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paternity tests will actually decrease the number of abortions.","credit":"Courtesy of Petteri Sulonen from Helsinki, Finland via Wikimedia 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Barry Starr","firstName":"Dr. Barry","lastName":"Starr","slug":"dr-barry-starr","email":"bstarr@thetech.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Dr. Barry Starr (\u003ca href=\"https://twitter.com/geneticsboy\">@geneticsboy\u003c/a>) is a Geneticist-in-Residence at The Tech Museum of Innovation in San Jose, CA and runs their Stanford at The Tech program. The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_48545":{"type":"posts","id":"quest_48545","meta":{"index":"posts_1591205157","site":"quest","id":"48545","score":null,"sort":[1358179223000]},"guestAuthors":[],"slug":"pregnancy-and-paternity-new-fetal-dna-testing","title":"Pregnancy and Paternity: New Fetal DNA Testing","publishDate":1358179223,"format":"aside","headTitle":"QUEST | KQED Science","labelTerm":{},"content":"\u003cfigure id=\"attachment_48666\" class=\"wp-caption aligncenter\" style=\"max-width: 635px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/01/14/pregnancy-and-paternity-new-fetal-dna-testing/pregnantwomangraffiti/\" rel=\"attachment wp-att-48666\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/01/PregnantWomanGraffiti.jpg\" alt=\"\" title=\"PregnantWomanGraffiti\" width=\"635\" height=\"369\" class=\"size-full wp-image-48666\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/01/PregnantWomanGraffiti.jpg 635w, https://ww2.kqed.org/app/uploads/sites/39/2013/01/PregnantWomanGraffiti-400x232.jpg 400w\" sizes=\"(max-width: 635px) 100vw, 635px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Prenatal paternity tests will actually decrease the number of abortions. Image courtesy of Petteri Sulonen from Helsinki, Finland via Wikimedia Commons. \u003ccite>(Courtesy of Petteri Sulonen from Helsinki, Finland via Wikimedia Commons.)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Imagine you are a woman in a committed relationship. The worst happens and you are raped and become pregnant. What are your options?\u003c/p>\n\u003cp>Until recently, there was no reliable and safe way to determine paternity in the first trimester. This meant that many women chose to terminate their pregnancy without knowing who the child’s father was. Obviously this is not ideal.\u003c/p>\n\u003cp>If the woman could determine paternity, she could use that information to help in her decision on whether to terminate the pregnancy. Undoubtedly this would lead to fewer abortions as more women choose to carry their partner’s child to term.\u003c/p>\n\u003cp>The tricky part of a prenatal paternity test is obviously getting a hold of fetal DNA. One method is amniocentesis. In this procedure, a needle is inserted into the amniotic sac and fluid is withdrawn. This fluid contains a lot of fetal DNA but getting it is not only invasive, it is also normally done somewhere between the 15th and 18th week of pregnancy. This is too late for many women.\u003c/p>\n\u003cp>Other methods take advantage of the fact that there is a bit of fetal DNA floating around in the plasma of mom’s blood. These tests have the advantage that they are noninvasive and can be done much earlier in pregnancy…sometimes as early as 8 weeks. The disadvantage of the \u003ca href=\"http://www.newscientist.com/article/mg20827893.200-the-danger-of-unreliable-paternity-tests.html\">early versions of the test\u003c/a> was that they weren’t always as accurate as we’d like.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>There are anecdotal cases out there of women losing their partner’s child because they thought the child was the result of the rapist and keeping the rapist’s child because they thought the child was their partner’s. This is obviously unacceptable.\u003c/p>\n\u003cp>Recently a couple of new tests have come on line that appear to be much more accurate. Both use the fetal DNA found in mom’s blood but use novel strategies to improve accuracy.