SF Scientist Among Pair of California Researchers Awarded Nobel Prize for Work on How Humans Perceive Heat and Touch
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for our survival.'[/pullquote]One of the researchers is \u003ca href=\"https://www.ucsf.edu/news/2021/09/421481/david-julius-wins-nobel-prize-work-pain-sensation\">David Julius, a biochemist and molecular biologist at UCSF\u003c/a>. A few hundred miles south, Ardem Patapoutian at Scripps Research Institute in La Jolla also separately identified receptors in the skin that respond to heat and pressure.\u003c/p>\n\u003cp>Some hope the discoveries could eventually lead to pain treatments that reduce dependence on highly addictive opioids. But the breakthroughs, which happened decades ago, have not yet yielded many effective new therapies.\u003c/p>\n\u003cp>Julius used capsaicin, the active component in chili peppers, to help pinpoint the nerve sensors that respond to heat, the Nobel Committee said. Patapoutian found pressure-sensitive sensors in cells that respond to mechanical stimulation.\u003c/p>\n\u003cp>“This really unlocks one of the secrets of nature,” said Thomas Perlmann, secretary-general of the committee, in announcing the winners. “It’s actually something that is crucial for our survival, so it’s a very important and profound discovery.”\u003c/p>\n\u003cp>In keeping with a long tradition of difficulties in alerting Nobel winners, Julius, 65, said he was awakened by what he thought was a prank phone call shortly before the prize was announced.\u003c/p>\n\u003cp>“My phone sort of bleeped, and it was from a relative who had been contacted by somebody on the Nobel Committee trying to find my phone number,” he said from his home in San Francisco, where it was the middle of the night.\u003c/p>\n\u003cp>It was only when his wife heard Perlmann’s voice — his wife worked with Perlmann years ago, Julius said — and confirmed it was indeed the secretary-general of the committee who was calling, that he realized it wasn’t a joke.\u003c/p>\n\u003cp>Julius later said he hoped his work would lead to the development of new pain drugs, explaining that the biology behind even everyday activities can have enormous significance.\u003c/p>\n\u003cp>“We eat chili peppers and menthol, but oftentimes, you don’t think about how that works,” he said.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The Nobel Committee said their discoveries get at “one of the great mysteries facing humanity”: how we sense our environment.\u003c/p>\n\u003cp>The choice of winners underscored how little scientists knew about that question before the discoveries — and how much there still is to learn, said Oscar Marin, director of the MRC Centre for Neurodevelopmental Disorders at King’s College London.\u003c/p>\n\u003cp>“While we understood the physiology of the senses, what we didn’t understand was how we sensed differences in temperature or pressure,” Marin said. “Knowing how our body senses these changes is fundamental because once we know those molecules, they can be targeted. It’s like finding a lock, and now we know the precise keys that will be necessary to unlock it.”\u003c/p>\n\u003cp>Marin predicted that new treatments for pain would likely come first, but that understanding how the body detects changes in pressure could eventually lead to drugs for heart disease, if scientists can figure out how to alleviate pressure on blood vessels and other organs.\u003c/p>\n\u003cp>Richard Harris, of the Chronic Pain and Fatigue Research Center at the University of Michigan, also said the new laureates’ work might help design new pain medications, but noted the field has long been stalled.\u003c/p>\n\u003cp>He said that because pain also includes a psychological component, simply identifying how it is triggered in the body isn’t necessarily enough to address it. Still, he said Julius’s and Patapoutian’s work likely would help doctors better treat pain that is caused by things like extreme temperatures and chemical burns.\u003c/p>\n\u003cp>“Their discoveries are giving us the first inkling of how this type of pain starts, but whether it’s involved in many chronic pain patients remains to be seen,” he said.\u003c/p>\n\u003cp>Still, Fiona Boissonade, a pain specialist at the University of Sheffield in the U.K., said the Nobel laureates’ work was especially relevant for the one in five people globally who suffer from chronic pain.\u003c/p>\n\u003cp>Such pain — including from arthritis, migraines and chronic back problems — “is a huge medical problem, and it’s quite poorly treated across the board,” she said. “Their research may lead us to identify new compounds that are effective in treating pain that don’t come with the devastating impact of opioids,” which have spawned a crisis of addiction in the U.S.\u003c/p>\n\u003cp>[aside label ='Related Coverage' tag='science']The Nobel Committee tweeted a photo of Patapoutian in bed with his son while he watched the announcement on his computer.\u003c/p>\n\u003cp>“A day to be thankful: this country gave me a chance with a great education and support for basic research. And for my labbies and collaborators for partnering with me,” Patapoutian, who was born in Lebanon, tweeted.\u003c/p>\n\u003cp>The prestigious award comes with a gold medal and 10 million Swedish kronor (over $1.14 million). The prize money comes from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel, who died in 1896.\u003c/p>\n\u003cp>The prize is the first to be awarded this year. The other prizes are for outstanding work in the fields of physics, chemistry, literature, peace and economics.\u003cbr>\n[ad fullwidth]\u003c/p>\n\u003cp>\u003c/p>\n","blocks":[],"excerpt":"David Julius, a San Francisco-based biochemist at UCSF, is one of the recipients of this year's Nobel Prize in Physiology or Medicine for his research on capsaicin.","status":"publish","parent":0,"modified":1633382637,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":25,"wordCount":945},"headData":{"title":"SF Scientist Among Pair of California Researchers Awarded Nobel Prize for Work on How Humans Perceive Heat and Touch | KQED","description":"David Julius, a San Francisco-based biochemist at UCSF, is one of the recipients of this year's Nobel Prize in Physiology or Medicine for his research on capsaicin.","ogTitle":"SF Scientist Among Pair Awarded Nobel Prize for Research on How Humans Perceive Heat and Touch","ogDescription":"","ogImgId":"","twTitle":"SF Scientist Among Pair Awarded Nobel Prize for Research on How Humans Perceive Heat and Touch","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"NewsArticle","headline":"SF Scientist Among Pair of California Researchers Awarded Nobel Prize for Work on How Humans Perceive Heat and Touch","datePublished":"2021-10-04T17:12:26.000Z","dateModified":"2021-10-04T21:23:57.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png","isAccessibleForFree":"Y","publisher":{"@type":"NewsMediaOrganization","@id":"https://www.kqed.org/#organization","name":"KQED","url":"https://www.kqed.org","logo":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}}},"disqusIdentifier":"11890903 https://ww2.kqed.org/news/?p=11890903","disqusUrl":"https://ww2.kqed.org/news/2021/10/04/two-california-scientists-clinch-nobel-prize-for-research-on-how-humans-perceive-heat-and-touch/","disqusTitle":"SF Scientist Among Pair of California Researchers Awarded Nobel Prize for Work on How Humans Perceive Heat and Touch","nprByline":"David Keyton, Maria Cheng \u003cbr> The Associated Press","path":"/news/11890903/two-california-scientists-clinch-nobel-prize-for-research-on-how-humans-perceive-heat-and-touch","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Two scientists based in California won the Nobel Prize in medicine on Monday for their discoveries into how the human body perceives temperature and touch, revelations that could lead to new ways of treating pain or even heart disease.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"'This really unlocks one of the secrets of nature … It’s actually something that is crucial for our survival.'","name":"pullquote","attributes":{"named":{"align":"right","size":"medium","citation":"Thomas Perlmann, secretary-general of the Nobel Committee","label":""},"numeric":[]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>One of the researchers is \u003ca href=\"https://www.ucsf.edu/news/2021/09/421481/david-julius-wins-nobel-prize-work-pain-sensation\">David Julius, a biochemist and molecular biologist at UCSF\u003c/a>. A few hundred miles south, Ardem Patapoutian at Scripps Research Institute in La Jolla also separately identified receptors in the skin that respond to heat and pressure.\u003c/p>\n\u003cp>Some hope the discoveries could eventually lead to pain treatments that reduce dependence on highly addictive opioids. But the breakthroughs, which happened decades ago, have not yet yielded many effective new therapies.\u003c/p>\n\u003cp>Julius used capsaicin, the active component in chili peppers, to help pinpoint the nerve sensors that respond to heat, the Nobel Committee said. Patapoutian found pressure-sensitive sensors in cells that respond to mechanical stimulation.\u003c/p>\n\u003cp>“This really unlocks one of the secrets of nature,” said Thomas Perlmann, secretary-general of the committee, in announcing the winners. “It’s actually something that is crucial for our survival, so it’s a very important and profound discovery.”\u003c/p>\n\u003cp>In keeping with a long tradition of difficulties in alerting Nobel winners, Julius, 65, said he was awakened by what he thought was a prank phone call shortly before the prize was announced.