A Cure for AIDS: Scientists Say It's 'On the Horizon'
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But in the 35 years since the epidemic began—thanks to sophisticated anti-retrovirals—it’s become a chronic illness that people can live with for decades.\u003c/p>\n\u003cp>Today, on the eve of World AIDS Day, UCSF is scheduled to announce that it's receiving a $20 million grant to find a cure for AIDS over the next five years. It's part of a $100 million effort by the \u003ca href=\"http://www.amfar.org/\" target=\"_blank\">American Foundation for AIDS Research\u003c/a> or amfAR, to fund the most promising research that could lead to curing AIDS.\u003c/p>\n\u003cp>Not long ago this might have sounded unbelievable.\u003c/p>\n\u003cfigure id=\"attachment_65878\" class=\"wp-caption alignleft\" style=\"max-width: 766px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Paul-Volberding_1981-e1447277818233.jpg\">\u003cimg class=\"size-medium wp-image-65878\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Paul-Volberding_1981-766x600.jpg\" alt=\"In 1981 Marcus Conant, MD (left) and Paul Volberding, MD (right) discuss Kaposi's Sarcoma, a disease that became one of the original AIDS-defining illnesses. \" width=\"766\" height=\"600\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">In 1981, Dr. Marcus Conant (left) and Dr. Paul Volberding (right) discuss Kaposi's Sarcoma, which became one of the original AIDS-defining illnesses. \u003ccite>(UCSF)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>“I think it would have felt a lot like a moonshot, maybe five or six years ago,” Volberding says.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>But today, Volberding's lab and others in San Francisco are working for that moonshot: to develop treatments over the next several years that can drive the viral load down low enough that the body's own immune system can control or eliminate it.\u003c/p>\n\u003cp>\"If it can be done anywhere, it can be done here,\" he says. \"It's a really exciting moment.\"\u003c/p>\n\u003cp>\u003cstrong>The Problem With Treatment\u003c/strong>\u003c/p>\n\u003cp>The U.S. Food and Drug Administration \u003ca href=\"http://hab.hrsa.gov/livinghistory/timeline/1987.htm\" target=\"_blank\">approved zidovudine or AZT\u003c/a> in 1987; it was the first antiretroviral medication to treat HIV.\u003c/p>\n\u003cp>By 1996, \u003ca href=\"http://www.cdc.gov/hiv/prevention/research/tap/\" target=\"_blank\">drug \"cocktails\" to treat HIV\u003c/a> became the standard of care for most patients. These highly active anti-retroviral therapies (HAART) helped manage the patient's viral load, maintained function of the immune system and prevented infections that could become fatal.\u003c/p>\n\u003cp>After HAART became widespread, the Centers for Disease Control and Prevention \u003ca href=\"http://www.cdc.gov/nchs/hus/chartbook.htm\" target=\"_blank\">reported a marked reduction in HIV-related deaths\u003c/a>.\u003c/p>\n\u003cp>But these medications have side effects.\u003c/p>\n\u003cp>\"Antiretrovirals are not a panacea,\" says amfAR CEO Kevin Robert Frost, who's based at the organization's headquarters in New York.\u003c/p>\n\u003cfigure id=\"attachment_72312\" class=\"wp-caption alignright\" style=\"max-width: 480px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad.jpg\">\u003cimg class=\"wp-image-72312 size-medium\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756-480x600.jpg\" alt=\"A Kenneth Cole/amfAR ad from 1993 when 234,225 died of AIDS.\" width=\"480\" height=\"600\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756-480x600.jpg 480w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756-400x500.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756.jpg 574w\" sizes=\"(max-width: 480px) 100vw, 480px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A Kenneth Cole/amfAR ad from 1993 when 234,225 people died of AIDS. \u003ccite>(amfAR)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Frost says the drugs have side effects that include chronic inflammation and a range of infections that attack the weakened immune system.\u003c/p>\n\u003cp>That's why amfAR is spending $100 million to find a cure for the \u003ca href=\"http://www.amfar.org/worldwide-aids-stats/\" target=\"_blank\">nearly 37 million people living with HIV\u003c/a> around the world.\u003c/p>\n\u003cp>\"The only real way out of an epidemic like this is through a cure and a vaccine,\" says Frost. \"Because we’re gonna have to cure the people who have it now and we’re gonna have to vaccinate those to prevent them from getting it in the future.