\u003c/p>\n\u003cp>Scientists at one \u003ca href=\"http://www.ravgen.com/index.php?page=prenatal-dna-paternity-test-2\">testing company\u003c/a> present results in a recent \u003ca href=\"http://www.nejm.org/doi/full/10.1056/NEJMc1113044\">article \u003c/a>in the New England Journal of Medicine to back up their claims of accuracy. They set up an experiment where they had the mother’s, father’s, and an unrelated man’s DNA along with DNA from the mother’s blood plasma. This was a blind experiment in that the scientists did not know which of the two tubes containing the men’s DNA was from the father. They were able to correctly pick the father in 30 out of 30 cases. They claim the odds of this happening by chance are less than one out of a billion. (For those interested, the test is available \u003ca href=\"http://prenatal.ptclabs.com/\">here\u003c/a>.)\u003c/p>\n\u003cp>What was their secret? Well, as I talk about \u003ca href=\"http://genetics.thetech.org/ask-a-geneticist/prenatal-paternity-tests\">here\u003c/a>, the key difference is that they focus on small bits of DNA that could have only have come from the dad. Any DNA they find in mom’s blood that doesn’t match hers had to come from the fetus. This eliminates any issues of contaminating DNA from mom. If all of this DNA matches a prospective father’s, then he is most likely the dad.\u003c/p>\n\u003cp>This company has competition from another \u003ca href=\"http://natera.com/non-invasive-prenatal-paternity-test.html\">testing company\u003c/a> that is offering another high-powered test using fetal DNA found in mom’s blood. I’ve talked about the science behind this sort of test recently right \u003ca href=\"http://ww2.kqed.org/quest/2012/07/23/pregnant-women-face-big-questions-with-cheaper-dna-sequencing/\">here \u003c/a>at QUEST. There isn’t a New England Journal article that focuses on their prenatal test per se, but they did manage to sequence the entire genome of a fetus so they are probably up to the task!\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Even though it might seem counterintuitive, these tests will almost certainly decrease the number of abortions. And not only in cases of rape. These tests will also lead to more women keeping their children in cases of incest and even in some cases where a child might be conceived because of an extramarital affair.\u003c/p>\n\n","blocks":[],"excerpt":"Imagine you are a woman in a committed relationship. The worst happens and you are raped and become pregnant. What are your options?","status":"publish","parent":0,"modified":1442783343,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":13,"wordCount":696},"headData":{"title":"Pregnancy and Paternity: New Fetal DNA Testing | KQED","description":"Imagine you are a woman in a committed relationship. The worst happens and you are raped and become pregnant. What are your options?","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Pregnancy and Paternity: New Fetal DNA Testing","datePublished":"2013-01-14T16:00:23.000Z","dateModified":"2015-09-20T21:09:03.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"48545 http://science.kqed.org/quest/?p=48545","disqusUrl":"https://ww2.kqed.org/quest/2013/01/14/pregnancy-and-paternity-new-fetal-dna-testing/","disqusTitle":"Pregnancy and Paternity: New Fetal DNA Testing","source":"Health","sourceUrl":"https://ww2.kqed.org/quest/category/health/","path":"/quest/48545/pregnancy-and-paternity-new-fetal-dna-testing","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_48666\" class=\"wp-caption aligncenter\" style=\"max-width: 635px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/01/14/pregnancy-and-paternity-new-fetal-dna-testing/pregnantwomangraffiti/\" rel=\"attachment wp-att-48666\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/01/PregnantWomanGraffiti.jpg\" alt=\"\" title=\"PregnantWomanGraffiti\" width=\"635\" height=\"369\" class=\"size-full wp-image-48666\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/01/PregnantWomanGraffiti.jpg 635w, https://ww2.kqed.org/app/uploads/sites/39/2013/01/PregnantWomanGraffiti-400x232.jpg 400w\" sizes=\"(max-width: 635px) 100vw, 635px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Prenatal paternity tests will actually decrease the number of abortions. Image courtesy of Petteri Sulonen from Helsinki, Finland via Wikimedia Commons. \u003ccite>(Courtesy of Petteri Sulonen from Helsinki, Finland via Wikimedia Commons.)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Imagine you are a woman in a committed relationship. The worst happens and you are raped and become pregnant. What are your options?\u003c/p>\n\u003cp>Until recently, there was no reliable and safe way to determine paternity in the first trimester. This meant that many women chose to terminate their pregnancy without knowing who the child’s father was. Obviously this is not ideal.