\u003c/p>\n\u003cp>“My phone sort of bleeped, and it was from a relative who had been contacted by somebody on the Nobel Committee trying to find my phone number,” he said from his home in San Francisco, where it was the middle of the night.\u003c/p>\n\u003cp>It was only when his wife heard Perlmann’s voice — his wife worked with Perlmann years ago, Julius said — and confirmed it was indeed the secretary-general of the committee who was calling, that he realized it wasn’t a joke.\u003c/p>\n\u003cp>Julius later said he hoped his work would lead to the development of new pain drugs, explaining that the biology behind even everyday activities can have enormous significance.\u003c/p>\n\u003cp>“We eat chili peppers and menthol, but oftentimes, you don’t think about how that works,” he said.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The Nobel Committee said their discoveries get at “one of the great mysteries facing humanity”: how we sense our environment.\u003c/p>\n\u003cp>The choice of winners underscored how little scientists knew about that question before the discoveries — and how much there still is to learn, said Oscar Marin, director of the MRC Centre for Neurodevelopmental Disorders at King’s College London.\u003c/p>\n\u003cp>“While we understood the physiology of the senses, what we didn’t understand was how we sensed differences in temperature or pressure,” Marin said. “Knowing how our body senses these changes is fundamental because once we know those molecules, they can be targeted. It’s like finding a lock, and now we know the precise keys that will be necessary to unlock it.”\u003c/p>\n\u003cp>Marin predicted that new treatments for pain would likely come first, but that understanding how the body detects changes in pressure could eventually lead to drugs for heart disease, if scientists can figure out how to alleviate pressure on blood vessels and other organs.\u003c/p>\n\u003cp>Richard Harris, of the Chronic Pain and Fatigue Research Center at the University of Michigan, also said the new laureates’ work might help design new pain medications, but noted the field has long been stalled.\u003c/p>\n\u003cp>He said that because pain also includes a psychological component, simply identifying how it is triggered in the body isn’t necessarily enough to address it. Still, he said Julius’s and Patapoutian’s work likely would help doctors better treat pain that is caused by things like extreme temperatures and chemical burns.\u003c/p>\n\u003cp>“Their discoveries are giving us the first inkling of how this type of pain starts, but whether it’s involved in many chronic pain patients remains to be seen,” he said.\u003c/p>\n\u003cp>Still, Fiona Boissonade, a pain specialist at the University of Sheffield in the U.K., said the Nobel laureates’ work was especially relevant for the one in five people globally who suffer from chronic pain.\u003c/p>\n\u003cp>Such pain — including from arthritis, migraines and chronic back problems — “is a huge medical problem, and it’s quite poorly treated across the board,” she said. “Their research may lead us to identify new compounds that are effective in treating pain that don’t come with the devastating impact of opioids,” which have spawned a crisis of addiction in the U.S.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"aside","attributes":{"named":{"label":"Related Coverage ","tag":"science"},"numeric":[]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>The Nobel Committee tweeted a photo of Patapoutian in bed with his son while he watched the announcement on his computer.\u003c/p>\n\u003cp>“A day to be thankful: this country gave me a chance with a great education and support for basic research. And for my labbies and collaborators for partnering with me,” Patapoutian, who was born in Lebanon, tweeted.\u003c/p>\n\u003cp>The prestigious award comes with a gold medal and 10 million Swedish kronor (over $1.14 million). The prize money comes from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel, who died in 1896.\u003c/p>\n\u003cp>The prize is the first to be awarded this year. The other prizes are for outstanding work in the fields of physics, chemistry, literature, peace and economics.\u003cbr>\n\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/news/11890903/two-california-scientists-clinch-nobel-prize-for-research-on-how-humans-perceive-heat-and-touch","authors":["byline_news_11890903"],"categories":["news_457","news_8","news_356"],"tags":["news_29983","news_29980","news_29982","news_3332","news_29981","news_29984","news_3187","news_20292","news_922"],"featImg":"news_11890904","label":"news"},"futureofyou_444705":{"type":"posts","id":"futureofyou_444705","meta":{"index":"posts_1591205157","site":"futureofyou","id":"444705","score":null,"sort":[1538417110000]},"guestAuthors":[],"slug":"nobel-prize-for-landmark-cancer-research-conducted-at-berkeley","title":"Nobel Prize for 'Landmark' Cancer Research Conducted at UC Berkeley","publishDate":1538417110,"format":"aside","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>https://www.youtube.com/watch?time_continue=899&v=ScuTG1bzSHY\u003c/p>\n\u003cp>The Nobel Prize in medicine was awarded Monday to two researchers from the United States and Japan for advances in discovering how the body’s immune system can fight off the scourge of cancer.[contextly_sidebar id=\"CWuF65jUQjKNMEH73SFwE7Eh0o965day\"]\u003c/p>\n\u003cp>The $1.01 million prize will be shared by James Allison and Tasuku Honjo.\u003c/p>\n\u003cp>Allison conducted his research at the University of California-Berkeley and is now at the M.D. Anderson cancer center in Houston. Honju works at Japan’s Kyoto University.\u003c/p>\n\u003cp>Their parallel work concerned proteins that act as brakes on the body’s immune system and it constitutes “a landmark in our fight against cancer,” said a statement from the Nobel Assembly of Sweden’s Karolinska Institute, which selects winners of the annual prestigious award.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Allison studied a known protein and developed the concept into a new treatment approach, while Honjo discovered a new protein that also operated as a brake on immune cells.\u003c/p>\n\u003cp>“I’m honored and humbled to receive this prestigious recognition,” Allison said in a statement released by the university’s MD Anderson Cancer Center in Houston, where he is a professor.\u003c/p>\n\u003cp>“A driving motivation for scientists is simply to push the frontiers of knowledge. I didn’t set out to study cancer, but to understand the biology of T cells, these incredible cells that travel our bodies and work to protect us,” he said.[contextly_sidebar id=\"TrEVYlEaRWGIwxl3wZCxQN7b50EP4tx2\"]\u003c/p>\n\u003cp>Allison takes care in his statement to give credit to “a succession of graduate students, postdoctoral fellows and colleagues at MD Anderson, the University of California, Berkeley, and Memorial Sloan Kettering Cancer Center” who joined in the research.\u003c/p>\n\u003cp>Allison’s and Honjo’s prize-winning work started in the 1990s and was part of significant advances in cancer immunotherapy.\u003c/p>\n\u003cp>“In some patients, this therapy is remarkably effective,” Jeremy Berg, editor-in-chief of the \u003cem>Science\u003c/em> family of journals, told The Associated Press. “The number of different types of cancers for which this approach to immunotherapy is being found to be effective in at least some patients continues to grow.”\u003c/p>\n\u003cp>Therapy developed from Honjo’s work led to long-term remission in patients with metastatic cancer that had been considered essentially untreatable, the Nobel Assembly said.[contextly_sidebar id=\"JxHmQ4y9gmGqrPe0YiiMCtrrGiOV1Oid\"]\u003c/p>\n\u003cp>Berg said that former President Jimmy Carter’s cancer, which had spread to his brain, was treated with one of the drugs developed from Honjo’s work.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The physics prize is to be announced Tuesday, followed by chemistry. The winner of the Nobel Peace Prize will be named Friday and the economics laureate will be announced next Monday. No literature prize is being given this year.\u003c/p>\n\n","blocks":[],"excerpt":"The research, which has led to drugs that release the brakes on the immune system, constitutes “a landmark\" in the fight against cancer.","status":"publish","parent":0,"modified":1538445547,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":471},"headData":{"title":"Nobel Prize for 'Landmark' Cancer Research Conducted at UC Berkeley | KQED","description":"The research, which has led to drugs that release the brakes on the immune system, constitutes “a landmark" in the fight against cancer.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Nobel Prize for 'Landmark' Cancer Research Conducted at UC Berkeley","datePublished":"2018-10-01T18:05:10.000Z","dateModified":"2018-10-02T01:59:07.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"444705 https://ww2.kqed.org/futureofyou/?p=444705","disqusUrl":"https://ww2.kqed.org/futureofyou/2018/10/01/nobel-prize-for-landmark-cancer-research-conducted-at-berkeley/","disqusTitle":"Nobel Prize for 'Landmark' Cancer Research Conducted at UC Berkeley","source":"Events","nprByline":"David Keyton\u003cbr />Jim Heintz \u003cbr />The Associated Press","path":"/futureofyou/444705/nobel-prize-for-landmark-cancer-research-conducted-at-berkeley","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/ScuTG1bzSHY'\n title='//www.youtube.com/embed/ScuTG1bzSHY'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>The Nobel Prize in medicine was awarded Monday to two researchers from the United States and Japan for advances in discovering how the body’s immune system can fight off the scourge of cancer.