\"\u003c/p>\n\u003cp>\u003cstrong>'Shock and Kill' the Virus\u003c/strong>\u003c/p>\n\u003cp>Like many HIV patients, TJ Lee is active and pain-free.\u003c/p>\n\u003cp>\"Once you get on meds and take care of yourself, you can live a very normal life,\" says Lee, who has been HIV-positive for 16 years.\u003c/p>\n\u003cp>The San Francisco resident takes just one pill a day to manage his HIV. As a program manager at the San Francisco AIDS Foundation he works with newly diagnosed people who don't know HIV is no longer a death sentence.\u003c/p>\n\u003cp>\"I had somebody call me about a month ago,\" Lee says. \"He recently found out he had HIV and he thought he was going to die soon.\"\u003c/p>\n\u003cp>For people who have access to treatment, that's not really a concern anymore.\u003c/p>\n\u003cp>However, even people who are free of symptoms can have HIV lying dormant in their body’s T cells for years. The inactive virus could one day become active and reproduce.\u003c/p>\n\u003cp>Eliminating that latent virus is the focus of UCSF's research. With the $20 million amfAR grant, Volberding wants to target these viral cells with a method he calls shock and kill.\u003c/p>\n\u003cp>\u003cem>The Shock and Kill Method of Eliminating the Virus\u003c/em>\u003cbr>\n\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Shock-and-kill_edited1.jpg\">\u003cimg class=\"size-medium wp-image-66472 aligncenter\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Shock-and-kill_edited1-800x230.jpg\" alt=\"Shock and kill_edited\" width=\"800\" height=\"230\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-800x230.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-400x115.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-1180x339.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-960x276.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1.jpg 1592w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003c/a>\u003c/p>\n\u003cp>\"If the virus is dormant, we first need to wake up that cell to start producing the virus, that’s the shock part of it,\" Volberding says. \"And then, once the virus has been activated we want to do something to help the body kill off those cells, to get rid of the virus.\"\u003c/p>\n\u003cp>Researchers have to wake up the virus because when it’s dormant, the infected cell is invisible to the immune system. By shocking it out of latency, scientists can kill the infected cells, and kill the virus as it reproduces.\u003c/p>\n\u003cp>\u003cstrong>Listen to the Story:\u003c/strong>\u003cbr>\nhttp://www.kqed.org/.stream/anon/radio//2015/11/AIDSCure.mp3\u003c/p>\n\u003cp>This method could be \u003cem>an \u003c/em>answer, Frost says, not \u003cem>the\u003c/em> answer. Researchers are working on multiple ways of reducing the body's viral load, including rapid early treatment to abort the infection and gene therapy to engineer cells to make them resistant to infection. Plus, public health efforts aimed at prevention and treatment will continue to be important, especially in places like sub-Saharan Africa, where 28.5 million people are infected with HIV.\u003c/p>\n\u003cp>\"I don’t think we’re gonna wake up one day and see a headline in the newspaper that says 'Cure for AIDS Found,'” Frost says. \"It’s not that kind of a disease, it’s much more complicated than that.\"\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘People who say a cure for AIDS is impossible simply don’t understand the science.’\u003ccite> Kevin Robert Frost,\u003cbr>\namfAR CEO\u003c/cite>\u003c/aside>\n\u003cp>Because HIV mutates so quickly, he adds, a cure is likely to come in stages—sort of like a cancer model where a patient goes into remission.\u003c/p>\n\u003cp>Remission would mean a point where the patient doesn’t need treatment, can’t infect anyone, and doesn't have chronic illnesses.\u003c/p>\n\u003cp>\"We’re likely to start out curing some of the people some of the time, then more of the people more of the time,\" he says, \"and hopefully get to a place where we cure most of the people most of the time, and everybody who needs it has access to it.\"\u003c/p>\n\u003cp>Frost says eliminating the virus will take not one, but a series of scientific breakthroughs, as researchers work on all fronts from latency to gene editing and gene therapy.