\u003c/p>\n\u003cp>If the woman could determine paternity, she could use that information to help in her decision on whether to terminate the pregnancy. Undoubtedly this would lead to fewer abortions as more women choose to carry their partner’s child to term.\u003c/p>\n\u003cp>The tricky part of a prenatal paternity test is obviously getting a hold of fetal DNA. One method is amniocentesis. In this procedure, a needle is inserted into the amniotic sac and fluid is withdrawn. This fluid contains a lot of fetal DNA but getting it is not only invasive, it is also normally done somewhere between the 15th and 18th week of pregnancy. This is too late for many women.\u003c/p>\n\u003cp>Other methods take advantage of the fact that there is a bit of fetal DNA floating around in the plasma of mom’s blood. These tests have the advantage that they are noninvasive and can be done much earlier in pregnancy…sometimes as early as 8 weeks. The disadvantage of the \u003ca href=\"http://www.newscientist.com/article/mg20827893.200-the-danger-of-unreliable-paternity-tests.html\">early versions of the test\u003c/a> was that they weren’t always as accurate as we’d like.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>There are anecdotal cases out there of women losing their partner’s child because they thought the child was the result of the rapist and keeping the rapist’s child because they thought the child was their partner’s. This is obviously unacceptable.\u003c/p>\n\u003cp>Recently a couple of new tests have come on line that appear to be much more accurate. Both use the fetal DNA found in mom’s blood but use novel strategies to improve accuracy.\u003c/p>\n\u003cp>Scientists at one \u003ca href=\"http://www.ravgen.com/index.php?page=prenatal-dna-paternity-test-2\">testing company\u003c/a> present results in a recent \u003ca href=\"http://www.nejm.org/doi/full/10.1056/NEJMc1113044\">article \u003c/a>in the New England Journal of Medicine to back up their claims of accuracy. They set up an experiment where they had the mother’s, father’s, and an unrelated man’s DNA along with DNA from the mother’s blood plasma. This was a blind experiment in that the scientists did not know which of the two tubes containing the men’s DNA was from the father. They were able to correctly pick the father in 30 out of 30 cases. They claim the odds of this happening by chance are less than one out of a billion. (For those interested, the test is available \u003ca href=\"http://prenatal.ptclabs.com/\">here\u003c/a>.)\u003c/p>\n\u003cp>What was their secret? Well, as I talk about \u003ca href=\"http://genetics.thetech.org/ask-a-geneticist/prenatal-paternity-tests\">here\u003c/a>, the key difference is that they focus on small bits of DNA that could have only have come from the dad. Any DNA they find in mom’s blood that doesn’t match hers had to come from the fetus. This eliminates any issues of contaminating DNA from mom. If all of this DNA matches a prospective father’s, then he is most likely the dad.\u003c/p>\n\u003cp>This company has competition from another \u003ca href=\"http://natera.com/non-invasive-prenatal-paternity-test.html\">testing company\u003c/a> that is offering another high-powered test using fetal DNA found in mom’s blood. I’ve talked about the science behind this sort of test recently right \u003ca href=\"http://ww2.kqed.org/quest/2012/07/23/pregnant-women-face-big-questions-with-cheaper-dna-sequencing/\">here \u003c/a>at QUEST. There isn’t a New England Journal article that focuses on their prenatal test per se, but they did manage to sequence the entire genome of a fetus so they are probably up to the task!\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Even though it might seem counterintuitive, these tests will almost certainly decrease the number of abortions. And not only in cases of rape. These tests will also lead to more women keeping their children in cases of incest and even in some cases where a child might be conceived because of an extramarital affair.