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>The $1.01 million prize will be shared by James Allison and Tasuku Honjo.\u003c/p>\n\u003cp>Allison conducted his research at the University of California-Berkeley and is now at the M.D. Anderson cancer center in Houston. Honju works at Japan’s Kyoto University.\u003c/p>\n\u003cp>Their parallel work concerned proteins that act as brakes on the body’s immune system and it constitutes “a landmark in our fight against cancer,” said a statement from the Nobel Assembly of Sweden’s Karolinska Institute, which selects winners of the annual prestigious award.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Allison studied a known protein and developed the concept into a new treatment approach, while Honjo discovered a new protein that also operated as a brake on immune cells.\u003c/p>\n\u003cp>“I’m honored and humbled to receive this prestigious recognition,” Allison said in a statement released by the university’s MD Anderson Cancer Center in Houston, where he is a professor.\u003c/p>\n\u003cp>“A driving motivation for scientists is simply to push the frontiers of knowledge. I didn’t set out to study cancer, but to understand the biology of T cells, these incredible cells that travel our bodies and work to protect us,” he said.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>Allison takes care in his statement to give credit to “a succession of graduate students, postdoctoral fellows and colleagues at MD Anderson, the University of California, Berkeley, and Memorial Sloan Kettering Cancer Center” who joined in the research.\u003c/p>\n\u003cp>Allison’s and Honjo’s prize-winning work started in the 1990s and was part of significant advances in cancer immunotherapy.\u003c/p>\n\u003cp>“In some patients, this therapy is remarkably effective,” Jeremy Berg, editor-in-chief of the \u003cem>Science\u003c/em> family of journals, told The Associated Press. “The number of different types of cancers for which this approach to immunotherapy is being found to be effective in at least some patients continues to grow.”\u003c/p>\n\u003cp>Therapy developed from Honjo’s work led to long-term remission in patients with metastatic cancer that had been considered essentially untreatable, the Nobel Assembly said.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>Berg said that former President Jimmy Carter’s cancer, which had spread to his brain, was treated with one of the drugs developed from Honjo’s work.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The physics prize is to be announced Tuesday, followed by chemistry. The winner of the Nobel Peace Prize will be named Friday and the economics laureate will be announced next Monday. No literature prize is being given this year.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/444705/nobel-prize-for-landmark-cancer-research-conducted-at-berkeley","authors":["byline_futureofyou_444705"],"categories":["futureofyou_1","futureofyou_73"],"tags":["futureofyou_103","futureofyou_686","futureofyou_80","futureofyou_607"],"collections":["futureofyou_1097"],"featImg":"futureofyou_444717","label":"source_futureofyou_444705"},"news_114340":{"type":"posts","id":"news_114340","meta":{"index":"posts_1591205157","site":"news","id":"114340","score":null,"sort":[1381333330000]},"guestAuthors":[],"slug":"stanford-biologist-shares-nobel-in-chemistry","title":"2013 Nobels: Stanford Biologist Shares Prize in Chemistry ","publishDate":1381333330,"format":"aside","headTitle":"News Fix | KQED News","labelTerm":{"term":6944,"site":"news"},"content":"\u003cfigure id=\"attachment_114341\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/news/2013/10/09/michael-levitt-stanford-university-2013-nobel-prize-chemistry/attachment/183691930/\" rel=\"attachment wp-att-114341\">\u003cimg class=\"size-large wp-image-114341\" src=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/183691930-1024x544.jpg\" alt=\"The three researchers who share the 2013 Nobel Prize in Chemistry. From left: Martin Karplus of Harvard, Michael Levitt of Stanford, and Arieh Warshel of the University of Southern California. (Getty Images)\" width=\"640\" height=\"340\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The three researchers who share the 2013 Nobel Prize in Chemistry. From left: Martin Karplus of Harvard, Michael Levitt of Stanford, and Arieh Warshel of the University of Southern California. (Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>Stanford biologist \u003ca href=\"http://news.stanford.edu/news/2013/october/levitt-nobel-chemistry-100913.html\" target=\"_blank\">Michael Levitt\u003c/a> is one of three scientists to share the Nobel Prize in chemistry for developing powerful, computer-aided tools to model the complex chemical processes at the foundation of life. Levitt's co-winners are \u003ca href=\"http://news.harvard.edu/gazette/story/2013/10/harvard-professor-wins-nobel-in-chemistry/\" target=\"_blank\">Martin Karplus\u003c/a> of the University of Strasbourg in France and Harvard University, and \u003ca href=\"http://chem.usc.edu/faculty/Warshel.html\" target=\"_blank\">Arieh Warshel\u003c/a> of the University of Southern California.\u003c/p>\n\u003caside class=\"pullquote alignleft\">\"I heard a Swedish accent and got very excited. It was like having five double espressos.\"\u003c/aside>\n\u003cp>When the three men started studying chemistry, scientists built models of atoms and molecules with sticks and balls. As you can imagine, that made it cumbersome to portray complex molecules, and nigh impossible to create a model of the light-speed chemical reactions by which cells consume food, say, or drugs battle bacteria.\u003c/p>\n\u003cp>Levitt, Karplus and Warshel won the Nobel prize for figuring out how to model these chemical reactions in cyberspace, at a time when computers still ran on punch cards, and didn't have the power to run the complex calculations needed. In his fascinating blog post, \u003ca href=\"http://www.npr.org/blogs/health/2013/10/09/230645376/nobel-goes-to-scientists-who-took-chemistry-into-cyberspace\" target=\"_blank\">NPR's Michaeleen Doucleff explains\u003c/a> how the work of each man dovetailed precisely with the others, to break open whole new possibilities for scientific research that had previously seemed out of reach.\u003c/p>\n\u003cp>Their work \"led to such practical applications such as the production of human antibodies for modern anticancer therapy and catalysts to clean car exhaust fumes,\" Mercury News reporter \u003ca href=\"http://www.mercurynews.com/science/ci_24271770/stanford-nobel-prize-chemistry-second-2013-levitt\" target=\"_blank\">Lisa M. Krieger explains\u003c/a>.\u003c/p>\n\u003cp>Levitt said \u003ca href=\"http://news.stanford.edu/features/2013/nobel/\" target=\"_blank\">on a Stanford website honoring his award\u003c/a> that he got the news early this morning.\u003c/p>\n\u003cblockquote>\u003cp>\"Like everyone else, one is surprised,\" said Levitt of the early morning call. \"Now I just hope to get through the day and make sure that, in the end, my life doesn't change very much. Because I really have a wonderful life.\u003c/p>\n\u003cp>\"My phone never rings,\" he added. \"Everyone sends me texts and email. So when the phone first rang, I was sure it was a wrong number. When it rang a second time, I picked it up. I immediately heard a Swedish accent and got very excited. It was like having five double espressos.\"\u003c/p>\u003c/blockquote>\n\u003cp>\u003c!--more-->All three of today's winners are immigrants who came to the United States early in their research careers: Levitt is a U.S.-U.K.-Israeli citizen born in South Africa; Karplus is a dual U.S.-Austrian citizen; and Warshel is a dual national of Israel and the United States.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Levitt gave an overview of his research to KQED's Joshua Johnson this morning:\u003c/p>\n\u003cblockquote>\u003cp>It’s research that started in 1967, so it’s research that’s been going on ever since I was 20 years old, so for 46 years. Basically, it tries to simulate the molecules of life. And simulation is now quite common — flight simulators and for bridges. I’m sure the Bay Bridge was simulated to pieces before it was built. So simulation is a very important tool. We started doing simulations on molecules back in the late ‘60s, principally because it had become clear that molecules had very well-defined shapes. They were complicated, they consisted of a thousand spheres, or a thousand atoms, and all these atoms were very precisely arranged.\u003c/p>\n\u003cfigure id=\"attachment_114402\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://scopeblog.stanford.edu/2013/10/09/nobel-winner-michael-levitts-work-animates-biological-processes/\" rel=\"attachment wp-att-114402\">\u003cimg class=\"size-full wp-image-114402 \" src=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/protein-folding.jpg\" alt=\"This Stanford video explains how the work of Levitt and his Nobel colleagues benefits medicine, as researchers observe how protein molecules come together in ways that are healthy, or that promote disease. (Courtesy of Stanford University)\" width=\"300\" height=\"225\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">This Stanford video explains how the work of Levitt and his Nobel colleagues benefits medicine, as researchers observe how protein molecules come together in ways that are healthy, or that promote disease. (Courtesy of Stanford University)\u003c/figcaption>\u003c/figure>\n\u003cp>The molecules are much like the inside of a clock … they were all highly arranged in space. Once things are very arranged in space, you can do very precise calculations. You can simulate how they move, how they will behave under stress and so on. So it becomes a rather mechanical calculation, not exactly the same as simulating a jet airliner or a bridge or a nuclear explosion, but it’s a similar principal where you have a system and \u003ca href=\"http://scopeblog.stanford.edu/2013/10/09/nobel-winner-michael-levitts-work-animates-biological-processes/\" target=\"_blank\">you see how it changes over time.