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\"There are those who said space travel would never happen,\" says Frost. \"People who say a cure for AIDS is impossible simply don’t understand the science. We’re going to find a cure for AIDS; I can tell you that without the slightest hesitation or doubt in my mind.\"\u003c/p>\n\n","blocks":[],"excerpt":"Thirty years since the AIDS epidemic broke out, we're closer than ever to finding a cure. And Bay Area scientists are getting $20 million to help find it.\r\n","status":"publish","parent":0,"modified":1456901661,"stats":{"hasAudio":true,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":38,"wordCount":1141},"headData":{"title":"A Cure for AIDS: Scientists Say It's 'On the Horizon' | KQED","description":"Thirty years since the AIDS epidemic broke out, we're closer than ever to finding a cure. And Bay Area scientists are getting $20 million to help find it.\r\n","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"64080 http://ww2.kqed.org/futureofyou/?p=64080","disqusUrl":"https://ww2.kqed.org/futureofyou/2015/11/30/a-cure-for-aids-scientists-say-its-on-the-horizon/","disqusTitle":"A Cure for AIDS: Scientists Say It's 'On the Horizon'","path":"/futureofyou/64080/a-cure-for-aids-scientists-say-its-on-the-horizon","audioUrl":"http://www.kqed.org/.stream/anon/radio//2015/11/AIDSCure.mp3","audioDuration":null,"audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan style=\"font-size: 4.6875em;float: left;line-height: 0.733em;padding: 0.05em 0.1em 0 0;font-family: times, serif, georgia\">P\u003c/span>aul Volberding is a UCSF oncologist who treated San Francisco's first HIV patients in the early 1980s.\u003c/p>\n\u003cp>\"The patients were, in many cases, blind and demented and had cancer and had infections in their brains causing pressure and headaches,\" says Volberding. \"People now can’t imagine it, it was so bad.\"\u003c/p>\n\u003cp>Volberding says for years, HIV infection was a rapid death sentence. But in the 35 years since the epidemic began—thanks to sophisticated anti-retrovirals—it’s become a chronic illness that people can live with for decades.\u003c/p>\n\u003cp>Today, on the eve of World AIDS Day, UCSF is scheduled to announce that it's receiving a $20 million grant to find a cure for AIDS over the next five years. It's part of a $100 million effort by the \u003ca href=\"http://www.amfar.org/\" target=\"_blank\">American Foundation for AIDS Research\u003c/a> or amfAR, to fund the most promising research that could lead to curing AIDS.\u003c/p>\n\u003cp>Not long ago this might have sounded unbelievable.\u003c/p>\n\u003cfigure id=\"attachment_65878\" class=\"wp-caption alignleft\" style=\"max-width: 766px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Paul-Volberding_1981-e1447277818233.jpg\">\u003cimg class=\"size-medium wp-image-65878\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Paul-Volberding_1981-766x600.jpg\" alt=\"In 1981 Marcus Conant, MD (left) and Paul Volberding, MD (right) discuss Kaposi's Sarcoma, a disease that became one of the original AIDS-defining illnesses. \" width=\"766\" height=\"600\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">In 1981, Dr. Marcus Conant (left) and Dr. Paul Volberding (right) discuss Kaposi's Sarcoma, which became one of the original AIDS-defining illnesses. \u003ccite>(UCSF)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>“I think it would have felt a lot like a moonshot, maybe five or six years ago,” Volberding says.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>But today, Volberding's lab and others in San Francisco are working for that moonshot: to develop treatments over the next several years that can drive the viral load down low enough that the body's own immune system can control or eliminate it.\u003c/p>\n\u003cp>\"If it can be done anywhere, it can be done here,\" he says. \"It's a really exciting moment.\"\u003c/p>\n\u003cp>\u003cstrong>The Problem With Treatment\u003c/strong>\u003c/p>\n\u003cp>The U.S. Food and Drug Administration \u003ca href=\"http://hab.hrsa.gov/livinghistory/timeline/1987.htm\" target=\"_blank\">approved zidovudine or AZT\u003c/a> in 1987; it was the first antiretroviral medication to treat HIV.\u003c/p>\n\u003cp>By 1996, \u003ca href=\"http://www.cdc.gov/hiv/prevention/research/tap/\" target=\"_blank\">drug \"cocktails\" to treat HIV\u003c/a> became the standard of care for most patients. These highly active anti-retroviral therapies (HAART) helped manage the patient's viral load, maintained function of the immune system and prevented infections that could become fatal.