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/48545/pregnancy-and-paternity-new-fetal-dna-testing","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_11680","quest_146","quest_2282","quest_11679","quest_13","quest_11681","quest_3319"],"featImg":"quest_48666","label":"source_quest_48545"},"quest_879":{"type":"posts","id":"quest_879","meta":{"index":"posts_1591205157","site":"quest","id":"879","score":null,"sort":[1224005144000]},"guestAuthors":[],"slug":"safer-prenatal-testing","title":"Safer Prenatal Testing","publishDate":1224005144,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://www.thetech.org/exhibits/online/ugenetics/images/ask/21.jpg\" width=\"300\" height=\"200\">\u003cem>Testing for Down syndrome may get much safer in the near future\u003c/em>\u003c/span>A \u003ca href=\"http://www.pnas.org/content/early/2008/10/03/0808319105.full.pdf+html\">new study\u003c/a> out from Stanford (yay Stanford!) promises to revolutionize prenatal testing. Instead of looking at a fetus’ cells, the test looks at mom’s blood. More specifically, it looks at the small amounts of fetal DNA found in her blood. \u003c/p>\n\u003cp>This test will get around the small but very real risk of miscarriage that comes with more invasive forms of testing like amniocentesis. Instead of inserting a needle through mom’s belly and into the amniotic sac, a doctor will insert a needle into her arm. This is obviously much safer for the fetus.\u003c/p>\n\u003cp>The test won’t be able to find everything though. It can’t find subtle genetic mutations like those that cause cystic fibrosis or sickle cell anemia.\u003c/p>\n\u003cp>What the test can do is identify fetuses with extra chromosomes. This is one of the main reasons women get prenatal testing--to screen for diseases like Down, Edward's or Patau syndrome. Each one of these is due to an extra chromosome that the test can detect. \u003c/p>\n\u003cp>The test is actually marvelously simple. A sample of blood is taken from mom and the cells are removed. The researchers then take a close look at the DNA that is left behind. Most of this DNA comes from mom but some comes from the fetus too.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The researchers then figure out what millions of bits of the DNA look like. Next they match the bits of DNA to the chromosomes they came from. If more of the DNA bits match a certain chromosome than expected, then there is most likely an extra copy of that particular chromosome. \u003c/p>\n\u003cp>Think about it this way. Imagine a bag full of 23 different colored marbles where each color represents one human chromosome. You pull out marbles millions of times and then tally up the colors you get. (This can either be a ginormous bag or you can put the marbles back in once you pick one.)\u003c/p>\n\u003cp>If you pick more blue marbles, then there were probably more blue ones in the bag to start with. Of course this only works if you pick marbles many, many times. \u003c/p>\n\u003cp>Instead of using marbles, the researchers looked at the millions of bits of DNA they collected. They found that if there was an extra chromosome, then DNA bits from that chromosome were overrepresented. For example, they found that the 9 Down syndrome pregnancies they looked at had anywhere from 4-18% more chromosome 21 DNA than normal pregnancies*. \u003c/p>\n\u003cp>The 4% number was good enough to find pregnancies with extra chromosomes in this small study. They’ll need to repeat it in a larger study to turn this great idea into a diagnostic test for the public.\u003c/p>\n\u003cp>The test costs about 700 dollars to run right now but as sequencing gets cheaper (and it will), that cost should go way down. Also, right now they had to wait for the 14th week (which is a bit earlier than the 15-18 weeks for an amnio). Hopefully they’ll be able to improve the method to get testing done even earlier.\u003c/p>\n\u003cp>*\u003cem>The reason they didn’t get 50% more (as you might expect from having an extra chromosome) is that the fetal DNA made up only a small fraction of the DNA in the sample. In other words, most of the DNA was mom's.\u003c/em>\u003cbr>\n\u003cbr clear=\"all\">\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n","blocks":[],"excerpt":"A new study out from Stanford (yay Stanford!) promises to revolutionize prenatal testing. Instead of looking at a fetus’ cells, the test looks at mom’s blood. More specifically, it looks at the small amounts of fetal DNA found in her blood.","status":"publish","parent":0,"modified":1309998669,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":583},"headData":{"title":"Safer Prenatal Testing | KQED","description":"A new study out from Stanford (yay Stanford!) promises to revolutionize prenatal testing. Instead of looking at a fetus’ cells, the test looks at mom’s blood. More specifically, it looks at the small amounts of fetal DNA found in her blood.