\u003c/a>\u003c/p>\n\u003cp>… This is something which ties in very closely to experiment because the shapes of these molecules were actually determined experimentally by crystallography, and that resulted in many Nobel Prizes--I guess in the early 1960s. Since then, it took a long, long time for people to appreciate that computation had a role to play. For me, the big excitement is to see computational biology honored in this way, because computers have had such a massive impact on everything else we do.\u003c/p>\u003c/blockquote>\n\u003cp>He also said simplicity in models remains crucial even though computer time, once a crushing research expense, has “become cheaper by a factor of 100 million or so.” Levitt said the computational representations of chemical processes he employs now are very similar to those he and his colleagues pioneered in the late ‘60s and early ‘70s.\u003c/p>\n\u003cp>Here's the summary of the trio's groundbreaking work from the Royal Swedish Academy of Sciences, which awards the Nobel in chemistry:\u003c/p>\n\u003cblockquote>\u003cp>Chemical reactions occur at lightning speed. In a fraction of a millisecond, electrons jump from one atomic nucleus to the other. Classical chemistry has a hard time keeping up; it is virtually impossible to experimentally map every little step in a chemical process. Aided by the methods now awarded with the Nobel Prize in Chemistry, scientists let computers unveil chemical processes, such as a catalyst’s purification of exhaust fumes or the photosynthesis in green leaves.\u003c/p>\n\u003cp>The work of Karplus, Levitt and Warshel is groundbreaking in that they managed to make Newton’s classical physics work side by side with the fundamentally different quantum physics. Previously, chemists had to choose to use either or. The strength of classical physics was that calculations were simple and could be used to model really large molecules. Its weakness, it offered no way to simulate chemical reactions. For that purpose, chemists instead had to use quantum physics. But such calculations required enormous computing power and could therefore only be carried out for small molecules.\u003c/p>\n\u003cp>This year’s Nobel Laureates in chemistry took the best from both worlds and devised methods that use both classical and quantum physics. For instance, in simulations of how a drug couples to its target protein in the body, the computer performs quantum theoretical calculations on those atoms in the target protein that interact with the drug. The rest of the large protein is simulated using less demanding classical physics.\u003c/p>\u003c/blockquote>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>Joshua Johnson and Kat Snow of KQED News contributed to this report.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"Michael Levitt is one of three scientists honored for pioneering work in computerized chemical analysis. ","status":"publish","parent":0,"modified":1381366674,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":20,"wordCount":1120},"headData":{"title":"2013 Nobels: Stanford Biologist Shares Prize in Chemistry | KQED","description":"Michael Levitt is one of three scientists honored for pioneering work in computerized chemical analysis. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"NewsArticle","headline":"2013 Nobels: Stanford Biologist Shares Prize in Chemistry ","datePublished":"2013-10-09T15:42:10.000Z","dateModified":"2013-10-10T00:57:54.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png","isAccessibleForFree":"Y","publisher":{"@type":"NewsMediaOrganization","@id":"https://www.kqed.org/#organization","name":"KQED","url":"https://www.kqed.org","logo":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}}},"disqusIdentifier":"114340 http://ww2.kqed.org/news/?p=114340","disqusUrl":"https://ww2.kqed.org/news/2013/10/09/stanford-biologist-shares-nobel-in-chemistry/","disqusTitle":"2013 Nobels: Stanford Biologist Shares Prize in Chemistry ","customPermalink":"2013/10/09/michael-levitt-stanford-university-2013-nobel-prize-chemistry/","path":"/news/114340/stanford-biologist-shares-nobel-in-chemistry","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_114341\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/news/2013/10/09/michael-levitt-stanford-university-2013-nobel-prize-chemistry/attachment/183691930/\" rel=\"attachment wp-att-114341\">\u003cimg class=\"size-large wp-image-114341\" src=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/183691930-1024x544.jpg\" alt=\"The three researchers who share the 2013 Nobel Prize in Chemistry. From left: Martin Karplus of Harvard, Michael Levitt of Stanford, and Arieh Warshel of the University of Southern California. (Getty Images)\" width=\"640\" height=\"340\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The three researchers who share the 2013 Nobel Prize in Chemistry. From left: Martin Karplus of Harvard, Michael Levitt of Stanford, and Arieh Warshel of the University of Southern California. (Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>Stanford biologist \u003ca href=\"http://news.stanford.edu/news/2013/october/levitt-nobel-chemistry-100913.html\" target=\"_blank\">Michael Levitt\u003c/a> is one of three scientists to share the Nobel Prize in chemistry for developing powerful, computer-aided tools to model the complex chemical processes at the foundation of life. Levitt's co-winners are \u003ca href=\"http://news.harvard.edu/gazette/story/2013/10/harvard-professor-wins-nobel-in-chemistry/\" target=\"_blank\">Martin Karplus\u003c/a> of the University of Strasbourg in France and Harvard University, and \u003ca href=\"http://chem.usc.edu/faculty/Warshel.html\" target=\"_blank\">Arieh Warshel\u003c/a> of the University of Southern California.\u003c/p>\n\u003caside class=\"pullquote alignleft\">\"I heard a Swedish accent and got very excited. It was like having five double espressos.\"\u003c/aside>\n\u003cp>When the three men started studying chemistry, scientists built models of atoms and molecules with sticks and balls. As you can imagine, that made it cumbersome to portray complex molecules, and nigh impossible to create a model of the light-speed chemical reactions by which cells consume food, say, or drugs battle bacteria.\u003c/p>\n\u003cp>Levitt, Karplus and Warshel won the Nobel prize for figuring out how to model these chemical reactions in cyberspace, at a time when computers still ran on punch cards, and didn't have the power to run the complex calculations needed. In his fascinating blog post, \u003ca href=\"http://www.npr.org/blogs/health/2013/10/09/230645376/nobel-goes-to-scientists-who-took-chemistry-into-cyberspace\" target=\"_blank\">NPR's Michaeleen Doucleff explains\u003c/a> how the work of each man dovetailed precisely with the others, to break open whole new possibilities for scientific research that had previously seemed out of reach.\u003c/p>\n\u003cp>Their work \"led to such practical applications such as the production of human antibodies for modern anticancer therapy and catalysts to clean car exhaust fumes,\" Mercury News reporter \u003ca href=\"http://www.mercurynews.com/science/ci_24271770/stanford-nobel-prize-chemistry-second-2013-levitt\" target=\"_blank\">Lisa M. Krieger explains\u003c/a>.\u003c/p>\n\u003cp>Levitt said \u003ca href=\"http://news.stanford.edu/features/2013/nobel/\" target=\"_blank\">on a Stanford website honoring his award\u003c/a> that he got the news early this morning.\u003c/p>\n\u003cblockquote>\u003cp>\"Like everyone else, one is surprised,\" said Levitt of the early morning call. \"Now I just hope to get through the day and make sure that, in the end, my life doesn't change very much. Because I really have a wonderful life.\u003c/p>\n\u003cp>\"My phone never rings,\" he added. \"Everyone sends me texts and email. So when the phone first rang, I was sure it was a wrong number. When it rang a second time, I picked it up. I immediately heard a Swedish accent and got very excited. It was like having five double espressos.\"\u003c/p>\u003c/blockquote>\n\u003cp>\u003c!--more-->All three of today's winners are immigrants who came to the United States early in their research careers: Levitt is a U.S.-U.K.-Israeli citizen born in South Africa; Karplus is a dual U.S.-Austrian citizen; and Warshel is a dual national of Israel and the United States.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Levitt gave an overview of his research to KQED's Joshua Johnson this morning:\u003c/p>\n\u003cblockquote>\u003cp>It’s research that started in 1967, so it’s research that’s been going on ever since I was 20 years old, so for 46 years. Basically, it tries to simulate the molecules of life. And simulation is now quite common — flight simulators and for bridges. I’m sure the Bay Bridge was simulated to pieces before it was built. So simulation is a very important tool. We started doing simulations on molecules back in the late ‘60s, principally because it had become clear that molecules had very well-defined shapes. They were complicated, they consisted of a thousand spheres, or a thousand atoms, and all these atoms were very precisely arranged.