\u003c/p>\n\u003cp>After HAART became widespread, the Centers for Disease Control and Prevention \u003ca href=\"http://www.cdc.gov/nchs/hus/chartbook.htm\" target=\"_blank\">reported a marked reduction in HIV-related deaths\u003c/a>.\u003c/p>\n\u003cp>But these medications have side effects.\u003c/p>\n\u003cp>\"Antiretrovirals are not a panacea,\" says amfAR CEO Kevin Robert Frost, who's based at the organization's headquarters in New York.\u003c/p>\n\u003cfigure id=\"attachment_72312\" class=\"wp-caption alignright\" style=\"max-width: 480px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad.jpg\">\u003cimg class=\"wp-image-72312 size-medium\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756-480x600.jpg\" alt=\"A Kenneth Cole/amfAR ad from 1993 when 234,225 died of AIDS.\" width=\"480\" height=\"600\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756-480x600.jpg 480w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756-400x500.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Kenneth-Cole_AIDS_ad-e1448386139756.jpg 574w\" sizes=\"(max-width: 480px) 100vw, 480px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A Kenneth Cole/amfAR ad from 1993 when 234,225 people died of AIDS. \u003ccite>(amfAR)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Frost says the drugs have side effects that include chronic inflammation and a range of infections that attack the weakened immune system.\u003c/p>\n\u003cp>That's why amfAR is spending $100 million to find a cure for the \u003ca href=\"http://www.amfar.org/worldwide-aids-stats/\" target=\"_blank\">nearly 37 million people living with HIV\u003c/a> around the world.\u003c/p>\n\u003cp>\"The only real way out of an epidemic like this is through a cure and a vaccine,\" says Frost. \"Because we’re gonna have to cure the people who have it now and we’re gonna have to vaccinate those to prevent them from getting it in the future.\"\u003c/p>\n\u003cp>\u003cstrong>'Shock and Kill' the Virus\u003c/strong>\u003c/p>\n\u003cp>Like many HIV patients, TJ Lee is active and pain-free.\u003c/p>\n\u003cp>\"Once you get on meds and take care of yourself, you can live a very normal life,\" says Lee, who has been HIV-positive for 16 years.\u003c/p>\n\u003cp>The San Francisco resident takes just one pill a day to manage his HIV. As a program manager at the San Francisco AIDS Foundation he works with newly diagnosed people who don't know HIV is no longer a death sentence.\u003c/p>\n\u003cp>\"I had somebody call me about a month ago,\" Lee says. \"He recently found out he had HIV and he thought he was going to die soon.\"\u003c/p>\n\u003cp>For people who have access to treatment, that's not really a concern anymore.\u003c/p>\n\u003cp>However, even people who are free of symptoms can have HIV lying dormant in their body’s T cells for years. The inactive virus could one day become active and reproduce.\u003c/p>\n\u003cp>Eliminating that latent virus is the focus of UCSF's research. With the $20 million amfAR grant, Volberding wants to target these viral cells with a method he calls shock and kill.\u003c/p>\n\u003cp>\u003cem>The Shock and Kill Method of Eliminating the Virus\u003c/em>\u003cbr>\n\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Shock-and-kill_edited1.jpg\">\u003cimg class=\"size-medium wp-image-66472 aligncenter\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/11/Shock-and-kill_edited1-800x230.jpg\" alt=\"Shock and kill_edited\" width=\"800\" height=\"230\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-800x230.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-400x115.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-1180x339.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1-960x276.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2015/11/Shock-and-kill_edited1.jpg 1592w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003c/a>\u003c/p>\n\u003cp>\"If the virus is dormant, we first need to wake up that cell to start producing the virus, that’s the shock part of it,\" Volberding says. \"And then, once the virus has been activated we want to do something to help the body kill off those cells, to get rid of the virus.\"\u003c/p>\n\u003cp>Researchers have to wake up the virus because when it’s dormant, the infected cell is invisible to the immune system. By shocking it out of latency, scientists can kill the infected cells, and kill the virus as it reproduces.