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Safer Prenatal Testing","datePublished":"2008-10-14T17:25:44.000Z","dateModified":"2011-07-07T00:31:09.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"879 http://www.kqed.org/quest/blog/?p=879","disqusUrl":"https://ww2.kqed.org/quest/2008/10/14/safer-prenatal-testing/","disqusTitle":"Safer Prenatal Testing","path":"/quest/879/safer-prenatal-testing","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://www.thetech.org/exhibits/online/ugenetics/images/ask/21.jpg\" width=\"300\" height=\"200\">\u003cem>Testing for Down syndrome may get much safer in the near future\u003c/em>\u003c/span>A \u003ca href=\"http://www.pnas.org/content/early/2008/10/03/0808319105.full.pdf+html\">new study\u003c/a> out from Stanford (yay Stanford!) promises to revolutionize prenatal testing. Instead of looking at a fetus’ cells, the test looks at mom’s blood. More specifically, it looks at the small amounts of fetal DNA found in her blood. \u003c/p>\n\u003cp>This test will get around the small but very real risk of miscarriage that comes with more invasive forms of testing like amniocentesis. Instead of inserting a needle through mom’s belly and into the amniotic sac, a doctor will insert a needle into her arm. This is obviously much safer for the fetus.\u003c/p>\n\u003cp>The test won’t be able to find everything though. It can’t find subtle genetic mutations like those that cause cystic fibrosis or sickle cell anemia.\u003c/p>\n\u003cp>What the test can do is identify fetuses with extra chromosomes. This is one of the main reasons women get prenatal testing--to screen for diseases like Down, Edward's or Patau syndrome. Each one of these is due to an extra chromosome that the test can detect. \u003c/p>\n\u003cp>The test is actually marvelously simple. A sample of blood is taken from mom and the cells are removed. The researchers then take a close look at the DNA that is left behind. Most of this DNA comes from mom but some comes from the fetus too.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The researchers then figure out what millions of bits of the DNA look like. Next they match the bits of DNA to the chromosomes they came from. If more of the DNA bits match a certain chromosome than expected, then there is most likely an extra copy of that particular chromosome. \u003c/p>\n\u003cp>Think about it this way. Imagine a bag full of 23 different colored marbles where each color represents one human chromosome. You pull out marbles millions of times and then tally up the colors you get. (This can either be a ginormous bag or you can put the marbles back in once you pick one.)\u003c/p>\n\u003cp>If you pick more blue marbles, then there were probably more blue ones in the bag to start with. Of course this only works if you pick marbles many, many times. \u003c/p>\n\u003cp>Instead of using marbles, the researchers looked at the millions of bits of DNA they collected. They found that if there was an extra chromosome, then DNA bits from that chromosome were overrepresented. For example, they found that the 9 Down syndrome pregnancies they looked at had anywhere from 4-18% more chromosome 21 DNA than normal pregnancies*. \u003c/p>\n\u003cp>The 4% number was good enough to find pregnancies with extra chromosomes in this small study. They’ll need to repeat it in a larger study to turn this great idea into a diagnostic test for the public.\u003c/p>\n\u003cp>The test costs about 700 dollars to run right now but as sequencing gets cheaper (and it will), that cost should go way down. Also, right now they had to wait for the 14th week (which is a bit earlier than the 15-18 weeks for an amnio). Hopefully they’ll be able to improve the method to get testing done even earlier.\u003c/p>\n\u003cp>*\u003cem>The reason they didn’t get 50% more (as you might expect from having an extra chromosome) is that the fetal DNA made up only a small fraction of the DNA in the sample. In other words, most of the DNA was mom's.\u003c/em>\u003cbr>\n\u003cbr clear=\"all\">\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/879/safer-prenatal-testing","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_145","quest_146","quest_848","quest_868","quest_1192","quest_1197","quest_3351","quest_2141","quest_2282","quest_2907"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. 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