\u003c/p>\n\u003cfigure id=\"attachment_114402\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://scopeblog.stanford.edu/2013/10/09/nobel-winner-michael-levitts-work-animates-biological-processes/\" rel=\"attachment wp-att-114402\">\u003cimg class=\"size-full wp-image-114402 \" src=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/protein-folding.jpg\" alt=\"This Stanford video explains how the work of Levitt and his Nobel colleagues benefits medicine, as researchers observe how protein molecules come together in ways that are healthy, or that promote disease. (Courtesy of Stanford University)\" width=\"300\" height=\"225\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">This Stanford video explains how the work of Levitt and his Nobel colleagues benefits medicine, as researchers observe how protein molecules come together in ways that are healthy, or that promote disease. (Courtesy of Stanford University)\u003c/figcaption>\u003c/figure>\n\u003cp>The molecules are much like the inside of a clock … they were all highly arranged in space. Once things are very arranged in space, you can do very precise calculations. You can simulate how they move, how they will behave under stress and so on. So it becomes a rather mechanical calculation, not exactly the same as simulating a jet airliner or a bridge or a nuclear explosion, but it’s a similar principal where you have a system and \u003ca href=\"http://scopeblog.stanford.edu/2013/10/09/nobel-winner-michael-levitts-work-animates-biological-processes/\" target=\"_blank\">you see how it changes over time.\u003c/a>\u003c/p>\n\u003cp>… This is something which ties in very closely to experiment because the shapes of these molecules were actually determined experimentally by crystallography, and that resulted in many Nobel Prizes--I guess in the early 1960s. Since then, it took a long, long time for people to appreciate that computation had a role to play. For me, the big excitement is to see computational biology honored in this way, because computers have had such a massive impact on everything else we do.\u003c/p>\u003c/blockquote>\n\u003cp>He also said simplicity in models remains crucial even though computer time, once a crushing research expense, has “become cheaper by a factor of 100 million or so.” Levitt said the computational representations of chemical processes he employs now are very similar to those he and his colleagues pioneered in the late ‘60s and early ‘70s.\u003c/p>\n\u003cp>Here's the summary of the trio's groundbreaking work from the Royal Swedish Academy of Sciences, which awards the Nobel in chemistry:\u003c/p>\n\u003cblockquote>\u003cp>Chemical reactions occur at lightning speed. In a fraction of a millisecond, electrons jump from one atomic nucleus to the other. Classical chemistry has a hard time keeping up; it is virtually impossible to experimentally map every little step in a chemical process. Aided by the methods now awarded with the Nobel Prize in Chemistry, scientists let computers unveil chemical processes, such as a catalyst’s purification of exhaust fumes or the photosynthesis in green leaves.\u003c/p>\n\u003cp>The work of Karplus, Levitt and Warshel is groundbreaking in that they managed to make Newton’s classical physics work side by side with the fundamentally different quantum physics. Previously, chemists had to choose to use either or. The strength of classical physics was that calculations were simple and could be used to model really large molecules. Its weakness, it offered no way to simulate chemical reactions. For that purpose, chemists instead had to use quantum physics. But such calculations required enormous computing power and could therefore only be carried out for small molecules.\u003c/p>\n\u003cp>This year’s Nobel Laureates in chemistry took the best from both worlds and devised methods that use both classical and quantum physics. For instance, in simulations of how a drug couples to its target protein in the body, the computer performs quantum theoretical calculations on those atoms in the target protein that interact with the drug. The rest of the large protein is simulated using less demanding classical physics.\u003c/p>\u003c/blockquote>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cem>Joshua Johnson and Kat Snow of KQED News contributed to this report.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/news/114340/stanford-biologist-shares-nobel-in-chemistry","authors":["222"],"programs":["news_6944"],"categories":["news_356"],"tags":["news_4938","news_3332","news_178"],"featImg":"news_114341","label":"news_6944"},"news_114002":{"type":"posts","id":"news_114002","meta":{"index":"posts_1591205157","site":"news","id":"114002","score":null,"sort":[1381155607000]},"guestAuthors":[],"slug":"berkeley-stanford-scientists-share-nobel-prize-for-medicine","title":"Berkeley, Stanford Scientists Share Nobel Prize for Medicine","publishDate":1381155607,"format":"aside","headTitle":"News Fix | KQED News","labelTerm":{"term":6944,"site":"news"},"content":"\u003cfigure id=\"attachment_114025\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/nobel640.jpg\">\u003cimg class=\"size-full wp-image-114025\" src=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/nobel640.jpg\" alt=\"At a press conference at the Karolinska Institute in Stockholm, Goran Hansson, Secretary of the Nobel Committee for Physiology or Medicine, announced James Rothman from Yale, Randy Schekman from UC Berkeley and Thomas Suedhof from Stanford, as joint winners of the 2013 Nobel Prize. Photo: Jonathan Nackstrand/AFP/Getty Images\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">At a press conference at the Karolinska Institute in Stockholm, Goran Hansson, secretary of the Nobel Committee for Physiology or Medicine, announced James Rothman from Yale, Randy Schekman from UC Berkeley and Thomas Südhof from Stanford, as joint winners of the 2013 Nobel Prize.(Jonathan Nackstrand/AFP/Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>Update 10:30 a.m. Monday: \u003c/strong>Two Bay Area scientists are part of a trio of researchers to win the 2013 Nobel Prize for Medicine or Physiology for unraveling how cells move major molecules. Sweden's Karolinska Institute announced the prize early this morning for Randy Schekman of UC Berkeley, \u003ca href=\"http://neuroscience.stanford.edu/research/laboratories/SudhofLab.html\" target=\"_blank\">Thomas Südhof \u003c/a>of Stanford and James Rothman of Yale.\u003c/p>\n\u003cp>In an interview this morning with KQED's Joshua Johnson, Schekman said he planned to use the award as a platform for calling attention to cuts in federal funding for basic scientific research. \"I think the biomedical enterprise in the U.S. is in considerable peril as a result of this federal paralysis,\" he said.\u003c/p>\n\u003cp>Südhof and Schekman were informed of the award in early-morning phone calls. Before we get to that, here's what the Nobel Prize organization says about the research it's honoring today:\u003c/p>\n\u003cblockquote>\u003cp>The 2013 Nobel Prize honours three scientists who have solved the mystery of how the cell organizes its transport system. Each cell is a factory that produces and exports molecules. For instance, insulin is manufactured and released into the blood and chemical signals called neurotransmitters are sent from one nerve cell to another. These molecules are transported around the cell in small packages called vesicles. The three Nobel Laureates have discovered the molecular principles that govern how this cargo is delivered to the right place at the right time in the cell.\u003c/p>\n\u003cp>Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.\u003c/p>\n\u003cp>Through their discoveries, Rothman, Schekman and Südhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo. Disturbances in this system have deleterious effects and contribute to conditions such as neurological diseases, diabetes, and immunological disorders.\u003c/p>\u003c/blockquote>\n\u003cp>Schekman told us he got the call from Nobel officials at 1:30 this morning. When the phone rang, he said, \"My wife called out, 'This is it! This is it!' and I picked it up, and I was kind of shaking. And — but I heard a reassuring, Swedish accent on the other side, offering me congratulations and reassuring me that this was not a hoax call.\"\u003c/p>\n\u003cp>Stanford's \u003ca href=\"http://scopeblog.stanford.edu/2013/10/07/stanfordsthomas-sudhof-wins-2013-nobel-prize-in-medicine/\" target=\"_blank\">Scope science blog says\u003c/a> Südhof got the word while traveling overseas: \"So, where was Südhof when he got the big news? 'I got the call while I was driving [in Spain] and like a good citizen I pulled over and picked up the phone,' he told the Associated Press this morning. 'To be honest, I thought at first it was a joke. I have a lot of friends who might play these kinds of tricks.'\" Südhof, like Schekman, also \u003ca href=\"http://med.stanford.edu/ism/2013/october/nobel-sudhof.html\" target=\"_blank\">expressed surprise\u003c/a>: \"I'm absolutely surprised. Every scientist dreams of this. I didn't realize there was chance I would be awarded the prize. I am stunned and really happy. ...\"\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Lisa Krieger of the San Jose Mercury News \u003ca href=\"http://www.insidebayarea.com/news/ci_24251685/nobel-prizes-this-week-5-breakthroughs-that-have\" target=\"_blank\">points out\u003c/a> that all three of today's winners have Stanford connections: \"Schekman earned his Ph.D. there, and Rothman's early research started on campus labs. Südhof is a current member of the faculty.