\u003c/p>\n\u003cp>\u003cstrong>Listen to the Story:\u003c/strong>\u003cbr>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"audioLink","attributes":{"named":{"src":"http://www.kqed.org/.stream/anon/radio//2015/11/AIDSCure.mp3"},"numeric":[]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>This method could be \u003cem>an \u003c/em>answer, Frost says, not \u003cem>the\u003c/em> answer. Researchers are working on multiple ways of reducing the body's viral load, including rapid early treatment to abort the infection and gene therapy to engineer cells to make them resistant to infection. Plus, public health efforts aimed at prevention and treatment will continue to be important, especially in places like sub-Saharan Africa, where 28.5 million people are infected with HIV.\u003c/p>\n\u003cp>\"I don’t think we’re gonna wake up one day and see a headline in the newspaper that says 'Cure for AIDS Found,'” Frost says. \"It’s not that kind of a disease, it’s much more complicated than that.\"\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘People who say a cure for AIDS is impossible simply don’t understand the science.’\u003ccite> Kevin Robert Frost,\u003cbr>\namfAR CEO\u003c/cite>\u003c/aside>\n\u003cp>Because HIV mutates so quickly, he adds, a cure is likely to come in stages—sort of like a cancer model where a patient goes into remission.\u003c/p>\n\u003cp>Remission would mean a point where the patient doesn’t need treatment, can’t infect anyone, and doesn't have chronic illnesses.\u003c/p>\n\u003cp>\"We’re likely to start out curing some of the people some of the time, then more of the people more of the time,\" he says, \"and hopefully get to a place where we cure most of the people most of the time, and everybody who needs it has access to it.\"\u003c/p>\n\u003cp>Frost says eliminating the virus will take not one, but a series of scientific breakthroughs, as researchers work on all fronts from latency to gene editing and gene therapy.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"There are those who said space travel would never happen,\" says Frost. \"People who say a cure for AIDS is impossible simply don’t understand the science. We’re going to find a cure for AIDS; I can tell you that without the slightest hesitation or doubt in my mind.\"\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/64080/a-cure-for-aids-scientists-say-its-on-the-horizon","authors":["5432"],"categories":["futureofyou_1","futureofyou_73"],"tags":["futureofyou_650","futureofyou_669","futureofyou_80","futureofyou_113"],"featImg":"futureofyou_66445","label":"futureofyou"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2023/08/possible-5gxfizEbKOJ-pbF5ASgxrs_.1400x1400.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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But is this once sleepy suburb ready for them?","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/powerpress/1440_0018_AmericanSuburb_iTunesTile_01.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/powerpress/1440_0017_BayCurious_iTunesTile_01.jpg","imageAlt":"\"KQED Bay Curious","officialWebsiteLink":"/news/series/baycurious","meta":{"site":"news","source":"kqed","order":"4"},"link":"/podcasts/baycurious","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/bay-curious/id1172473406","npr":"https://www.npr.org/podcasts/500557090/bay-curious","rss":"https://ww2.kqed.org/news/category/bay-curious-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvbmV3cy9jYXRlZ29yeS9iYXktY3VyaW91cy1wb2RjYXN0L2ZlZWQvcG9kY2FzdA","stitcher":"https://www.stitcher.com/podcast/kqed/bay-curious","spotify":"https://open.spotify.com/show/6O76IdmhixfijmhTZLIJ8k"}},"bbc-world-service":{"id":"bbc-world-service","title":"BBC World Service","info":"The day's top stories from BBC News compiled twice daily in the week, once at weekends.","airtime":"MON-FRI 9pm-10pm, TUE-FRI 1am-2am","imageSrc":"https://ww2.kqed.org/app/uploads/2021/10/BBC_1400.jpg","officialWebsiteLink":"https://www.bbc.co.uk/sounds/play/live:bbc_world_service","meta":{"site":"news","source":"BBC World Service"},"link":"/radio/program/bbc-world-service","subscribe":{"apple":"https://itunes.apple.com/us/podcast/global-news-podcast/id135067274?mt=2","tuneIn":"https://tunein.com/radio/BBC-World-Service-p455581/","rss":"https://podcasts.files.bbci.co.uk/p02nq0gn.rss"}},"code-switch-life-kit":{"id":"code-switch-life-kit","title":"Code Switch / Life Kit","info":"\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2021/12/CodeSwitchLifeKit_StationGraphics_300x300EmailGraphic.png","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. 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