpheart.01036.2010.abstract\">New research\u003c/a> from UC Davis sheds light on how triglycerides induce atherosclerosis—the hardening of artery walls that causes heart disease—particularly in individuals with abdominal obesity. Unfortunately, however, the researchers credit the fat in the fast food meal they used to induce the triglyceride spike, while letting the more likely culprit, orange juice, completely off the hook.\u003c/p>\n\u003cp>In the study, researchers fed a fast food meal (two breakfast sandwiches, hash browns and orange juice, as noted in the \u003ca href=\"http://www.news.ucdavis.edu/search/news_detail.lasso?id=9767\">press release\u003c/a>) to people with either normal or elevated blood triglycerides. Triglycerides correlate strongly with risk of heart disease and are \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/19436658\">a better predictor of cardiovascular risk than total or LDL cholesterol\u003c/a>.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>After eating the horrible meal, triglycerides rose and LDL cholesterol was transported into cells in the artery wall, a process that leads to artery hardening and heart disease. This effect was worsened in the presence of cytokines, which are known to cause inflammation and correlate with a larger waist size.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The implication is that poor diet choices become more dangerous as a person's metabolic health declines, making good nutrition an even greater priority for people with abdominal obesity.\u003c/p>\n\u003cp>“The new study shows that eating a common fast food meal can affect inflammatory responses in the blood vessels,\" said the lead researcher, Anthony Passerini, and the effect seems to be worse in those with chronic inflammation and larger waists.\u003c/p>\n\u003cp>But why do they extrapolate and claim that this problem is caused by dietary fat?\u003c/p>\n\u003cp>The authors describe the fast food meal as “high-fat”, but neglect that it is also high in processed carbohydrates (two buns and hash browns) and fructose, the fruit sugar present in orange juice. Fructose is converted to triglycerides in the liver and is the \u003ca href=\"http://www.ajcn.org/content/20/2/131.long\">most effective way to increase triglyceride levels\u003c/a>.\u003c/p>\n\u003cp>Not only is fructose from the orange juice the most likely cause of the triglyceride effect, but it is particularly unlikely the fat had an impact. \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/5916038\">High-fat, low-carbohydrate diets have been used to \u003cem>treat\u003c/em> high triglycerides since the 1960s\u003c/a>, even at levels as high as 65% of calories from fat. In the current study the fat in the fast food meal represented only 47% of calories.\u003c/p>\n\u003cp>Though the fast food meal used by the researchers undoubtedly matches the “typical western diet,” it is unlikely that the fat content is responsible for elevating triglycerides and the risk of heart disease that comes with them.\u003c/p>\n\u003cp>A better message for people worried about triglycerides: watch your sugar.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 38.5397702 -121.7554965\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/12346/scientists-understand-heart-disease-better-still-give-bad-advice","authors":["10218"],"categories":["quest_12"],"tags":["quest_3441","quest_3467","quest_3498","quest_3543","quest_1077","quest_3583","quest_1332","quest_2822","quest_3804"],"featImg":"quest_12370","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. 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