\"\u003c/p>\n\u003cp>Both Südhof and Schekman are also investigators with the \u003ca href=\"http://www.hhmi.org/\" target=\"_blank\">Howard Hughes Medical Institute\u003c/a>. UC Berkeley now \u003ca href=\"http://www.berkeley.edu/news/features/nobel/\" target=\"_blank\">boasts\u003c/a> 23 Nobel laureates. Stanford is home to \u003ca href=\"http://news.stanford.edu/nobel/\" target=\"_blank\">20 Nobel winners\u003c/a>.\u003c/p>\n\u003cp>Schekman said today that he had let his federal National Institutes of Health funding lapse since beginning work as a Hughes investigator. That means his research is not vulnerable to what he called \"the assault on the federal government and in particular the drastic cutbacks in funding at the level of the NIH.\"\u003c/p>\n\u003cp>Schekman added that the United States is risking the loss of precious intellectual resources by pulling back on research funding.\u003c/p>\n\u003cp>\"We have experience here at Berkeley, other institutions likewise, of foreign scholars who come here to set up shop, who are returning home as a result of what's going on in Washington,\" Schekman said. \"We're losing a generation of young scholars who are unwilling to fight this battle.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Schekman, Südhof and Rothman will split a prize of about $1.2 million.\u003cbr>\n\u003cem>\u003cbr>\n\u003cstrong>\u003ca href=\"http://www.kqed.org/radio/about/staff/joshua-johnson.jsp\" target=\"_blank\">Joshua Johnson\u003c/a> of KQED News contributed to this report. \u003c/strong>\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"Bay Area researchers among a trio who discovered the machinery cells use to transport key molecules. ","status":"publish","parent":0,"modified":1381180882,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":791},"headData":{"title":"Berkeley, Stanford Scientists Share Nobel Prize for Medicine | KQED","description":"Bay Area researchers among a trio who discovered the machinery cells use to transport key molecules. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"NewsArticle","headline":"Berkeley, Stanford Scientists Share Nobel Prize for Medicine","datePublished":"2013-10-07T14:20:07.000Z","dateModified":"2013-10-07T21:21:22.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png","isAccessibleForFree":"Y","publisher":{"@type":"NewsMediaOrganization","@id":"https://www.kqed.org/#organization","name":"KQED","url":"https://www.kqed.org","logo":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}}},"disqusIdentifier":"114002 http://ww2.kqed.org/news/?p=114002","disqusUrl":"https://ww2.kqed.org/news/2013/10/07/berkeley-stanford-scientists-share-nobel-prize-for-medicine/","disqusTitle":"Berkeley, Stanford Scientists Share Nobel Prize for Medicine","path":"/news/114002/berkeley-stanford-scientists-share-nobel-prize-for-medicine","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_114025\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/nobel640.jpg\">\u003cimg class=\"size-full wp-image-114025\" src=\"http://ww2.kqed.org/news/wp-content/uploads/sites/10/2013/10/nobel640.jpg\" alt=\"At a press conference at the Karolinska Institute in Stockholm, Goran Hansson, Secretary of the Nobel Committee for Physiology or Medicine, announced James Rothman from Yale, Randy Schekman from UC Berkeley and Thomas Suedhof from Stanford, as joint winners of the 2013 Nobel Prize. Photo: Jonathan Nackstrand/AFP/Getty Images\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">At a press conference at the Karolinska Institute in Stockholm, Goran Hansson, secretary of the Nobel Committee for Physiology or Medicine, announced James Rothman from Yale, Randy Schekman from UC Berkeley and Thomas Südhof from Stanford, as joint winners of the 2013 Nobel Prize.(Jonathan Nackstrand/AFP/Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>Update 10:30 a.m. Monday: \u003c/strong>Two Bay Area scientists are part of a trio of researchers to win the 2013 Nobel Prize for Medicine or Physiology for unraveling how cells move major molecules. Sweden's Karolinska Institute announced the prize early this morning for Randy Schekman of UC Berkeley, \u003ca href=\"http://neuroscience.stanford.edu/research/laboratories/SudhofLab.html\" target=\"_blank\">Thomas Südhof \u003c/a>of Stanford and James Rothman of Yale.\u003c/p>\n\u003cp>In an interview this morning with KQED's Joshua Johnson, Schekman said he planned to use the award as a platform for calling attention to cuts in federal funding for basic scientific research. \"I think the biomedical enterprise in the U.S. is in considerable peril as a result of this federal paralysis,\" he said.\u003c/p>\n\u003cp>Südhof and Schekman were informed of the award in early-morning phone calls. Before we get to that, here's what the Nobel Prize organization says about the research it's honoring today:\u003c/p>\n\u003cblockquote>\u003cp>The 2013 Nobel Prize honours three scientists who have solved the mystery of how the cell organizes its transport system. Each cell is a factory that produces and exports molecules. For instance, insulin is manufactured and released into the blood and chemical signals called neurotransmitters are sent from one nerve cell to another. These molecules are transported around the cell in small packages called vesicles. The three Nobel Laureates have discovered the molecular principles that govern how this cargo is delivered to the right place at the right time in the cell.\u003c/p>\n\u003cp>Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.\u003c/p>\n\u003cp>Through their discoveries, Rothman, Schekman and Südhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo. Disturbances in this system have deleterious effects and contribute to conditions such as neurological diseases, diabetes, and immunological disorders.\u003c/p>\u003c/blockquote>\n\u003cp>Schekman told us he got the call from Nobel officials at 1:30 this morning. When the phone rang, he said, \"My wife called out, 'This is it! This is it!' and I picked it up, and I was kind of shaking. And — but I heard a reassuring, Swedish accent on the other side, offering me congratulations and reassuring me that this was not a hoax call.\"\u003c/p>\n\u003cp>Stanford's \u003ca href=\"http://scopeblog.stanford.edu/2013/10/07/stanfordsthomas-sudhof-wins-2013-nobel-prize-in-medicine/\" target=\"_blank\">Scope science blog says\u003c/a> Südhof got the word while traveling overseas: \"So, where was Südhof when he got the big news? 'I got the call while I was driving [in Spain] and like a good citizen I pulled over and picked up the phone,' he told the Associated Press this morning. 'To be honest, I thought at first it was a joke. I have a lot of friends who might play these kinds of tricks.'\" Südhof, like Schekman, also \u003ca href=\"http://med.stanford.edu/ism/2013/october/nobel-sudhof.html\" target=\"_blank\">expressed surprise\u003c/a>: \"I'm absolutely surprised. Every scientist dreams of this. I didn't realize there was chance I would be awarded the prize. I am stunned and really happy. ...\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Lisa Krieger of the San Jose Mercury News \u003ca href=\"http://www.insidebayarea.com/news/ci_24251685/nobel-prizes-this-week-5-breakthroughs-that-have\" target=\"_blank\">points out\u003c/a> that all three of today's winners have Stanford connections: \"Schekman earned his Ph.D. there, and Rothman's early research started on campus labs. Südhof is a current member of the faculty.\"\u003c/p>\n\u003cp>Both Südhof and Schekman are also investigators with the \u003ca href=\"http://www.hhmi.org/\" target=\"_blank\">Howard Hughes Medical Institute\u003c/a>. UC Berkeley now \u003ca href=\"http://www.berkeley.edu/news/features/nobel/\" target=\"_blank\">boasts\u003c/a> 23 Nobel laureates. Stanford is home to \u003ca href=\"http://news.stanford.edu/nobel/\" target=\"_blank\">20 Nobel winners\u003c/a>.\u003c/p>\n\u003cp>Schekman said today that he had let his federal National Institutes of Health funding lapse since beginning work as a Hughes investigator. That means his research is not vulnerable to what he called \"the assault on the federal government and in particular the drastic cutbacks in funding at the level of the NIH.\"\u003c/p>\n\u003cp>Schekman added that the United States is risking the loss of precious intellectual resources by pulling back on research funding.\u003c/p>\n\u003cp>\"We have experience here at Berkeley, other institutions likewise, of foreign scholars who come here to set up shop, who are returning home as a result of what's going on in Washington,\" Schekman said. \"We're losing a generation of young scholars who are unwilling to fight this battle.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Schekman, Südhof and Rothman will split a prize of about $1.2 million.\u003cbr>\n\u003cem>\u003cbr>\n\u003cstrong>\u003ca href=\"http://www.kqed.org/radio/about/staff/joshua-johnson.jsp\" target=\"_blank\">Joshua Johnson\u003c/a> of KQED News contributed to this report. \u003c/strong>\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/news/114002/berkeley-stanford-scientists-share-nobel-prize-for-medicine","authors":["222"],"programs":["news_6944"],"categories":["news_356"],"tags":["news_3332","news_4925","news_3187","news_178","news_4926","news_17597"],"featImg":"news_114008","label":"news_6944"},"news_78244":{"type":"posts","id":"news_78244","meta":{"index":"posts_1591205157","site":"news","id":"78244","score":null,"sort":[1350316906000]},"guestAuthors":[],"slug":"a-m-splash-218","title":"A.M. Splash: Stanford Economist Wins Nobel; Chevron Workers Warned of Pipe Weakness; Court to Review Marijuana Classification ","publishDate":1350316906,"format":"aside","headTitle":"News Fix | KQED News","labelTerm":{"term":6944,"site":"news"},"content":"\u003cul>\n\u003cli>\u003ca href=\"http://www.sfgate.com/bayarea/article/Guest-Stanford-prof-wins-economic-Nobel-3949622.php\">Guest Stanford prof wins economic Nobel\u003c/a> (SF Chronicle)\u003cbr>\n\u003cblockquote>\u003cp>A visiting Stanford University professor was awarded the Nobel economics prize Monday for research that helped improve the performance of markets. Alvin Roth, 60, is a professor at Harvard University but is currently a guest scholar at Stanford. He will share the award with Lloyd Shapley, 89, a professor emeritus at UCLA.\n\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.insidebayarea.com/news/ci_21773029/chevron-blaze-linked-fire-2011\"> Chevron blaze linked to fire in 2011\u003c/a> (Contra Costa Times)\u003cbr>\n\u003cblockquote>\u003cp>The suspected cause of the massive fire at the Chevron refinery in August has been linked to a fire there last year, according to state safety inspection documents in which two refinery workers complained the company was ignoring the issue. \"We're afraid something is going to fall through the cracks,\" one worker told Cal/OSHA safety inspector Carla Fritz during her inspection visit to the refinery after the October 2011 fire.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.sfgate.com/bayarea/matier-ross/article/Port-official-blows-4-500-at-strip-club-3948621.php\">Port official blows $4,500 at strip club\u003c/a> (SF Chronicle)\u003cbr>\n\u003cblockquote>\u003cp> A high-ranking Port of Oakland official is in hot water for throwing down $4,500 in public funds for a party at a Houston strip club. Port commissioners met in an emergency closed session late Friday to discuss the case involving Maritime Director James Kwon and his $4,537 bill for a \"drink and dinner reception\" at Treasures, an upscale gentlemen's club where Kwon entertained about a dozen shipping industry executives during a 2008 conference in Houston.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.huffingtonpost.com/2012/10/12/court-marijuana-medical-benefits_n_1961843.html?utm_hp_ref=san-francisco&ir=San%20Francisco\">Court To Review Marijuana's Medical Benefits \u003c/a> (Huffington Post)\u003cbr>\n\u003cblockquote>\u003cp>It started with a coalition of disgruntled Americans, then a handful of governors took up the cause last year, and now -- for the first time in nearly 20 years -- a federal court will hear oral arguments in a lawsuit challenging the classification of cannabis as a dangerous drug without medical benefits. In the case, Americans for Safe Access v. Drug Enforcement Administration, the court will be presented with scientific evidence regarding the medicinal effects of marijuana, and is expected to rule on whether or not the Drug Enforcement Administration acted appropriately in denying a petition to reclassify cannabis, filed by a collection of public interest organizations back in 2002.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.insidebayarea.com/california/ci_21767772/californias-retiring-state-workers-cash-vacation-big-bucks\">California's retiring state workers cash in vacation for big bucks\u003c/a> (Bay Area News Group)\u003cbr>\n\u003cblockquote>\u003cp>They could leave their hearts in San Francisco -- or any of the Golden State's other big vacation spots -- but thousands of California's state workers won't even leave their desks. An analysis of the last three years of government salary data shows state employees are continuing to store up massive banks of vacation, instead of heading to Big Sur or hitting the slopes at Lake Tahoe. They're cashing in by retiring with whopping final paychecks worth, in some cases, more than $500,000 in unused time off.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.insidebayarea.com/breaking-news/ci_21775610/fatal-shooting-east-oakland-is-citys-100th-homicide\">Man fatally shot in Oakland's 100th homicide of year\u003c/a> (Oakland Tribune)\u003cbr>\n\u003cblockquote>\u003cp>A 21-year-old man was fatally shot early Monday in East Oakland, becoming the city's 100th homicide of the year. The man's name was not released pending notification of relatives... It is the fourth time since 2008 that Oakland has recorded at least 100 homicides in a year. Of the 100 so far this year, 96 are considered murders and the other four, including a fatal police shooting, have been determined by the district attorney to be justifiable homicides. Last year there were 110 total homicides in the city, including 92 at this time last year. There were 95 homicides in 2010, 110 in 2009 and 125 in 2008.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.sfexaminer.com/local/2012/10/san-francisco-release-preliminary-ranked-choice-votes-election-night\">San Francisco to release preliminary ranked-choice votes on election night\u003c/a> (SF Examiner)\u003cbr>\n\u003cblockquote>\u003cp>For the first time, preliminary results of ranked-choice voting will be released on Election Night, which should help to calm nerves and lessen suspense. In the past, the Department of Elections would wait days to run the first tabulation of ranked-choice voting, which left many guessing where people’s second- and third-place votes would go in the close races.\u003c/p>\u003c/blockquote>\n\u003c/li>\u003cli>\u003ca href=\"http://www.marinij.com/westmarin/ci_21753293/delicate-fish-species-showing-rebound-west-marin-creeks\"> Delicate fish species showing rebound in West Marin creeks\u003c/a> (Marin Independent Journal)\u003cbr>\n\u003cblockquote>\u003cp>The news is good for two of Marin's sensitive fish populations: Recent counts show the number of young coho salmon in West Marin creeks is higher than average — and there are more young steelhead than had been counted ever before. Marin Municipal Water District biologists spent recent weeks painstakingly capturing and counting juvenile fish in Lagunitas Creek and its two main tributaries, San Geronimo Creek and Devil's Gulch.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.baycitizen.org/education/story/sf-official-sought-limit-special/\">School official targeted special education program to cut costs\u003c/a> (Bay Citizen)\u003cbr>\n\u003cblockquote>\u003cp> A San Francisco Unified School District administrator urged teachers to re-evaluate whether to offer summer school to special education students as a way to cut costs, a move that special education teachers and attorneys say violates federal regulations. Lisa Miller, the district’s head of middle school special education, said in a Jan. 4 email to her staff that the cost of summer school – known as extended school year, or ESY – had become “exorbitant” and instructed all middle school special education staff not to authorize the service without her approval.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\n\u003c/ul>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n","blocks":[],"excerpt":null,"status":"publish","parent":0,"modified":1350318456,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":11,"wordCount":846},"headData":{"title":"A.M. Splash: Stanford Economist Wins Nobel; Chevron Workers Warned of Pipe Weakness; Court to Review Marijuana Classification | KQED","description":"Guest Stanford prof wins economic Nobel (SF Chronicle) A visiting Stanford University professor was awarded the Nobel economics prize Monday for research that helped improve the performance of markets. Alvin Roth, 60, is a professor at Harvard University but is currently a guest scholar at Stanford. He will share the award with Lloyd Shapley, 89,","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"NewsArticle","headline":"A.M. Splash: Stanford Economist Wins Nobel; Chevron Workers Warned of Pipe Weakness; Court to Review Marijuana Classification ","datePublished":"2012-10-15T16:01:46.000Z","dateModified":"2012-10-15T16:27:36.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png","isAccessibleForFree":"Y","publisher":{"@type":"NewsMediaOrganization","@id":"https://www.kqed.org/#organization","name":"KQED","url":"https://www.kqed.org","logo":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}}},"disqusIdentifier":"78244 http://ww2.kqed.org/news/?p=78244","disqusUrl":"https://ww2.kqed.org/news/2012/10/15/a-m-splash-218/","disqusTitle":"A.M. Splash: Stanford Economist Wins Nobel; Chevron Workers Warned of Pipe Weakness; Court to Review Marijuana Classification ","path":"/news/78244/a-m-splash-218","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cul>\n\u003cli>\u003ca href=\"http://www.sfgate.com/bayarea/article/Guest-Stanford-prof-wins-economic-Nobel-3949622.php\">Guest Stanford prof wins economic Nobel\u003c/a> (SF Chronicle)\u003cbr>\n\u003cblockquote>\u003cp>A visiting Stanford University professor was awarded the Nobel economics prize Monday for research that helped improve the performance of markets. Alvin Roth, 60, is a professor at Harvard University but is currently a guest scholar at Stanford. He will share the award with Lloyd Shapley, 89, a professor emeritus at UCLA.\n\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.insidebayarea.com/news/ci_21773029/chevron-blaze-linked-fire-2011\"> Chevron blaze linked to fire in 2011\u003c/a> (Contra Costa Times)\u003cbr>\n\u003cblockquote>\u003cp>The suspected cause of the massive fire at the Chevron refinery in August has been linked to a fire there last year, according to state safety inspection documents in which two refinery workers complained the company was ignoring the issue. \"We're afraid something is going to fall through the cracks,\" one worker told Cal/OSHA safety inspector Carla Fritz during her inspection visit to the refinery after the October 2011 fire.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.sfgate.com/bayarea/matier-ross/article/Port-official-blows-4-500-at-strip-club-3948621.php\">Port official blows $4,500 at strip club\u003c/a> (SF Chronicle)\u003cbr>\n\u003cblockquote>\u003cp> A high-ranking Port of Oakland official is in hot water for throwing down $4,500 in public funds for a party at a Houston strip club. Port commissioners met in an emergency closed session late Friday to discuss the case involving Maritime Director James Kwon and his $4,537 bill for a \"drink and dinner reception\" at Treasures, an upscale gentlemen's club where Kwon entertained about a dozen shipping industry executives during a 2008 conference in Houston.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.huffingtonpost.com/2012/10/12/court-marijuana-medical-benefits_n_1961843.html?utm_hp_ref=san-francisco&ir=San%20Francisco\">Court To Review Marijuana's Medical Benefits \u003c/a> (Huffington Post)\u003cbr>\n\u003cblockquote>\u003cp>It started with a coalition of disgruntled Americans, then a handful of governors took up the cause last year, and now -- for the first time in nearly 20 years -- a federal court will hear oral arguments in a lawsuit challenging the classification of cannabis as a dangerous drug without medical benefits. In the case, Americans for Safe Access v. Drug Enforcement Administration, the court will be presented with scientific evidence regarding the medicinal effects of marijuana, and is expected to rule on whether or not the Drug Enforcement Administration acted appropriately in denying a petition to reclassify cannabis, filed by a collection of public interest organizations back in 2002.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.insidebayarea.com/california/ci_21767772/californias-retiring-state-workers-cash-vacation-big-bucks\">California's retiring state workers cash in vacation for big bucks\u003c/a> (Bay Area News Group)\u003cbr>\n\u003cblockquote>\u003cp>They could leave their hearts in San Francisco -- or any of the Golden State's other big vacation spots -- but thousands of California's state workers won't even leave their desks. An analysis of the last three years of government salary data shows state employees are continuing to store up massive banks of vacation, instead of heading to Big Sur or hitting the slopes at Lake Tahoe. They're cashing in by retiring with whopping final paychecks worth, in some cases, more than $500,000 in unused time off.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.insidebayarea.com/breaking-news/ci_21775610/fatal-shooting-east-oakland-is-citys-100th-homicide\">Man fatally shot in Oakland's 100th homicide of year\u003c/a> (Oakland Tribune)\u003cbr>\n\u003cblockquote>\u003cp>A 21-year-old man was fatally shot early Monday in East Oakland, becoming the city's 100th homicide of the year. The man's name was not released pending notification of relatives... It is the fourth time since 2008 that Oakland has recorded at least 100 homicides in a year. Of the 100 so far this year, 96 are considered murders and the other four, including a fatal police shooting, have been determined by the district attorney to be justifiable homicides. Last year there were 110 total homicides in the city, including 92 at this time last year. There were 95 homicides in 2010, 110 in 2009 and 125 in 2008.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.sfexaminer.com/local/2012/10/san-francisco-release-preliminary-ranked-choice-votes-election-night\">San Francisco to release preliminary ranked-choice votes on election night\u003c/a> (SF Examiner)\u003cbr>\n\u003cblockquote>\u003cp>For the first time, preliminary results of ranked-choice voting will be released on Election Night, which should help to calm nerves and lessen suspense. In the past, the Department of Elections would wait days to run the first tabulation of ranked-choice voting, which left many guessing where people’s second- and third-place votes would go in the close races.\u003c/p>\u003c/blockquote>\n\u003c/li>\u003cli>\u003ca href=\"http://www.marinij.com/westmarin/ci_21753293/delicate-fish-species-showing-rebound-west-marin-creeks\"> Delicate fish species showing rebound in West Marin creeks\u003c/a> (Marin Independent Journal)\u003cbr>\n\u003cblockquote>\u003cp>The news is good for two of Marin's sensitive fish populations: Recent counts show the number of young coho salmon in West Marin creeks is higher than average — and there are more young steelhead than had been counted ever before. Marin Municipal Water District biologists spent recent weeks painstakingly capturing and counting juvenile fish in Lagunitas Creek and its two main tributaries, San Geronimo Creek and Devil's Gulch.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\u003cli>\u003ca href=\"http://www.baycitizen.org/education/story/sf-official-sought-limit-special/\">School official targeted special education program to cut costs\u003c/a> (Bay Citizen)\u003cbr>\n\u003cblockquote>\u003cp> A San Francisco Unified School District administrator urged teachers to re-evaluate whether to offer summer school to special education students as a way to cut costs, a move that special education teachers and attorneys say violates federal regulations. Lisa Miller, the district’s head of middle school special education, said in a Jan. 4 email to her staff that the cost of summer school – known as extended school year, or ESY – had become “exorbitant” and instructed all middle school special education staff not to authorize the service without her approval.\u003c/p>\u003c/blockquote>\n\u003c/li>\n\n\u003c/ul>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/news/78244/a-m-splash-218","authors":["1367"],"programs":["news_6944"],"categories":["news_8"],"tags":["news_424","news_1761","news_3332","news_2045","news_579","news_178"],"label":"news_6944"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. Michel Martin hosts on the weekends.","airtime":"MON-FRI 1pm-2pm, 4:30pm-6:30pm\u003cbr />SAT-SUN 5pm-6pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/All-Things-Considered-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/all-things-considered/","meta":{"site":"news","source":"npr"},"link":"/radio/program/all-things-considered"},"american-suburb-podcast":{"id":"american-suburb-podcast","title":"American Suburb: The Podcast","tagline":"The flip side of gentrification, told through one town","info":"Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Bay-Curious-Podcast-Tile-703x703-1.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/BBC-World-Service-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg","imageAlt":"On Our Watch from NPR and KQED","officialWebsiteLink":"/podcasts/onourwatch","meta":{"site":"news","source":"kqed","order":"1"},"link":"/podcasts/onourwatch","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1567098962","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw","npr":"https://rpb3r.app.goo.gl/onourwatch","spotify":"https://open.spotify.com/show/0OLWoyizopu6tY1XiuX70x","tuneIn":"https://tunein.com/radio/On-Our-Watch-p1436229/","stitcher":"https://www.stitcher.com/show/on-our-watch","rss":"https://feeds.npr.org/510360/podcast.xml"}},"on-the-media":{"id":"on-the-media","title":"On The Media","info":"Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us","airtime":"SUN 2pm-3pm, MON 12am-1am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png","officialWebsiteLink":"https://www.wnycstudios.org/shows/otm","meta":{"site":"news","source":"wnyc"},"link":"/radio/program/on-the-media","subscribe":{"apple":"https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2","tuneIn":"https://tunein.com/radio/On-the-Media-p69/","rss":"http://feeds.wnyc.org/onthemedia"}},"our-body-politic":{"id":"our-body-politic","title":"Our Body Politic","info":"Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.","airtime":"SAT 6pm-7pm, SUN 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://our-body-politic.simplecast.com/","meta":{"site":"news","source":"kcrw"},"link":"/radio/program/our-body-politic","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/our-body-politic/id1533069868","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw","spotify":"https://open.spotify.com/show/4ApAiLT1kV153TttWAmqmc","rss":"https://feeds.simplecast.com/_xaPhs1s","tuneIn":"https://tunein.com/podcasts/News--Politics-Podcasts/Our-Body-Politic-p1369211/"}},"pbs-newshour":{"id":"pbs-newshour","title":"PBS NewsHour","info":"Analysis, background reports and updates from the PBS NewsHour putting today's news in context.","airtime":"MON-FRI 3pm-4pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.pbs.org/newshour/","meta":{"site":"news","source":"pbs"},"link":"/radio/program/pbs-newshour","subscribe":{"apple":"https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2","tuneIn":"https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/","rss":"https://www.pbs.org/newshour/feeds/rss/podcasts/show"}},"perspectives":{"id":"perspectives","title":"Perspectives","tagline":"KQED's series of of daily listener commentaries since 1991","info":"KQED's series of of daily listener commentaries since 1991.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Perspectives-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/perspectives/","meta":{"site":"radio","source":"kqed","order":"15"},"link":"/perspectives","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/id73801135","npr":"https://www.npr.org/podcasts/432309616/perspectives","rss":"https://ww2.kqed.org/perspectives/category/perspectives/feed/","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"}},"planet-money":{"id":"planet-money","title":"Planet Money","info":"The economy explained. 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